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P62854

- RS26_HUMAN

UniProt

P62854 - RS26_HUMAN

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Protein
40S ribosomal protein S26
Gene
RPS26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. gene expression Source: Reactome
  5. mRNA metabolic process Source: Reactome
  6. negative regulation of RNA splicing Source: UniProtKB
  7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  8. translation Source: UniProtKB
  9. translational elongation Source: Reactome
  10. translational initiation Source: Reactome
  11. translational termination Source: Reactome
  12. viral life cycle Source: Reactome
  13. viral process Source: Reactome
  14. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26
Gene namesi
Name:RPS26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10414. RPS26.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. nucleolus Source: HPA
  6. small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331D → N in DBA10. 1 Publication
VAR_063580
Natural varianti115 – 1151M → T in DBA10. 1 Publication
VAR_063581

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

MIMi613309. phenotype.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 11511440S ribosomal protein S26
PRO_0000204509Add
BLAST

Proteomic databases

MaxQBiP62854.
PaxDbiP62854.
PRIDEiP62854.

PTM databases

PhosphoSiteiP62854.

Expressioni

Gene expression databases

BgeeiP62854.
CleanExiHS_RPS26.
GenevestigatoriP62854.

Organism-specific databases

HPAiHPA043961.
HPA055803.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TSR2Q969E83EBI-353438,EBI-746981

Protein-protein interaction databases

BioGridi112145. 119 interactions.
IntActiP62854. 15 interactions.
MINTiMINT-4824850.
STRINGi9606.ENSP00000348849.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00a1-115[»]
ProteinModelPortaliP62854.
SMRiP62854. Positions 2-108.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4830.
HOGENOMiHOG000108824.
HOVERGENiHBG079147.
InParanoidiP62854.
KOiK02976.
OMAiTERVEHV.
OrthoDBiEOG7B31Q7.
PhylomeDBiP62854.
TreeFamiTF300234.

Family and domain databases

InterProiIPR000892. Ribosomal_S26e.
[Graphical view]
PANTHERiPTHR12538. PTHR12538. 1 hit.
PfamiPF01283. Ribosomal_S26e. 1 hit.
[Graphical view]
PROSITEiPS00733. RIBOSOMAL_S26E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62854-1 [UniParc]FASTAAdd to Basket

« Hide

MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV    50
RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR 100
FRPAGAAPRP PPKPM 115
Length:115
Mass (Da):13,015
Last modified:January 23, 2007 - v3
Checksum:iF60DF98F8900D968
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331D → N in DBA10. 1 Publication
VAR_063580
Natural varianti115 – 1151M → T in DBA10. 1 Publication
VAR_063581

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781A → V in CAA54808. 1 Publication
Sequence conflicti109 – 1091R → A in CAA49345. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69654 mRNA. Translation: CAA49345.1.
X77770 mRNA. Translation: CAA54808.1.
X79236 Genomic DNA. Translation: CAA55818.1.
U41448 Genomic DNA. Translation: AAC26987.1.
BC002604 mRNA. Translation: AAH02604.1.
BC015832 mRNA. Translation: AAH15832.1.
BC070220 mRNA. Translation: AAH70220.1.
BC105276 mRNA. Translation: AAI05277.1.
BC105798 mRNA. Translation: AAI05799.1.
CCDSiCCDS31832.1.
PIRiS55545.
T50824.
RefSeqiNP_001020.2. NM_001029.3.
XP_005276741.1. XM_005276684.1.
UniGeneiHs.447562.
Hs.567235.
Hs.711461.

Genome annotation databases

EnsembliENST00000356464; ENSP00000348849; ENSG00000197728.
ENST00000552361; ENSP00000450339; ENSG00000197728.
GeneIDi101929876.
6231.
KEGGihsa:101929876.
hsa:6231.
UCSCiuc001sjf.3. human.

Polymorphism databases

DMDMi51338650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69654 mRNA. Translation: CAA49345.1 .
X77770 mRNA. Translation: CAA54808.1 .
X79236 Genomic DNA. Translation: CAA55818.1 .
U41448 Genomic DNA. Translation: AAC26987.1 .
BC002604 mRNA. Translation: AAH02604.1 .
BC015832 mRNA. Translation: AAH15832.1 .
BC070220 mRNA. Translation: AAH70220.1 .
BC105276 mRNA. Translation: AAI05277.1 .
BC105798 mRNA. Translation: AAI05799.1 .
CCDSi CCDS31832.1.
PIRi S55545.
T50824.
RefSeqi NP_001020.2. NM_001029.3.
XP_005276741.1. XM_005276684.1.
UniGenei Hs.447562.
Hs.567235.
Hs.711461.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 a 1-115 [» ]
ProteinModelPortali P62854.
SMRi P62854. Positions 2-108.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112145. 119 interactions.
IntActi P62854. 15 interactions.
MINTi MINT-4824850.
STRINGi 9606.ENSP00000348849.

PTM databases

PhosphoSitei P62854.

Polymorphism databases

DMDMi 51338650.

Proteomic databases

MaxQBi P62854.
PaxDbi P62854.
PRIDEi P62854.

Protocols and materials databases

DNASUi 6231.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356464 ; ENSP00000348849 ; ENSG00000197728 .
ENST00000552361 ; ENSP00000450339 ; ENSG00000197728 .
GeneIDi 101929876.
6231.
KEGGi hsa:101929876.
hsa:6231.
UCSCi uc001sjf.3. human.

Organism-specific databases

CTDi 6231.
GeneCardsi GC12P056438.
GeneReviewsi RPS26.
H-InvDB HIX0161895.
HGNCi HGNC:10414. RPS26.
HPAi HPA043961.
HPA055803.
MIMi 603701. gene.
613309. phenotype.
neXtProti NX_P62854.
Orphaneti 124. Blackfan-Diamond anemia.
PharmGKBi PA34818.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4830.
HOGENOMi HOG000108824.
HOVERGENi HBG079147.
InParanoidi P62854.
KOi K02976.
OMAi TERVEHV.
OrthoDBi EOG7B31Q7.
PhylomeDBi P62854.
TreeFami TF300234.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

GeneWikii RPS26.
NextBioi 24189.
PROi P62854.
SOURCEi Search...

Gene expression databases

Bgeei P62854.
CleanExi HS_RPS26.
Genevestigatori P62854.

Family and domain databases

InterProi IPR000892. Ribosomal_S26e.
[Graphical view ]
PANTHERi PTHR12538. PTHR12538. 1 hit.
Pfami PF01283. Ribosomal_S26e. 1 hit.
[Graphical view ]
PROSITEi PS00733. RIBOSOMAL_S26E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues."
    Vincent S., Marty L., Fort P.
    Nucleic Acids Res. 21:1498-1498(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning cDNA of human S26 ribosomal protein and determination of its primary structure."
    Filipenko M.L., Vladimirov S.N., Muravlev A.I., Karpova G.G., Mertvetsov N.P.
    Bioorg. Khim. 20:644-649(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26."
    Filipenko M.L., Vinichenko N.A., Karpova G.G., Mertvetsov N.P., Amaldi F.
    Gene 211:287-292(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lymph and Prostate.
  5. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
  9. Cited for: VARIANTS DBA10 ASN-33 AND THR-115.

Entry informationi

Entry nameiRS26_HUMAN
AccessioniPrimary (citable) accession number: P62854
Secondary accession number(s): P02383
, P70394, Q06722, Q3MHD8, Q6IRY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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