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P62875

- RPAB5_HUMAN

UniProt

P62875 - RPAB5_HUMAN

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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

POLR2L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71ZincBy similarity
Metal bindingi10 – 101ZincBy similarity
Metal bindingi44 – 441ZincBy similarity
Metal bindingi45 – 451ZincBy similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: ProtInc
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: Reactome
  2. DNA repair Source: Reactome
  3. gene expression Source: Reactome
  4. innate immune response Source: Reactome
  5. mRNA splicing, via spliceosome Source: Reactome
  6. nucleotide-excision repair Source: Reactome
  7. positive regulation of type I interferon production Source: Reactome
  8. positive regulation of viral transcription Source: Reactome
  9. regulation of transcription from RNA polymerase I promoter Source: ProtInc
  10. RNA splicing Source: Reactome
  11. termination of RNA polymerase III transcription Source: Reactome
  12. transcription-coupled nucleotide-excision repair Source: Reactome
  13. transcription elongation from RNA polymerase III promoter Source: Reactome
  14. transcription elongation from RNA polymerase II promoter Source: Reactome
  15. transcription from RNA polymerase III promoter Source: Reactome
  16. transcription from RNA polymerase II promoter Source: UniProtKB
  17. transcription from RNA polymerase I promoter Source: GOC
  18. transcription initiation from RNA polymerase II promoter Source: Reactome
  19. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_1074. RNA Polymerase I Transcription Termination.
REACT_12417. MicroRNA (miRNA) biogenesis.
REACT_125. Processing of Capped Intron-Containing Pre-mRNA.
REACT_1470. mRNA Capping.
REACT_1628. Transcription-coupled NER (TC-NER).
REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1753. mRNA Splicing - Minor Pathway.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
REACT_2222. Dual incision reaction in TC-NER.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_267668. Transcriptional regulation by small RNAs.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_467. mRNA Splicing - Major Pathway.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_6143. Pausing and recovery of Tat-mediated HIV elongation.
REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
REACT_6233. Transcription of the HIV genome.
REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_6244. Pausing and recovery of HIV elongation.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6259. HIV elongation arrest and recovery.
REACT_6261. Abortive elongation of HIV-1 transcript in the absence of Tat.
REACT_63. RNA Polymerase III Transcription Termination.
REACT_6319. Formation of the HIV-1 Early Elongation Complex.
REACT_6332. HIV Transcription Initiation.
REACT_6344. Tat-mediated HIV elongation arrest and recovery.
REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_756. RNA Polymerase III Chain Elongation.
REACT_833. RNA Polymerase II Transcription Elongation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_846. Formation of the Early Elongation Complex.
REACT_953. RNA Polymerase I Transcription Initiation.
REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
DNA-directed RNA polymerase III subunit L
RNA polymerase II 7.6 kDa subunit
Short name:
RPB7.6
RPB10 homolog
Gene namesi
Name:POLR2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9199. POLR2L.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. DNA-directed RNA polymerase I complex Source: RefGenome
  3. DNA-directed RNA polymerase II, core complex Source: UniProtKB
  4. DNA-directed RNA polymerase III complex Source: RefGenome
  5. nucleoplasm Source: Reactome
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767DNA-directed RNA polymerases I, II, and III subunit RPABC5PRO_0000121333Add
BLAST

Proteomic databases

MaxQBiP62875.
PaxDbiP62875.
PRIDEiP62875.

PTM databases

PhosphoSiteiP62875.

Expressioni

Gene expression databases

BgeeiP62875.
CleanExiHS_POLR2L.
GenevestigatoriP62875.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi111437. 30 interactions.
IntActiP62875. 11 interactions.
MINTiMINT-1132504.
STRINGi9606.ENSP00000324124.

Structurei

3D structure databases

ProteinModelPortaliP62875.
SMRiP62875. Positions 1-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1644.
GeneTreeiENSGT00390000007087.
HOVERGENiHBG061475.
InParanoidiP62875.
KOiK03007.
OMAiRRAKFIF.
OrthoDBiEOG79CZ2Z.
PhylomeDBiP62875.
TreeFamiTF103046.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62875-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL
60
AHVDLIEKLL NYAPLEK
Length:67
Mass (Da):7,645
Last modified:August 16, 2004 - v1
Checksum:i9E8A72F667FE7EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37690 mRNA. Translation: AAA91459.1.
CR536565 mRNA. Translation: CAG38802.1.
AK311997 mRNA. Translation: BAG34935.1.
BC005903 mRNA. Translation: AAH05903.1.
BC018649 mRNA. Translation: AAH18649.1.
Z47729 Genomic DNA. Translation: CAA87658.1.
Z47728 Genomic DNA. Translation: CAA87657.1.
CCDSiCCDS7720.1.
PIRiS53015.
RefSeqiNP_066951.1. NM_021128.4.
UniGeneiHs.441072.

Genome annotation databases

EnsembliENST00000322028; ENSP00000324124; ENSG00000177700.
ENST00000534030; ENSP00000432807; ENSG00000177700.
GeneIDi5441.
KEGGihsa:5441.
UCSCiuc001lsc.3. human.

Polymorphism databases

DMDMi51338657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37690 mRNA. Translation: AAA91459.1 .
CR536565 mRNA. Translation: CAG38802.1 .
AK311997 mRNA. Translation: BAG34935.1 .
BC005903 mRNA. Translation: AAH05903.1 .
BC018649 mRNA. Translation: AAH18649.1 .
Z47729 Genomic DNA. Translation: CAA87658.1 .
Z47728 Genomic DNA. Translation: CAA87657.1 .
CCDSi CCDS7720.1.
PIRi S53015.
RefSeqi NP_066951.1. NM_021128.4.
UniGenei Hs.441072.

3D structure databases

ProteinModelPortali P62875.
SMRi P62875. Positions 1-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111437. 30 interactions.
IntActi P62875. 11 interactions.
MINTi MINT-1132504.
STRINGi 9606.ENSP00000324124.

PTM databases

PhosphoSitei P62875.

Polymorphism databases

DMDMi 51338657.

Proteomic databases

MaxQBi P62875.
PaxDbi P62875.
PRIDEi P62875.

Protocols and materials databases

DNASUi 5441.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322028 ; ENSP00000324124 ; ENSG00000177700 .
ENST00000534030 ; ENSP00000432807 ; ENSG00000177700 .
GeneIDi 5441.
KEGGi hsa:5441.
UCSCi uc001lsc.3. human.

Organism-specific databases

CTDi 5441.
GeneCardsi GC11M000829.
HGNCi HGNC:9199. POLR2L.
MIMi 601189. gene.
neXtProti NX_P62875.
PharmGKBi PA33519.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1644.
GeneTreei ENSGT00390000007087.
HOVERGENi HBG061475.
InParanoidi P62875.
KOi K03007.
OMAi RRAKFIF.
OrthoDBi EOG79CZ2Z.
PhylomeDBi P62875.
TreeFami TF103046.

Enzyme and pathway databases

Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_1074. RNA Polymerase I Transcription Termination.
REACT_12417. MicroRNA (miRNA) biogenesis.
REACT_125. Processing of Capped Intron-Containing Pre-mRNA.
REACT_1470. mRNA Capping.
REACT_1628. Transcription-coupled NER (TC-NER).
REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1753. mRNA Splicing - Minor Pathway.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
REACT_2222. Dual incision reaction in TC-NER.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_267668. Transcriptional regulation by small RNAs.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_467. mRNA Splicing - Major Pathway.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_6143. Pausing and recovery of Tat-mediated HIV elongation.
REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
REACT_6233. Transcription of the HIV genome.
REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_6244. Pausing and recovery of HIV elongation.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6259. HIV elongation arrest and recovery.
REACT_6261. Abortive elongation of HIV-1 transcript in the absence of Tat.
REACT_63. RNA Polymerase III Transcription Termination.
REACT_6319. Formation of the HIV-1 Early Elongation Complex.
REACT_6332. HIV Transcription Initiation.
REACT_6344. Tat-mediated HIV elongation arrest and recovery.
REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_756. RNA Polymerase III Chain Elongation.
REACT_833. RNA Polymerase II Transcription Elongation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_846. Formation of the Early Elongation Complex.
REACT_953. RNA Polymerase I Transcription Initiation.
REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

GeneWikii POLR2L.
GenomeRNAii 5441.
NextBioi 21055.
PROi P62875.
SOURCEi Search...

Gene expression databases

Bgeei P62875.
CleanExi HS_POLR2L.
Genevestigatori P62875.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
HAMAPi MF_00250. RNApol_arch_N.
InterProi IPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view ]
Pfami PF01194. RNA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF46924. SSF46924. 1 hit.
PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Six human RNA polymerase subunits functionally substitute for their yeast counterparts."
    McKune K., Moore P.A., Hull M.W., Woychik N.A.
    Mol. Cell. Biol. 15:6895-6900(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow and Kidney.
  5. "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae."
    Shpakovski G.V., Acker J., Wintzerith M., Lacroix J.F., Thuriaux P., Vigneron M.
    Mol. Cell. Biol. 15:4702-4710(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
  6. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."
    Kershnar E., Wu S.-Y., Chiang C.-M.
    J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RNA POLYMERASE II CORE-COMPLEX, SUBCELLULAR LOCATION.
  7. "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor."
    Panov K.I., Panova T.B., Gadal O., Nishiyama K., Saito T., Russell J., Zomerdijk J.C.B.M.
    Mol. Cell. Biol. 26:5436-5448(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPAB5_HUMAN
AccessioniPrimary (citable) accession number: P62875
Secondary accession number(s): P52436, Q6FHX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3