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Protein

40S ribosomal protein S28

Gene

RPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: UniProtKB
  • maturation of SSU-rRNA Source: GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit assembly Source: GO_Central
  • ribosomal small subunit biogenesis Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S28
Alternative name(s):
Small ribosomal subunit protein eS281 Publication
Gene namesi
Name:RPS28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000233927.4
HGNCiHGNC:10418 RPS28
MIMi603685 gene
neXtProtiNX_P62857

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:606164

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6234
MalaCardsiRPS28
MIMi606164 phenotype
OpenTargetsiENSG00000233927
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34825

Polymorphism and mutation databases

BioMutaiRPS28
DMDMi51338652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368221 – 6940S ribosomal protein S28Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62857
MaxQBiP62857
PaxDbiP62857
PeptideAtlasiP62857
PRIDEiP62857
TopDownProteomicsiP62857

PTM databases

iPTMnetiP62857
PhosphoSitePlusiP62857
SwissPalmiP62857

Expressioni

Gene expression databases

BgeeiENSG00000233927
CleanExiHS_RPS28
ExpressionAtlasiP62857 baseline and differential
GenevisibleiP62857 HS

Organism-specific databases

HPAiHPA047132

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112148, 116 interactors
CORUMiP62857
IntActiP62857, 29 interactors
MINTiP62857
STRINGi9606.ENSP00000472469

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sc1-69[»]
4V6Xelectron microscopy5.00Ac1-69[»]
5A2Qelectron microscopy3.90c8-68[»]
5AJ0electron microscopy3.50Bc1-69[»]
5FLXelectron microscopy3.90c1-69[»]
5LKSelectron microscopy3.60Sc1-69[»]
5OA3electron microscopy4.30c8-68[»]
5T2Celectron microscopy3.60AF1-69[»]
5VYCX-ray6.00c1/c2/c3/c4/c5/c61-69[»]
6EK0electron microscopy2.90Sc1-69[»]
6FECelectron microscopy6.30l5-68[»]
ProteinModelPortaliP62857
SMRiP62857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3502 Eukaryota
COG2053 LUCA
GeneTreeiENSGT00910000144227
HOVERGENiHBG000219
InParanoidiP62857
KOiK02979
OMAiMHGEASQ
OrthoDBiEOG091G19WT
PhylomeDBiP62857
TreeFamiTF300136

Family and domain databases

CDDicd04457 S1_S28E, 1 hit
HAMAPiMF_00292 Ribosomal_S28e, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000289 Ribosomal_S28e
IPR028626 Ribosomal_S28e_CS
PANTHERiPTHR10769 PTHR10769, 1 hit
PfamiView protein in Pfam
PF01200 Ribosomal_S28e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005541 Ribosomal_S28e, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00961 RIBOSOMAL_S28E, 1 hit

Sequencei

Sequence statusi: Complete.

P62857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV
60
REGDVLTLLE SEREARRLR
Length:69
Mass (Da):7,841
Last modified:August 16, 2004 - v1
Checksum:i49902FE9376EB74F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66R → P AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05091 mRNA Translation: AAC15855.1
U58682 mRNA Translation: AAB07066.1
AB061846 Genomic DNA Translation: BAB79484.1
CR457055 mRNA Translation: CAG33336.1
BC000354 mRNA Translation: AAH00354.1
BC021239 mRNA Translation: AAH21239.1
BC070217 mRNA Translation: AAH70217.1
BC070218 mRNA Translation: AAH70218.1
AB007164 Genomic DNA Translation: BAA28594.1
CCDSiCCDS45953.1
PIRiS68914
RefSeqiNP_001022.1, NM_001031.4
UniGeneiHs.153177
Hs.322473

Genome annotation databases

EnsembliENST00000600659; ENSP00000472469; ENSG00000233927
GeneIDi6234
KEGGihsa:6234
UCSCiuc002mjn.4 human

Similar proteinsi

Entry informationi

Entry nameiRS28_HUMAN
AccessioniPrimary (citable) accession number: P62857
Secondary accession number(s): P25112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health