ID   RS15_MOUSE              Reviewed;         145 AA.
AC   P62843; P11174; Q52KC9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=Small ribosomal subunit protein uS19 {ECO:0000305};
DE   AltName: Full=40S ribosomal protein S15;
DE   AltName: Full=RIG protein;
GN   Name=Rps15; Synonyms=Rig;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2154983; DOI=10.1016/0006-291x(90)91037-s;
RA   Sugawara A., Nata K., Inoue C., Takasawa S., Yamamoto H., Okamoto H.;
RT   "Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig
RT   cDNAs: the rig-encoded protein is extremely conserved during vertebrate
RT   evolution.";
RL   Biochem. Biophys. Res. Commun. 166:1501-1507(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Kidney, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
RC   Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0007744|PDB:7CPU, ECO:0007744|PDB:7CPV}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS) OF RIBOSOME, FUNCTION,
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=36517592; DOI=10.1038/s41586-022-05508-0;
RA   Li H., Huo Y., He X., Yao L., Zhang H., Cui Y., Xiao H., Xie W., Zhang D.,
RA   Wang Y., Zhang S., Tu H., Cheng Y., Guo Y., Cao X., Zhu Y., Jiang T.,
RA   Guo X., Qin Y., Sha J.;
RT   "A male germ-cell-specific ribosome controls male fertility.";
RL   Nature 0:0-0(2022).
CC   -!- FUNCTION: Component of the small ribosomal subunit (PubMed:36517592).
CC       The ribosome is a large ribonucleoprotein complex responsible for the
CC       synthesis of proteins in the cell (PubMed:36517592).
CC       {ECO:0000269|PubMed:36517592}.
CC   -!- SUBUNIT: Component of the small ribosomal subunit.
CC       {ECO:0000269|PubMed:36517592}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36517592}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS19 family.
CC       {ECO:0000305}.
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DR   EMBL; M33330; AAA40055.1; -; mRNA.
DR   EMBL; BC010763; AAH10763.1; -; mRNA.
DR   EMBL; BC094409; AAH94409.1; -; mRNA.
DR   CCDS; CCDS35978.1; -.
DR   PIR; A34823; A34823.
DR   RefSeq; NP_033117.1; NM_009091.2.
DR   PDB; 7CPU; EM; 2.82 A; SP=1-145.
DR   PDB; 7CPV; EM; 3.03 A; SP=1-145.
DR   PDB; 7LS1; EM; 3.30 A; x2=1-145.
DR   PDB; 7LS2; EM; 3.10 A; x2=1-145.
DR   PDBsum; 7CPU; -.
DR   PDBsum; 7CPV; -.
DR   PDBsum; 7LS1; -.
DR   PDBsum; 7LS2; -.
DR   AlphaFoldDB; P62843; -.
DR   EMDB; EMD-23500; -.
DR   EMDB; EMD-23501; -.
DR   EMDB; EMD-30432; -.
DR   EMDB; EMD-30433; -.
DR   SMR; P62843; -.
DR   BioGRID; 203003; 66.
DR   ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR   IntAct; P62843; 5.
DR   MINT; P62843; -.
DR   STRING; 10090.ENSMUSP00000069004; -.
DR   GlyGen; P62843; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P62843; -.
DR   PhosphoSitePlus; P62843; -.
DR   EPD; P62843; -.
DR   jPOST; P62843; -.
DR   MaxQB; P62843; -.
DR   PaxDb; 10090-ENSMUSP00000069004; -.
DR   PeptideAtlas; P62843; -.
DR   ProteomicsDB; 299937; -.
DR   Pumba; P62843; -.
DR   TopDownProteomics; P62843; -.
DR   Antibodypedia; 22700; 240 antibodies from 28 providers.
DR   DNASU; 20054; -.
DR   Ensembl; ENSMUST00000068408.14; ENSMUSP00000069004.8; ENSMUSG00000063457.15.
DR   GeneID; 20054; -.
DR   KEGG; mmu:20054; -.
DR   UCSC; uc007gcn.2; mouse.
DR   AGR; MGI:98117; -.
DR   CTD; 6209; -.
DR   MGI; MGI:98117; Rps15.
DR   VEuPathDB; HostDB:ENSMUSG00000063457; -.
DR   eggNOG; KOG0898; Eukaryota.
DR   GeneTree; ENSGT00390000000475; -.
DR   InParanoid; P62843; -.
DR   OMA; IKTHVRD; -.
DR   OrthoDB; 8624at2759; -.
DR   PhylomeDB; P62843; -.
DR   TreeFam; TF318650; -.
DR   Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-MMU-72649; Translation initiation complex formation.
DR   Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   BioGRID-ORCS; 20054; 27 hits in 55 CRISPR screens.
DR   ChiTaRS; Rps15; mouse.
DR   PRO; PR:P62843; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P62843; Protein.
DR   Bgee; ENSMUSG00000063457; Expressed in mammary bud and 246 other cell types or tissues.
DR   ExpressionAtlas; P62843; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; NAS:ComplexPortal.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0045202; C:synapse; ISO:MGI.
DR   GO; GO:0097371; F:MDM2/MDM4 family protein binding; ISO:MGI.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB.
DR   GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:MGI.
DR   GO; GO:0002181; P:cytoplasmic translation; NAS:ComplexPortal.
DR   GO; GO:0097421; P:liver regeneration; IEA:Ensembl.
DR   GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; ISO:MGI.
DR   GO; GO:0000028; P:ribosomal small subunit assembly; ISO:MGI.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; ISO:MGI.
DR   GO; GO:0006364; P:rRNA processing; ISO:MGI.
DR   HAMAP; MF_00531; Ribosomal_uS19; 1.
DR   InterPro; IPR002222; Ribosomal_uS19.
DR   InterPro; IPR020934; Ribosomal_uS19_CS.
DR   InterPro; IPR005713; Ribosomal_uS19_euk/arc.
DR   InterPro; IPR023575; Ribosomal_uS19_SF.
DR   NCBIfam; TIGR01025; uS19_arch; 1.
DR   PANTHER; PTHR11880:SF2; 40S RIBOSOMAL PROTEIN S15; 1.
DR   PANTHER; PTHR11880; RIBOSOMAL PROTEIN S19P FAMILY MEMBER; 1.
DR   Pfam; PF00203; Ribosomal_S19; 1.
DR   PIRSF; PIRSF002144; Ribosomal_S19; 1.
DR   PRINTS; PR00975; RIBOSOMALS19.
DR   SUPFAM; SSF54570; Ribosomal protein S19; 1.
DR   PROSITE; PS00323; RIBOSOMAL_S19; 1.
DR   Genevisible; P62843; MM.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P62841"
FT   CHAIN           2..145
FT                   /note="Small ribosomal subunit protein uS19"
FT                   /id="PRO_0000130029"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P62841"
FT   CROSSLNK        108
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P62841"
SQ   SEQUENCE   145 AA;  17040 MW;  CA2C682302C7B387 CRC64;
     MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL
     RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS
     ITYKPVKHGR PGIGATHSSR FIPLK
//