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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene

GNB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041 Activation of G protein gated Potassium channels
R-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-202040 G-protein activation
R-BTA-2485179 Activation of the phototransduction cascade
R-BTA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-BTA-381753 Olfactory Signaling Pathway
R-BTA-392170 ADP signalling through P2Y purinoceptor 12
R-BTA-392451 G beta:gamma signalling through PI3Kgamma
R-BTA-392851 Prostacyclin signalling through prostacyclin receptor
R-BTA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-BTA-4086398 Ca2+ pathway
R-BTA-416476 G alpha (q) signalling events
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-418217 G beta:gamma signalling through PLC beta
R-BTA-418555 G alpha (s) signalling events
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418594 G alpha (i) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-420092 Glucagon-type ligand receptors
R-BTA-428930 Thromboxane signalling through TP receptor
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-500657 Presynaptic function of Kainate receptors
R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-BTA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Alternative name(s):
Transducin beta chain 1
Gene namesi
Name:GNB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:29457 GNB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001276842 – 340Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei266Phosphohistidine1 Publication1

Post-translational modificationi

Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62871
PeptideAtlasiP62871
PRIDEiP62871

PTM databases

iPTMnetiP62871

Expressioni

Gene expression databases

BgeeiENSBTAG00000000215

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi158560, 5 interactors
CORUMiP62871
DIPiDIP-29227N
IntActiP62871, 10 interactors
MINTiP62871
STRINGi9913.ENSBTAP00000042481

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 24Combined sources22
Helixi30 – 33Combined sources4
Turni34 – 36Combined sources3
Beta strandi46 – 51Combined sources6
Beta strandi58 – 63Combined sources6
Beta strandi67 – 74Combined sources8
Turni75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Turni84 – 87Combined sources4
Beta strandi88 – 94Combined sources7
Beta strandi96 – 98Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi109 – 116Combined sources8
Beta strandi121 – 126Combined sources6
Beta strandi130 – 132Combined sources3
Beta strandi134 – 139Combined sources6
Beta strandi146 – 153Combined sources8
Beta strandi156 – 161Combined sources6
Beta strandi166 – 170Combined sources5
Turni171 – 174Combined sources4
Beta strandi175 – 180Combined sources6
Beta strandi187 – 192Combined sources6
Beta strandi196 – 203Combined sources8
Beta strandi208 – 212Combined sources5
Turni213 – 216Combined sources4
Beta strandi217 – 222Combined sources6
Beta strandi229 – 234Combined sources6
Beta strandi238 – 245Combined sources8
Beta strandi250 – 254Combined sources5
Turni255 – 258Combined sources4
Beta strandi259 – 264Combined sources6
Beta strandi273 – 278Combined sources6
Beta strandi282 – 289Combined sources8
Beta strandi294 – 298Combined sources5
Turni299 – 301Combined sources3
Beta strandi304 – 308Combined sources5
Helixi309 – 311Combined sources3
Beta strandi315 – 320Combined sources6
Beta strandi327 – 331Combined sources5
Beta strandi336 – 340Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0RX-ray2.80B2-340[»]
1B9XX-ray3.00A1-340[»]
1B9YX-ray3.00A1-340[»]
1GG2X-ray2.40B1-340[»]
1GOTX-ray2.00B1-340[»]
1GP2X-ray2.30B1-340[»]
1OMWX-ray2.50B1-340[»]
1TBGX-ray2.10A/B/C/D1-340[»]
1XHMX-ray2.70A1-340[»]
2BCJX-ray3.06B2-340[»]
2TRCX-ray2.40B1-340[»]
3AH8X-ray2.90B1-340[»]
3CIKX-ray2.75B1-340[»]
3KRWX-ray2.90B1-340[»]
3KRXX-ray3.10B1-340[»]
3PSCX-ray2.67B1-340[»]
3PVUX-ray2.48B1-340[»]
3PVWX-ray2.49B1-340[»]
3UZSX-ray4.52B1-340[»]
3V5WX-ray2.07B1-340[»]
4MK0X-ray2.40B2-340[»]
5KDOX-ray1.90B1-340[»]
5WG3X-ray2.90B1-340[»]
5WG4X-ray2.31B1-340[»]
5WG5X-ray3.10B1-340[»]
ProteinModelPortaliP62871
SMRiP62871
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62871

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 83WD 1Add BLAST31
Repeati95 – 125WD 2Add BLAST31
Repeati141 – 170WD 3Add BLAST30
Repeati182 – 212WD 4Add BLAST31
Repeati224 – 254WD 5Add BLAST31
Repeati268 – 298WD 6Add BLAST31
Repeati310 – 340WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000176356
HOVERGENiHBG000188
InParanoidiP62871
KOiK04536
OMAiTCNVWDT
OrthoDBiEOG091G0A7T
TreeFamiTF106149

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR
160 170 180 190 200
FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV
210 220 230 240 250
SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC
260 270 280 290 300
RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL
310 320 330 340
KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,377
Last modified:January 23, 2007 - v3
Checksum:i896CBD32D2686598
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71V → L in CAA26875 (PubMed:2414128).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03073 mRNA Translation: CAA26875.1
M13236 mRNA Translation: AAA30792.1
BC105260 mRNA Translation: AAI05261.1
PIRiA24225 RGBOB1
RefSeqiNP_786971.2, NM_175777.3
XP_005217074.1, XM_005217017.1
XP_010811610.1, XM_010813308.2
UniGeneiBt.57702

Genome annotation databases

EnsembliENSBTAT00000000259; ENSBTAP00000000259; ENSBTAG00000000215
ENSBTAT00000045065; ENSBTAP00000042481; ENSBTAG00000000215
GeneIDi281201
KEGGibta:281201

Similar proteinsi

Entry informationi

Entry nameiGBB1_BOVIN
AccessioniPrimary (citable) accession number: P62871
Secondary accession number(s): P04697, P04901, Q3MHF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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