SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P62873

- GBB1_HUMAN

UniProt

P62873 - GBB1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene
GNB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.1 Publication

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. GTPase binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein complex binding Source: MGI
  5. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  2. blood coagulation Source: Reactome
  3. cardiac muscle cell apoptotic process Source: Ensembl
  4. cell proliferation Source: Ensembl
  5. cellular response to catecholamine stimulus Source: BHF-UCL
  6. cellular response to glucagon stimulus Source: Reactome
  7. cellular response to hypoxia Source: Ensembl
  8. cellular response to prostaglandin E stimulus Source: BHF-UCL
  9. energy reserve metabolic process Source: Reactome
  10. G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
  11. GTP catabolic process Source: GOC
  12. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  13. phototransduction, visible light Source: Reactome
  14. platelet activation Source: Reactome
  15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  16. Ras protein signal transduction Source: ProtInc
  17. regulation of rhodopsin mediated signaling pathway Source: Reactome
  18. retina development in camera-type eye Source: Ensembl
  19. rhodopsin mediated signaling pathway Source: Reactome
  20. sensory perception of taste Source: Ensembl
  21. signal transduction Source: ProtInc
  22. small molecule metabolic process Source: Reactome
  23. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_15488. Olfactory Signaling Pathway.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_163932. Activation of the phototransduction cascade.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinkiP62873.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Alternative name(s):
Transducin beta chain 1
Gene namesi
Name:GNB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4396. GNB1.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. heterotrimeric G-protein complex Source: MGI
  5. intracellular Source: BHF-UCL
  6. lysosomal membrane Source: UniProtKB
  7. membrane Source: BHF-UCL
  8. photoreceptor disc membrane Source: Reactome
  9. photoreceptor inner segment Source: Ensembl
  10. photoreceptor outer segment membrane Source: Ensembl
  11. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi47 – 471T → A: Abolishes interaction with PTH1R and signaling in response to PTH1R agonist; when associated with A-337 and A-339. 1 Publication
Mutagenesisi337 – 3371K → A: Abolishes interaction with PTH1R and signaling in response to PTH1R agonist; when associated with A-47 and A-339. 1 Publication
Mutagenesisi339 – 3391W → A: Abolishes interaction with PTH1R and signaling in response to PTH1R agonist; when associated with A-47 and A-337. 1 Publication

Organism-specific databases

PharmGKBiPA28776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 340339Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1PRO_0000127687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine4 Publications
Modified residuei266 – 2661Phosphohistidine By similarity

Post-translational modificationi

Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP62873.
PaxDbiP62873.
PRIDEiP62873.

2D gel databases

OGPiP62873.
REPRODUCTION-2DPAGEIPI00026268.

PTM databases

PhosphoSiteiP62873.

Expressioni

Gene expression databases

ArrayExpressiP62873.
BgeeiP62873.
CleanExiHS_GNB1.
GenevestigatoriP62873.

Organism-specific databases

HPAiHPA040736.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCF2P198782EBI-357130,EBI-489611

Protein-protein interaction databases

BioGridi109044. 70 interactions.
DIPiDIP-599N.
IntActiP62873. 21 interactions.
MINTiMINT-94562.
STRINGi9606.ENSP00000367872.

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2523
Helixi30 – 345
Beta strandi47 – 515
Beta strandi58 – 636
Beta strandi67 – 748
Beta strandi77 – 837
Turni84 – 863
Beta strandi89 – 946
Beta strandi100 – 1056
Beta strandi109 – 1168
Beta strandi121 – 1277
Beta strandi134 – 1396
Beta strandi146 – 1538
Beta strandi156 – 1616
Beta strandi164 – 1707
Turni171 – 1733
Beta strandi176 – 1816
Beta strandi187 – 1926
Beta strandi196 – 2038
Beta strandi208 – 2125
Turni213 – 2164
Beta strandi217 – 2226
Beta strandi229 – 2346
Beta strandi238 – 2458
Beta strandi250 – 2545
Turni255 – 2584
Beta strandi259 – 2646
Beta strandi273 – 2786
Beta strandi284 – 2896
Beta strandi292 – 2987
Turni299 – 3013
Beta strandi303 – 3097
Beta strandi315 – 3206
Beta strandi327 – 3315
Beta strandi336 – 3394

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45B1-340[»]
ProteinModelPortaliP62873.
SMRiP62873. Positions 2-340.

Miscellaneous databases

EvolutionaryTraceiP62873.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 8331WD 1Add
BLAST
Repeati95 – 12531WD 2Add
BLAST
Repeati141 – 17030WD 3Add
BLAST
Repeati182 – 21231WD 4Add
BLAST
Repeati224 – 25431WD 5Add
BLAST
Repeati268 – 29831WD 6Add
BLAST
Repeati310 – 34031WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62873.
KOiK04536.
OMAiRIVMRPR.
OrthoDBiEOG7GN2N5.
PhylomeDBiP62873.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62873-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT    50
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV 100
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR 150
FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV 200
SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC 250
RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL 300
KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN 340
Length:340
Mass (Da):37,377
Last modified:January 23, 2007 - v3
Checksum:i896CBD32D2686598
GO
Isoform 2 (identifier: P62873-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-340: TGSWDSFLKIWN → SVLG

Note: No experimental confirmation available.

Show »
Length:332
Mass (Da):36,298
Checksum:iB974CB3B43FEFFC4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 34012TGSWD…LKIWN → SVLG in isoform 2. VSP_055232Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04526 mRNA. Translation: CAA28207.1.
AF501882 mRNA. Translation: AAM15918.1.
BT007305 mRNA. Translation: AAP35969.1.
CR456784 mRNA. Translation: CAG33065.1.
AL031282, AL109917 Genomic DNA. Translation: CAI20029.1.
AL109917, AL031282 Genomic DNA. Translation: CAI95654.1.
CH471183 Genomic DNA. Translation: EAW56147.1.
BC004186 mRNA. Translation: AAH04186.1.
BC005888 mRNA. Translation: AAH05888.1.
BC008991 mRNA. Translation: AAH08991.1.
BC114618 mRNA. Translation: AAI14619.1.
M36430 mRNA. Translation: AAA63265.1.
CCDSiCCDS34.1. [P62873-1]
PIRiA24853. RGHUB1.
RefSeqiNP_001269467.1. NM_001282538.1.
NP_001269468.1. NM_001282539.1.
NP_002065.1. NM_002074.4.
UniGeneiHs.430425.
Hs.721030.

Genome annotation databases

EnsembliENST00000378609; ENSP00000367872; ENSG00000078369.
GeneIDi2782.
KEGGihsa:2782.
UCSCiuc001aif.3. human. [P62873-1]

Polymorphism databases

DMDMi51317302.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04526 mRNA. Translation: CAA28207.1 .
AF501882 mRNA. Translation: AAM15918.1 .
BT007305 mRNA. Translation: AAP35969.1 .
CR456784 mRNA. Translation: CAG33065.1 .
AL031282 , AL109917 Genomic DNA. Translation: CAI20029.1 .
AL109917 , AL031282 Genomic DNA. Translation: CAI95654.1 .
CH471183 Genomic DNA. Translation: EAW56147.1 .
BC004186 mRNA. Translation: AAH04186.1 .
BC005888 mRNA. Translation: AAH05888.1 .
BC008991 mRNA. Translation: AAH08991.1 .
BC114618 mRNA. Translation: AAI14619.1 .
M36430 mRNA. Translation: AAA63265.1 .
CCDSi CCDS34.1. [P62873-1 ]
PIRi A24853. RGHUB1.
RefSeqi NP_001269467.1. NM_001282538.1.
NP_001269468.1. NM_001282539.1.
NP_002065.1. NM_002074.4.
UniGenei Hs.430425.
Hs.721030.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KFM X-ray 3.45 B 1-340 [» ]
ProteinModelPortali P62873.
SMRi P62873. Positions 2-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109044. 70 interactions.
DIPi DIP-599N.
IntActi P62873. 21 interactions.
MINTi MINT-94562.
STRINGi 9606.ENSP00000367872.

PTM databases

PhosphoSitei P62873.

Polymorphism databases

DMDMi 51317302.

2D gel databases

OGPi P62873.
REPRODUCTION-2DPAGE IPI00026268.

Proteomic databases

MaxQBi P62873.
PaxDbi P62873.
PRIDEi P62873.

Protocols and materials databases

DNASUi 2782.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378609 ; ENSP00000367872 ; ENSG00000078369 .
GeneIDi 2782.
KEGGi hsa:2782.
UCSCi uc001aif.3. human. [P62873-1 ]

Organism-specific databases

CTDi 2782.
GeneCardsi GC01M001748.
HGNCi HGNC:4396. GNB1.
HPAi HPA040736.
MIMi 139380. gene.
neXtProti NX_P62873.
PharmGKBi PA28776.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000176356.
HOVERGENi HBG000188.
InParanoidi P62873.
KOi K04536.
OMAi RIVMRPR.
OrthoDBi EOG7GN2N5.
PhylomeDBi P62873.
TreeFami TF106149.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_15488. Olfactory Signaling Pathway.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_163932. Activation of the phototransduction cascade.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinki P62873.

Miscellaneous databases

ChiTaRSi GNB1. human.
EvolutionaryTracei P62873.
GeneWikii GNB1.
GenomeRNAii 2782.
NextBioi 10959.
PROi P62873.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62873.
Bgeei P62873.
CleanExi HS_GNB1.
Genevestigatori P62873.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
PRINTSi PR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical."
    Codina J., Stengel D., Woo S.L.C., Birnbaumer L.
    FEBS Lett. 207:187-192(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Muscle and Uterus.
  8. Bienvenut W.V., Quadroni M.
    Submitted (JUL-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-15; 58-89; 284-301 AND 305-314, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma and Melanoma.
  9. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-8; 69-78 AND 90-96, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  10. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 23-42; 58-78; 138-150; 198-209 AND 315-337, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  11. "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production."
    Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T.
    Circ. Res. 93:848-856(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF18.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The cationic region of Rhes mediates its interactions with specific Gbeta subunits."
    Hill C., Goddard A., Ladds G., Davey J.
    Cell. Physiol. Biochem. 23:1-8(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASD2.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2."
    Johnston C.A., Kimple A.J., Giguere P.M., Siderovski D.P.
    Structure 16:1086-1094(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEXES WITH GNG2 AND PTH1R, FUNCTION, SUBUNIT, MUTAGENESIS OF THR-47; LYS-337 AND TRP-339.
  17. Cited for: RETRACTION.

Entry informationi

Entry nameiGBB1_HUMAN
AccessioniPrimary (citable) accession number: P62873
Secondary accession number(s): B1AJZ7
, P04697, P04901, Q1RMY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi