Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S30

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S30
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3597. FAU.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nucleoplasm Source: Reactome
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi51338655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595940S ribosomal protein S30PRO_0000173999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-succinyllysineBy similarity

Proteomic databases

EPDiP62861.
MaxQBiP62861.
PaxDbiP62861.
PeptideAtlasiP62861.
PRIDEiP62861.
TopDownProteomicsiP62861.

PTM databases

iPTMnetiP62861.
PhosphoSiteiP62861.
SwissPalmiP62861.

Expressioni

Gene expression databases

BgeeiENSG00000149806.
CleanExiHS_FAU.
ExpressionAtlasiP62861. baseline and differential.
GenevisibleiP62861. HS.

Organism-specific databases

HPAiHPA059015.

Interactioni

Protein-protein interaction databases

IntActiP62861. 15 interactions.
MINTiMINT-5001188.
STRINGi9606.ENSP00000431822.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Se1-59[»]
4V6Xelectron microscopy5.00Ae1-59[»]
5A2Qelectron microscopy3.90e4-59[»]
5AJ0electron microscopy3.50Be1-59[»]
5FLXelectron microscopy3.90e1-59[»]
ProteinModelPortaliP62861.
SMRiP62861. Positions 4-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S30e family.Curated

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
KOG0009. Eukaryota.
ENOG41123KC. LUCA.
HOGENOMiHOG000233941.
HOVERGENiHBG000057.
OrthoDBiEOG091G0X8P.

Family and domain databases

InterProiIPR006846. Ribosomal_S30.
[Graphical view]
PfamiPF04758. Ribosomal_S30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG

KKKGPNANS
Length:59
Mass (Da):6,648
Last modified:August 16, 2004 - v1
Checksum:i012AC1FB555B01A4
GO

Sequence cautioni

The sequence AAH33877 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ87877 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15515 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA46714 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA46716 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAG46772 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191V → M.1 Publication
VAR_019643

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different initiation.
X65923 mRNA. Translation: CAA46716.1. Different initiation.
AK026639 mRNA. Translation: BAB15515.1. Different initiation.
CR541974 mRNA. Translation: CAG46772.1. Different initiation.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different initiation.
PIRiJC1278.
UniGeneiHs.387208.

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
UCSCiuc001ocx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different initiation.
X65923 mRNA. Translation: CAA46716.1. Different initiation.
AK026639 mRNA. Translation: BAB15515.1. Different initiation.
CR541974 mRNA. Translation: CAG46772.1. Different initiation.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different initiation.
PIRiJC1278.
UniGeneiHs.387208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Se1-59[»]
4V6Xelectron microscopy5.00Ae1-59[»]
5A2Qelectron microscopy3.90e4-59[»]
5AJ0electron microscopy3.50Be1-59[»]
5FLXelectron microscopy3.90e1-59[»]
ProteinModelPortaliP62861.
SMRiP62861. Positions 4-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62861. 15 interactions.
MINTiMINT-5001188.
STRINGi9606.ENSP00000431822.

PTM databases

iPTMnetiP62861.
PhosphoSiteiP62861.
SwissPalmiP62861.

Polymorphism and mutation databases

DMDMi51338655.

Proteomic databases

EPDiP62861.
MaxQBiP62861.
PaxDbiP62861.
PeptideAtlasiP62861.
PRIDEiP62861.
TopDownProteomicsiP62861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
UCSCiuc001ocx.4. human.

Organism-specific databases

GeneCardsiFAU.
HGNCiHGNC:3597. FAU.
HPAiHPA059015.
MIMi134690. gene.
neXtProtiNX_P62861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
KOG0009. Eukaryota.
ENOG41123KC. LUCA.
HOGENOMiHOG000233941.
HOVERGENiHBG000057.
OrthoDBiEOG091G0X8P.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiFAU. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149806.
CleanExiHS_FAU.
ExpressionAtlasiP62861. baseline and differential.
GenevisibleiP62861. HS.

Family and domain databases

InterProiIPR006846. Ribosomal_S30.
[Graphical view]
PfamiPF04758. Ribosomal_S30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS30_HUMAN
AccessioniPrimary (citable) accession number: P62861
Secondary accession number(s): Q05472, Q95261, Q9H5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.