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P62861

- RS30_HUMAN

UniProt

P62861 - RS30_HUMAN

Protein

40S ribosomal protein S30

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. RNA binding Source: ProtInc
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. antibacterial humoral response Source: UniProt
    2. cellular protein metabolic process Source: Reactome
    3. defense response to Gram-positive bacterium Source: UniProt
    4. gene expression Source: Reactome
    5. innate immune response in mucosa Source: UniProt
    6. mRNA metabolic process Source: Reactome
    7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    8. RNA metabolic process Source: Reactome
    9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    10. translation Source: UniProtKB
    11. translational elongation Source: Reactome
    12. translational initiation Source: Reactome
    13. translational termination Source: Reactome
    14. viral life cycle Source: Reactome
    15. viral process Source: Reactome
    16. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S30
    Gene namesi
    Name:FAU
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3597. FAU.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic small ribosomal subunit Source: UniProtKB
    3. extracellular space Source: UniProt
    4. small ribosomal subunit Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595940S ribosomal protein S30PRO_0000173999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiP62861.
    PaxDbiP62861.
    PRIDEiP62861.

    PTM databases

    PhosphoSiteiP62861.

    Expressioni

    Gene expression databases

    BgeeiP62861.
    CleanExiHS_FAU.
    GenevestigatoriP62861.

    Interactioni

    Protein-protein interaction databases

    IntActiP62861. 8 interactions.
    MINTiMINT-5001188.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00e1-59[»]
    ProteinModelPortaliP62861.
    SMRiP62861. Positions 1-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S30e family.Curated

    Phylogenomic databases

    eggNOGiNOG285974.
    HOGENOMiHOG000233941.
    HOVERGENiHBG000057.
    InParanoidiP62861.
    OrthoDBiEOG7TTQ9R.

    Family and domain databases

    InterProiIPR006846. Ribosomal_S30.
    [Graphical view]
    PfamiPF04758. Ribosomal_S30. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62861-1 [UniParc]FASTAAdd to Basket

    « Hide

    KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG   50
    KKKGPNANS 59
    Length:59
    Mass (Da):6,648
    Last modified:August 16, 2004 - v1
    Checksum:i012AC1FB555B01A4
    GO

    Sequence cautioni

    The sequence AAH33877.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAQ87877.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15515.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA46714.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA46716.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAG46772.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191V → M.1 Publication
    VAR_019643

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65921 Genomic DNA. Translation: CAA46714.1. Different initiation.
    X65923 mRNA. Translation: CAA46716.1. Different initiation.
    AK026639 mRNA. Translation: BAB15515.1. Different initiation.
    CR541974 mRNA. Translation: CAG46772.1. Different initiation.
    AY398663 Genomic DNA. Translation: AAQ87877.1. Different initiation.
    AP003068 Genomic DNA. No translation available.
    BC033877 mRNA. Translation: AAH33877.1. Different initiation.
    PIRiJC1278.
    UniGeneiHs.387208.

    Genome annotation databases

    EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
    ENST00000529639; ENSP00000435370; ENSG00000149806.
    ENST00000531743; ENSP00000431822; ENSG00000149806.

    Polymorphism databases

    DMDMi51338655.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65921 Genomic DNA. Translation: CAA46714.1 . Different initiation.
    X65923 mRNA. Translation: CAA46716.1 . Different initiation.
    AK026639 mRNA. Translation: BAB15515.1 . Different initiation.
    CR541974 mRNA. Translation: CAG46772.1 . Different initiation.
    AY398663 Genomic DNA. Translation: AAQ87877.1 . Different initiation.
    AP003068 Genomic DNA. No translation available.
    BC033877 mRNA. Translation: AAH33877.1 . Different initiation.
    PIRi JC1278.
    UniGenei Hs.387208.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 e 1-59 [» ]
    ProteinModelPortali P62861.
    SMRi P62861. Positions 1-59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P62861. 8 interactions.
    MINTi MINT-5001188.

    PTM databases

    PhosphoSitei P62861.

    Polymorphism databases

    DMDMi 51338655.

    Proteomic databases

    MaxQBi P62861.
    PaxDbi P62861.
    PRIDEi P62861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000527548 ; ENSP00000434440 ; ENSG00000149806 .
    ENST00000529639 ; ENSP00000435370 ; ENSG00000149806 .
    ENST00000531743 ; ENSP00000431822 ; ENSG00000149806 .

    Organism-specific databases

    GeneCardsi GC11M064888.
    HGNCi HGNC:3597. FAU.
    MIMi 134690. gene.
    neXtProti NX_P62861.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285974.
    HOGENOMi HOG000233941.
    HOVERGENi HBG000057.
    InParanoidi P62861.
    OrthoDBi EOG7TTQ9R.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi FAU. human.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62861.
    CleanExi HS_FAU.
    Genevestigatori P62861.

    Family and domain databases

    InterProi IPR006846. Ribosomal_S30.
    [Graphical view ]
    Pfami PF04758. Ribosomal_S30. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein."
      Kas K., Michiels L., Merregaert J.
      Biochem. Biophys. Res. Commun. 187:927-933(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus."
      Michiels L., van der Rauwelaert E., van Hasselt F., Kas K., Merregaert J.
      Oncogene 8:2537-2546(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-19.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    8. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-25.
      Tissue: Placenta.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS30_HUMAN
    AccessioniPrimary (citable) accession number: P62861
    Secondary accession number(s): Q05472, Q95261, Q9H5V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3