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Protein

Cytochrome c

Gene

CYCS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Heme (covalent)1
Binding sitei18Heme (covalent)1
Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-111457. Release of apoptotic factors from the mitochondria.
R-BTA-111458. Formation of apoptosome.
R-BTA-111459. Activation of caspases through apoptosome-mediated cleavage.
R-BTA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-BTA-3299685. Detoxification of Reactive Oxygen Species.
R-BTA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYCS
Synonyms:CYC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 11, Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3396942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082092 – 105Cytochrome cAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei49Phosphotyrosine1 Publication1
Modified residuei56N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysine; alternateBy similarity1
Modified residuei73N6-succinyllysine; alternateBy similarity1
Modified residuei98Phosphotyrosine1 Publication1
Modified residuei100N6-acetyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62894.
PeptideAtlasiP62894.
PRIDEiP62894.

PTM databases

iPTMnetiP62894.

Expressioni

Gene expression databases

BgeeiENSBTAG00000022613.

Interactioni

Protein-protein interaction databases

DIPiDIP-58978N.
IntActiP62894. 1 interactor.
STRINGi9913.ENSBTAP00000051780.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Turni15 – 18Combined sources4
Helixi51 – 55Combined sources5
Helixi62 – 68Combined sources7
Helixi72 – 75Combined sources4
Helixi89 – 102Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B4ZX-ray1.50A2-105[»]
2YBBelectron microscopy19.00Y2-105[»]
3J2Telectron microscopy9.50H/I/J/K/L/M/N2-105[»]
5JUYelectron microscopy4.10H/I/J/K/L/M/N2-105[»]
ProteinModelPortaliP62894.
SMRiP62894.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62894.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62894.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKNKGITW GEETLMEYLE NPKKYIPGTK MIFAGIKKKG EREDLIAYLK

KATNE
Length:105
Mass (Da):11,704
Last modified:January 23, 2007 - v2
Checksum:iAF0CA628EDF40483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105397 mRNA. Translation: AAI05398.1.
PIRiA92022. CCBO.
RefSeqiNP_001039526.1. NM_001046061.2.
XP_005194076.1. XM_005194019.3.
XP_010802623.1. XM_010804321.2.
XP_010808799.1. XM_010810497.2.
UniGeneiBt.23981.

Genome annotation databases

EnsembliENSBTAT00000004594; ENSBTAP00000051780; ENSBTAG00000023823.
ENSBTAT00000007918; ENSBTAP00000007918; ENSBTAG00000022613.
GeneIDi100847700.
510767.
KEGGibta:100847700.
bta:510767.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105397 mRNA. Translation: AAI05398.1.
PIRiA92022. CCBO.
RefSeqiNP_001039526.1. NM_001046061.2.
XP_005194076.1. XM_005194019.3.
XP_010802623.1. XM_010804321.2.
XP_010808799.1. XM_010810497.2.
UniGeneiBt.23981.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B4ZX-ray1.50A2-105[»]
2YBBelectron microscopy19.00Y2-105[»]
3J2Telectron microscopy9.50H/I/J/K/L/M/N2-105[»]
5JUYelectron microscopy4.10H/I/J/K/L/M/N2-105[»]
ProteinModelPortaliP62894.
SMRiP62894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58978N.
IntActiP62894. 1 interactor.
STRINGi9913.ENSBTAP00000051780.

Chemistry databases

ChEMBLiCHEMBL3396942.

PTM databases

iPTMnetiP62894.

Proteomic databases

PaxDbiP62894.
PeptideAtlasiP62894.
PRIDEiP62894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004594; ENSBTAP00000051780; ENSBTAG00000023823.
ENSBTAT00000007918; ENSBTAP00000007918; ENSBTAG00000022613.
GeneIDi100847700.
510767.
KEGGibta:100847700.
bta:510767.

Organism-specific databases

CTDi54205.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP62894.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG091G0UQY.
TreeFamiTF300226.

Enzyme and pathway databases

ReactomeiR-BTA-111457. Release of apoptotic factors from the mitochondria.
R-BTA-111458. Formation of apoptosome.
R-BTA-111459. Activation of caspases through apoptosome-mediated cleavage.
R-BTA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-BTA-3299685. Detoxification of Reactive Oxygen Species.
R-BTA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP62894.

Gene expression databases

BgeeiENSBTAG00000022613.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_BOVIN
AccessioniPrimary (citable) accession number: P62894
Secondary accession number(s): P00006, Q2KJD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.