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Protein

Transcription elongation factor B polypeptide 2

Gene

Tceb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • protein complex binding Source: RGD
  • transcription coactivator activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor B polypeptide 2
Alternative name(s):
Elongin 18 kDa subunit
Elongin-B
Short name:
EloB
RNA polymerase II transcription factor SIII subunit B
SIII p18
Gene namesi
Name:Tceb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621200. Tceb2.

Subcellular locationi

GO - Cellular componenti

  • elongin complex Source: GO_Central
  • transcription factor complex Source: RGD
  • VCB complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Transcription elongation factor B polypeptide 2PRO_0000114916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei84 – 841PhosphothreonineBy similarity
Modified residuei108 – 1081PhosphoserineBy similarity
Modified residuei111 – 1111PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62870.
PRIDEiP62870.

PTM databases

iPTMnetiP62870.
PhosphoSiteiP62870.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004814.
GenevisibleiP62870. RN.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi249665. 8 interactions.
IntActiP62870. 6 interactions.
MINTiMINT-4094305.
STRINGi10116.ENSRNOP00000006892.

Structurei

3D structure databases

ProteinModelPortaliP62870.
SMRiP62870. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7979Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4495. Eukaryota.
ENOG4111UGJ. LUCA.
GeneTreeiENSGT00390000018316.
HOGENOMiHOG000293425.
HOVERGENiHBG008581.
InParanoidiP62870.
KOiK03873.
OMAiDCGFTNQ.
PhylomeDBiP62870.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPE EQRLYKDDQL
60 70 80 90 100
LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALRI EPFSSPPELP
110
DVMKPQDSGG SANEQAVQ
Length:118
Mass (Da):13,170
Last modified:August 16, 2004 - v1
Checksum:iBA702F24CEC0FC02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42855 mRNA. Translation: AAA80968.1.
BC058463 mRNA. Translation: AAH58463.1.
RefSeqiNP_112391.1. NM_031129.3.
UniGeneiRn.108140.

Genome annotation databases

EnsembliENSRNOT00000087768; ENSRNOP00000072621; ENSRNOG00000004814.
GeneIDi81807.
KEGGirno:81807.
UCSCiRGD:621200. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42855 mRNA. Translation: AAA80968.1.
BC058463 mRNA. Translation: AAH58463.1.
RefSeqiNP_112391.1. NM_031129.3.
UniGeneiRn.108140.

3D structure databases

ProteinModelPortaliP62870.
SMRiP62870. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249665. 8 interactions.
IntActiP62870. 6 interactions.
MINTiMINT-4094305.
STRINGi10116.ENSRNOP00000006892.

PTM databases

iPTMnetiP62870.
PhosphoSiteiP62870.

Proteomic databases

PaxDbiP62870.
PRIDEiP62870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087768; ENSRNOP00000072621; ENSRNOG00000004814.
GeneIDi81807.
KEGGirno:81807.
UCSCiRGD:621200. rat.

Organism-specific databases

CTDi6923.
RGDi621200. Tceb2.

Phylogenomic databases

eggNOGiKOG4495. Eukaryota.
ENOG4111UGJ. LUCA.
GeneTreeiENSGT00390000018316.
HOGENOMiHOG000293425.
HOVERGENiHBG008581.
InParanoidiP62870.
KOiK03873.
OMAiDCGFTNQ.
PhylomeDBiP62870.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

PROiP62870.

Gene expression databases

BgeeiENSRNOG00000004814.
GenevisibleiP62870. RN.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOB_RAT
AccessioniPrimary (citable) accession number: P62870
Secondary accession number(s): Q63529, Q80W20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.