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Protein

40S ribosomal protein S30

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-9010553. Regulation of expression of SLITs and ROBOs.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S30
Alternative name(s):
Small ribosomal subunit protein eS301 Publication
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149806.10.
HGNCiHGNC:3597. FAU.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi2197.

Polymorphism and mutation databases

DMDMi51338655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001739991 – 5940S ribosomal protein S30Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-succinyllysineBy similarity1

Proteomic databases

EPDiP62861.
MaxQBiP62861.
PaxDbiP62861.
PeptideAtlasiP62861.
PRIDEiP62861.
TopDownProteomicsiP62861.

PTM databases

iPTMnetiP62861.
PhosphoSitePlusiP62861.
SwissPalmiP62861.

Expressioni

Gene expression databases

BgeeiENSG00000149806.
CleanExiHS_FAU.
ExpressionAtlasiP62861. baseline and differential.
GenevisibleiP62861. HS.

Organism-specific databases

HPAiHPA059015.

Interactioni

Protein-protein interaction databases

CORUMiP62861.
IntActiP62861. 15 interactors.
MINTiMINT-5001188.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Se1-59[»]
4V6Xelectron microscopy5.00Ae1-59[»]
5A2Qelectron microscopy3.90e4-59[»]
5AJ0electron microscopy3.50Be1-59[»]
5FLXelectron microscopy3.90e1-59[»]
5OA3electron microscopy4.30e4-59[»]
5T2Celectron microscopy3.60AT1-59[»]
ProteinModelPortaliP62861.
SMRiP62861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
KOG0009. Eukaryota.
ENOG41123KC. LUCA.
HOGENOMiHOG000233941.
HOVERGENiHBG000057.
OrthoDBiEOG091G0X8P.

Family and domain databases

InterProiView protein in InterPro
IPR006846. Ribosomal_S30.
PfamiView protein in Pfam
PF04758. Ribosomal_S30. 1 hit.

Sequencei

Sequence statusi: Complete.

P62861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG

KKKGPNANS
Length:59
Mass (Da):6,648
Last modified:August 16, 2004 - v1
Checksum:i012AC1FB555B01A4
GO

Sequence cautioni

The sequence AAH33877 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ87877 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15515 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46714 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46716 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG46772 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01964319V → M1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different initiation.
X65923 mRNA. Translation: CAA46716.1. Different initiation.
AK026639 mRNA. Translation: BAB15515.1. Different initiation.
CR541974 mRNA. Translation: CAG46772.1. Different initiation.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different initiation.
PIRiJC1278.
UniGeneiHs.387208.

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
UCSCiuc001ocx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRS30_HUMAN
AccessioniPrimary (citable) accession number: P62861
Secondary accession number(s): Q05472, Q95261, Q9H5V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families