Reviewed, UniProtKB/Swiss-Prot P62841 (RS15_HUMAN)

Names and origin

Protein names

Recommended name:
    40S ribosomal protein S15
Alternative name(s):
    RIG protein

Gene names

Name:	RPS15
Synonyms:	RIG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S19P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	rRNA processing Inferred from mutant phenotype. Source: UniProtKB ribosomal small subunit biogenesis Inferred from mutant phenotype. Source: UniProtKB ribosomal small subunit export from nucleus Inferred from mutant phenotype. Source: UniProtKB translational elongation Inferred from Experiment. Source: Reactome
Cellular component	cytosolic small ribosomal subunit Ref.5 Inferred from direct assay. Source: UniProtKB nucleoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	DNA binding Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UPF2	Q9HAU5	1	EBI-372635,EBI-372073

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 145	144	40S ribosomal protein S15		PRO_0000130027
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62841-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CA2C682302C7B387	FASTA	145	17,040
	10 20 30 40 50 60 MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 70 80 90 100 110 120 RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 130 140 ITYKPVKHGR PGIGATHSSR FIPLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary conservation of the insulinoma gene rig and its possible function." Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed: 2821540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes." Shiga K., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed: 2159154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and characterization of human insulinoma protein." Yu L., Zhao S.Y. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[5]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract] Cited for: PROTEIN SEQUENCE OF 101-116. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	J02984 mRNA. Translation: AAA36036.1. M32405 Genomic DNA. Translation: AAA36568.1. AF145025 mRNA. Translation: AAP97277.1. BC064908 mRNA. Translation: AAH64908.1. BC105810 mRNA. Translation: AAI05811.1.
PIR	R3HU15. A35908.
RefSeq	NP_001009.1.
UniGene	Hs.406683
3D structure databases
HSSP	HSSP built from PDB template 1QKF based on UniProtKB P80381.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62841.
PTM databases
PhosphoSite	P62841.
Genome annotation databases
Ensembl	ENSG00000115268. Homo sapiens. [Contig view]
GeneID	6209.
KEGG	hsa:6209.
Organism-specific databases
H-InvDB	HIX0040116.
HGNC	HGNC:10388. RPS15.
MIM	180535. gene.
PharmGKB	PA30999.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P62841.
HOVERGEN	P62841.
Enzyme and pathway databases
Reactome	REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
CleanEx	HS_RPS15.
GermOnline	ENSG00000115268. Homo sapiens.
Family and domain databases
InterPro	IPR005713. Ribosomal_S15_euk/arc. IPR002222. Ribosomal_S19. [Graphical view]
Gene3D	G3DSA:3.30.860.10. Ribosomal_S19. 1 hit.
PANTHER	PTHR11880:SF2. Ribosomal_S15e/a. 1 hit. PTHR11880. Ribosomal_S19. 1 hit.
Pfam	PF00203. Ribosomal_S19. 1 hit. [Graphical view]
PIRSF	PIRSF002144. Ribosomal_S19. 1 hit.
PRINTS	PR00975. RIBOSOMALS19.
ProDom	PD001012. Ribosomal_S19. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01025. rpsS_arch. 1 hit.
PROSITE	PS00323. RIBOSOMAL_S19. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24119.
SOURCE	Search...

Entry information

Entry name

RS15_HUMAN

Accession

Primary (citable) accession number: P62841
Secondary accession number(s): P11174, Q3KRA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)