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P62874 (GBB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Alternative name(s):
Transducin beta chain 1
Gene names
Name:Gnb1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.

Post-translational modification

Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP By similarity.

Sequence similarities

Belongs to the WD repeat G protein beta family.

Contains 7 WD repeats.

Ontologies

Keywords
   DomainRepeat
WD repeat
   Molecular functionTransducer
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 14712229. Source: MGI

cardiac muscle cell apoptotic process

Inferred from sequence orthology PubMed 19723622. Source: MGI

cell proliferation

Inferred from direct assay PubMed 14712229. Source: MGI

cellular response to hypoxia

Inferred from sequence orthology PubMed 19723622. Source: MGI

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 10570481. Source: MGI

phototransduction, visible light

Inferred from sequence alignment PubMed 2328987. Source: MGI

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

retina development in camera-type eye

Inferred from mutant phenotype PubMed 21052544. Source: MGI

sensory perception of taste

Inferred from direct assay PubMed 10570481. Source: MGI

   Cellular_componentcell body

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

heterotrimeric G-protein complex

Inferred from physical interaction PubMed 10570481. Source: MGI

lysosomal membrane

Inferred from electronic annotation. Source: Ensembl

photoreceptor inner segment

Inferred from electronic annotation. Source: Ensembl

photoreceptor outer segment

Inferred from direct assay PubMed 18367617. Source: MGI

photoreceptor outer segment membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionGTPase activity

Inferred from sequence alignment PubMed 1543505. Source: MGI

protein complex binding

Inferred from sequence orthology PubMed 23209302. Source: MGI

signal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

spectrin binding

Inferred from sequence orthology PubMed 23704327. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 340339Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
PRO_0000127688

Regions

Repeat53 – 8331WD 1
Repeat95 – 12531WD 2
Repeat141 – 17030WD 3
Repeat182 – 21231WD 4
Repeat224 – 25431WD 5
Repeat268 – 29831WD 6
Repeat310 – 34031WD 7

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue2661Phosphohistidine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62874 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 896CBD32D2686598

FASTA34037,377
        10         20         30         40         50         60 
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA 

        70         80         90        100        110        120 
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 

       130        140        150        160        170        180 
CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF 

       190        200        210        220        230        240 
TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA 

       250        260        270        280        290        300 
FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL 

       310        320        330        340 
KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN 

« Hide

References

« Hide 'large scale' references
[1]Qiu R., Schimmer B.P.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.
[2]"Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes."
Kitanaka J., Wang X., Kitanaka N., Hembree C.M., Uhl G.R.
DNA Seq. 12:345-354(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 24-42; 58-96; 138-150; 198-209 AND 284-301, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29055 mRNA. Translation: AAC52905.1.
AB042854 Genomic DNA. Translation: BAB63904.1.
BC013058 mRNA. Translation: AAH13058.1.
CCDSCCDS19030.1.
PIRJC5057.
RefSeqNP_001153488.1. NM_001160016.1.
NP_001153489.1. NM_001160017.1.
NP_032168.1. NM_008142.4.
UniGeneMm.2344.

3D structure databases

ProteinModelPortalP62874.
SMRP62874. Positions 2-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199976. 14 interactions.
IntActP62874. 8 interactions.
MINTMINT-248027.

PTM databases

PhosphoSiteP62874.

Proteomic databases

MaxQBP62874.
PaxDbP62874.
PRIDEP62874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030940; ENSMUSP00000030940; ENSMUSG00000029064.
ENSMUST00000105616; ENSMUSP00000101241; ENSMUSG00000029064.
ENSMUST00000165335; ENSMUSP00000130123; ENSMUSG00000029064.
ENSMUST00000176637; ENSMUSP00000135091; ENSMUSG00000029064.
GeneID14688.
KEGGmmu:14688.
UCSCuc008wdp.2. mouse.

Organism-specific databases

CTD2782.
MGIMGI:95781. Gnb1.

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000176356.
HOVERGENHBG000188.
InParanoidP62874.
KOK04536.
OMARIVMRPR.
OrthoDBEOG7GN2N5.
PhylomeDBP62874.
TreeFamTF106149.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressP62874.
BgeeP62874.
GenevestigatorP62874.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 7 hits.
[Graphical view]
PIRSFPIRSF002394. GN-bd_beta. 1 hit.
PRINTSPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGNB1. mouse.
NextBio286631.
PROP62874.
SOURCESearch...

Entry information

Entry nameGBB1_MOUSE
AccessionPrimary (citable) accession number: P62874
Secondary accession number(s): P04697, P04901
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot