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P62854

- RS26_HUMAN

UniProt

P62854 - RS26_HUMAN

Protein

40S ribosomal protein S26

Gene

RPS26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. mRNA binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. negative regulation of RNA splicing Source: UniProtKB
    5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S26
    Gene namesi
    Name:RPS26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10414. RPS26.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. nucleolus Source: HPA
    7. small ribosomal subunit Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331D → N in DBA10. 1 Publication
    VAR_063580
    Natural varianti115 – 1151M → T in DBA10. 1 Publication
    VAR_063581

    Keywords - Diseasei

    Diamond-Blackfan anemia, Disease mutation

    Organism-specific databases

    MIMi613309. phenotype.
    Orphaneti124. Blackfan-Diamond anemia.
    PharmGKBiPA34818.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 11511440S ribosomal protein S26PRO_0000204509Add
    BLAST

    Proteomic databases

    MaxQBiP62854.
    PaxDbiP62854.
    PRIDEiP62854.

    PTM databases

    PhosphoSiteiP62854.

    Expressioni

    Gene expression databases

    BgeeiP62854.
    CleanExiHS_RPS26.
    GenevestigatoriP62854.

    Organism-specific databases

    HPAiHPA043961.
    HPA055803.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TSR2Q969E83EBI-353438,EBI-746981

    Protein-protein interaction databases

    BioGridi112145. 119 interactions.
    IntActiP62854. 15 interactions.
    MINTiMINT-4824850.
    STRINGi9606.ENSP00000348849.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00a1-115[»]
    ProteinModelPortaliP62854.
    SMRiP62854. Positions 2-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S26e family.Curated

    Phylogenomic databases

    eggNOGiCOG4830.
    HOGENOMiHOG000108824.
    HOVERGENiHBG079147.
    InParanoidiP62854.
    KOiK02976.
    OMAiTERVEHV.
    OrthoDBiEOG7B31Q7.
    PhylomeDBiP62854.
    TreeFamiTF300234.

    Family and domain databases

    InterProiIPR000892. Ribosomal_S26e.
    [Graphical view]
    PANTHERiPTHR12538. PTHR12538. 1 hit.
    PfamiPF01283. Ribosomal_S26e. 1 hit.
    [Graphical view]
    PROSITEiPS00733. RIBOSOMAL_S26E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62854-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV    50
    RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR 100
    FRPAGAAPRP PPKPM 115
    Length:115
    Mass (Da):13,015
    Last modified:January 23, 2007 - v3
    Checksum:iF60DF98F8900D968
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781A → V in CAA54808. (PubMed:7945460)Curated
    Sequence conflicti109 – 1091R → A in CAA49345. (PubMed:8464749)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331D → N in DBA10. 1 Publication
    VAR_063580
    Natural varianti115 – 1151M → T in DBA10. 1 Publication
    VAR_063581

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69654 mRNA. Translation: CAA49345.1.
    X77770 mRNA. Translation: CAA54808.1.
    X79236 Genomic DNA. Translation: CAA55818.1.
    U41448 Genomic DNA. Translation: AAC26987.1.
    BC002604 mRNA. Translation: AAH02604.1.
    BC015832 mRNA. Translation: AAH15832.1.
    BC070220 mRNA. Translation: AAH70220.1.
    BC105276 mRNA. Translation: AAI05277.1.
    BC105798 mRNA. Translation: AAI05799.1.
    CCDSiCCDS31832.1.
    PIRiS55545.
    T50824.
    RefSeqiNP_001020.2. NM_001029.3.
    XP_005276741.1. XM_005276684.1.
    UniGeneiHs.447562.
    Hs.567235.
    Hs.711461.

    Genome annotation databases

    EnsembliENST00000356464; ENSP00000348849; ENSG00000197728.
    ENST00000552361; ENSP00000450339; ENSG00000197728.
    GeneIDi101929876.
    6231.
    KEGGihsa:101929876.
    hsa:6231.
    UCSCiuc001sjf.3. human.

    Polymorphism databases

    DMDMi51338650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69654 mRNA. Translation: CAA49345.1 .
    X77770 mRNA. Translation: CAA54808.1 .
    X79236 Genomic DNA. Translation: CAA55818.1 .
    U41448 Genomic DNA. Translation: AAC26987.1 .
    BC002604 mRNA. Translation: AAH02604.1 .
    BC015832 mRNA. Translation: AAH15832.1 .
    BC070220 mRNA. Translation: AAH70220.1 .
    BC105276 mRNA. Translation: AAI05277.1 .
    BC105798 mRNA. Translation: AAI05799.1 .
    CCDSi CCDS31832.1.
    PIRi S55545.
    T50824.
    RefSeqi NP_001020.2. NM_001029.3.
    XP_005276741.1. XM_005276684.1.
    UniGenei Hs.447562.
    Hs.567235.
    Hs.711461.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 a 1-115 [» ]
    ProteinModelPortali P62854.
    SMRi P62854. Positions 2-108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112145. 119 interactions.
    IntActi P62854. 15 interactions.
    MINTi MINT-4824850.
    STRINGi 9606.ENSP00000348849.

    PTM databases

    PhosphoSitei P62854.

    Polymorphism databases

    DMDMi 51338650.

    Proteomic databases

    MaxQBi P62854.
    PaxDbi P62854.
    PRIDEi P62854.

    Protocols and materials databases

    DNASUi 6231.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356464 ; ENSP00000348849 ; ENSG00000197728 .
    ENST00000552361 ; ENSP00000450339 ; ENSG00000197728 .
    GeneIDi 101929876.
    6231.
    KEGGi hsa:101929876.
    hsa:6231.
    UCSCi uc001sjf.3. human.

    Organism-specific databases

    CTDi 6231.
    GeneCardsi GC12P056438.
    GeneReviewsi RPS26.
    H-InvDB HIX0161895.
    HGNCi HGNC:10414. RPS26.
    HPAi HPA043961.
    HPA055803.
    MIMi 603701. gene.
    613309. phenotype.
    neXtProti NX_P62854.
    Orphaneti 124. Blackfan-Diamond anemia.
    PharmGKBi PA34818.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4830.
    HOGENOMi HOG000108824.
    HOVERGENi HBG079147.
    InParanoidi P62854.
    KOi K02976.
    OMAi TERVEHV.
    OrthoDBi EOG7B31Q7.
    PhylomeDBi P62854.
    TreeFami TF300234.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPS26.
    NextBioi 24189.
    PROi P62854.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62854.
    CleanExi HS_RPS26.
    Genevestigatori P62854.

    Family and domain databases

    InterProi IPR000892. Ribosomal_S26e.
    [Graphical view ]
    PANTHERi PTHR12538. PTHR12538. 1 hit.
    Pfami PF01283. Ribosomal_S26e. 1 hit.
    [Graphical view ]
    PROSITEi PS00733. RIBOSOMAL_S26E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues."
      Vincent S., Marty L., Fort P.
      Nucleic Acids Res. 21:1498-1498(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning cDNA of human S26 ribosomal protein and determination of its primary structure."
      Filipenko M.L., Vladimirov S.N., Muravlev A.I., Karpova G.G., Mertvetsov N.P.
      Bioorg. Khim. 20:644-649(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26."
      Filipenko M.L., Vinichenko N.A., Karpova G.G., Mertvetsov N.P., Amaldi F.
      Gene 211:287-292(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lymph and Prostate.
    5. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-11.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
    9. Cited for: VARIANTS DBA10 ASN-33 AND THR-115.

    Entry informationi

    Entry nameiRS26_HUMAN
    AccessioniPrimary (citable) accession number: P62854
    Secondary accession number(s): P02383
    , P70394, Q06722, Q3MHD8, Q6IRY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3