Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription elongation factor B polypeptide 2

Gene

Tceb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-MMU-75955. RNA Polymerase II Transcription Elongation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor B polypeptide 2
Alternative name(s):
Elongin 18 kDa subunit
Elongin-B
Short name:
EloB
RNA polymerase II transcription factor SIII subunit B
SIII p18
Gene namesi
Name:Tceb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914923. Tceb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Transcription elongation factor B polypeptide 2PRO_0000114915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei84 – 841PhosphothreonineCombined sources
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei111 – 1111PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62869.
MaxQBiP62869.
PaxDbiP62869.
PeptideAtlasiP62869.
PRIDEiP62869.

2D gel databases

REPRODUCTION-2DPAGEP62869.

PTM databases

iPTMnetiP62869.
PhosphoSiteiP62869.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055839.
GenevisibleiP62869. MM.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.3 Publications

Protein-protein interaction databases

BioGridi212356. 12 interactions.
IntActiP62869. 8 interactions.
MINTiMINT-2789207.
STRINGi10090.ENSMUSP00000066210.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 109Combined sources
Beta strandi12 – 198Combined sources
Helixi24 – 3512Combined sources
Helixi39 – 413Combined sources
Beta strandi42 – 465Combined sources
Helixi57 – 604Combined sources
Turni64 – 663Combined sources
Beta strandi73 – 8311Combined sources
Helixi101 – 1033Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FNJX-ray1.80B1-118[»]
4JGHX-ray3.00B1-118[»]
ProteinModelPortaliP62869.
SMRiP62869. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62869.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7979Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4495. Eukaryota.
ENOG4111UGJ. LUCA.
GeneTreeiENSGT00390000018316.
HOGENOMiHOG000293425.
HOVERGENiHBG008581.
InParanoidiP62869.
KOiK03873.
OMAiDCGFTNQ.
OrthoDBiEOG091G10A8.
PhylomeDBiP62869.
TreeFamiTF325964.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPE EQRLYKDDQL
60 70 80 90 100
LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALRI EPFSSPPELP
110
DVMKPQDSGG SANEQAVQ
Length:118
Mass (Da):13,170
Last modified:August 16, 2004 - v1
Checksum:iBA702F24CEC0FC02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019358 mRNA. Translation: BAB31677.1.
AK002223 mRNA. Translation: BAB21946.1.
AK002868 mRNA. Translation: BAB22417.1.
AK003277 mRNA. Translation: BAB22684.1.
AK008477 mRNA. Translation: BAB25690.1.
AK008534 mRNA. Translation: BAB25727.1.
AK012254 mRNA. Translation: BAB28121.1.
AK019181 mRNA. Translation: BAB31590.1.
AK019218 mRNA. Translation: BAB31608.1.
BC051927 mRNA. Translation: AAH51927.2.
BC056983 mRNA. Translation: AAH56983.1.
CCDSiCCDS57055.1.
RefSeqiNP_080581.1. NM_026305.2.
UniGeneiMm.153758.

Genome annotation databases

EnsembliENSMUST00000069579; ENSMUSP00000066210; ENSMUSG00000055839.
GeneIDi67673.
KEGGimmu:67673.
UCSCiuc008atr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019358 mRNA. Translation: BAB31677.1.
AK002223 mRNA. Translation: BAB21946.1.
AK002868 mRNA. Translation: BAB22417.1.
AK003277 mRNA. Translation: BAB22684.1.
AK008477 mRNA. Translation: BAB25690.1.
AK008534 mRNA. Translation: BAB25727.1.
AK012254 mRNA. Translation: BAB28121.1.
AK019181 mRNA. Translation: BAB31590.1.
AK019218 mRNA. Translation: BAB31608.1.
BC051927 mRNA. Translation: AAH51927.2.
BC056983 mRNA. Translation: AAH56983.1.
CCDSiCCDS57055.1.
RefSeqiNP_080581.1. NM_026305.2.
UniGeneiMm.153758.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FNJX-ray1.80B1-118[»]
4JGHX-ray3.00B1-118[»]
ProteinModelPortaliP62869.
SMRiP62869. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212356. 12 interactions.
IntActiP62869. 8 interactions.
MINTiMINT-2789207.
STRINGi10090.ENSMUSP00000066210.

PTM databases

iPTMnetiP62869.
PhosphoSiteiP62869.

2D gel databases

REPRODUCTION-2DPAGEP62869.

Proteomic databases

EPDiP62869.
MaxQBiP62869.
PaxDbiP62869.
PeptideAtlasiP62869.
PRIDEiP62869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069579; ENSMUSP00000066210; ENSMUSG00000055839.
GeneIDi67673.
KEGGimmu:67673.
UCSCiuc008atr.1. mouse.

Organism-specific databases

CTDi6923.
MGIiMGI:1914923. Tceb2.

Phylogenomic databases

eggNOGiKOG4495. Eukaryota.
ENOG4111UGJ. LUCA.
GeneTreeiENSGT00390000018316.
HOGENOMiHOG000293425.
HOVERGENiHBG008581.
InParanoidiP62869.
KOiK03873.
OMAiDCGFTNQ.
OrthoDBiEOG091G10A8.
PhylomeDBiP62869.
TreeFamiTF325964.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-MMU-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

EvolutionaryTraceiP62869.
PROiP62869.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055839.
GenevisibleiP62869. MM.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOB_MOUSE
AccessioniPrimary (citable) accession number: P62869
Secondary accession number(s): Q63529, Q80W20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.