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P62857 (RS28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S28
Gene names
Name:RPS28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length69 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S28e family.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

rRNA processing

Inferred from mutant phenotype PubMed 18697920. Source: UniProtKB

ribosomal small subunit biogenesis

Inferred from mutant phenotype PubMed 18697920. Source: UniProtKB

translation

Inferred by curator PubMed 15883184Ref.6. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

cytosolic small ribosomal subunit

Inferred from direct assay PubMed 15883184Ref.6. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337PubMed 23376485. Source: UniProt

small ribosomal subunit

Inferred from direct assay PubMed 15883184. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PINX1Q96BK51EBI-353027,EBI-721782

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696940S ribosomal protein S28 HAMAP-Rule MF_00292
PRO_0000136822

Experimental info

Sequence conflict661R → P AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P62857 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 49902FE9376EB74F

FASTA697,841
        10         20         30         40         50         60 
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE 


SEREARRLR 

« Hide

References

« Hide 'large scale' references
[1]Bhat K.S.
Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Kim J.M., Bae Y.S.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell, Muscle and Prostate.
[6]"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 48-68.
Tissue: Placenta.
[7]"A map of 75 human ribosomal protein genes."
Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-69.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05091 mRNA. Translation: AAC15855.1.
U58682 mRNA. Translation: AAB07066.1.
AB061846 Genomic DNA. Translation: BAB79484.1.
CR457055 mRNA. Translation: CAG33336.1.
BC000354 mRNA. Translation: AAH00354.1.
BC021239 mRNA. Translation: AAH21239.1.
BC070217 mRNA. Translation: AAH70217.1.
BC070218 mRNA. Translation: AAH70218.1.
AB007164 Genomic DNA. Translation: BAA28594.1.
CCDSCCDS45953.1.
PIRS68914.
RefSeqNP_001022.1. NM_001031.4.
UniGeneHs.153177.
Hs.322473.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00c1-69[»]
ProteinModelPortalP62857.
SMRP62857. Positions 5-68.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112148. 105 interactions.
IntActP62857. 12 interactions.
MINTMINT-5000390.
STRING9606.ENSP00000397872.

PTM databases

PhosphoSiteP62857.

Polymorphism databases

DMDM51338652.

Proteomic databases

MaxQBP62857.
PaxDbP62857.
PRIDEP62857.

Protocols and materials databases

DNASU6234.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000600659; ENSP00000472469; ENSG00000233927.
GeneID6234.
KEGGhsa:6234.
UCSCuc002mjn.3. human.

Organism-specific databases

CTD6234.
GeneCardsGC19P008386.
HGNCHGNC:10418. RPS28.
HPAHPA047132.
MIM603685. gene.
neXtProtNX_P62857.
PharmGKBPA34825.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2053.
HOVERGENHBG000219.
KOK02979.
OMAAIVMKVI.
OrthoDBEOG7SN8GQ.
PhylomeDBP62857.
TreeFamTF300136.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressP62857.
BgeeP62857.
CleanExHS_RPS28.
GenevestigatorP62857.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00292. Ribosomal_S28e.
InterProIPR012340. NA-bd_OB-fold.
IPR000289. Ribosomal_S28e.
IPR028626. Ribosomal_S28e_CS.
[Graphical view]
PANTHERPTHR10769. PTHR10769. 1 hit.
PfamPF01200. Ribosomal_S28e. 1 hit.
[Graphical view]
ProDomPD005541. Ribosomal_S28e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50249. SSF50249. 1 hit.
PROSITEPS00961. RIBOSOMAL_S28E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRPS28.
GenomeRNAi6234.
NextBio24201.
PROP62857.
SOURCESearch...

Entry information

Entry nameRS28_HUMAN
AccessionPrimary (citable) accession number: P62857
Secondary accession number(s): P25112
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM