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Protein

40S ribosomal protein S26

Gene

RPS26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26
Alternative name(s):
Small ribosomal subunit protein eS261 Publication
Gene namesi
Name:RPS26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10414. RPS26.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
  • small ribosomal subunit Source: UniProtKB

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 10 (DBA10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:613309
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06358033D → N in DBA10. 1 PublicationCorresponds to variant dbSNP:rs267607023Ensembl.1
Natural variantiVAR_063581115M → T in DBA10. 1 Publication1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi101929876.
6231.
MalaCardsiRPS26.
MIMi613309. phenotype.
OpenTargetsiENSG00000197728.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34818.

Polymorphism and mutation databases

BioMutaiRPS26.
DMDMi51338650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002045092 – 11540S ribosomal protein S26Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62854.
MaxQBiP62854.
PaxDbiP62854.
PeptideAtlasiP62854.
PRIDEiP62854.
TopDownProteomicsiP62854.

PTM databases

iPTMnetiP62854.
PhosphoSitePlusiP62854.
SwissPalmiP62854.

Expressioni

Gene expression databases

BgeeiENSG00000197728.
CleanExiHS_RPS26.
ExpressionAtlasiP62854. baseline and differential.
GenevisibleiP62854. HS.

Organism-specific databases

HPAiHPA043961.
HPA055803.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TSR2Q969E810EBI-353438,EBI-746981

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112145. 136 interactors.
3193504. 66 interactors.
IntActiP62854. 22 interactors.
MINTiMINT-4824850.
STRINGi9606.ENSP00000348849.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sa1-115[»]
4V6Xelectron microscopy5.00Aa1-115[»]
5A2Qelectron microscopy3.90a2-102[»]
5AJ0electron microscopy3.50Ba1-115[»]
5FLXelectron microscopy3.90a1-115[»]
5LKSelectron microscopy3.60Sa1-115[»]
5T2Celectron microscopy3.60AE1-115[»]
ProteinModelPortaliP62854.
SMRiP62854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1768. Eukaryota.
COG4830. LUCA.
GeneTreeiENSGT00390000002517.
HOGENOMiHOG000108824.
HOVERGENiHBG079147.
InParanoidiP62854.
KOiK02976.
OMAiDKAICVT.
OrthoDBiEOG091G19WY.
PhylomeDBiP62854.
TreeFamiTF300234.

Family and domain databases

InterProiView protein in InterPro
IPR000892. Ribosomal_S26e.
PANTHERiPTHR12538. PTHR12538. 1 hit.
PfamiView protein in Pfam
PF01283. Ribosomal_S26e. 1 hit.
PROSITEiView protein in PROSITE
PS00733. RIBOSOMAL_S26E. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV
60 70 80 90 100
RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR
110
FRPAGAAPRP PPKPM
Length:115
Mass (Da):13,015
Last modified:January 23, 2007 - v3
Checksum:iF60DF98F8900D968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78A → V in CAA54808 (PubMed:7945460).Curated1
Sequence conflicti109R → A in CAA49345 (PubMed:8464749).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06358033D → N in DBA10. 1 PublicationCorresponds to variant dbSNP:rs267607023Ensembl.1
Natural variantiVAR_063581115M → T in DBA10. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69654 mRNA. Translation: CAA49345.1.
X77770 mRNA. Translation: CAA54808.1.
X79236 Genomic DNA. Translation: CAA55818.1.
U41448 Genomic DNA. Translation: AAC26987.1.
BC002604 mRNA. Translation: AAH02604.1.
BC015832 mRNA. Translation: AAH15832.1.
BC070220 mRNA. Translation: AAH70220.1.
BC105276 mRNA. Translation: AAI05277.1.
BC105798 mRNA. Translation: AAI05799.1.
CCDSiCCDS31832.1.
PIRiS55545.
T50824.
RefSeqiNP_001020.2. NM_001029.3.
XP_005276741.1. XM_005276684.3.
UniGeneiHs.447562.
Hs.567235.
Hs.711461.

Genome annotation databases

EnsembliENST00000356464; ENSP00000348849; ENSG00000197728.
ENST00000552361; ENSP00000450339; ENSG00000197728.
GeneIDi101929876.
6231.
KEGGihsa:101929876.
hsa:6231.
UCSCiuc001sjf.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRS26_HUMAN
AccessioniPrimary (citable) accession number: P62854
Secondary accession number(s): P02383
, P70394, Q06722, Q3MHD8, Q6IRY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families