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P62854 (RS26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S26
Gene names
Name:RPS26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Involvement in disease

Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Sequence similarities

Belongs to the ribosomal protein S26e family.

Ontologies

Keywords
   DiseaseDiamond-Blackfan anemia
Disease mutation
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

negative regulation of RNA splicing

Inferred from direct assay PubMed 15716004. Source: UniProtKB

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

translation

Inferred by curator PubMed 15883184Ref.5. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

cytosolic small ribosomal subunit

Inferred from direct assay PubMed 15883184Ref.5. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

nucleolus

Inferred from direct assay. Source: HPA

small ribosomal subunit

Inferred from direct assay PubMed 15883184. Source: UniProtKB

   Molecular_functionmRNA binding

Inferred from direct assay PubMed 15716004. Source: UniProtKB

poly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TSR2Q969E83EBI-353438,EBI-746981

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 11511440S ribosomal protein S26
PRO_0000204509

Natural variations

Natural variant331D → N in DBA10. Ref.9
VAR_063580
Natural variant1151M → T in DBA10. Ref.9
VAR_063581

Experimental info

Sequence conflict781A → V in CAA54808. Ref.2
Sequence conflict1091R → A in CAA49345. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P62854 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F60DF98F8900D968

FASTA11513,015
        10         20         30         40         50         60 
MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD 

        70         80         90        100        110 
AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR FRPAGAAPRP PPKPM 

« Hide

References

« Hide 'large scale' references
[1]"S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues."
Vincent S., Marty L., Fort P.
Nucleic Acids Res. 21:1498-1498(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning cDNA of human S26 ribosomal protein and determination of its primary structure."
Filipenko M.L., Vladimirov S.N., Muravlev A.I., Karpova G.G., Mertvetsov N.P.
Bioorg. Khim. 20:644-649(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26."
Filipenko M.L., Vinichenko N.A., Karpova G.G., Mertvetsov N.P., Amaldi F.
Gene 211:287-292(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lymph and Prostate.
[5]"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-11.
[6]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
[9]"Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia."
Doherty L., Sheen M.R., Vlachos A., Choesmel V., O'Donohue M.F., Clinton C., Schneider H.E., Sieff C.A., Newburger P.E., Ball S.E., Niewiadomska E., Matysiak M., Glader B., Arceci R.J., Farrar J.E., Atsidaftos E., Lipton J.M., Gleizes P.E., Gazda H.T.
Am. J. Hum. Genet. 86:222-228(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DBA10 ASN-33 AND THR-115.
[10]Erratum
Doherty L., Sheen M.R., Vlachos A., Choesmel V., O'Donohue M.F., Clinton C., Schneider H.E., Sieff C.A., Newburger P.E., Ball S.E., Niewiadomska E., Matysiak M., Glader B., Arceci R.J., Farrar J.E., Atsidaftos E., Lipton J.M., Gleizes P.E., Gazda H.T.
Am. J. Hum. Genet. 86:655-655(2010)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69654 mRNA. Translation: CAA49345.1.
X77770 mRNA. Translation: CAA54808.1.
X79236 Genomic DNA. Translation: CAA55818.1.
U41448 Genomic DNA. Translation: AAC26987.1.
BC002604 mRNA. Translation: AAH02604.1.
BC015832 mRNA. Translation: AAH15832.1.
BC070220 mRNA. Translation: AAH70220.1.
BC105276 mRNA. Translation: AAI05277.1.
BC105798 mRNA. Translation: AAI05799.1.
PIRS55545.
T50824.
RefSeqNP_001020.2. NM_001029.3.
XP_005276741.1. XM_005276684.1.
UniGeneHs.447562.
Hs.567235.
Hs.711461.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00a1-115[»]
ProteinModelPortalP62854.
SMRP62854. Positions 2-108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112145. 131 interactions.
IntActP62854. 15 interactions.
MINTMINT-4824850.
STRING9606.ENSP00000348849.

PTM databases

PhosphoSiteP62854.

Polymorphism databases

DMDM51338650.

Proteomic databases

PaxDbP62854.
PRIDEP62854.

Protocols and materials databases

DNASU6231.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356464; ENSP00000348849; ENSG00000197728.
ENST00000552361; ENSP00000450339; ENSG00000197728.
GeneID101929876.
6231.
KEGGhsa:101929876.
hsa:6231.
UCSCuc001sjf.3. human.

Organism-specific databases

CTD6231.
GeneCardsGC12P056438.
H-InvDBHIX0161895.
HGNCHGNC:10414. RPS26.
HPAHPA043961.
HPA055803.
MIM603701. gene.
613309. phenotype.
neXtProtNX_P62854.
Orphanet124. Blackfan-Diamond anemia.
PharmGKBPA34818.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4830.
HOGENOMHOG000108824.
HOVERGENHBG079147.
InParanoidP62854.
KOK02976.
OMAASVYQEY.
OrthoDBEOG7B31Q7.
PhylomeDBP62854.
TreeFamTF300234.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

BgeeP62854.
CleanExHS_RPS26.
GenevestigatorP62854.

Family and domain databases

InterProIPR000892. Ribosomal_S26e.
[Graphical view]
PANTHERPTHR12538. PTHR12538. 1 hit.
PfamPF01283. Ribosomal_S26e. 1 hit.
[Graphical view]
PROSITEPS00733. RIBOSOMAL_S26E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRPS26.
NextBio24189.
PROP62854.
SOURCESearch...

Entry information

Entry nameRS26_HUMAN
AccessionPrimary (citable) accession number: P62854
Secondary accession number(s): P02383 expand/collapse secondary AC list , P70394, Q06722, Q3MHD8, Q6IRY4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM