P62854 (RS26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S26

Gene names

Name:

RPS26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Involvement in disease

Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities

Belongs to the ribosomal protein S26e family.

Ontologies

Keywords
Disease	Diamond-Blackfan anemia Disease mutation
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome negative regulation of RNA splicing Inferred from direct assay PubMed 15716004. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.5. Source: UniProtKB
Molecular_function	mRNA binding Inferred from direct assay PubMed 15716004. Source: UniProtKB structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TSR2	Q969E8	3	EBI-353438,EBI-746981

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 115	114	40S ribosomal protein S26		PRO_0000204509
Natural variations
	Natural variant	33	1	D → N in DBA10. Ref.8		VAR_063580
	Natural variant	115	1	M → T in DBA10. Ref.8		VAR_063581
Experimental info
	Sequence conflict	78	1	A → V in CAA54808. Ref.2
	Sequence conflict	109	1	R → A in CAA49345. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P62854 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F60DF98F8900D968	FASTA	115	13,015
	10 20 30 40 50 60 MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD 70 80 90 100 110 AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR FRPAGAAPRP PPKPM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues." Vincent S., Marty L., Fort P. Nucleic Acids Res. 21:1498-1498(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning cDNA of human S26 ribosomal protein and determination of its primary structure." Filipenko M.L., Vladimirov S.N., Muravlev A.I., Karpova G.G., Mertvetsov N.P. Bioorg. Khim. 20:644-649(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26." Filipenko M.L., Vinichenko N.A., Karpova G.G., Mertvetsov N.P., Amaldi F. Gene 211:287-292(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lymph and Prostate.
[5]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia." Doherty L., Sheen M.R., Vlachos A., Choesmel V., O'Donohue M.F., Clinton C., Schneider H.E., Sieff C.A., Newburger P.E., Ball S.E., Niewiadomska E., Matysiak M., Glader B., Arceci R.J., Farrar J.E., Atsidaftos E., Lipton J.M., Gleizes P.E., Gazda H.T. Am. J. Hum. Genet. 86:222-228(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS DBA10 ASN-33 AND THR-115.
[9]	Erratum Doherty L., Sheen M.R., Vlachos A., Choesmel V., O'Donohue M.F., Clinton C., Schneider H.E., Sieff C.A., Newburger P.E., Ball S.E., Niewiadomska E., Matysiak M., Glader B., Arceci R.J., Farrar J.E., Atsidaftos E., Lipton J.M., Gleizes P.E., Gazda H.T. Am. J. Hum. Genet. 86:655-655(2010)
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69654 mRNA. Translation: CAA49345.1. X77770 mRNA. Translation: CAA54808.1. X79236 Genomic DNA. Translation: CAA55818.1. U41448 Genomic DNA. Translation: AAC26987.1. BC002604 mRNA. Translation: AAH02604.1. BC015832 mRNA. Translation: AAH15832.1. BC070220 mRNA. Translation: AAH70220.1. BC105276 mRNA. Translation: AAI05277.1. BC105798 mRNA. Translation: AAI05799.1.
IPI	IPI00655650.
PIR	S55545. T50824.
RefSeq	NP_001020.2. NM_001029.3.
UniGene	Hs.447562. Hs.567235. Hs.711461.
3D structure databases
ProteinModelPortal	P62854.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62854. 11 interactions.
STRING	9606.ENSP00000348849.
PTM databases
PhosphoSite	P62854.
Polymorphism databases
DMDM	51338650.
Proteomic databases
PaxDb	P62854.
PRIDE	P62854.
Protocols and materials databases
DNASU	6231.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356464; ENSP00000348849; ENSG00000197728. ENST00000552361; ENSP00000450339; ENSG00000197728.
GeneID	6231.
KEGG	hsa:6231.
UCSC	uc001sjf.3. human.
Organism-specific databases
CTD	6231.
GeneCards	GC12P056438.
H-InvDB	HIX0161895.
HGNC	HGNC:10414. RPS26.
HPA	HPA043961.
MIM	603701. gene. 613309. phenotype.
neXtProt	NX_P62854.
Orphanet	124. Blackfan-Diamond disease.
PharmGKB	PA34818.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4830.
HOGENOM	HOG000108824.
HOVERGEN	HBG079147.
InParanoid	P62854.
KO	K02976.
OMA	SKHGRGH.
OrthoDB	EOG4JWVG2.
PhylomeDB	P62854.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62854.
Bgee	P62854.
CleanEx	HS_RPS26.
Genevestigator	P62854.
GermOnline	ENSG00000196656. Homo sapiens. ENSG00000197728. Homo sapiens.
Family and domain databases
InterPro	IPR000892. Ribosomal_S26e. [Graphical view]
PANTHER	PTHR12538. PTHR12538. 1 hit.
Pfam	PF01283. Ribosomal_S26e. 1 hit. [Graphical view]
PROSITE	PS00733. RIBOSOMAL_S26E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6231.
NextBio	24189.
SOURCE	Search...

Entry information

Entry name

RS26_HUMAN

Accession

Primary (citable) accession number: P62854
Secondary accession number(s): P02383 , P70394, Q06722, Q3MHD8, Q6IRY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.