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Protein

40S ribosomal protein S24

Gene

RPS24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

  • erythrocyte homeostasis Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24
Alternative name(s):
Small ribosomal subunit protein eS241 Publication
Gene namesi
Name:RPS24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138326.18
HGNCiHGNC:10411 RPS24
MIMi602412 gene
neXtProtiNX_P62847

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 3 (DBA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:610629

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6229
GeneReviewsiRPS24
MalaCardsiRPS24
MIMi610629 phenotype
OpenTargetsiENSG00000138326
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34815

Polymorphism and mutation databases

BioMutaiRPS24
DMDMi51338645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376231 – 13340S ribosomal protein S24Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei9PhosphothreonineCombined sources1
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62847
MaxQBiP62847
PaxDbiP62847
PeptideAtlasiP62847
PRIDEiP62847
TopDownProteomicsiP62847-1 [P62847-1]
P62847-2 [P62847-2]
P62847-4 [P62847-4]

PTM databases

iPTMnetiP62847
PhosphoSitePlusiP62847
SwissPalmiP62847

Expressioni

Tissue specificityi

Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.1 Publication

Gene expression databases

BgeeiENSG00000138326
CleanExiHS_RPS24
ExpressionAtlasiP62847 baseline and differential
GenevisibleiP62847 HS

Organism-specific databases

HPAiHPA003364

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112143, 159 interactors
CORUMiP62847
IntActiP62847, 42 interactors
MINTiP62847
STRINGi9606.ENSP00000414321

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SY1-133[»]
4V6Xelectron microscopy5.00AY1-133[»]
5A2Qelectron microscopy3.90Y1-130[»]
5AJ0electron microscopy3.50BY1-133[»]
5FLXelectron microscopy3.90Y1-133[»]
5LKSelectron microscopy3.60SY1-133[»]
5OA3electron microscopy4.30Y1-130[»]
5T2Celectron microscopy3.60AQ1-133[»]
5VYCX-ray6.00Y1/Y2/Y3/Y4/Y5/Y61-133[»]
6EK0electron microscopy2.90SY1-133[»]
6FECelectron microscopy6.30s3-133[»]
ProteinModelPortaliP62847
SMRiP62847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3424 Eukaryota
COG2004 LUCA
GeneTreeiENSGT00390000000153
HOGENOMiHOG000186306
HOVERGENiHBG000969
InParanoidiP62847
KOiK02974
OMAiTENREQC
OrthoDBiEOG091G0WLL
PhylomeDBiP62847
TreeFamiTF314134

Family and domain databases

HAMAPiMF_00545 Ribosomal_S24e, 1 hit
InterProiView protein in InterPro
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001976 Ribosomal_S24e
IPR018098 Ribosomal_S24e_CS
PANTHERiPTHR10496 PTHR10496, 1 hit
PfamiView protein in Pfam
PF01282 Ribosomal_S24e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006052 Ribosomal_S24e, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
PROSITEiView protein in PROSITE
PS00529 RIBOSOMAL_S24E, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62847-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT
60 70 80 90 100
TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK
110 120 130
KTSRKQRKER KNRMKKVRGT AKANVGAGKK PKE
Length:133
Mass (Da):15,423
Last modified:August 16, 2004 - v1
Checksum:iCE9065C0764D60A6
GO
Isoform 2 (identifier: P62847-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: Missing.

Show »
Length:130
Mass (Da):15,069
Checksum:iE0764D60A6DD576E
GO
Isoform 3 (identifier: P62847-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: PKE → KK

Show »
Length:132
Mass (Da):15,325
Checksum:i107190764D60A6DD
GO
Isoform 4 (identifier: P62847-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-133: PKE → MRELGLGVQA...PPSCLSGLGH

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,431
Checksum:i611E080AF85103CD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005724131 – 133Missing in isoform 2. 2 Publications3
Alternative sequenceiVSP_039113131 – 133PKE → KK in isoform 3. 1 Publication3
Alternative sequenceiVSP_045672131 – 133PKE → MRELGLGVQALGRISQEERC TDVKNSKARESRGVVWQVEV PGPWSVWTCGRLRRGCGKYL QVAVTWRKTENREQCCQACL LERALVRNGAFMSPASPAPA GSPHPVDGDLVLHLPEALSA TLTLSPHIQAINKSFGPFFE IHQESSCFSPPSCLSGLGH in isoform 4. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31520 mRNA Translation: AAA36588.1
U12202 Genomic DNA Translation: AAB08007.1
U12202 Genomic DNA Translation: AAB08006.1
BX336465 mRNA No translation available.
AK311776 mRNA Translation: BAG34719.1
AK311910 mRNA Translation: BAG34851.1
BX537975 mRNA Translation: CAD97939.1
AL512628 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54623.1
CH471083 Genomic DNA Translation: EAW54625.1
BC000523 mRNA Translation: AAH00523.1
BC003149 mRNA No translation available.
BC071926 mRNA Translation: AAH71926.1
CCDSiCCDS44443.1 [P62847-4]
CCDS7355.1
CCDS7356.1 [P62847-2]
PIRiJC4671
JH0213
RefSeqiNP_001017.1, NM_001026.4 [P62847-1]
NP_001135755.1, NM_001142283.1 [P62847-3]
NP_001135757.1, NM_001142285.1 [P62847-4]
NP_148982.1, NM_033022.3 [P62847-2]
UniGeneiHs.280130

Genome annotation databases

EnsembliENST00000360830; ENSP00000354074; ENSG00000138326 [P62847-2]
ENST00000372360; ENSP00000361435; ENSG00000138326 [P62847-1]
ENST00000440692; ENSP00000414321; ENSG00000138326 [P62847-4]
GeneIDi6229
KEGGihsa:6229
UCSCiuc001jzp.4 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS24_HUMAN
AccessioniPrimary (citable) accession number: P62847
Secondary accession number(s): E7EPK6
, P16632, Q5T0P7, Q5T0P8, Q7Z3D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health