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Protein

40S ribosomal protein S24

Gene

Rps24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24
Gene namesi
Name:Rps24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98147. Rps24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13313340S ribosomal protein S24PRO_0000137625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei9 – 91PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62849.
MaxQBiP62849.
PaxDbiP62849.
PRIDEiP62849.

PTM databases

iPTMnetiP62849.
PhosphoSiteiP62849.

Expressioni

Inductioni

Down-regulated during adipocyte differentiation and up-regulated during cellular transformation.1 Publication

Gene expression databases

BgeeiP62849.
CleanExiMM_RPS24.
ExpressionAtlasiP62849. baseline and differential.
GenevisibleiP62849. MM.

Interactioni

Protein-protein interaction databases

BioGridi203008. 3 interactions.
IntActiP62849. 3 interactions.
STRINGi10090.ENSMUSP00000125977.

Structurei

3D structure databases

ProteinModelPortaliP62849.
SMRiP62849. Positions 3-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S24e family.Curated

Phylogenomic databases

eggNOGiKOG3424. Eukaryota.
COG2004. LUCA.
GeneTreeiENSGT00390000000153.
HOGENOMiHOG000186306.
HOVERGENiHBG000969.
InParanoidiP62849.
KOiK02974.
OMAiWISFAEM.
OrthoDBiEOG7PS1J8.
PhylomeDBiP62849.
TreeFamiTF314134.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P62849-1) [UniParc]FASTAAdd to basket

Also known as: S24c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT
60 70 80 90 100
TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK
110 120 130
KTSRKQRKER KNRMKKVRGT AKANVGAGKK PKE
Length:133
Mass (Da):15,423
Last modified:August 16, 2004 - v1
Checksum:iCE9065C0764D60A6
GO
Isoform 2 (identifier: P62849-2) [UniParc] [UniParc]FASTAAdd to basket

Also known as: S24a

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: Missing.

Show »
Length:130
Mass (Da):15,069
Checksum:iE0764D60A6DD576E
GO
Isoform 3 (identifier: P62849-3) [UniParc]FASTAAdd to basket

Also known as: S24b

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: PKE → K

Show »
Length:131
Mass (Da):15,197
Checksum:i3190764D60A6DD57
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 1333Missing in isoform 2. 3 PublicationsVSP_011365
Alternative sequencei131 – 1333PKE → K in isoform 3. 1 PublicationVSP_011366

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60289 mRNA. Translation: CAA42829.1.
X71972 Genomic DNA. Translation: CAA50792.1.
AK005358 mRNA. Translation: BAB23973.1.
AK007776 mRNA. Translation: BAB25248.1.
AK012537 mRNA. Translation: BAB28304.1.
AK018704 mRNA. Translation: BAB31355.1.
AK049387 mRNA. Translation: BAC33727.1.
BC058817 mRNA. Translation: AAH58817.1.
BC081457 mRNA. Translation: AAH81457.1.
CCDSiCCDS36829.1.
CCDS36830.1. [P62849-2]
RefSeqiNP_035427.2. NM_011297.2. [P62849-2]
NP_997517.1. NM_207634.1. [P62849-1]
NP_997518.1. NM_207635.1. [P62849-3]
XP_006518797.1. XM_006518734.1. [P62849-3]
XP_006543363.1. XM_006543300.1. [P62849-1]
UniGeneiMm.16775.

Genome annotation databases

EnsembliENSMUST00000112384; ENSMUSP00000108003; ENSMUSG00000025290. [P62849-2]
ENSMUST00000169826; ENSMUSP00000125977; ENSMUSG00000025290. [P62849-1]
GeneIDi102642752.
20088.
KEGGimmu:102642752.
mmu:20088.
UCSCiuc007sra.1. mouse.
uc007src.1. mouse. [P62849-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60289 mRNA. Translation: CAA42829.1.
X71972 Genomic DNA. Translation: CAA50792.1.
AK005358 mRNA. Translation: BAB23973.1.
AK007776 mRNA. Translation: BAB25248.1.
AK012537 mRNA. Translation: BAB28304.1.
AK018704 mRNA. Translation: BAB31355.1.
AK049387 mRNA. Translation: BAC33727.1.
BC058817 mRNA. Translation: AAH58817.1.
BC081457 mRNA. Translation: AAH81457.1.
CCDSiCCDS36829.1.
CCDS36830.1. [P62849-2]
RefSeqiNP_035427.2. NM_011297.2. [P62849-2]
NP_997517.1. NM_207634.1. [P62849-1]
NP_997518.1. NM_207635.1. [P62849-3]
XP_006518797.1. XM_006518734.1. [P62849-3]
XP_006543363.1. XM_006543300.1. [P62849-1]
UniGeneiMm.16775.

3D structure databases

ProteinModelPortaliP62849.
SMRiP62849. Positions 3-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203008. 3 interactions.
IntActiP62849. 3 interactions.
STRINGi10090.ENSMUSP00000125977.

PTM databases

iPTMnetiP62849.
PhosphoSiteiP62849.

Proteomic databases

EPDiP62849.
MaxQBiP62849.
PaxDbiP62849.
PRIDEiP62849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112384; ENSMUSP00000108003; ENSMUSG00000025290. [P62849-2]
ENSMUST00000169826; ENSMUSP00000125977; ENSMUSG00000025290. [P62849-1]
GeneIDi102642752.
20088.
KEGGimmu:102642752.
mmu:20088.
UCSCiuc007sra.1. mouse.
uc007src.1. mouse. [P62849-3]

Organism-specific databases

CTDi6229.
MGIiMGI:98147. Rps24.

Phylogenomic databases

eggNOGiKOG3424. Eukaryota.
COG2004. LUCA.
GeneTreeiENSGT00390000000153.
HOGENOMiHOG000186306.
HOVERGENiHBG000969.
InParanoidiP62849.
KOiK02974.
OMAiWISFAEM.
OrthoDBiEOG7PS1J8.
PhylomeDBiP62849.
TreeFamiTF314134.

Miscellaneous databases

PROiP62849.
SOURCEiSearch...

Gene expression databases

BgeeiP62849.
CleanExiMM_RPS24.
ExpressionAtlasiP62849. baseline and differential.
GenevisibleiP62849. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of a cDNA clone encoding mouse ribosomal protein S24."
    Ro H.-S., Xu L.
    Nucleic Acids Res. 19:6647-6647(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs."
    Xu L., He G.-P., Li A., Ro H.-S.
    Nucleic Acids Res. 22:646-655(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), INDUCTION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Kidney and Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C3H/He and C57BL/6.
    Tissue: Brain and Osteoblast.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRS24_MOUSE
AccessioniPrimary (citable) accession number: P62849
Secondary accession number(s): P16632, Q642L0, Q6PDB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.