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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Gene

Gnb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Alternative name(s):
G protein subunit beta-2
Transducin beta chain 2
Gene namesi
Name:Gnb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95784 Gnb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001276962 – 340Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei239PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62880
PaxDbiP62880
PeptideAtlasiP62880
PRIDEiP62880

2D gel databases

REPRODUCTION-2DPAGEiIPI00162780

PTM databases

iPTMnetiP62880
PhosphoSitePlusiP62880
SwissPalmiP62880

Expressioni

Developmental stagei

Expressed in meiotically incompetent oocytes. Expression increases in fully grown meiotically competent oocytes. Expression then decreases during metaphase-II arrested eggs, one-cell embryo, two-cell embryo and eight-cell embryo stages, and increases again during blastocyst stage.1 Publication

Gene expression databases

BgeeiENSMUSG00000029713
ExpressionAtlasiP62880 baseline and differential
GenevisibleiP62880 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199977, 8 interactors
IntActiP62880, 9 interactors
MINTiP62880
STRINGi10090.ENSMUSP00000031726

Structurei

3D structure databases

ProteinModelPortaliP62880
SMRiP62880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 83WD 1Add BLAST31
Repeati95 – 125WD 2Add BLAST31
Repeati141 – 170WD 3Add BLAST30
Repeati182 – 212WD 4Add BLAST31
Repeati224 – 254WD 5Add BLAST31
Repeati268 – 298WD 6Add BLAST31
Repeati310 – 340WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000176356
HOVERGENiHBG000188
InParanoidiP62880
KOiK04537
PhylomeDBiP62880
TreeFamiTF106149

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNI CSIYSLKTRE GNVRVSRELP GHTGYLSCCR
160 170 180 190 200
FLDDNQIITS SGDTTCALWD IETGQQTVGF AGHSGDVMSL SLAPDGRTFV
210 220 230 240 250
SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA FTTGSDDATC
260 270 280 290 300
RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
310 320 330 340
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,331
Last modified:January 23, 2007 - v3
Checksum:i5D08FFA240ADEEE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106A → G in AAC72250 (Ref. 1) Curated1
Sequence conflicti248A → S in AAC72250 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34960 mRNA Translation: AAC72250.1
AB045007 Genomic DNA Translation: BAB19816.1
AF312033 Genomic DNA Translation: AAK28828.1
BC029077 mRNA Translation: AAH29077.1
BC059942 mRNA Translation: AAH59942.1
BC062178 mRNA Translation: AAH62178.1
U38505 mRNA Translation: AAB01736.1
CCDSiCCDS19769.1
RefSeqiNP_034442.1, NM_010312.4
XP_006504616.1, XM_006504553.3
UniGeneiMm.30141

Genome annotation databases

EnsembliENSMUST00000031726; ENSMUSP00000031726; ENSMUSG00000029713
ENSMUST00000150063; ENSMUSP00000129353; ENSMUSG00000029713
GeneIDi14693
KEGGimmu:14693
UCSCiuc009act.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGBB2_MOUSE
AccessioniPrimary (citable) accession number: P62880
Secondary accession number(s): P11016, P54312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health