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P62851

- RS25_HUMAN

UniProt

P62851 - RS25_HUMAN

Protein

40S ribosomal protein S25

Gene

RPS25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProt
    3. RNA binding Source: UniProtKB
    4. structural constituent of ribosome Source: Ensembl

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. ribosomal small subunit assembly Source: Ensembl
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S25
    Gene namesi
    Name:RPS25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10413. RPS25.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. nucleolus Source: UniProtKB
    6. nucleus Source: UniProt
    7. ribosome Source: UniProtKB
    8. small ribosomal subunit Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34817.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12512540S ribosomal protein S25PRO_0000192869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431N6-acetyllysineBy similarity
    Modified residuei52 – 521N6-acetyllysine; alternate1 Publication
    Modified residuei52 – 521N6-succinyllysine; alternateBy similarity
    Modified residuei60 – 601N6-acetyllysine1 Publication
    Modified residuei66 – 661N6-acetyllysine1 Publication
    Modified residuei94 – 941N6-acetyllysine; alternate1 Publication
    Modified residuei94 – 941N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP62851.
    PaxDbiP62851.
    PRIDEiP62851.

    PTM databases

    PhosphoSiteiP62851.

    Expressioni

    Gene expression databases

    BgeeiP62851.
    CleanExiHS_RPS25.
    GenevestigatoriP62851.

    Organism-specific databases

    HPAiHPA031801.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UPF2Q9HAU51EBI-353054,EBI-372073

    Protein-protein interaction databases

    BioGridi112144. 104 interactions.
    IntActiP62851. 15 interactions.
    MINTiMINT-5000124.
    STRINGi9606.ENSP00000236900.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00Z1-125[»]
    ProteinModelPortaliP62851.
    SMRiP62851. Positions 41-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S25e family.Curated

    Phylogenomic databases

    eggNOGiCOG4901.
    HOGENOMiHOG000203673.
    HOVERGENiHBG054579.
    InParanoidiP62851.
    KOiK02975.
    OMAiQLIYTRS.
    PhylomeDBiP62851.
    TreeFamiTF314909.

    Family and domain databases

    InterProiIPR004977. Ribosomal_S25.
    [Graphical view]
    PANTHERiPTHR12850. PTHR12850. 1 hit.
    PfamiPF03297. Ribosomal_S25. 1 hit.
    [Graphical view]
    ProDomiPD012268. Ribosomal_S25. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P62851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF    50
    DKATYDKLCK EVPNYKLITP AVVSERLKIR GSLARAALQE LLSKGLIKLV 100
    SKHRAQVIYT RNTKGGDAPA AGEDA 125
    Length:125
    Mass (Da):13,742
    Last modified:August 16, 2004 - v1
    Checksum:iB8E05F04FCF2F1A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64716 mRNA. Translation: AAA16105.1.
    AB061844 Genomic DNA. Translation: BAB79482.1.
    AK311883 mRNA. Translation: BAG34824.1.
    CH471065 Genomic DNA. Translation: EAW67426.1.
    BC003537 mRNA. Translation: AAH03537.1.
    BC004294 mRNA. Translation: AAH04294.1.
    BC004986 mRNA. Translation: AAH04986.1.
    CCDSiCCDS8406.1.
    PIRiJQ1347.
    RefSeqiNP_001019.1. NM_001028.2.
    UniGeneiHs.512676.

    Genome annotation databases

    EnsembliENST00000527673; ENSP00000435096; ENSG00000118181.
    GeneIDi6230.
    KEGGihsa:6230.
    UCSCiuc001pun.2. human.

    Polymorphism databases

    DMDMi51338648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64716 mRNA. Translation: AAA16105.1 .
    AB061844 Genomic DNA. Translation: BAB79482.1 .
    AK311883 mRNA. Translation: BAG34824.1 .
    CH471065 Genomic DNA. Translation: EAW67426.1 .
    BC003537 mRNA. Translation: AAH03537.1 .
    BC004294 mRNA. Translation: AAH04294.1 .
    BC004986 mRNA. Translation: AAH04986.1 .
    CCDSi CCDS8406.1.
    PIRi JQ1347.
    RefSeqi NP_001019.1. NM_001028.2.
    UniGenei Hs.512676.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 Z 1-125 [» ]
    ProteinModelPortali P62851.
    SMRi P62851. Positions 41-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112144. 104 interactions.
    IntActi P62851. 15 interactions.
    MINTi MINT-5000124.
    STRINGi 9606.ENSP00000236900.

    PTM databases

    PhosphoSitei P62851.

    Polymorphism databases

    DMDMi 51338648.

    Proteomic databases

    MaxQBi P62851.
    PaxDbi P62851.
    PRIDEi P62851.

    Protocols and materials databases

    DNASUi 6230.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000527673 ; ENSP00000435096 ; ENSG00000118181 .
    GeneIDi 6230.
    KEGGi hsa:6230.
    UCSCi uc001pun.2. human.

    Organism-specific databases

    CTDi 6230.
    GeneCardsi GC11M118886.
    HGNCi HGNC:10413. RPS25.
    HPAi HPA031801.
    MIMi 180465. gene.
    neXtProti NX_P62851.
    PharmGKBi PA34817.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4901.
    HOGENOMi HOG000203673.
    HOVERGENi HBG054579.
    InParanoidi P62851.
    KOi K02975.
    OMAi QLIYTRS.
    PhylomeDBi P62851.
    TreeFami TF314909.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPS25. human.
    GeneWikii RPS25.
    GenomeRNAii 6230.
    NextBioi 24185.
    PROi P62851.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62851.
    CleanExi HS_RPS25.
    Genevestigatori P62851.

    Family and domain databases

    InterProi IPR004977. Ribosomal_S25.
    [Graphical view ]
    PANTHERi PTHR12850. PTHR12850. 1 hit.
    Pfami PF03297. Ribosomal_S25. 1 hit.
    [Graphical view ]
    ProDomi PD012268. Ribosomal_S25. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing a cDNA encoding human ribosomal protein S25."
      Li M., Latoud C., Center M.S.
      Gene 107:329-333(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Skin.
    6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 103-114.
      Tissue: Placenta.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52; LYS-60; LYS-66 AND LYS-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS25_HUMAN
    AccessioniPrimary (citable) accession number: P62851
    Secondary accession number(s): B2R4M7, P25111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3