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Protein

40S ribosomal protein S25

Gene

RPS25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118181-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S25
Gene namesi
Name:RPS25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10413. RPS25.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • ribosome Source: UniProtKB
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118181.
ENSG00000280831.
PharmGKBiPA34817.

Polymorphism and mutation databases

BioMutaiRPS25.
DMDMi51338648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928691 – 12540S ribosomal protein S25Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineBy similarity1
Modified residuei52N6-acetyllysine; alternateCombined sources1
Modified residuei52N6-succinyllysine; alternateBy similarity1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei66N6-acetyllysineCombined sources1
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62851.
MaxQBiP62851.
PaxDbiP62851.
PeptideAtlasiP62851.
PRIDEiP62851.
TopDownProteomicsiP62851.

PTM databases

iPTMnetiP62851.
PhosphoSitePlusiP62851.
SwissPalmiP62851.

Expressioni

Gene expression databases

BgeeiENSG00000118181.
CleanExiHS_RPS25.
ExpressionAtlasiP62851. baseline and differential.
GenevisibleiP62851. HS.

Organism-specific databases

HPAiHPA031801.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
THAP1Q9NVV93EBI-353054,EBI-741515

Protein-protein interaction databases

BioGridi112144. 154 interactors.
IntActiP62851. 34 interactors.
MINTiMINT-5000124.
STRINGi9606.ENSP00000435096.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SZ1-125[»]
4V6Xelectron microscopy5.00AZ1-125[»]
5A2Qelectron microscopy3.90Z1-125[»]
5AJ0electron microscopy3.50BZ1-125[»]
5FLXelectron microscopy3.90Z1-125[»]
ProteinModelPortaliP62851.
SMRiP62851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S25e family.Curated

Phylogenomic databases

eggNOGiKOG1767. Eukaryota.
COG4901. LUCA.
GeneTreeiENSGT00390000004856.
HOGENOMiHOG000203673.
HOVERGENiHBG054579.
InParanoidiP62851.
KOiK02975.
OMAiIRMISSH.
OrthoDBiEOG091G134K.
PhylomeDBiP62851.
TreeFamiTF314909.

Family and domain databases

InterProiIPR004977. Ribosomal_S25.
[Graphical view]
PANTHERiPTHR12850. PTHR12850. 1 hit.
PfamiPF03297. Ribosomal_S25. 1 hit.
[Graphical view]
ProDomiPD012268. Ribosomal_S25. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P62851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF
60 70 80 90 100
DKATYDKLCK EVPNYKLITP AVVSERLKIR GSLARAALQE LLSKGLIKLV
110 120
SKHRAQVIYT RNTKGGDAPA AGEDA
Length:125
Mass (Da):13,742
Last modified:August 16, 2004 - v1
Checksum:iB8E05F04FCF2F1A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64716 mRNA. Translation: AAA16105.1.
AB061844 Genomic DNA. Translation: BAB79482.1.
AK311883 mRNA. Translation: BAG34824.1.
CH471065 Genomic DNA. Translation: EAW67426.1.
BC003537 mRNA. Translation: AAH03537.1.
BC004294 mRNA. Translation: AAH04294.1.
BC004986 mRNA. Translation: AAH04986.1.
CCDSiCCDS8406.1.
PIRiJQ1347.
RefSeqiNP_001019.1. NM_001028.2.
UniGeneiHs.512676.

Genome annotation databases

EnsembliENST00000527673; ENSP00000435096; ENSG00000118181.
ENST00000628770; ENSP00000486392; ENSG00000280831.
GeneIDi6230.
KEGGihsa:6230.
UCSCiuc001pun.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64716 mRNA. Translation: AAA16105.1.
AB061844 Genomic DNA. Translation: BAB79482.1.
AK311883 mRNA. Translation: BAG34824.1.
CH471065 Genomic DNA. Translation: EAW67426.1.
BC003537 mRNA. Translation: AAH03537.1.
BC004294 mRNA. Translation: AAH04294.1.
BC004986 mRNA. Translation: AAH04986.1.
CCDSiCCDS8406.1.
PIRiJQ1347.
RefSeqiNP_001019.1. NM_001028.2.
UniGeneiHs.512676.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SZ1-125[»]
4V6Xelectron microscopy5.00AZ1-125[»]
5A2Qelectron microscopy3.90Z1-125[»]
5AJ0electron microscopy3.50BZ1-125[»]
5FLXelectron microscopy3.90Z1-125[»]
ProteinModelPortaliP62851.
SMRiP62851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112144. 154 interactors.
IntActiP62851. 34 interactors.
MINTiMINT-5000124.
STRINGi9606.ENSP00000435096.

PTM databases

iPTMnetiP62851.
PhosphoSitePlusiP62851.
SwissPalmiP62851.

Polymorphism and mutation databases

BioMutaiRPS25.
DMDMi51338648.

Proteomic databases

EPDiP62851.
MaxQBiP62851.
PaxDbiP62851.
PeptideAtlasiP62851.
PRIDEiP62851.
TopDownProteomicsiP62851.

Protocols and materials databases

DNASUi6230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527673; ENSP00000435096; ENSG00000118181.
ENST00000628770; ENSP00000486392; ENSG00000280831.
GeneIDi6230.
KEGGihsa:6230.
UCSCiuc001pun.4. human.

Organism-specific databases

CTDi6230.
GeneCardsiRPS25.
HGNCiHGNC:10413. RPS25.
HPAiHPA031801.
MIMi180465. gene.
neXtProtiNX_P62851.
OpenTargetsiENSG00000118181.
ENSG00000280831.
PharmGKBiPA34817.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1767. Eukaryota.
COG4901. LUCA.
GeneTreeiENSGT00390000004856.
HOGENOMiHOG000203673.
HOVERGENiHBG054579.
InParanoidiP62851.
KOiK02975.
OMAiIRMISSH.
OrthoDBiEOG091G134K.
PhylomeDBiP62851.
TreeFamiTF314909.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118181-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS25. human.
GeneWikiiRPS25.
GenomeRNAii6230.
PROiP62851.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118181.
CleanExiHS_RPS25.
ExpressionAtlasiP62851. baseline and differential.
GenevisibleiP62851. HS.

Family and domain databases

InterProiIPR004977. Ribosomal_S25.
[Graphical view]
PANTHERiPTHR12850. PTHR12850. 1 hit.
PfamiPF03297. Ribosomal_S25. 1 hit.
[Graphical view]
ProDomiPD012268. Ribosomal_S25. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiRS25_HUMAN
AccessioniPrimary (citable) accession number: P62851
Secondary accession number(s): B2R4M7, P25111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.