Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c

Gene

CYCS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)
Binding sitei18 – 181Heme (covalent)
Metal bindingi19 – 191Iron (heme axial ligand)
Metal bindingi81 – 811Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-111457. Release of apoptotic factors from the mitochondria.
R-SSC-111458. Formation of apoptosome.
R-SSC-111459. Activation of caspases through apoptosome-mediated cleavage.
R-SSC-2151201. Transcriptional activation of mitochondrial biogenesis.
R-SSC-3299685. Detoxification of Reactive Oxygen Species.
R-SSC-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYCS
Synonyms:CYC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity1 Publication
Chaini2 – 105104Cytochrome cPRO_0000108228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei49 – 491PhosphotyrosineBy similarity
Modified residuei56 – 561N6-succinyllysineBy similarity
Modified residuei73 – 731N6-acetyllysine; alternateBy similarity
Modified residuei73 – 731N6-succinyllysine; alternateBy similarity
Modified residuei98 – 981PhosphotyrosineBy similarity
Modified residuei100 – 1001N6-acetyllysineBy similarity

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62895.
PeptideAtlasiP62895.
PRIDEiP62895.

PTM databases

iPTMnetiP62895.

Expressioni

Gene expression databases

BgeeiENSSSCG00000016714.
GenevisibleiP62895. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017704.

Structurei

3D structure databases

ProteinModelPortaliP62895.
SMRiP62895. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62895.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKNKGITW GEETLMEYLE NPKKYIPGTK MIFAGIKKKG EREDLIAYLK

KATNE
Length:105
Mass (Da):11,704
Last modified:January 23, 2007 - v2
Checksum:iAF0CA628EDF40483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864613 mRNA. Translation: AAX77008.1.
PIRiA00007. CCPG.
RefSeqiNP_001123442.1. NM_001129970.1.
UniGeneiSsc.50553.

Genome annotation databases

EnsembliENSSSCT00000018195; ENSSSCP00000017704; ENSSSCG00000016714.
GeneIDi100170131.
KEGGissc:100170131.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864613 mRNA. Translation: AAX77008.1.
PIRiA00007. CCPG.
RefSeqiNP_001123442.1. NM_001129970.1.
UniGeneiSsc.50553.

3D structure databases

ProteinModelPortaliP62895.
SMRiP62895. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017704.

PTM databases

iPTMnetiP62895.

Proteomic databases

PaxDbiP62895.
PeptideAtlasiP62895.
PRIDEiP62895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018195; ENSSSCP00000017704; ENSSSCG00000016714.
GeneIDi100170131.
KEGGissc:100170131.

Organism-specific databases

CTDi54205.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62895.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Enzyme and pathway databases

ReactomeiR-SSC-111457. Release of apoptotic factors from the mitochondria.
R-SSC-111458. Formation of apoptosome.
R-SSC-111459. Activation of caspases through apoptosome-mediated cleavage.
R-SSC-2151201. Transcriptional activation of mitochondrial biogenesis.
R-SSC-3299685. Detoxification of Reactive Oxygen Species.
R-SSC-611105. Respiratory electron transport.

Gene expression databases

BgeeiENSSSCG00000016714.
GenevisibleiP62895. SS.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_PIG
AccessioniPrimary (citable) accession number: P62895
Secondary accession number(s): P00006, Q56P24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.