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P62857

- RS28_HUMAN

UniProt

P62857 - RS28_HUMAN

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Protein
40S ribosomal protein S28
Gene
RPS28
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. gene expression Source: Reactome
  5. mRNA metabolic process Source: Reactome
  6. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  7. rRNA processing Source: UniProtKB
  8. ribosomal small subunit biogenesis Source: UniProtKB
  9. translation Source: UniProtKB
  10. translational elongation Source: Reactome
  11. translational initiation Source: Reactome
  12. translational termination Source: Reactome
  13. viral life cycle Source: Reactome
  14. viral process Source: Reactome
  15. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S28
Gene namesi
Name:RPS28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10418. RPS28.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696940S ribosomal protein S28UniRule annotation
PRO_0000136822Add
BLAST

Proteomic databases

MaxQBiP62857.
PaxDbiP62857.
PRIDEiP62857.

PTM databases

PhosphoSiteiP62857.

Expressioni

Gene expression databases

ArrayExpressiP62857.
BgeeiP62857.
CleanExiHS_RPS28.
GenevestigatoriP62857.

Organism-specific databases

HPAiHPA047132.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PINX1Q96BK51EBI-353027,EBI-721782

Protein-protein interaction databases

BioGridi112148. 102 interactions.
IntActiP62857. 12 interactions.
MINTiMINT-5000390.
STRINGi9606.ENSP00000397872.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00c1-69[»]
ProteinModelPortaliP62857.
SMRiP62857. Positions 5-68.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2053.
HOVERGENiHBG000219.
KOiK02979.
OMAiAIVMKVI.
OrthoDBiEOG7SN8GQ.
PhylomeDBiP62857.
TreeFamiTF300136.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00292. Ribosomal_S28e.
InterProiIPR012340. NA-bd_OB-fold.
IPR000289. Ribosomal_S28e.
IPR028626. Ribosomal_S28e_CS.
[Graphical view]
PANTHERiPTHR10769. PTHR10769. 1 hit.
PfamiPF01200. Ribosomal_S28e. 1 hit.
[Graphical view]
ProDomiPD005541. Ribosomal_S28e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00961. RIBOSOMAL_S28E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62857-1 [UniParc]FASTAAdd to Basket

« Hide

MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV   50
REGDVLTLLE SEREARRLR 69
Length:69
Mass (Da):7,841
Last modified:August 16, 2004 - v1
Checksum:i49902FE9376EB74F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661R → P AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05091 mRNA. Translation: AAC15855.1.
U58682 mRNA. Translation: AAB07066.1.
AB061846 Genomic DNA. Translation: BAB79484.1.
CR457055 mRNA. Translation: CAG33336.1.
BC000354 mRNA. Translation: AAH00354.1.
BC021239 mRNA. Translation: AAH21239.1.
BC070217 mRNA. Translation: AAH70217.1.
BC070218 mRNA. Translation: AAH70218.1.
AB007164 Genomic DNA. Translation: BAA28594.1.
CCDSiCCDS45953.1.
PIRiS68914.
RefSeqiNP_001022.1. NM_001031.4.
UniGeneiHs.153177.
Hs.322473.

Genome annotation databases

EnsembliENST00000600659; ENSP00000472469; ENSG00000233927.
GeneIDi6234.
KEGGihsa:6234.
UCSCiuc002mjn.3. human.

Polymorphism databases

DMDMi51338652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05091 mRNA. Translation: AAC15855.1 .
U58682 mRNA. Translation: AAB07066.1 .
AB061846 Genomic DNA. Translation: BAB79484.1 .
CR457055 mRNA. Translation: CAG33336.1 .
BC000354 mRNA. Translation: AAH00354.1 .
BC021239 mRNA. Translation: AAH21239.1 .
BC070217 mRNA. Translation: AAH70217.1 .
BC070218 mRNA. Translation: AAH70218.1 .
AB007164 Genomic DNA. Translation: BAA28594.1 .
CCDSi CCDS45953.1.
PIRi S68914.
RefSeqi NP_001022.1. NM_001031.4.
UniGenei Hs.153177.
Hs.322473.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 c 1-69 [» ]
ProteinModelPortali P62857.
SMRi P62857. Positions 5-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112148. 102 interactions.
IntActi P62857. 12 interactions.
MINTi MINT-5000390.
STRINGi 9606.ENSP00000397872.

PTM databases

PhosphoSitei P62857.

Polymorphism databases

DMDMi 51338652.

Proteomic databases

MaxQBi P62857.
PaxDbi P62857.
PRIDEi P62857.

Protocols and materials databases

DNASUi 6234.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000600659 ; ENSP00000472469 ; ENSG00000233927 .
GeneIDi 6234.
KEGGi hsa:6234.
UCSCi uc002mjn.3. human.

Organism-specific databases

CTDi 6234.
GeneCardsi GC19P008386.
HGNCi HGNC:10418. RPS28.
HPAi HPA047132.
MIMi 603685. gene.
neXtProti NX_P62857.
PharmGKBi PA34825.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2053.
HOVERGENi HBG000219.
KOi K02979.
OMAi AIVMKVI.
OrthoDBi EOG7SN8GQ.
PhylomeDBi P62857.
TreeFami TF300136.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

GeneWikii RPS28.
GenomeRNAii 6234.
NextBioi 24201.
PROi P62857.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62857.
Bgeei P62857.
CleanExi HS_RPS28.
Genevestigatori P62857.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00292. Ribosomal_S28e.
InterProi IPR012340. NA-bd_OB-fold.
IPR000289. Ribosomal_S28e.
IPR028626. Ribosomal_S28e_CS.
[Graphical view ]
PANTHERi PTHR10769. PTHR10769. 1 hit.
Pfami PF01200. Ribosomal_S28e. 1 hit.
[Graphical view ]
ProDomi PD005541. Ribosomal_S28e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50249. SSF50249. 1 hit.
PROSITEi PS00961. RIBOSOMAL_S28E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Bhat K.S.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Kim J.M., Bae Y.S.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
    Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
    Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell, Muscle and Prostate.
  6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 48-68.
    Tissue: Placenta.
  7. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-69.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS28_HUMAN
AccessioniPrimary (citable) accession number: P62857
Secondary accession number(s): P25112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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