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Protein

40S ribosomal protein S28

Gene

RPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • maturation of SSU-rRNA Source: GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit assembly Source: GO_Central
  • ribosomal small subunit biogenesis Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:G66-31704-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S28
Gene namesi
Name:RPS28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10418. RPS28.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:606164

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6234.
MalaCardsiRPS28.
MIMi606164. phenotype.
OpenTargetsiENSG00000233927.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34825.

Polymorphism and mutation databases

BioMutaiRPS28.
DMDMi51338652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368221 – 6940S ribosomal protein S28Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62857.
MaxQBiP62857.
PaxDbiP62857.
PeptideAtlasiP62857.
PRIDEiP62857.
TopDownProteomicsiP62857.

PTM databases

iPTMnetiP62857.
PhosphoSitePlusiP62857.
SwissPalmiP62857.

Expressioni

Gene expression databases

BgeeiENSG00000233927.
CleanExiHS_RPS28.
ExpressionAtlasiP62857. baseline and differential.
GenevisibleiP62857. HS.

Organism-specific databases

HPAiHPA047132.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-353027,EBI-748961
KRTAP10-7P604093EBI-353027,EBI-10172290
KRTAP10-8P604103EBI-353027,EBI-10171774
KRTAP2-3P0C7H83EBI-353027,EBI-10196781
NOTCH2NLQ7Z3S93EBI-353027,EBI-945833

Protein-protein interaction databases

BioGridi112148. 110 interactors.
IntActiP62857. 26 interactors.
MINTiMINT-5000390.
STRINGi9606.ENSP00000472469.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sc1-69[»]
4V6Xelectron microscopy5.00Ac1-69[»]
5A2Qelectron microscopy3.90c8-68[»]
5AJ0electron microscopy3.50Bc1-69[»]
5FLXelectron microscopy3.90c1-69[»]
ProteinModelPortaliP62857.
SMRiP62857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S28e family.Curated

Phylogenomic databases

eggNOGiKOG3502. Eukaryota.
COG2053. LUCA.
GeneTreeiENSGT00390000003580.
HOVERGENiHBG000219.
InParanoidiP62857.
KOiK02979.
OMAiTEVLCRT.
OrthoDBiEOG091G19WT.
PhylomeDBiP62857.
TreeFamiTF300136.

Family and domain databases

CDDicd04457. S1_S28E. 1 hit.
HAMAPiMF_00292. Ribosomal_S28e. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR000289. Ribosomal_S28e.
IPR028626. Ribosomal_S28e_CS.
[Graphical view]
PANTHERiPTHR10769. PTHR10769. 1 hit.
PfamiPF01200. Ribosomal_S28e. 1 hit.
[Graphical view]
ProDomiPD005541. Ribosomal_S28e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00961. RIBOSOMAL_S28E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV
60
REGDVLTLLE SEREARRLR
Length:69
Mass (Da):7,841
Last modified:August 16, 2004 - v1
Checksum:i49902FE9376EB74F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66R → P AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05091 mRNA. Translation: AAC15855.1.
U58682 mRNA. Translation: AAB07066.1.
AB061846 Genomic DNA. Translation: BAB79484.1.
CR457055 mRNA. Translation: CAG33336.1.
BC000354 mRNA. Translation: AAH00354.1.
BC021239 mRNA. Translation: AAH21239.1.
BC070217 mRNA. Translation: AAH70217.1.
BC070218 mRNA. Translation: AAH70218.1.
AB007164 Genomic DNA. Translation: BAA28594.1.
CCDSiCCDS45953.1.
PIRiS68914.
RefSeqiNP_001022.1. NM_001031.4.
UniGeneiHs.153177.
Hs.322473.

Genome annotation databases

EnsembliENST00000600659; ENSP00000472469; ENSG00000233927.
GeneIDi6234.
KEGGihsa:6234.
UCSCiuc002mjn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05091 mRNA. Translation: AAC15855.1.
U58682 mRNA. Translation: AAB07066.1.
AB061846 Genomic DNA. Translation: BAB79484.1.
CR457055 mRNA. Translation: CAG33336.1.
BC000354 mRNA. Translation: AAH00354.1.
BC021239 mRNA. Translation: AAH21239.1.
BC070217 mRNA. Translation: AAH70217.1.
BC070218 mRNA. Translation: AAH70218.1.
AB007164 Genomic DNA. Translation: BAA28594.1.
CCDSiCCDS45953.1.
PIRiS68914.
RefSeqiNP_001022.1. NM_001031.4.
UniGeneiHs.153177.
Hs.322473.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sc1-69[»]
4V6Xelectron microscopy5.00Ac1-69[»]
5A2Qelectron microscopy3.90c8-68[»]
5AJ0electron microscopy3.50Bc1-69[»]
5FLXelectron microscopy3.90c1-69[»]
ProteinModelPortaliP62857.
SMRiP62857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112148. 110 interactors.
IntActiP62857. 26 interactors.
MINTiMINT-5000390.
STRINGi9606.ENSP00000472469.

PTM databases

iPTMnetiP62857.
PhosphoSitePlusiP62857.
SwissPalmiP62857.

Polymorphism and mutation databases

BioMutaiRPS28.
DMDMi51338652.

Proteomic databases

EPDiP62857.
MaxQBiP62857.
PaxDbiP62857.
PeptideAtlasiP62857.
PRIDEiP62857.
TopDownProteomicsiP62857.

Protocols and materials databases

DNASUi6234.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000600659; ENSP00000472469; ENSG00000233927.
GeneIDi6234.
KEGGihsa:6234.
UCSCiuc002mjn.4. human.

Organism-specific databases

CTDi6234.
DisGeNETi6234.
GeneCardsiRPS28.
HGNCiHGNC:10418. RPS28.
HPAiHPA047132.
MalaCardsiRPS28.
MIMi603685. gene.
606164. phenotype.
neXtProtiNX_P62857.
OpenTargetsiENSG00000233927.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3502. Eukaryota.
COG2053. LUCA.
GeneTreeiENSGT00390000003580.
HOVERGENiHBG000219.
InParanoidiP62857.
KOiK02979.
OMAiTEVLCRT.
OrthoDBiEOG091G19WT.
PhylomeDBiP62857.
TreeFamiTF300136.

Enzyme and pathway databases

BioCyciZFISH:G66-31704-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GeneWikiiRPS28.
GenomeRNAii6234.
PROiP62857.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000233927.
CleanExiHS_RPS28.
ExpressionAtlasiP62857. baseline and differential.
GenevisibleiP62857. HS.

Family and domain databases

CDDicd04457. S1_S28E. 1 hit.
HAMAPiMF_00292. Ribosomal_S28e. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR000289. Ribosomal_S28e.
IPR028626. Ribosomal_S28e_CS.
[Graphical view]
PANTHERiPTHR10769. PTHR10769. 1 hit.
PfamiPF01200. Ribosomal_S28e. 1 hit.
[Graphical view]
ProDomiPD005541. Ribosomal_S28e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00961. RIBOSOMAL_S28E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS28_HUMAN
AccessioniPrimary (citable) accession number: P62857
Secondary accession number(s): P25112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.