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Protein

Cytochrome c, somatic

Gene

Cycs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.1 Publication
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Heme (covalent)1
Binding sitei18Heme (covalent)1
Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-111457. Release of apoptotic factors from the mitochondria.
R-MMU-111458. Formation of apoptosome.
R-MMU-111459. Activation of caspases through apoptosome-mediated cleavage.
R-MMU-2151201. Transcriptional activation of mitochondrial biogenesis.
R-MMU-3299685. Detoxification of Reactive Oxygen Species.
R-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c, somatic
Gene namesi
Name:Cycs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 19, Chromosome 6

Organism-specific databases

MGIiMGI:88578. Cycs.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • mitochondrial intermembrane space Source: GO_Central
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
  • nucleus Source: MGI
  • respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082252 – 105Cytochrome c, somaticAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei49PhosphotyrosineBy similarity1
Modified residuei56N6-succinyllysineCombined sources1
Modified residuei73N6-acetyllysine; alternateCombined sources1
Modified residuei73N6-succinyllysine; alternateCombined sources1
Modified residuei98PhosphotyrosineBy similarity1
Modified residuei100N6-acetyllysineCombined sources1

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62897.
PaxDbiP62897.
PRIDEiP62897.

PTM databases

iPTMnetiP62897.
PhosphoSitePlusiP62897.
SwissPalmiP62897.

Expressioni

Tissue specificityi

Found in embryos and in adult liver and heart.

Gene expression databases

BgeeiENSMUSG00000058927.
CleanExiMM_CYCS.
ExpressionAtlasiP62897. baseline and differential.
GenevisibleiP62897. MM.

Interactioni

Protein-protein interaction databases

BioGridi198992. 3 interactors.
IntActiP62897. 6 interactors.
MINTiMINT-1860070.
STRINGi10090.ENSMUSP00000124523.

Structurei

3D structure databases

ProteinModelPortaliP62897.
SMRiP62897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62897.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG091G0UQY.
PhylomeDBiP62897.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAAGFSYT
60 70 80 90 100
DANKNKGITW GEDTLMEYLE NPKKYIPGTK MIFAGIKKKG ERADLIAYLK

KATNE
Length:105
Mass (Da):11,605
Last modified:January 23, 2007 - v2
Checksum:iB5BCA779BCE40492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01756 Genomic DNA. Translation: CAA25899.1.
AK088098 mRNA. Translation: BAC40143.1.
BC034363 mRNA. Translation: AAH34363.1.
CCDSiCCDS20131.1.
PIRiA23057. CCMS.
RefSeqiNP_031834.1. NM_007808.4.
UniGeneiMm.35389.

Genome annotation databases

EnsembliENSMUST00000073080; ENSMUSP00000072829; ENSMUSG00000058927.
ENSMUST00000161401; ENSMUSP00000124523; ENSMUSG00000063694.
GeneIDi13063.
KEGGimmu:13063.
UCSCiuc009bxc.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01756 Genomic DNA. Translation: CAA25899.1.
AK088098 mRNA. Translation: BAC40143.1.
BC034363 mRNA. Translation: AAH34363.1.
CCDSiCCDS20131.1.
PIRiA23057. CCMS.
RefSeqiNP_031834.1. NM_007808.4.
UniGeneiMm.35389.

3D structure databases

ProteinModelPortaliP62897.
SMRiP62897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198992. 3 interactors.
IntActiP62897. 6 interactors.
MINTiMINT-1860070.
STRINGi10090.ENSMUSP00000124523.

PTM databases

iPTMnetiP62897.
PhosphoSitePlusiP62897.
SwissPalmiP62897.

Proteomic databases

EPDiP62897.
PaxDbiP62897.
PRIDEiP62897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073080; ENSMUSP00000072829; ENSMUSG00000058927.
ENSMUST00000161401; ENSMUSP00000124523; ENSMUSG00000063694.
GeneIDi13063.
KEGGimmu:13063.
UCSCiuc009bxc.1. mouse.

Organism-specific databases

CTDi54205.
MGIiMGI:88578. Cycs.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62897.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG091G0UQY.
PhylomeDBiP62897.
TreeFamiTF300226.

Enzyme and pathway databases

ReactomeiR-MMU-111457. Release of apoptotic factors from the mitochondria.
R-MMU-111458. Formation of apoptosome.
R-MMU-111459. Activation of caspases through apoptosome-mediated cleavage.
R-MMU-2151201. Transcriptional activation of mitochondrial biogenesis.
R-MMU-3299685. Detoxification of Reactive Oxygen Species.
R-MMU-611105. Respiratory electron transport.

Miscellaneous databases

PROiP62897.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058927.
CleanExiMM_CYCS.
ExpressionAtlasiP62897. baseline and differential.
GenevisibleiP62897. MM.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_MOUSE
AccessioniPrimary (citable) accession number: P62897
Secondary accession number(s): P00009, Q8C2S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.