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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

Polr2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7ZincBy similarity1
Metal bindingi10ZincBy similarity1
Metal bindingi44ZincBy similarity1
Metal bindingi45ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
DNA-directed RNA polymerase III subunit L
RPB10 homolog
Gene namesi
Name:Polr2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913741 Polr2l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213341 – 67DNA-directed RNA polymerases I, II, and III subunit RPABC5Add BLAST67

Proteomic databases

EPDiP62876
MaxQBiP62876
PaxDbiP62876
PRIDEiP62876

PTM databases

iPTMnetiP62876
PhosphoSitePlusiP62876

Expressioni

Gene expression databases

BgeeiENSMUSG00000038489
CleanExiMM_POLR2L
GenevisibleiP62876 MM

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

IntActiP62876, 2 interactors
MINTiP62876
STRINGi10090.ENSMUSP00000043204

Structurei

3D structure databases

ProteinModelPortaliP62876
SMRiP62876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3497 Eukaryota
COG1644 LUCA
GeneTreeiENSGT00390000007087
HOVERGENiHBG061475
InParanoidiP62876
KOiK03007
OMAiYCCRRMF
OrthoDBiEOG091G15FJ
PhylomeDBiP62876
TreeFamiTF103046

Family and domain databases

HAMAPiMF_00250 RNApol_arch_N, 1 hit
InterProiView protein in InterPro
IPR023580 RNA_pol_su_RPB10
IPR020789 RNA_pol_suN_Zn-BS
IPR000268 RNAP_N/Rpb10
PANTHERiPTHR23431 PTHR23431, 1 hit
PfamiView protein in Pfam
PF01194 RNA_pol_N, 1 hit
PIRSFiPIRSF005653 RNA_pol_N/8_sub, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006539 RNA_pol_N/8_sub, 1 hit
SUPFAMiSSF46924 SSF46924, 1 hit
PROSITEiView protein in PROSITE
PS01112 RNA_POL_N_8KD, 1 hit

Sequencei

Sequence statusi: Complete.

P62876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL
60
AHVDLIEKLL NYAPLEK
Length:67
Mass (Da):7,645
Last modified:August 16, 2004 - v1
Checksum:i9E8A72F667FE7EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011021 mRNA Translation: BAB27338.1
AK149137 mRNA Translation: BAE28747.1
AK168159 mRNA Translation: BAE40122.1
CCDSiCCDS52446.1
RefSeqiNP_079869.1, NM_025593.1
UniGeneiMm.380115

Genome annotation databases

EnsembliENSMUST00000043870; ENSMUSP00000043204; ENSMUSG00000038489
GeneIDi66491
KEGGimmu:66491
UCSCiuc009klm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRPAB5_MOUSE
AccessioniPrimary (citable) accession number: P62876
Secondary accession number(s): P52436, Q3UF14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health