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Protein

60S ribosomal protein L39

Gene

RPL39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L39
Gene namesi
Name:RPL39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10350. RPL39.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34743.

Polymorphism and mutation databases

DMDMi51702812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 515060S ribosomal protein L39PRO_0000127024Add
BLAST

Proteomic databases

EPDiP62891.
MaxQBiP62891.
PaxDbiP62891.
PRIDEiP62891.
TopDownProteomicsiP62891.

PTM databases

iPTMnetiP62891.
PhosphoSiteiP62891.

Expressioni

Gene expression databases

BgeeiP62891.
CleanExiHS_RPL39.
GenevisibleiP62891. HS.

Organism-specific databases

HPAiHPA047105.

Interactioni

Subunit structurei

Interacts with IMPACT.By similarity

Protein-protein interaction databases

BioGridi112089. 19 interactions.
IntActiP62891. 1 interaction.
MINTiMINT-4824878.
STRINGi9606.ENSP00000355315.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Ll1-51[»]
4V6Xelectron microscopy5.00Cl1-51[»]
5AJ0electron microscopy3.50Al1-51[»]
ProteinModelPortaliP62891.
SMRiP62891. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L39e family.Curated

Phylogenomic databases

eggNOGiKOG0002. Eukaryota.
COG2167. LUCA.
GeneTreeiENSGT00390000014814.
HOVERGENiHBG001245.
InParanoidiP62891.
KOiK02924.
OMAiARQNRPI.
OrthoDBiEOG789CF5.
PhylomeDBiP62891.
TreeFamiTF300223.

Family and domain databases

Gene3Di1.10.1620.10. 1 hit.
HAMAPiMF_00629. Ribosomal_L39e.
InterProiIPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view]
PANTHERiPTHR19970. PTHR19970. 1 hit.
PfamiPF00832. Ribosomal_L39. 1 hit.
[Graphical view]
SUPFAMiSSF48662. SSF48662. 1 hit.
PROSITEiPS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG

L
Length:51
Mass (Da):6,407
Last modified:January 23, 2007 - v2
Checksum:i2023CA8590C7752C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57846 mRNA. Translation: AAB02265.1.
D79205 mRNA. Translation: BAA11465.1.
AB061835 Genomic DNA. Translation: BAB79473.1.
BC001019 mRNA. Translation: AAH01019.1.
BC070205 mRNA. Translation: AAH70205.1.
AB046411 Genomic DNA. Translation: BAB21257.1.
CCDSiCCDS14586.1.
PIRiG02654.
RefSeqiNP_000991.1. NM_001000.3.
UniGeneiHs.300141.
Hs.558387.

Genome annotation databases

EnsembliENST00000361575; ENSP00000355315; ENSG00000198918.
GeneIDi6170.
KEGGihsa:6170.
UCSCiuc004erx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57846 mRNA. Translation: AAB02265.1.
D79205 mRNA. Translation: BAA11465.1.
AB061835 Genomic DNA. Translation: BAB79473.1.
BC001019 mRNA. Translation: AAH01019.1.
BC070205 mRNA. Translation: AAH70205.1.
AB046411 Genomic DNA. Translation: BAB21257.1.
CCDSiCCDS14586.1.
PIRiG02654.
RefSeqiNP_000991.1. NM_001000.3.
UniGeneiHs.300141.
Hs.558387.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Ll1-51[»]
4V6Xelectron microscopy5.00Cl1-51[»]
5AJ0electron microscopy3.50Al1-51[»]
ProteinModelPortaliP62891.
SMRiP62891. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112089. 19 interactions.
IntActiP62891. 1 interaction.
MINTiMINT-4824878.
STRINGi9606.ENSP00000355315.

PTM databases

iPTMnetiP62891.
PhosphoSiteiP62891.

Polymorphism and mutation databases

DMDMi51702812.

Proteomic databases

EPDiP62891.
MaxQBiP62891.
PaxDbiP62891.
PRIDEiP62891.
TopDownProteomicsiP62891.

Protocols and materials databases

DNASUi6170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361575; ENSP00000355315; ENSG00000198918.
GeneIDi6170.
KEGGihsa:6170.
UCSCiuc004erx.3. human.

Organism-specific databases

CTDi6170.
GeneCardsiRPL39.
HGNCiHGNC:10350. RPL39.
HPAiHPA047105.
MIMi300899. gene.
neXtProtiNX_P62891.
PharmGKBiPA34743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0002. Eukaryota.
COG2167. LUCA.
GeneTreeiENSGT00390000014814.
HOVERGENiHBG001245.
InParanoidiP62891.
KOiK02924.
OMAiARQNRPI.
OrthoDBiEOG789CF5.
PhylomeDBiP62891.
TreeFamiTF300223.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL39. human.
GeneWikiiRPL39.
GenomeRNAii6170.
PROiP62891.
SOURCEiSearch...

Gene expression databases

BgeeiP62891.
CleanExiHS_RPL39.
GenevisibleiP62891. HS.

Family and domain databases

Gene3Di1.10.1620.10. 1 hit.
HAMAPiMF_00629. Ribosomal_L39e.
InterProiIPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view]
PANTHERiPTHR19970. PTHR19970. 1 hit.
PfamiPF00832. Ribosomal_L39. 1 hit.
[Graphical view]
SUPFAMiSSF48662. SSF48662. 1 hit.
PROSITEiPS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structures and sequence analysis of human ribosomal proteins L39 and S27."
    Tsui S.K.W., Lee S.M.Y., Fung K.P., Waye M.M.Y., Lee C.Y.
    Biochem. Mol. Biol. Int. 40:611-616(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Molecular cloning of a cDNA encoding human ribosomal protein L39."
    Otsuka S., Tanaka M., Saito S., Yoshimoto K., Itakura M.
    Biochim. Biophys. Acta 1308:119-121(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
    Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
    Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders."
    Uechi T., Tanaka T., Kenmochi N.
    Genomics 72:223-230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
  6. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL39_HUMAN
AccessioniPrimary (citable) accession number: P62891
Secondary accession number(s): P02404, P39025, Q9BYF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is the smallest and one of the most basic of the proteins in liver ribosomes.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.