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Protein

40S ribosomal protein S24

Gene

Rps24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24
Gene namesi
Name:Rps24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98147. Rps24.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376251 – 13340S ribosomal protein S24Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62849.
PeptideAtlasiP62849.
PRIDEiP62849.

PTM databases

iPTMnetiP62849.
PhosphoSitePlusiP62849.

Expressioni

Inductioni

Down-regulated during adipocyte differentiation and up-regulated during cellular transformation.1 Publication

Gene expression databases

BgeeiENSMUSG00000025290.
CleanExiMM_RPS24.
ExpressionAtlasiP62849. baseline and differential.
GenevisibleiP62849. MM.

Interactioni

Protein-protein interaction databases

BioGridi203008. 3 interactors.
IntActiP62849. 3 interactors.
STRINGi10090.ENSMUSP00000125977.

Structurei

3D structure databases

ProteinModelPortaliP62849.
SMRiP62849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3424. Eukaryota.
COG2004. LUCA.
GeneTreeiENSGT00390000000153.
HOGENOMiHOG000186306.
HOVERGENiHBG000969.
InParanoidiP62849.
KOiK02974.
OMAiTHFGGGR.
OrthoDBiEOG091G0WLL.
PhylomeDBiP62849.
TreeFamiTF314134.

Family and domain databases

HAMAPiMF_00545. Ribosomal_S24e. 1 hit.
InterProiView protein in InterPro
IPR012678. Ribosomal_L23/L15e_core_dom_sf.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiView protein in Pfam
PF01282. Ribosomal_S24e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006052. Ribosomal_S24e. 1 hit.
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiView protein in PROSITE
PS00529. RIBOSOMAL_S24E. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P62849-1) [UniParc]FASTAAdd to basket
Also known as: S24c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT
60 70 80 90 100
TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK
110 120 130
KTSRKQRKER KNRMKKVRGT AKANVGAGKK PKE
Length:133
Mass (Da):15,423
Last modified:August 16, 2004 - v1
Checksum:iCE9065C0764D60A6
GO
Isoform 2 (identifier: P62849-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: S24a

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: Missing.

Show »
Length:130
Mass (Da):15,069
Checksum:iE0764D60A6DD576E
GO
Isoform 3 (identifier: P62849-3) [UniParc]FASTAAdd to basket
Also known as: S24b

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: PKE → K

Show »
Length:131
Mass (Da):15,197
Checksum:i3190764D60A6DD57
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011365131 – 133Missing in isoform 2. 3 Publications3
Alternative sequenceiVSP_011366131 – 133PKE → K in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60289 mRNA. Translation: CAA42829.1.
X71972 Genomic DNA. Translation: CAA50792.1.
AK005358 mRNA. Translation: BAB23973.1.
AK007776 mRNA. Translation: BAB25248.1.
AK012537 mRNA. Translation: BAB28304.1.
AK018704 mRNA. Translation: BAB31355.1.
AK049387 mRNA. Translation: BAC33727.1.
BC058817 mRNA. Translation: AAH58817.1.
BC081457 mRNA. Translation: AAH81457.1.
CCDSiCCDS36829.1.
CCDS36830.1. [P62849-2]
RefSeqiNP_035427.2. NM_011297.2. [P62849-2]
NP_997517.1. NM_207634.1. [P62849-1]
NP_997518.1. NM_207635.1. [P62849-3]
XP_006518797.1. XM_006518734.1. [P62849-3]
UniGeneiMm.16775.

Genome annotation databases

EnsembliENSMUST00000112384; ENSMUSP00000108003; ENSMUSG00000025290. [P62849-2]
ENSMUST00000169826; ENSMUSP00000125977; ENSMUSG00000025290. [P62849-2]
ENSMUST00000223999; ENSMUSP00000153659; ENSMUSG00000025290. [P62849-3]
ENSMUST00000225023; ENSMUSP00000152944; ENSMUSG00000025290. [P62849-1]
GeneIDi20088.
KEGGimmu:20088.
UCSCiuc007sra.1. mouse.
uc007src.1. mouse. [P62849-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS24_MOUSE
AccessioniPrimary (citable) accession number: P62849
Secondary accession number(s): P16632, Q642L0, Q6PDB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families