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P62861

- RS30_HUMAN

UniProt

P62861 - RS30_HUMAN

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Protein

40S ribosomal protein S30

Gene
FAU
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. antibacterial humoral response Source: UniProt
  2. cellular protein metabolic process Source: Reactome
  3. defense response to Gram-positive bacterium Source: UniProt
  4. gene expression Source: Reactome
  5. innate immune response in mucosa Source: UniProt
  6. mRNA metabolic process Source: Reactome
  7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  8. RNA metabolic process Source: Reactome
  9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  10. translation Source: UniProtKB
  11. translational elongation Source: Reactome
  12. translational initiation Source: Reactome
  13. translational termination Source: Reactome
  14. viral life cycle Source: Reactome
  15. viral process Source: Reactome
  16. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S30
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3597. FAU.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic small ribosomal subunit Source: UniProtKB
  3. extracellular space Source: UniProt
  4. small ribosomal subunit Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595940S ribosomal protein S30PRO_0000173999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-succinyllysine By similarity

Proteomic databases

MaxQBiP62861.
PaxDbiP62861.
PRIDEiP62861.

PTM databases

PhosphoSiteiP62861.

Expressioni

Gene expression databases

BgeeiP62861.
CleanExiHS_FAU.
GenevestigatoriP62861.

Interactioni

Protein-protein interaction databases

IntActiP62861. 8 interactions.
MINTiMINT-5001188.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00e1-59[»]
ProteinModelPortaliP62861.
SMRiP62861. Positions 1-59.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG285974.
HOGENOMiHOG000233941.
HOVERGENiHBG000057.
InParanoidiP62861.
OrthoDBiEOG7TTQ9R.

Family and domain databases

InterProiIPR006846. Ribosomal_S30.
[Graphical view]
PfamiPF04758. Ribosomal_S30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62861-1 [UniParc]FASTAAdd to Basket

« Hide

KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG   50
KKKGPNANS 59
Length:59
Mass (Da):6,648
Last modified:August 16, 2004 - v1
Checksum:i012AC1FB555B01A4
GO

Sequence cautioni

The sequence AAH33877.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAQ87877.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15515.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA46714.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA46716.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAG46772.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191V → M.1 Publication
VAR_019643

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different initiation.
X65923 mRNA. Translation: CAA46716.1. Different initiation.
AK026639 mRNA. Translation: BAB15515.1. Different initiation.
CR541974 mRNA. Translation: CAG46772.1. Different initiation.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different initiation.
PIRiJC1278.
UniGeneiHs.387208.

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.

Polymorphism databases

DMDMi51338655.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1 . Different initiation.
X65923 mRNA. Translation: CAA46716.1 . Different initiation.
AK026639 mRNA. Translation: BAB15515.1 . Different initiation.
CR541974 mRNA. Translation: CAG46772.1 . Different initiation.
AY398663 Genomic DNA. Translation: AAQ87877.1 . Different initiation.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1 . Different initiation.
PIRi JC1278.
UniGenei Hs.387208.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 e 1-59 [» ]
ProteinModelPortali P62861.
SMRi P62861. Positions 1-59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P62861. 8 interactions.
MINTi MINT-5001188.

PTM databases

PhosphoSitei P62861.

Polymorphism databases

DMDMi 51338655.

Proteomic databases

MaxQBi P62861.
PaxDbi P62861.
PRIDEi P62861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000527548 ; ENSP00000434440 ; ENSG00000149806 .

Organism-specific databases

GeneCardsi GC11M064888.
HGNCi HGNC:3597. FAU.
MIMi 134690. gene.
neXtProti NX_P62861.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285974.
HOGENOMi HOG000233941.
HOVERGENi HBG000057.
InParanoidi P62861.
OrthoDBi EOG7TTQ9R.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi FAU. human.
SOURCEi Search...

Gene expression databases

Bgeei P62861.
CleanExi HS_FAU.
Genevestigatori P62861.

Family and domain databases

InterProi IPR006846. Ribosomal_S30.
[Graphical view ]
Pfami PF04758. Ribosomal_S30. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein."
    Kas K., Michiels L., Merregaert J.
    Biochem. Biophys. Res. Commun. 187:927-933(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus."
    Michiels L., van der Rauwelaert E., van Hasselt F., Kas K., Merregaert J.
    Oncogene 8:2537-2546(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. NIEHS SNPs program
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-19.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  8. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25.
    Tissue: Placenta.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS30_HUMAN
AccessioniPrimary (citable) accession number: P62861
Secondary accession number(s): Q05472, Q95261, Q9H5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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