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Protein

Guanine nucleotide-binding protein subunit beta-5

Gene

Gnb5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D2 dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).By similarityCurated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-5
Alternative name(s):
Gbeta5
Transducin beta chain 5
Gene namesi
Name:Gnb5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620759 Gnb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277091 – 353Guanine nucleotide-binding protein subunit beta-5Add BLAST353

Proteomic databases

PaxDbiP62882
PRIDEiP62882

PTM databases

PhosphoSitePlusiP62882

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Interactioni

Subunit structurei

Component of a complex composed of RGS9, GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By similarity). Interacts with RGS6 and RGS7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249765, 1 interactor
CORUMiP62882
IntActiP62882, 2 interactors
MINTiP62882
STRINGi10116.ENSRNOP00000011963

Structurei

3D structure databases

ProteinModelPortaliP62882
SMRiP62882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 100WD 1Add BLAST40
Repeati103 – 142WD 2Add BLAST40
Repeati151 – 192WD 3Add BLAST42
Repeati194 – 236WD 4Add BLAST43
Repeati237 – 276WD 5Add BLAST40
Repeati278 – 320WD 6Add BLAST43
Repeati323 – 352WD 7Add BLAST30

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG000188
InParanoidiP62882
KOiK04539
PhylomeDBiP62882

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P62882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDGLHENE TLASLKSEAE SLKGKLEEER AKLHDVELHQ VAERVEALGQ
60 70 80 90 100
FVMKTRRTLK GHGNKVLCMD WCKDKRRIVS SSQDGKVIVW DSFTTNKEHA
110 120 130 140 150
VTMPCTWVMA CAYAPSGCAI ACGGLDNKCS VYPLTFDKNE NMAAKKKSVA
160 170 180 190 200
MHTNYLSACS FTNSDMQILT ASGDGTCALW DVESGQLLQS FHGHGADVLC
210 220 230 240 250
LDLAPSETGN TFVSGGCDKK AMVWDMRSGQ CVQAFETHES DVNSVRYYPS
260 270 280 290 300
GDAFASGSDD ATCRLYDLRA DREVAIYSKE SIIFGASSVD FSLSGRLLFA
310 320 330 340 350
GYNDYTINVW DVLKGSRVSI LFGHENRVST LRVSPDGTAF CSGSWDHTLR

VWA
Length:353
Mass (Da):38,732
Last modified:August 16, 2004 - v1
Checksum:i30FCF51C125A024D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001953 mRNA Translation: AAB59974.1
AY552803 mRNA Translation: AAS59141.1
BC089221 mRNA Translation: AAH89221.1
AF022086 mRNA Translation: AAB82553.1
RefSeqiNP_113958.1, NM_031770.3
UniGeneiRn.23042

Genome annotation databases

GeneIDi83579
KEGGirno:83579
UCSCiRGD:620759 rat

Similar proteinsi

Entry informationi

Entry nameiGNB5_RAT
AccessioniPrimary (citable) accession number: P62882
Secondary accession number(s): O35354
, P54314, Q5FWS8, Q91WB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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