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P62879

- GBB2_HUMAN

UniProt

P62879 - GBB2_HUMAN

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Gene
GNB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. GTPase binding Source: UniProtKB
  3. calcium channel regulator activity Source: Ensembl
  4. protein binding Source: UniProtKB
  5. protein complex binding Source: MGI
  6. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. GTP catabolic process Source: GOC
  3. cellular response to glucagon stimulus Source: Reactome
  4. energy reserve metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinkiP62879.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Alternative name(s):
G protein subunit beta-2
Transducin beta chain 2
Gene namesi
Name:GNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4398. GNB2.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. lysosomal membrane Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
  6. plasma membrane Source: Reactome
  7. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 340339Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
PRO_0000127695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei239 – 2391Phosphotyrosine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP62879.
PaxDbiP62879.
PRIDEiP62879.

2D gel databases

OGPiP62879.
REPRODUCTION-2DPAGEP62879.

PTM databases

PhosphoSiteiP62879.

Expressioni

Gene expression databases

ArrayExpressiP62879.
BgeeiP62879.
CleanExiHS_GNB2.
GenevestigatoriP62879.

Organism-specific databases

HPAiCAB010032.
HPA040736.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10.3 Publications

Protein-protein interaction databases

BioGridi109045. 53 interactions.
IntActiP62879. 27 interactions.
MINTiMINT-1139073.
STRINGi9606.ENSP00000305260.

Structurei

3D structure databases

ProteinModelPortaliP62879.
SMRiP62879. Positions 1-340.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 8331WD 1
Add
BLAST
Repeati95 – 12531WD 2
Add
BLAST
Repeati141 – 17030WD 3
Add
BLAST
Repeati182 – 21231WD 4
Add
BLAST
Repeati224 – 25431WD 5
Add
BLAST
Repeati268 – 29831WD 6
Add
BLAST
Repeati310 – 34031WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62879.
KOiK04537.
OMAiWDIETSQ.
OrthoDBiEOG7GN2N5.
PhylomeDBiP62879.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62879-1 [UniParc]FASTAAdd to Basket

« Hide

MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT    50
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV 100
MTCAYAPSGN FVACGGLDNI CSIYSLKTRE GNVRVSRELP GHTGYLSCCR 150
FLDDNQIITS SGDTTCALWD IETGQQTVGF AGHSGDVMSL SLAPDGRTFV 200
SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA FTTGSDDATC 250
RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM 300
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN 340
Length:340
Mass (Da):37,331
Last modified:January 23, 2007 - v3
Checksum:i5D08FFA240ADEEE6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951D → N in AAA35922. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16514 mRNA. Translation: AAA03179.1.
M36429 mRNA. Translation: AAA63264.1.
M16538 mRNA. Translation: AAA35922.1.
AF053356 Genomic DNA. Translation: AAC78794.1.
AF501883 mRNA. Translation: AAM15919.1.
BC010073 mRNA. Translation: AAH10073.1.
BC012348 mRNA. Translation: AAH12348.1.
BC068003 mRNA. Translation: AAH68003.1.
CCDSiCCDS5703.1.
PIRiB26617. RGHUB2.
RefSeqiNP_005264.2. NM_005273.3.
UniGeneiHs.185172.

Genome annotation databases

EnsembliENST00000303210; ENSP00000305260; ENSG00000172354.
ENST00000393924; ENSP00000377501; ENSG00000172354.
ENST00000393926; ENSP00000377503; ENSG00000172354.
GeneIDi2783.
KEGGihsa:2783.
UCSCiuc003uwb.3. human.

Polymorphism databases

DMDMi51317304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16514 mRNA. Translation: AAA03179.1 .
M36429 mRNA. Translation: AAA63264.1 .
M16538 mRNA. Translation: AAA35922.1 .
AF053356 Genomic DNA. Translation: AAC78794.1 .
AF501883 mRNA. Translation: AAM15919.1 .
BC010073 mRNA. Translation: AAH10073.1 .
BC012348 mRNA. Translation: AAH12348.1 .
BC068003 mRNA. Translation: AAH68003.1 .
CCDSi CCDS5703.1.
PIRi B26617. RGHUB2.
RefSeqi NP_005264.2. NM_005273.3.
UniGenei Hs.185172.

3D structure databases

ProteinModelPortali P62879.
SMRi P62879. Positions 1-340.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109045. 53 interactions.
IntActi P62879. 27 interactions.
MINTi MINT-1139073.
STRINGi 9606.ENSP00000305260.

PTM databases

PhosphoSitei P62879.

Polymorphism databases

DMDMi 51317304.

2D gel databases

OGPi P62879.
REPRODUCTION-2DPAGE P62879.

Proteomic databases

MaxQBi P62879.
PaxDbi P62879.
PRIDEi P62879.

Protocols and materials databases

DNASUi 2783.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303210 ; ENSP00000305260 ; ENSG00000172354 .
ENST00000393924 ; ENSP00000377501 ; ENSG00000172354 .
ENST00000393926 ; ENSP00000377503 ; ENSG00000172354 .
GeneIDi 2783.
KEGGi hsa:2783.
UCSCi uc003uwb.3. human.

Organism-specific databases

CTDi 2783.
GeneCardsi GC07P100271.
HGNCi HGNC:4398. GNB2.
HPAi CAB010032.
HPA040736.
MIMi 139390. gene.
neXtProti NX_P62879.
PharmGKBi PA28778.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000176356.
HOVERGENi HBG000188.
InParanoidi P62879.
KOi K04537.
OMAi WDIETSQ.
OrthoDBi EOG7GN2N5.
PhylomeDBi P62879.
TreeFami TF106149.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinki P62879.

Miscellaneous databases

GeneWikii GNB2.
GenomeRNAii 2783.
NextBioi 10963.
PROi P62879.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62879.
Bgeei P62879.
CleanExi HS_GNB2.
Genevestigatori P62879.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
PRINTSi PR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning."
    Fong H.K.W., Amatruda T.T. III, Birren B.W., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 84:3792-3796(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A second form of the beta subunit of signal-transducing G proteins."
    Gao B., Gilman A.G., Robishaw J.D.
    Proc. Natl. Acad. Sci. U.S.A. 84:6122-6125(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
    Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A.
    Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas, Skin and Uterus.
  6. Bienvenut W.V.
    Submitted (JUL-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-15 AND 58-78, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Melanoma.
  7. "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production."
    Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T.
    Circ. Res. 93:848-856(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF18.
  8. "Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit."
    Waragai M., Nagamitsu S., Xu W., Li Y.J., Lin X., Ashizawa T.
    J. Neurosci. Res. 83:1170-1178(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ATXN10.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The cationic region of Rhes mediates its interactions with specific Gbeta subunits."
    Hill C., Goddard A., Ladds G., Davey J.
    Cell. Physiol. Biochem. 23:1-8(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASD2.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBB2_HUMAN
AccessioniPrimary (citable) accession number: P62879
Secondary accession number(s): P11016, P54312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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