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P62896 (CYC_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
Gene names
Name:CYCS
Synonyms:CYC
OrganismOvis aries (Sheep) [Reference proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration By similarity.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 105104Cytochrome c
PRO_0000108234

Sites

Metal binding191Iron (heme axial ligand) By similarity
Metal binding811Iron (heme axial ligand) By similarity
Binding site151Heme (covalent) By similarity
Binding site181Heme (covalent) By similarity

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue491Phosphotyrosine By similarity
Modified residue981Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62896 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AF0CA628EDF40483

FASTA10511,704
        10         20         30         40         50         60 
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGFSYT DANKNKGITW 

        70         80         90        100 
GEETLMEYLE NPKKYIPGTK MIFAGIKKKG EREDLIAYLK KATNE 

« Hide

References

[1]"Evolution of cytochrome c."
Smith E.L., Margoliash E.
Fed. Proc. 23:1243-1247(1964) [PubMed] [Europe PMC] [Abstract]
Cited for: AMINO-ACID COMPOSITION, MOBILITIES OF TRYPTIC AND CHYMOTRYPTIC PEPTIDES.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

PIRCCSH. A91454.
RefSeqXP_004007999.1. XM_004007950.1.

3D structure databases

ProteinModelPortalP62896.
SMRP62896. Positions 2-105.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP62896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOART00000027071; ENSOARP00000022795; ENSOARG00000025169.
GeneID101107954.

Phylogenomic databases

GeneTreeENSGT00390000009405.
HOVERGENHBG003023.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYC_SHEEP
AccessionPrimary (citable) accession number: P62896
Secondary accession number(s): P00006
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries