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P62874

- GBB1_MOUSE

UniProt

P62874 - GBB1_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene

Gnb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activity Source: MGI
    2. protein complex binding Source: MGI
    3. signal transducer activity Source: UniProtKB-KW
    4. spectrin binding Source: MGI

    GO - Biological processi

    1. cardiac muscle cell apoptotic process Source: MGI
    2. cell proliferation Source: MGI
    3. cellular response to hypoxia Source: MGI
    4. G-protein coupled receptor signaling pathway Source: MGI
    5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    6. phototransduction, visible light Source: MGI
    7. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    8. retina development in camera-type eye Source: MGI
    9. sensory perception of taste Source: MGI

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_198612. Presynaptic function of Kainate receptors.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_205726. G-protein activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_221970. Ca2+ pathway.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Alternative name(s):
    Transducin beta chain 1
    Gene namesi
    Name:Gnb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95781. Gnb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. dendrite Source: Ensembl
    3. heterotrimeric G-protein complex Source: MGI
    4. lysosomal membrane Source: Ensembl
    5. photoreceptor inner segment Source: Ensembl
    6. photoreceptor outer segment Source: MGI
    7. photoreceptor outer segment membrane Source: Ensembl
    8. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 340339Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1PRO_0000127688Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei266 – 2661PhosphohistidineBy similarity

    Post-translational modificationi

    Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62874.
    PaxDbiP62874.
    PRIDEiP62874.

    PTM databases

    PhosphoSiteiP62874.

    Expressioni

    Gene expression databases

    ArrayExpressiP62874.
    BgeeiP62874.
    GenevestigatoriP62874.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199976. 14 interactions.
    IntActiP62874. 8 interactions.
    MINTiMINT-248027.

    Structurei

    3D structure databases

    ProteinModelPortaliP62874.
    SMRiP62874. Positions 2-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati53 – 8331WD 1Add
    BLAST
    Repeati95 – 12531WD 2Add
    BLAST
    Repeati141 – 17030WD 3Add
    BLAST
    Repeati182 – 21231WD 4Add
    BLAST
    Repeati224 – 25431WD 5Add
    BLAST
    Repeati268 – 29831WD 6Add
    BLAST
    Repeati310 – 34031WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat G protein beta family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000176356.
    HOVERGENiHBG000188.
    InParanoidiP62874.
    KOiK04536.
    OMAiRIVMRPR.
    OrthoDBiEOG7GN2N5.
    PhylomeDBiP62874.
    TreeFamiTF106149.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 7 hits.
    [Graphical view]
    PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
    PRINTSiPR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62874-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT    50
    LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV 100
    MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR 150
    FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV 200
    SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC 250
    RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL 300
    KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN 340
    Length:340
    Mass (Da):37,377
    Last modified:January 23, 2007 - v3
    Checksum:i896CBD32D2686598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29055 mRNA. Translation: AAC52905.1.
    AB042854 Genomic DNA. Translation: BAB63904.1.
    BC013058 mRNA. Translation: AAH13058.1.
    CCDSiCCDS19030.1.
    PIRiJC5057.
    RefSeqiNP_001153488.1. NM_001160016.1.
    NP_001153489.1. NM_001160017.1.
    NP_032168.1. NM_008142.4.
    UniGeneiMm.2344.

    Genome annotation databases

    EnsembliENSMUST00000030940; ENSMUSP00000030940; ENSMUSG00000029064.
    ENSMUST00000105616; ENSMUSP00000101241; ENSMUSG00000029064.
    ENSMUST00000165335; ENSMUSP00000130123; ENSMUSG00000029064.
    ENSMUST00000176637; ENSMUSP00000135091; ENSMUSG00000029064.
    GeneIDi14688.
    KEGGimmu:14688.
    UCSCiuc008wdp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29055 mRNA. Translation: AAC52905.1 .
    AB042854 Genomic DNA. Translation: BAB63904.1 .
    BC013058 mRNA. Translation: AAH13058.1 .
    CCDSi CCDS19030.1.
    PIRi JC5057.
    RefSeqi NP_001153488.1. NM_001160016.1.
    NP_001153489.1. NM_001160017.1.
    NP_032168.1. NM_008142.4.
    UniGenei Mm.2344.

    3D structure databases

    ProteinModelPortali P62874.
    SMRi P62874. Positions 2-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199976. 14 interactions.
    IntActi P62874. 8 interactions.
    MINTi MINT-248027.

    PTM databases

    PhosphoSitei P62874.

    Proteomic databases

    MaxQBi P62874.
    PaxDbi P62874.
    PRIDEi P62874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030940 ; ENSMUSP00000030940 ; ENSMUSG00000029064 .
    ENSMUST00000105616 ; ENSMUSP00000101241 ; ENSMUSG00000029064 .
    ENSMUST00000165335 ; ENSMUSP00000130123 ; ENSMUSG00000029064 .
    ENSMUST00000176637 ; ENSMUSP00000135091 ; ENSMUSG00000029064 .
    GeneIDi 14688.
    KEGGi mmu:14688.
    UCSCi uc008wdp.2. mouse.

    Organism-specific databases

    CTDi 2782.
    MGIi MGI:95781. Gnb1.

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000176356.
    HOVERGENi HBG000188.
    InParanoidi P62874.
    KOi K04536.
    OMAi RIVMRPR.
    OrthoDBi EOG7GN2N5.
    PhylomeDBi P62874.
    TreeFami TF106149.

    Enzyme and pathway databases

    Reactomei REACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_198612. Presynaptic function of Kainate receptors.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_205726. G-protein activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_221970. Ca2+ pathway.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi GNB1. mouse.
    NextBioi 286631.
    PROi P62874.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62874.
    Bgeei P62874.
    Genevestigatori P62874.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 7 hits.
    [Graphical view ]
    PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
    PRINTSi PR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Qiu R., Schimmer B.P.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal gland.
    2. "Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes."
      Kitanaka J., Wang X., Kitanaka N., Hembree C.M., Uhl G.R.
      DNA Seq. 12:345-354(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 24-42; 58-96; 138-150; 198-209 AND 284-301, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiGBB1_MOUSE
    AccessioniPrimary (citable) accession number: P62874
    Secondary accession number(s): P04697, P04901
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3