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P62876

- RPAB5_MOUSE

UniProt

P62876 - RPAB5_MOUSE

Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

Polr2l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71ZincBy similarity
    Metal bindingi10 – 101ZincBy similarity
    Metal bindingi44 – 441ZincBy similarity
    Metal bindingi45 – 451ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. zinc ion binding Source: RefGenome

    GO - Biological processi

    1. transcription from RNA polymerase III promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription from RNA polymerase I promoter Source: GOC

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_203462. Formation of the Early Elongation Complex.
    REACT_205207. RNA Polymerase III Chain Elongation.
    REACT_213655. Transcription-coupled NER (TC-NER).
    REACT_221178. MicroRNA (miRNA) biogenesis.
    REACT_221403. RNA Polymerase III Transcription Termination.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC5
    Short name:
    RNA polymerases I, II, and III subunit ABC5
    Alternative name(s):
    DNA-directed RNA polymerase III subunit L
    RPB10 homolog
    Gene namesi
    Name:Polr2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1913741. Polr2l.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. DNA-directed RNA polymerase I complex Source: RefGenome
    2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
    3. DNA-directed RNA polymerase III complex Source: RefGenome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6767DNA-directed RNA polymerases I, II, and III subunit RPABC5PRO_0000121334Add
    BLAST

    Proteomic databases

    MaxQBiP62876.
    PaxDbiP62876.
    PRIDEiP62876.

    PTM databases

    PhosphoSiteiP62876.

    Expressioni

    Gene expression databases

    BgeeiP62876.
    CleanExiMM_POLR2L.
    GenevestigatoriP62876.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

    Protein-protein interaction databases

    IntActiP62876. 2 interactions.
    MINTiMINT-4133017.
    STRINGi10090.ENSMUSP00000043204.

    Structurei

    3D structure databases

    ProteinModelPortaliP62876.
    SMRiP62876. Positions 1-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1644.
    GeneTreeiENSGT00390000007087.
    HOVERGENiHBG061475.
    InParanoidiP62876.
    KOiK03007.
    OMAiQIANINR.
    OrthoDBiEOG79CZ2Z.
    PhylomeDBiP62876.
    TreeFamiTF103046.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    HAMAPiMF_00250. RNApol_arch_N.
    InterProiIPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view]
    PfamiPF01194. RNA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF46924. SSF46924. 1 hit.
    PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62876-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL   50
    AHVDLIEKLL NYAPLEK 67
    Length:67
    Mass (Da):7,645
    Last modified:August 16, 2004 - v1
    Checksum:i9E8A72F667FE7EC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011021 mRNA. Translation: BAB27338.1.
    AK149137 mRNA. Translation: BAE28747.1.
    AK168159 mRNA. Translation: BAE40122.1.
    CCDSiCCDS52446.1.
    RefSeqiNP_079869.1. NM_025593.1.
    UniGeneiMm.380115.

    Genome annotation databases

    EnsembliENSMUST00000043870; ENSMUSP00000043204; ENSMUSG00000038489.
    GeneIDi66491.
    KEGGimmu:66491.
    UCSCiuc009klm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011021 mRNA. Translation: BAB27338.1 .
    AK149137 mRNA. Translation: BAE28747.1 .
    AK168159 mRNA. Translation: BAE40122.1 .
    CCDSi CCDS52446.1.
    RefSeqi NP_079869.1. NM_025593.1.
    UniGenei Mm.380115.

    3D structure databases

    ProteinModelPortali P62876.
    SMRi P62876. Positions 1-67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P62876. 2 interactions.
    MINTi MINT-4133017.
    STRINGi 10090.ENSMUSP00000043204.

    PTM databases

    PhosphoSitei P62876.

    Proteomic databases

    MaxQBi P62876.
    PaxDbi P62876.
    PRIDEi P62876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043870 ; ENSMUSP00000043204 ; ENSMUSG00000038489 .
    GeneIDi 66491.
    KEGGi mmu:66491.
    UCSCi uc009klm.2. mouse.

    Organism-specific databases

    CTDi 5441.
    MGIi MGI:1913741. Polr2l.

    Phylogenomic databases

    eggNOGi COG1644.
    GeneTreei ENSGT00390000007087.
    HOVERGENi HBG061475.
    InParanoidi P62876.
    KOi K03007.
    OMAi QIANINR.
    OrthoDBi EOG79CZ2Z.
    PhylomeDBi P62876.
    TreeFami TF103046.

    Enzyme and pathway databases

    Reactomei REACT_203462. Formation of the Early Elongation Complex.
    REACT_205207. RNA Polymerase III Chain Elongation.
    REACT_213655. Transcription-coupled NER (TC-NER).
    REACT_221178. MicroRNA (miRNA) biogenesis.
    REACT_221403. RNA Polymerase III Transcription Termination.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    NextBioi 21055.
    PROi P62876.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62876.
    CleanExi MM_POLR2L.
    Genevestigatori P62876.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    HAMAPi MF_00250. RNApol_arch_N.
    InterProi IPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view ]
    Pfami PF01194. RNA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF46924. SSF46924. 1 hit.
    PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Liver and Sympathetic ganglion.

    Entry informationi

    Entry nameiRPAB5_MOUSE
    AccessioniPrimary (citable) accession number: P62876
    Secondary accession number(s): P52436, Q3UF14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3