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Protein

60S ribosomal protein L30

Gene

RPL30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156482-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L30
Gene namesi
Name:RPL30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10333. RPL30.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6156.
OpenTargetsiENSG00000156482.
PharmGKBiPA34714.

Polymorphism and mutation databases

BioMutaiRPL30.
DMDMi51702805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001461201 – 11560S ribosomal protein L30Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei26N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62888.
MaxQBiP62888.
PaxDbiP62888.
PeptideAtlasiP62888.
PRIDEiP62888.
TopDownProteomicsiP62888.

2D gel databases

SWISS-2DPAGEP62888.

PTM databases

iPTMnetiP62888.
PhosphoSitePlusiP62888.
SwissPalmiP62888.

Expressioni

Gene expression databases

BgeeiENSG00000156482.
CleanExiHS_RPL30.
ExpressionAtlasiP62888. baseline and differential.
GenevisibleiP62888. HS.

Organism-specific databases

HPAiHPA002651.

Interactioni

Protein-protein interaction databases

BioGridi112075. 203 interactors.
IntActiP62888. 39 interactors.
MINTiMINT-5000026.
STRINGi9606.ENSP00000287038.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 24Combined sources10
Beta strandi25 – 30Combined sources6
Helixi31 – 39Combined sources9
Beta strandi44 – 48Combined sources5
Helixi54 – 66Combined sources13
Beta strandi70 – 73Combined sources4
Helixi78 – 84Combined sources7
Beta strandi93 – 98Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VI6X-ray1.59A1-115[»]
4UG0electron microscopy-Lc1-115[»]
4V6Xelectron microscopy5.00Cc1-115[»]
5AJ0electron microscopy3.50Ac1-115[»]
ProteinModelPortaliP62888.
SMRiP62888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L30e family.Curated

Phylogenomic databases

eggNOGiKOG2988. Eukaryota.
COG1911. LUCA.
GeneTreeiENSGT00390000012138.
HOGENOMiHOG000055224.
HOVERGENiHBG000449.
InParanoidiP62888.
KOiK02908.
OMAiNIPVYQH.
OrthoDBiEOG091G0W6G.
PhylomeDBiP62888.
TreeFamiTF300252.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
HAMAPiMF_00481. Ribosomal_L30e. 1 hit.
InterProiIPR029064. L30e-like.
IPR000231. Ribosomal_L30e.
IPR022991. Ribosomal_L30e_CS.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS00709. RIBOSOMAL_L30E_1. 1 hit.
PS00993. RIBOSOMAL_L30E_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN
60 70 80 90 100
NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG
110
DSDIIRSMPE QTGEK
Length:115
Mass (Da):12,784
Last modified:January 23, 2007 - v2
Checksum:i95186B081E39748C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05095 mRNA. Translation: AAC15858.1.
X79238 mRNA. Translation: CAA55820.1.
AB070559 Genomic DNA. Translation: BAB79491.1.
AK312102 mRNA. Translation: BAG35038.1.
CH471060 Genomic DNA. Translation: EAW91770.1.
BC032700 mRNA. Translation: AAH32700.1.
BC095426 mRNA. Translation: AAH95426.1.
CCDSiCCDS34928.1.
PIRiS45004.
RefSeqiNP_000980.1. NM_000989.3.
UniGeneiHs.400295.

Genome annotation databases

EnsembliENST00000287038; ENSP00000287038; ENSG00000156482.
ENST00000521291; ENSP00000428085; ENSG00000156482.
GeneIDi6156.
KEGGihsa:6156.
UCSCiuc003yif.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05095 mRNA. Translation: AAC15858.1.
X79238 mRNA. Translation: CAA55820.1.
AB070559 Genomic DNA. Translation: BAB79491.1.
AK312102 mRNA. Translation: BAG35038.1.
CH471060 Genomic DNA. Translation: EAW91770.1.
BC032700 mRNA. Translation: AAH32700.1.
BC095426 mRNA. Translation: AAH95426.1.
CCDSiCCDS34928.1.
PIRiS45004.
RefSeqiNP_000980.1. NM_000989.3.
UniGeneiHs.400295.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VI6X-ray1.59A1-115[»]
4UG0electron microscopy-Lc1-115[»]
4V6Xelectron microscopy5.00Cc1-115[»]
5AJ0electron microscopy3.50Ac1-115[»]
ProteinModelPortaliP62888.
SMRiP62888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112075. 203 interactors.
IntActiP62888. 39 interactors.
MINTiMINT-5000026.
STRINGi9606.ENSP00000287038.

PTM databases

iPTMnetiP62888.
PhosphoSitePlusiP62888.
SwissPalmiP62888.

Polymorphism and mutation databases

BioMutaiRPL30.
DMDMi51702805.

2D gel databases

SWISS-2DPAGEP62888.

Proteomic databases

EPDiP62888.
MaxQBiP62888.
PaxDbiP62888.
PeptideAtlasiP62888.
PRIDEiP62888.
TopDownProteomicsiP62888.

Protocols and materials databases

DNASUi6156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287038; ENSP00000287038; ENSG00000156482.
ENST00000521291; ENSP00000428085; ENSG00000156482.
GeneIDi6156.
KEGGihsa:6156.
UCSCiuc003yif.4. human.

Organism-specific databases

CTDi6156.
DisGeNETi6156.
GeneCardsiRPL30.
HGNCiHGNC:10333. RPL30.
HPAiHPA002651.
MIMi180467. gene.
neXtProtiNX_P62888.
OpenTargetsiENSG00000156482.
PharmGKBiPA34714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2988. Eukaryota.
COG1911. LUCA.
GeneTreeiENSGT00390000012138.
HOGENOMiHOG000055224.
HOVERGENiHBG000449.
InParanoidiP62888.
KOiK02908.
OMAiNIPVYQH.
OrthoDBiEOG091G0W6G.
PhylomeDBiP62888.
TreeFamiTF300252.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156482-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL30. human.
GeneWikiiRPL30.
GenomeRNAii6156.
PROiP62888.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156482.
CleanExiHS_RPL30.
ExpressionAtlasiP62888. baseline and differential.
GenevisibleiP62888. HS.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
HAMAPiMF_00481. Ribosomal_L30e. 1 hit.
InterProiIPR029064. L30e-like.
IPR000231. Ribosomal_L30e.
IPR022991. Ribosomal_L30e_CS.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS00709. RIBOSOMAL_L30E_1. 1 hit.
PS00993. RIBOSOMAL_L30E_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL30_HUMAN
AccessioniPrimary (citable) accession number: P62888
Secondary accession number(s): B2R591, P04645, Q502Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.