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Protein

40S ribosomal protein S24

Gene

Rps24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24
Gene namesi
Name:Rps24
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621040. Rps24.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • membrane Source: Ensembl
  • nucleus Source: Ensembl
  • ribosome Source: UniProtKB
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13313340S ribosomal protein S24PRO_0000137626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei9 – 91PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62850.
PRIDEiP62850.

PTM databases

iPTMnetiP62850.
SwissPalmiP62850.

Expressioni

Gene expression databases

ExpressionAtlasiP62850. baseline.
GenevisibleiP62850. RN.

Interactioni

GO - Molecular functioni

  • translation initiation factor binding Source: UniProtKB

Protein-protein interaction databases

IntActiP62850. 2 interactions.
MINTiMINT-1845718.
STRINGi10116.ENSRNOP00000048903.

Structurei

3D structure databases

ProteinModelPortaliP62850.
SMRiP62850. Positions 3-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S24e family.Curated

Phylogenomic databases

eggNOGiKOG3424. Eukaryota.
COG2004. LUCA.
GeneTreeiENSGT00390000000153.
HOGENOMiHOG000186306.
HOVERGENiHBG000969.
InParanoidiP62850.
KOiK02974.
OrthoDBiEOG7PS1J8.
PhylomeDBiP62850.
TreeFamiTF314134.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62850-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT
60 70 80 90 100
TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK
110 120 130
KTSRKQRKER KNRMKKVRGT AKANVGAGKK PKE
Length:133
Mass (Da):15,423
Last modified:August 16, 2004 - v1
Checksum:iCE9065C0764D60A6
GO
Isoform 2 (identifier: P62850-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: Missing.

Show »
Length:130
Mass (Da):15,069
Checksum:iE0764D60A6DD576E
GO
Isoform 3 (identifier: P62850-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: PKE → K

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):15,197
Checksum:i3190764D60A6DD57
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 1333Missing in isoform 2. CuratedVSP_011367
Alternative sequencei131 – 1333PKE → K in isoform 3. 1 PublicationVSP_011368

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52445 mRNA. Translation: CAA36684.1.
X51538 mRNA. Translation: CAA35918.1.
BC058140 mRNA. Translation: AAH58140.1.
PIRiS09197. R3RT24.
RefSeqiNP_112374.1. NM_031112.1. [P62850-1]
XP_006252593.1. XM_006252531.2. [P62850-3]
XP_006252594.1. XM_006252532.2. [P62850-3]
XP_006252595.1. XM_006252533.2. [P62850-2]
UniGeneiRn.979.

Genome annotation databases

EnsembliENSRNOT00000064788; ENSRNOP00000059382; ENSRNOG00000010189. [P62850-3]
GeneIDi81776.
KEGGirno:81776.
UCSCiRGD:621040. rat. [P62850-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52445 mRNA. Translation: CAA36684.1.
X51538 mRNA. Translation: CAA35918.1.
BC058140 mRNA. Translation: AAH58140.1.
PIRiS09197. R3RT24.
RefSeqiNP_112374.1. NM_031112.1. [P62850-1]
XP_006252593.1. XM_006252531.2. [P62850-3]
XP_006252594.1. XM_006252532.2. [P62850-3]
XP_006252595.1. XM_006252533.2. [P62850-2]
UniGeneiRn.979.

3D structure databases

ProteinModelPortaliP62850.
SMRiP62850. Positions 3-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62850. 2 interactions.
MINTiMINT-1845718.
STRINGi10116.ENSRNOP00000048903.

PTM databases

iPTMnetiP62850.
SwissPalmiP62850.

Proteomic databases

PaxDbiP62850.
PRIDEiP62850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064788; ENSRNOP00000059382; ENSRNOG00000010189. [P62850-3]
GeneIDi81776.
KEGGirno:81776.
UCSCiRGD:621040. rat. [P62850-1]

Organism-specific databases

CTDi6229.
RGDi621040. Rps24.

Phylogenomic databases

eggNOGiKOG3424. Eukaryota.
COG2004. LUCA.
GeneTreeiENSGT00390000000153.
HOGENOMiHOG000186306.
HOVERGENiHBG000969.
InParanoidiP62850.
KOiK02974.
OrthoDBiEOG7PS1J8.
PhylomeDBiP62850.
TreeFamiTF314134.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi615605.
PROiP62850.

Gene expression databases

ExpressionAtlasiP62850. baseline.
GenevisibleiP62850. RN.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein S24."
    Chan Y.-L., Paz V., Olvera J., Wool I.G.
    FEBS Lett. 262:253-255(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Pituitary.

Entry informationi

Entry nameiRS24_RAT
AccessioniPrimary (citable) accession number: P62850
Secondary accession number(s): P16632, Q6PEC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.