P62899 (RL31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L31

Gene names

Name:

RPL31

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L31e family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ASF1B	Q9NVP2	1	EBI-1053664,EBI-1055650
CNBP	P62633	1	EBI-1053664,EBI-1047529
DDX56	Q9NY93	1	EBI-1053664,EBI-372376
LYAR	Q9NX58	1	EBI-1053664,EBI-713507
MAGEB2	O15479	1	EBI-1053664,EBI-1057615
PINX1	Q96BK5	1	EBI-1053664,EBI-721782
PSTPIP1	O43586	1	EBI-1053664,EBI-1050964
WBP5	Q9UHQ7	1	EBI-1053664,EBI-1051372
YWHAZ	P63104	1	EBI-1053664,EBI-347088

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P62899-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P62899-2)

The sequence of this isoform differs from the canonical sequence as follows:
     116-125: NLQTVNVDEN → ISVLNSVTVAKSP

Note: No experimental confirmation available.

Isoform 3 (identifier: P62899-3)

The sequence of this isoform differs from the canonical sequence as follows:
     116-125: NLQTVNVDEN → SKFSIP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	60S ribosomal protein L31		PRO_0000153763
Amino acid modifications
	Modified residue	75	1	N6-acetyllysine Ref.12
	Modified residue	98	1	Phosphoserine Ref.9 Ref.10 Ref.14
Natural variations
	Alternative sequence	116 – 125	10	NLQTVNVDEN → ISVLNSVTVAKSP in isoform 2.		VSP_042572
	Alternative sequence	116 – 125	10	NLQTVNVDEN → SKFSIP in isoform 3.		VSP_043224

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: BA9DBE79B9E1C071	FASTA	125	14,463
	10 20 30 40 50 60 MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 70 80 90 100 110 120 DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKNLQTV NVDEN
	Isoform 2 [UniParc]. Checksum: 73178D90B1AE79A8	FASTA	128	14,632
	10 20 30 40 50 60 MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 70 80 90 100 110 120 DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKISVLN SVTVAKSP
	Isoform 3 [UniParc]. Checksum: BAD3547E9019CF61	FASTA	121	13,995
	10 20 30 40 50 60 MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 70 80 90 100 110 120 DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKSKFSI P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA sequence of human ribosomal protein L31." Nobori T., Hexdall L.E., Carson D.A. Nucleic Acids Res. 17:7105-7105(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Liver and Prostate.
[7]	"Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours." Chester K.A., Robson L., Beyent R.H.J., Talbot I.C., Pringle J.H., Primrose L., Macpherson A.J.S., Boxer G., Southhall P., Malcolm A.D.B. Biochim. Biophys. Acta 1009:297-300(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-125 (ISOFORM 1).
[8]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-75, MASS SPECTROMETRY.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15940 mRNA. Translation: CAA34066.1. AB061830 Genomic DNA. Translation: BAB79468.1. AK297483 mRNA. Translation: BAH12588.1. AC016738 Genomic DNA. Translation: AAY14823.1. CH471127 Genomic DNA. Translation: EAX01826.1. CH471127 Genomic DNA. Translation: EAX01827.1. CH471127 Genomic DNA. Translation: EAX01829.1. BC017343 mRNA. Translation: AAH17343.1. BC070210 mRNA. Translation: AAH70210.1. BC070373 mRNA. Translation: AAH70373.1. X69181 mRNA. Translation: CAA48925.1.
IPI	IPI00026302. IPI00848331. IPI00856058.
PIR	R5HU31. S05576.
RefSeq	NP_000984.1. NM_000993.4. NP_001092047.1. NM_001098577.2. NP_001093163.1. NM_001099693.1.
UniGene	Hs.469473.
3D structure databases
ProteinModelPortal	P62899.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62899. 17 interactions.
MINT	MINT-5000327.
STRING	9606.ENSP00000386717.
PTM databases
PhosphoSite	P62899.
Polymorphism databases
DMDM	51702807.
2D gel databases
SWISS-2DPAGE	P62899.
Proteomic databases
PaxDb	P62899.
PRIDE	P62899.
Protocols and materials databases
DNASU	6160.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264258; ENSP00000264258; ENSG00000071082. ENST00000409028; ENSP00000386717; ENSG00000071082. ENST00000409320; ENSP00000387163; ENSG00000071082. ENST00000409733; ENSP00000386681; ENSG00000071082.
GeneID	6160.
KEGG	hsa:6160.
UCSC	uc002taq.4. human.
Organism-specific databases
CTD	6160.
GeneCards	GC02P101618.
H-InvDB	HIX0017577.
HGNC	HGNC:10334. RPL31.
neXtProt	NX_P62899.
PharmGKB	PA34715.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2097.
HOGENOM	HOG000216660.
HOVERGEN	HBG001549.
KO	K02910.
OMA	TNDVRID.
OrthoDB	EOG4R5047.
PhylomeDB	P62899.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62899.
Bgee	P62899.
CleanEx	HS_RPL31.
Genevestigator	P62899.
GermOnline	ENSG00000071082. Homo sapiens.
Family and domain databases
Gene3D	3.10.440.10. 1 hit.
InterPro	IPR000054. Ribosomal_L31e. IPR020052. Ribosomal_L31e_CS. IPR023621. Ribosomal_L31e_dom. [Graphical view]
PANTHER	PTHR10956. PTHR10956. 1 hit.
Pfam	PF01198. Ribosomal_L31e. 1 hit. [Graphical view]
ProDom	PD006030. Ribosomal_L31e. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54575. Ribosomal_L31e. 1 hit.
PROSITE	PS01144. RIBOSOMAL_L31E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL31. human.
GenomeRNAi	6160.
NextBio	23923.

Entry information

Entry name

RL31_HUMAN

Accession

Primary (citable) accession number: P62899
Secondary accession number(s): B7Z4K2 , D3DVJ4, P12947, Q53SQ5, Q6IRZ0, Q6LBJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.