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P62857

- RS28_HUMAN

UniProt

P62857 - RS28_HUMAN

Protein

40S ribosomal protein S28

Gene

RPS28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. ribosomal small subunit biogenesis Source: UniProtKB
    6. RNA metabolic process Source: Reactome
    7. rRNA processing Source: UniProtKB
    8. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    9. translation Source: UniProtKB
    10. translational elongation Source: Reactome
    11. translational initiation Source: Reactome
    12. translational termination Source: Reactome
    13. viral life cycle Source: Reactome
    14. viral process Source: Reactome
    15. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S28
    Gene namesi
    Name:RPS28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10418. RPS28.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. small ribosomal subunit Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34825.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696940S ribosomal protein S28PRO_0000136822Add
    BLAST

    Proteomic databases

    MaxQBiP62857.
    PaxDbiP62857.
    PRIDEiP62857.

    PTM databases

    PhosphoSiteiP62857.

    Expressioni

    Gene expression databases

    ArrayExpressiP62857.
    BgeeiP62857.
    CleanExiHS_RPS28.
    GenevestigatoriP62857.

    Organism-specific databases

    HPAiHPA047132.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PINX1Q96BK51EBI-353027,EBI-721782

    Protein-protein interaction databases

    BioGridi112148. 102 interactions.
    IntActiP62857. 12 interactions.
    MINTiMINT-5000390.
    STRINGi9606.ENSP00000397872.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00c1-69[»]
    ProteinModelPortaliP62857.
    SMRiP62857. Positions 5-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S28e family.Curated

    Phylogenomic databases

    eggNOGiCOG2053.
    HOVERGENiHBG000219.
    KOiK02979.
    OMAiAIVMKVI.
    OrthoDBiEOG7SN8GQ.
    PhylomeDBiP62857.
    TreeFamiTF300136.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00292. Ribosomal_S28e.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR000289. Ribosomal_S28e.
    IPR028626. Ribosomal_S28e_CS.
    [Graphical view]
    PANTHERiPTHR10769. PTHR10769. 1 hit.
    PfamiPF01200. Ribosomal_S28e. 1 hit.
    [Graphical view]
    ProDomiPD005541. Ribosomal_S28e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    PROSITEiPS00961. RIBOSOMAL_S28E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62857-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV   50
    REGDVLTLLE SEREARRLR 69
    Length:69
    Mass (Da):7,841
    Last modified:August 16, 2004 - v1
    Checksum:i49902FE9376EB74F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661R → P AA sequence (PubMed:8706699)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05091 mRNA. Translation: AAC15855.1.
    U58682 mRNA. Translation: AAB07066.1.
    AB061846 Genomic DNA. Translation: BAB79484.1.
    CR457055 mRNA. Translation: CAG33336.1.
    BC000354 mRNA. Translation: AAH00354.1.
    BC021239 mRNA. Translation: AAH21239.1.
    BC070217 mRNA. Translation: AAH70217.1.
    BC070218 mRNA. Translation: AAH70218.1.
    AB007164 Genomic DNA. Translation: BAA28594.1.
    CCDSiCCDS45953.1.
    PIRiS68914.
    RefSeqiNP_001022.1. NM_001031.4.
    UniGeneiHs.153177.
    Hs.322473.

    Genome annotation databases

    EnsembliENST00000600659; ENSP00000472469; ENSG00000233927.
    GeneIDi6234.
    KEGGihsa:6234.
    UCSCiuc002mjn.3. human.

    Polymorphism databases

    DMDMi51338652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05091 mRNA. Translation: AAC15855.1 .
    U58682 mRNA. Translation: AAB07066.1 .
    AB061846 Genomic DNA. Translation: BAB79484.1 .
    CR457055 mRNA. Translation: CAG33336.1 .
    BC000354 mRNA. Translation: AAH00354.1 .
    BC021239 mRNA. Translation: AAH21239.1 .
    BC070217 mRNA. Translation: AAH70217.1 .
    BC070218 mRNA. Translation: AAH70218.1 .
    AB007164 Genomic DNA. Translation: BAA28594.1 .
    CCDSi CCDS45953.1.
    PIRi S68914.
    RefSeqi NP_001022.1. NM_001031.4.
    UniGenei Hs.153177.
    Hs.322473.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 c 1-69 [» ]
    ProteinModelPortali P62857.
    SMRi P62857. Positions 5-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112148. 102 interactions.
    IntActi P62857. 12 interactions.
    MINTi MINT-5000390.
    STRINGi 9606.ENSP00000397872.

    PTM databases

    PhosphoSitei P62857.

    Polymorphism databases

    DMDMi 51338652.

    Proteomic databases

    MaxQBi P62857.
    PaxDbi P62857.
    PRIDEi P62857.

    Protocols and materials databases

    DNASUi 6234.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000600659 ; ENSP00000472469 ; ENSG00000233927 .
    GeneIDi 6234.
    KEGGi hsa:6234.
    UCSCi uc002mjn.3. human.

    Organism-specific databases

    CTDi 6234.
    GeneCardsi GC19P008386.
    HGNCi HGNC:10418. RPS28.
    HPAi HPA047132.
    MIMi 603685. gene.
    neXtProti NX_P62857.
    PharmGKBi PA34825.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2053.
    HOVERGENi HBG000219.
    KOi K02979.
    OMAi AIVMKVI.
    OrthoDBi EOG7SN8GQ.
    PhylomeDBi P62857.
    TreeFami TF300136.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPS28.
    GenomeRNAii 6234.
    NextBioi 24201.
    PROi P62857.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62857.
    Bgeei P62857.
    CleanExi HS_RPS28.
    Genevestigatori P62857.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00292. Ribosomal_S28e.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR000289. Ribosomal_S28e.
    IPR028626. Ribosomal_S28e_CS.
    [Graphical view ]
    PANTHERi PTHR10769. PTHR10769. 1 hit.
    Pfami PF01200. Ribosomal_S28e. 1 hit.
    [Graphical view ]
    ProDomi PD005541. Ribosomal_S28e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    PROSITEi PS00961. RIBOSOMAL_S28E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bhat K.S.
      Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Kim J.M., Bae Y.S.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell, Muscle and Prostate.
    6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 48-68.
      Tissue: Placenta.
    7. "A map of 75 human ribosomal protein genes."
      Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
      Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-69.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS28_HUMAN
    AccessioniPrimary (citable) accession number: P62857
    Secondary accession number(s): P25112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3