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P62876

- RPAB5_MOUSE

UniProt

P62876 - RPAB5_MOUSE

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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene
Polr2l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Zinc By similarity
Metal bindingi10 – 101Zinc By similarity
Metal bindingi44 – 441Zinc By similarity
Metal bindingi45 – 451Zinc By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. transcription from RNA polymerase III promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription from RNA polymerase I promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_203462. Formation of the Early Elongation Complex.
REACT_205207. RNA Polymerase III Chain Elongation.
REACT_213655. Transcription-coupled NER (TC-NER).
REACT_221178. MicroRNA (miRNA) biogenesis.
REACT_221403. RNA Polymerase III Transcription Termination.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
DNA-directed RNA polymerase III subunit L
RPB10 homolog
Gene namesi
Name:Polr2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1913741. Polr2l.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: RefGenome
  2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
  3. DNA-directed RNA polymerase III complex Source: RefGenome
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767DNA-directed RNA polymerases I, II, and III subunit RPABC5UniRule annotationPRO_0000121334Add
BLAST

Proteomic databases

MaxQBiP62876.
PaxDbiP62876.
PRIDEiP62876.

PTM databases

PhosphoSiteiP62876.

Expressioni

Gene expression databases

BgeeiP62876.
CleanExiMM_POLR2L.
GenevestigatoriP62876.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively By similarity.

Protein-protein interaction databases

IntActiP62876. 2 interactions.
MINTiMINT-4133017.
STRINGi10090.ENSMUSP00000043204.

Structurei

3D structure databases

ProteinModelPortaliP62876.
SMRiP62876. Positions 1-67.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1644.
GeneTreeiENSGT00390000007087.
HOVERGENiHBG061475.
InParanoidiP62876.
KOiK03007.
OMAiQIANINR.
OrthoDBiEOG79CZ2Z.
PhylomeDBiP62876.
TreeFamiTF103046.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62876-1 [UniParc]FASTAAdd to Basket

« Hide

MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL   50
AHVDLIEKLL NYAPLEK 67
Length:67
Mass (Da):7,645
Last modified:August 16, 2004 - v1
Checksum:i9E8A72F667FE7EC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011021 mRNA. Translation: BAB27338.1.
AK149137 mRNA. Translation: BAE28747.1.
AK168159 mRNA. Translation: BAE40122.1.
CCDSiCCDS52446.1.
RefSeqiNP_079869.1. NM_025593.1.
UniGeneiMm.380115.

Genome annotation databases

EnsembliENSMUST00000043870; ENSMUSP00000043204; ENSMUSG00000038489.
GeneIDi66491.
KEGGimmu:66491.
UCSCiuc009klm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011021 mRNA. Translation: BAB27338.1 .
AK149137 mRNA. Translation: BAE28747.1 .
AK168159 mRNA. Translation: BAE40122.1 .
CCDSi CCDS52446.1.
RefSeqi NP_079869.1. NM_025593.1.
UniGenei Mm.380115.

3D structure databases

ProteinModelPortali P62876.
SMRi P62876. Positions 1-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P62876. 2 interactions.
MINTi MINT-4133017.
STRINGi 10090.ENSMUSP00000043204.

PTM databases

PhosphoSitei P62876.

Proteomic databases

MaxQBi P62876.
PaxDbi P62876.
PRIDEi P62876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043870 ; ENSMUSP00000043204 ; ENSMUSG00000038489 .
GeneIDi 66491.
KEGGi mmu:66491.
UCSCi uc009klm.2. mouse.

Organism-specific databases

CTDi 5441.
MGIi MGI:1913741. Polr2l.

Phylogenomic databases

eggNOGi COG1644.
GeneTreei ENSGT00390000007087.
HOVERGENi HBG061475.
InParanoidi P62876.
KOi K03007.
OMAi QIANINR.
OrthoDBi EOG79CZ2Z.
PhylomeDBi P62876.
TreeFami TF103046.

Enzyme and pathway databases

Reactomei REACT_203462. Formation of the Early Elongation Complex.
REACT_205207. RNA Polymerase III Chain Elongation.
REACT_213655. Transcription-coupled NER (TC-NER).
REACT_221178. MicroRNA (miRNA) biogenesis.
REACT_221403. RNA Polymerase III Transcription Termination.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

NextBioi 21055.
PROi P62876.
SOURCEi Search...

Gene expression databases

Bgeei P62876.
CleanExi MM_POLR2L.
Genevestigatori P62876.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
HAMAPi MF_00250. RNApol_arch_N.
InterProi IPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view ]
Pfami PF01194. RNA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF46924. SSF46924. 1 hit.
PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Liver and Sympathetic ganglion.

Entry informationi

Entry nameiRPAB5_MOUSE
AccessioniPrimary (citable) accession number: P62876
Secondary accession number(s): P52436, Q3UF14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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