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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Gene

GNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • GTPase activity Source: ProtInc
  • GTPase binding Source: UniProtKB
  • protein complex binding Source: MGI
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172354-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP62879.
SIGNORiP62879.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Alternative name(s):
G protein subunit beta-2
Transducin beta chain 2
Gene namesi
Name:GNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4398. GNB2.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • myelin sheath Source: Ensembl
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: Reactome
  • protein complex Source: Ensembl
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172354.
PharmGKBiPA28778.

Polymorphism and mutation databases

BioMutaiGNB2.
DMDMi51317304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001276952 – 340Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei239PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62879.
PaxDbiP62879.
PeptideAtlasiP62879.
PRIDEiP62879.
TopDownProteomicsiP62879-1. [P62879-1]

2D gel databases

OGPiP62879.
REPRODUCTION-2DPAGEP62879.

PTM databases

iPTMnetiP62879.
PhosphoSitePlusiP62879.
SwissPalmiP62879.

Expressioni

Gene expression databases

BgeeiENSG00000172354.
CleanExiHS_GNB2.
ExpressionAtlasiP62879. baseline and differential.
GenevisibleiP62879. HS.

Organism-specific databases

HPAiCAB010032.
HPA040736.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A (PubMed:26900580).4 Publications

GO - Molecular functioni

  • GTPase binding Source: UniProtKB
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi109045. 158 interactors.
IntActiP62879. 45 interactors.
MINTiMINT-1139073.
STRINGi9606.ENSP00000305260.

Structurei

3D structure databases

ProteinModelPortaliP62879.
SMRiP62879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 83WD 1Add BLAST31
Repeati95 – 125WD 2Add BLAST31
Repeati141 – 170WD 3Add BLAST30
Repeati182 – 212WD 4Add BLAST31
Repeati224 – 254WD 5Add BLAST31
Repeati268 – 298WD 6Add BLAST31
Repeati310 – 340WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62879.
KOiK04537.
OMAiEPVCGIT.
OrthoDBiEOG091G0A7T.
PhylomeDBiP62879.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62879-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNI CSIYSLKTRE GNVRVSRELP GHTGYLSCCR
160 170 180 190 200
FLDDNQIITS SGDTTCALWD IETGQQTVGF AGHSGDVMSL SLAPDGRTFV
210 220 230 240 250
SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA FTTGSDDATC
260 270 280 290 300
RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
310 320 330 340
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,331
Last modified:January 23, 2007 - v3
Checksum:i5D08FFA240ADEEE6
GO
Isoform 2 (identifier: P62879-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):25,931
Checksum:i88597902259DAF68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195D → N in AAA35922 (PubMed:3114742).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565151 – 100Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16514 mRNA. Translation: AAA03179.1.
M36429 mRNA. Translation: AAA63264.1.
M16538 mRNA. Translation: AAA35922.1.
AF053356 Genomic DNA. Translation: AAC78794.1.
AF501883 mRNA. Translation: AAM15919.1.
AK056750 mRNA. Translation: BAG51803.1.
AC009488 Genomic DNA. No translation available.
BC010073 mRNA. Translation: AAH10073.1.
BC012348 mRNA. Translation: AAH12348.1.
BC068003 mRNA. Translation: AAH68003.1.
CCDSiCCDS5703.1. [P62879-1]
PIRiB26617. RGHUB2.
RefSeqiNP_005264.2. NM_005273.3. [P62879-1]
UniGeneiHs.185172.

Genome annotation databases

EnsembliENST00000303210; ENSP00000305260; ENSG00000172354. [P62879-1]
ENST00000393924; ENSP00000377501; ENSG00000172354. [P62879-1]
ENST00000393926; ENSP00000377503; ENSG00000172354. [P62879-1]
ENST00000419828; ENSP00000390543; ENSG00000172354. [P62879-2]
ENST00000427895; ENSP00000400286; ENSG00000172354. [P62879-2]
GeneIDi2783.
KEGGihsa:2783.
UCSCiuc064ggx.1. human. [P62879-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16514 mRNA. Translation: AAA03179.1.
M36429 mRNA. Translation: AAA63264.1.
M16538 mRNA. Translation: AAA35922.1.
AF053356 Genomic DNA. Translation: AAC78794.1.
AF501883 mRNA. Translation: AAM15919.1.
AK056750 mRNA. Translation: BAG51803.1.
AC009488 Genomic DNA. No translation available.
BC010073 mRNA. Translation: AAH10073.1.
BC012348 mRNA. Translation: AAH12348.1.
BC068003 mRNA. Translation: AAH68003.1.
CCDSiCCDS5703.1. [P62879-1]
PIRiB26617. RGHUB2.
RefSeqiNP_005264.2. NM_005273.3. [P62879-1]
UniGeneiHs.185172.

3D structure databases

ProteinModelPortaliP62879.
SMRiP62879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109045. 158 interactors.
IntActiP62879. 45 interactors.
MINTiMINT-1139073.
STRINGi9606.ENSP00000305260.

PTM databases

iPTMnetiP62879.
PhosphoSitePlusiP62879.
SwissPalmiP62879.

Polymorphism and mutation databases

BioMutaiGNB2.
DMDMi51317304.

2D gel databases

OGPiP62879.
REPRODUCTION-2DPAGEP62879.

Proteomic databases

EPDiP62879.
PaxDbiP62879.
PeptideAtlasiP62879.
PRIDEiP62879.
TopDownProteomicsiP62879-1. [P62879-1]

Protocols and materials databases

DNASUi2783.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303210; ENSP00000305260; ENSG00000172354. [P62879-1]
ENST00000393924; ENSP00000377501; ENSG00000172354. [P62879-1]
ENST00000393926; ENSP00000377503; ENSG00000172354. [P62879-1]
ENST00000419828; ENSP00000390543; ENSG00000172354. [P62879-2]
ENST00000427895; ENSP00000400286; ENSG00000172354. [P62879-2]
GeneIDi2783.
KEGGihsa:2783.
UCSCiuc064ggx.1. human. [P62879-1]

Organism-specific databases

CTDi2783.
GeneCardsiGNB2.
HGNCiHGNC:4398. GNB2.
HPAiCAB010032.
HPA040736.
MIMi139390. gene.
neXtProtiNX_P62879.
OpenTargetsiENSG00000172354.
PharmGKBiPA28778.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62879.
KOiK04537.
OMAiEPVCGIT.
OrthoDBiEOG091G0A7T.
PhylomeDBiP62879.
TreeFamiTF106149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172354-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP62879.
SIGNORiP62879.

Miscellaneous databases

ChiTaRSiGNB2. human.
GeneWikiiGNB2.
GenomeRNAii2783.
PROiP62879.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172354.
CleanExiHS_GNB2.
ExpressionAtlasiP62879. baseline and differential.
GenevisibleiP62879. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBB2_HUMAN
AccessioniPrimary (citable) accession number: P62879
Secondary accession number(s): B3KPU1, P11016, P54312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.