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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene

GNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTPase binding Source: UniProtKB
  • protein complex binding Source: MGI
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-2485179. Activation of the phototransduction cascade.
R-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-381753. Olfactory Signaling Pathway.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP62873.
SIGNORiP62873.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Alternative name(s):
Transducin beta chain 1
Gene namesi
Name:GNB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4396. GNB1.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • cytosol Source: Reactome
  • dendrite Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • heterotrimeric G-protein complex Source: MGI
  • intracellular Source: BHF-UCL
  • lysosomal membrane Source: UniProtKB
  • membrane Source: BHF-UCL
  • myelin sheath Source: Ensembl
  • photoreceptor disc membrane Source: Reactome
  • photoreceptor inner segment Source: Ensembl
  • photoreceptor outer segment membrane Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 42 (MRD42)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD42 patients manifest global developmental delay commonly accompanied by hypotonia, seizures of various types, ophthalmological manifestations, and poor growth.
See also OMIM:616973
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761D → E in MRD42. 1 Publication
VAR_076644
Natural varianti76 – 761D → G in MRD42. 1 Publication
VAR_076643
Natural varianti77 – 771G → S in MRD42. 1 Publication
VAR_076645
Natural varianti78 – 781K → R in MRD42. 1 Publication
VAR_076646
Natural varianti80 – 801I → N in MRD42; also found in patients with acute lymphoblastic T-cell leukemia; reduces interaction with GNAI2, GNAI3, GNA13 and GNA11; induces activation of PI3K-AKT-mTOR and MAPK pathways. 2 Publications
VAR_076647
Natural varianti80 – 801I → T in MRD42; also found in patient with hematologic malignancies; reduces interaction with GNAI2, GNAI3, GNA13 and GNA11; induces activation of PI3K-AKT-mTOR and MAPK pathways. 2 Publications
VAR_076648
Natural varianti95 – 951L → P in MRD42. 1 Publication
VAR_076649
Natural varianti101 – 1011M → V in MRD42. 1 Publication
VAR_076650
Natural varianti326 – 3261A → T in MRD42. 1 Publication
VAR_076651

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi616973. phenotype.
PharmGKBiPA28776.

Polymorphism and mutation databases

DMDMi51317302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources2 Publications
Chaini2 – 340339Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1PRO_0000127687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources2 Publications
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei266 – 2661PhosphohistidineBy similarity

Post-translational modificationi

Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62873.
MaxQBiP62873.
PaxDbiP62873.
PeptideAtlasiP62873.
PRIDEiP62873.

2D gel databases

OGPiP62873.
REPRODUCTION-2DPAGEIPI00026268.

PTM databases

iPTMnetiP62873.
PhosphoSiteiP62873.
SwissPalmiP62873.

Expressioni

Gene expression databases

BgeeiENSG00000078369.
CleanExiHS_GNB1.
ExpressionAtlasiP62873. baseline and differential.
GenevisibleiP62873. HS.

Organism-specific databases

HPAiHPA040736.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2 (PubMed:14512443, PubMed:19255495). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCF2P198782EBI-357130,EBI-489611

GO - Molecular functioni

  • GTPase binding Source: UniProtKB
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi109044. 100 interactions.
DIPiDIP-599N.
IntActiP62873. 41 interactions.
MINTiMINT-94562.
STRINGi9606.ENSP00000367869.

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2321Combined sources
Helixi30 – 334Combined sources
Beta strandi35 – 373Combined sources
Beta strandi47 – 515Combined sources
Beta strandi58 – 636Combined sources
Beta strandi67 – 748Combined sources
Turni75 – 773Combined sources
Beta strandi78 – 836Combined sources
Turni84 – 863Combined sources
Beta strandi89 – 946Combined sources
Beta strandi96 – 983Combined sources
Beta strandi100 – 1056Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi120 – 1278Combined sources
Beta strandi135 – 1406Combined sources
Beta strandi146 – 1538Combined sources
Beta strandi156 – 1616Combined sources
Beta strandi166 – 1705Combined sources
Turni171 – 1733Combined sources
Beta strandi176 – 1805Combined sources
Beta strandi187 – 1926Combined sources
Beta strandi196 – 2038Combined sources
Beta strandi208 – 2125Combined sources
Turni213 – 2164Combined sources
Beta strandi217 – 2226Combined sources
Beta strandi229 – 2346Combined sources
Beta strandi238 – 2458Combined sources
Beta strandi250 – 2545Combined sources
Turni255 – 2584Combined sources
Beta strandi259 – 2646Combined sources
Beta strandi273 – 2786Combined sources
Beta strandi284 – 2896Combined sources
Beta strandi294 – 2985Combined sources
Turni299 – 3013Combined sources
Beta strandi304 – 3085Combined sources
Beta strandi315 – 3206Combined sources
Beta strandi327 – 3315Combined sources
Beta strandi336 – 3394Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45B1-340[»]
4PNKX-ray2.56B1-340[»]
5HE0X-ray2.56B2-340[»]
5HE1X-ray3.15B2-340[»]
5HE2X-ray2.79B2-340[»]
5HE3X-ray2.74B2-340[»]
ProteinModelPortaliP62873.
SMRiP62873. Positions 2-340.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62873.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 8331WD 1Add
BLAST
Repeati95 – 12531WD 2Add
BLAST
Repeati141 – 17030WD 3Add
BLAST
Repeati182 – 21231WD 4Add
BLAST
Repeati224 – 25431WD 5Add
BLAST
Repeati268 – 29831WD 6Add
BLAST
Repeati310 – 34031WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62873.
KOiK04536.
OMAiRIVMRPR.
OrthoDBiEOG091G0A7T.
PhylomeDBiP62873.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62873-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR
160 170 180 190 200
FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV
210 220 230 240 250
SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC
260 270 280 290 300
RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL
310 320 330 340
KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,377
Last modified:January 23, 2007 - v3
Checksum:i896CBD32D2686598
GO
Isoform 2 (identifier: P62873-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-340: TGSWDSFLKIWN → SVLG

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):36,298
Checksum:iB974CB3B43FEFFC4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761D → E in MRD42. 1 Publication
VAR_076644
Natural varianti76 – 761D → G in MRD42. 1 Publication
VAR_076643
Natural varianti77 – 771G → S in MRD42. 1 Publication
VAR_076645
Natural varianti78 – 781K → R in MRD42. 1 Publication
VAR_076646
Natural varianti80 – 801I → N in MRD42; also found in patients with acute lymphoblastic T-cell leukemia; reduces interaction with GNAI2, GNAI3, GNA13 and GNA11; induces activation of PI3K-AKT-mTOR and MAPK pathways. 2 Publications
VAR_076647
Natural varianti80 – 801I → T in MRD42; also found in patient with hematologic malignancies; reduces interaction with GNAI2, GNAI3, GNA13 and GNA11; induces activation of PI3K-AKT-mTOR and MAPK pathways. 2 Publications
VAR_076648
Natural varianti95 – 951L → P in MRD42. 1 Publication
VAR_076649
Natural varianti101 – 1011M → V in MRD42. 1 Publication
VAR_076650
Natural varianti326 – 3261A → T in MRD42. 1 Publication
VAR_076651

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 34012TGSWD…LKIWN → SVLG in isoform 2. 1 PublicationVSP_055232Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04526 mRNA. Translation: CAA28207.1.
AF501882 mRNA. Translation: AAM15918.1.
BT007305 mRNA. Translation: AAP35969.1.
CR456784 mRNA. Translation: CAG33065.1.
AL031282, AL109917 Genomic DNA. Translation: CAI20029.1.
AL109917, AL031282 Genomic DNA. Translation: CAI95654.1.
CH471183 Genomic DNA. Translation: EAW56147.1.
BC004186 mRNA. Translation: AAH04186.1.
BC005888 mRNA. Translation: AAH05888.1.
BC008991 mRNA. Translation: AAH08991.1.
BC114618 mRNA. Translation: AAI14619.1.
M36430 mRNA. Translation: AAA63265.1.
CCDSiCCDS34.1. [P62873-1]
PIRiA24853. RGHUB1.
RefSeqiNP_001269467.1. NM_001282538.1.
NP_001269468.1. NM_001282539.1. [P62873-1]
NP_002065.1. NM_002074.4. [P62873-1]
UniGeneiHs.430425.
Hs.721030.

Genome annotation databases

EnsembliENST00000378609; ENSP00000367872; ENSG00000078369. [P62873-1]
ENST00000610897; ENSP00000481878; ENSG00000078369. [P62873-1]
GeneIDi2782.
KEGGihsa:2782.
UCSCiuc001aif.5. human. [P62873-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04526 mRNA. Translation: CAA28207.1.
AF501882 mRNA. Translation: AAM15918.1.
BT007305 mRNA. Translation: AAP35969.1.
CR456784 mRNA. Translation: CAG33065.1.
AL031282, AL109917 Genomic DNA. Translation: CAI20029.1.
AL109917, AL031282 Genomic DNA. Translation: CAI95654.1.
CH471183 Genomic DNA. Translation: EAW56147.1.
BC004186 mRNA. Translation: AAH04186.1.
BC005888 mRNA. Translation: AAH05888.1.
BC008991 mRNA. Translation: AAH08991.1.
BC114618 mRNA. Translation: AAI14619.1.
M36430 mRNA. Translation: AAA63265.1.
CCDSiCCDS34.1. [P62873-1]
PIRiA24853. RGHUB1.
RefSeqiNP_001269467.1. NM_001282538.1.
NP_001269468.1. NM_001282539.1. [P62873-1]
NP_002065.1. NM_002074.4. [P62873-1]
UniGeneiHs.430425.
Hs.721030.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45B1-340[»]
4PNKX-ray2.56B1-340[»]
5HE0X-ray2.56B2-340[»]
5HE1X-ray3.15B2-340[»]
5HE2X-ray2.79B2-340[»]
5HE3X-ray2.74B2-340[»]
ProteinModelPortaliP62873.
SMRiP62873. Positions 2-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109044. 100 interactions.
DIPiDIP-599N.
IntActiP62873. 41 interactions.
MINTiMINT-94562.
STRINGi9606.ENSP00000367869.

PTM databases

iPTMnetiP62873.
PhosphoSiteiP62873.
SwissPalmiP62873.

Polymorphism and mutation databases

DMDMi51317302.

2D gel databases

OGPiP62873.
REPRODUCTION-2DPAGEIPI00026268.

Proteomic databases

EPDiP62873.
MaxQBiP62873.
PaxDbiP62873.
PeptideAtlasiP62873.
PRIDEiP62873.

Protocols and materials databases

DNASUi2782.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378609; ENSP00000367872; ENSG00000078369. [P62873-1]
ENST00000610897; ENSP00000481878; ENSG00000078369. [P62873-1]
GeneIDi2782.
KEGGihsa:2782.
UCSCiuc001aif.5. human. [P62873-1]

Organism-specific databases

CTDi2782.
GeneCardsiGNB1.
HGNCiHGNC:4396. GNB1.
HPAiHPA040736.
MIMi139380. gene.
616973. phenotype.
neXtProtiNX_P62873.
PharmGKBiPA28776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP62873.
KOiK04536.
OMAiRIVMRPR.
OrthoDBiEOG091G0A7T.
PhylomeDBiP62873.
TreeFamiTF106149.

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-2485179. Activation of the phototransduction cascade.
R-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-381753. Olfactory Signaling Pathway.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP62873.
SIGNORiP62873.

Miscellaneous databases

ChiTaRSiGNB1. human.
EvolutionaryTraceiP62873.
GeneWikiiGNB1.
GenomeRNAii2782.
PROiP62873.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078369.
CleanExiHS_GNB1.
ExpressionAtlasiP62873. baseline and differential.
GenevisibleiP62873. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBB1_HUMAN
AccessioniPrimary (citable) accession number: P62873
Secondary accession number(s): B1AJZ7
, P04697, P04901, Q1RMY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.