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P62888

- RL30_HUMAN

UniProt

P62888 - RL30_HUMAN

Protein

60S ribosomal protein L30

Gene

RPL30

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProt
    3. RNA binding Source: UniProtKB
    4. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L30
    Gene namesi
    Name:RPL30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:10333. RPL30.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34714.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511560S ribosomal protein L30PRO_0000146120Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine3 Publications
    Modified residuei26 – 261N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62888.
    PaxDbiP62888.
    PeptideAtlasiP62888.
    PRIDEiP62888.

    2D gel databases

    SWISS-2DPAGEP62888.

    PTM databases

    PhosphoSiteiP62888.

    Expressioni

    Gene expression databases

    ArrayExpressiP62888.
    BgeeiP62888.
    CleanExiHS_RPL30.
    GenevestigatoriP62888.

    Organism-specific databases

    HPAiHPA002651.

    Interactioni

    Protein-protein interaction databases

    BioGridi112075. 100 interactions.
    IntActiP62888. 28 interactions.
    MINTiMINT-5000026.
    STRINGi9606.ENSP00000287038.

    Structurei

    Secondary structure

    1
    115
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 2410
    Beta strandi25 – 306
    Helixi31 – 399
    Beta strandi44 – 485
    Helixi54 – 6613
    Beta strandi70 – 734
    Helixi78 – 847
    Beta strandi93 – 986

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00c1-115[»]
    3VI6X-ray1.59A1-115[»]
    ProteinModelPortaliP62888.
    SMRiP62888. Positions 9-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L30e family.Curated

    Phylogenomic databases

    eggNOGiCOG1911.
    HOGENOMiHOG000055224.
    HOVERGENiHBG000449.
    KOiK02908.
    OMAiMRNGKAK.
    OrthoDBiEOG70CR8V.
    PhylomeDBiP62888.
    TreeFamiTF300252.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    HAMAPiMF_00481. Ribosomal_L30e.
    InterProiIPR029064. L30e-like.
    IPR000231. Ribosomal_L30e.
    IPR022991. Ribosomal_L30e_CS.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view]
    PANTHERiPTHR11449. PTHR11449. 1 hit.
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.
    PROSITEiPS00709. RIBOSOMAL_L30E_1. 1 hit.
    PS00993. RIBOSOMAL_L30E_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN    50
    NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG 100
    DSDIIRSMPE QTGEK 115
    Length:115
    Mass (Da):12,784
    Last modified:January 23, 2007 - v2
    Checksum:i95186B081E39748C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05095 mRNA. Translation: AAC15858.1.
    X79238 mRNA. Translation: CAA55820.1.
    AB070559 Genomic DNA. Translation: BAB79491.1.
    AK312102 mRNA. Translation: BAG35038.1.
    CH471060 Genomic DNA. Translation: EAW91770.1.
    BC032700 mRNA. Translation: AAH32700.1.
    BC095426 mRNA. Translation: AAH95426.1.
    CCDSiCCDS34928.1.
    PIRiS45004.
    RefSeqiNP_000980.1. NM_000989.3.
    UniGeneiHs.400295.

    Genome annotation databases

    EnsembliENST00000287038; ENSP00000287038; ENSG00000156482.
    ENST00000521291; ENSP00000428085; ENSG00000156482.
    GeneIDi6156.
    KEGGihsa:6156.
    UCSCiuc003yif.3. human.

    Polymorphism databases

    DMDMi51702805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05095 mRNA. Translation: AAC15858.1 .
    X79238 mRNA. Translation: CAA55820.1 .
    AB070559 Genomic DNA. Translation: BAB79491.1 .
    AK312102 mRNA. Translation: BAG35038.1 .
    CH471060 Genomic DNA. Translation: EAW91770.1 .
    BC032700 mRNA. Translation: AAH32700.1 .
    BC095426 mRNA. Translation: AAH95426.1 .
    CCDSi CCDS34928.1.
    PIRi S45004.
    RefSeqi NP_000980.1. NM_000989.3.
    UniGenei Hs.400295.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 c 1-115 [» ]
    3VI6 X-ray 1.59 A 1-115 [» ]
    ProteinModelPortali P62888.
    SMRi P62888. Positions 9-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112075. 100 interactions.
    IntActi P62888. 28 interactions.
    MINTi MINT-5000026.
    STRINGi 9606.ENSP00000287038.

    PTM databases

    PhosphoSitei P62888.

    Polymorphism databases

    DMDMi 51702805.

    2D gel databases

    SWISS-2DPAGE P62888.

    Proteomic databases

    MaxQBi P62888.
    PaxDbi P62888.
    PeptideAtlasi P62888.
    PRIDEi P62888.

    Protocols and materials databases

    DNASUi 6156.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287038 ; ENSP00000287038 ; ENSG00000156482 .
    ENST00000521291 ; ENSP00000428085 ; ENSG00000156482 .
    GeneIDi 6156.
    KEGGi hsa:6156.
    UCSCi uc003yif.3. human.

    Organism-specific databases

    CTDi 6156.
    GeneCardsi GC08M099037.
    HGNCi HGNC:10333. RPL30.
    HPAi HPA002651.
    MIMi 180467. gene.
    neXtProti NX_P62888.
    PharmGKBi PA34714.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1911.
    HOGENOMi HOG000055224.
    HOVERGENi HBG000449.
    KOi K02908.
    OMAi MRNGKAK.
    OrthoDBi EOG70CR8V.
    PhylomeDBi P62888.
    TreeFami TF300252.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL30. human.
    GeneWikii RPL30.
    GenomeRNAii 6156.
    NextBioi 23907.
    PROi P62888.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62888.
    Bgeei P62888.
    CleanExi HS_RPL30.
    Genevestigatori P62888.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    HAMAPi MF_00481. Ribosomal_L30e.
    InterProi IPR029064. L30e-like.
    IPR000231. Ribosomal_L30e.
    IPR022991. Ribosomal_L30e_CS.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view ]
    PANTHERi PTHR11449. PTHR11449. 1 hit.
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    PROSITEi PS00709. RIBOSOMAL_L30E_1. 1 hit.
    PS00993. RIBOSOMAL_L30E_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Filipenko M.L., Karpova G.G.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Bhat K.S.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic stem cell and Mammary gland.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e."
      Kawaguchi A., Ose T., Yao M., Tanaka I.
      Acta Crystallogr. F 67:1516-1518(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS).

    Entry informationi

    Entry nameiRL30_HUMAN
    AccessioniPrimary (citable) accession number: P62888
    Secondary accession number(s): B2R591, P04645, Q502Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3