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Protein

Cytochrome c, somatic

Gene

Cycs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Heme (covalent)1
Binding sitei18Heme (covalent)1
Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

GO - Molecular functioni

  • electron transfer activity Source: InterPro
  • enzyme binding Source: RGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • apoptotic process Source: RGD
  • glial cell apoptotic process Source: RGD
  • mitochondrial electron transport, cytochrome c to oxygen Source: RGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
  • negative regulation of hydrogen peroxide biosynthetic process Source: RGD
  • positive regulation of cellular respiration Source: RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  • response to carbon monoxide Source: RGD
  • response to copper ion Source: RGD
  • response to gravity Source: RGD
  • response to ischemia Source: RGD
  • response to oxidative stress Source: RGD

Keywordsi

Biological processApoptosis, Electron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c, somatic
Gene namesi
Name:Cycs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2451 Cycs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082312 – 105Cytochrome c, somaticAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei49PhosphotyrosineBy similarity1
Modified residuei56N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysine; alternateBy similarity1
Modified residuei73N6-succinyllysine; alternateBy similarity1
Modified residuei98PhosphotyrosineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62898
PRIDEiP62898

PTM databases

CarbonylDBiP62898
iPTMnetiP62898
PhosphoSitePlusiP62898
SwissPalmiP62898

Expressioni

Tissue specificityi

Found in embryos and in adult liver and heart.

Gene expression databases

BgeeiENSRNOG00000010452
GenevisibleiP62898 RN

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

BioGridi247348, 2 interactors
MINTiP62898
STRINGi10116.ENSRNOP00000041521

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Turni15 – 18Combined sources4
Helixi51 – 55Combined sources5
Helixi62 – 70Combined sources9
Helixi72 – 75Combined sources4
Helixi89 – 102Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C0ZX-ray1.12A/B/C/D1-105[»]
5C9MX-ray1.36A/B/C/D1-105[»]
5DF5X-ray1.30A/B/C/D2-105[»]
ProteinModelPortaliP62898
SMRiP62898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453 Eukaryota
COG3474 LUCA
GeneTreeiENSGT00390000009405
HOGENOMiHOG000009762
HOVERGENiHBG003023
InParanoidiP62898
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG091G0UQY
PhylomeDBiP62898
TreeFamiTF300226

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAAGFSYT
60 70 80 90 100
DANKNKGITW GEDTLMEYLE NPKKYIPGTK MIFAGIKKKG ERADLIAYLK

KATNE
Length:105
Mass (Da):11,605
Last modified:January 23, 2007 - v2
Checksum:iB5BCA779BCE40492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00750 Genomic DNA Translation: AAA21711.1
M20622 mRNA Translation: AAA41014.1
BC081849 mRNA Translation: AAH81849.1
BC089051 mRNA Translation: AAH89051.1
PIRiA04605 CCRT
RefSeqiNP_036971.1, NM_012839.2
XP_003751847.1, XM_003751799.4
XP_003753106.1, XM_003753058.4
UniGeneiRn.161841
Rn.2202
Rn.93426

Genome annotation databases

EnsembliENSRNOT00000014058; ENSRNOP00000014058; ENSRNOG00000010452
ENSRNOT00000048429; ENSRNOP00000041521; ENSRNOG00000032885
GeneIDi100363502
25309
KEGGirno:100363502
rno:25309
UCSCiRGD:2451 rat

Similar proteinsi

Entry informationi

Entry nameiCYC_RAT
AccessioniPrimary (citable) accession number: P62898
Secondary accession number(s): P00009, Q8C2S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

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