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P62841

- RS15_HUMAN

UniProt

P62841 - RS15_HUMAN

Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. osteoblast differentiation Source: UniProt
    6. ribosomal small subunit biogenesis Source: UniProtKB
    7. ribosomal small subunit export from nucleus Source: UniProtKB
    8. RNA metabolic process Source: Reactome
    9. rRNA processing Source: UniProtKB
    10. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    11. translation Source: UniProtKB
    12. translational elongation Source: Reactome
    13. translational initiation Source: Reactome
    14. translational termination Source: Reactome
    15. viral life cycle Source: Reactome
    16. viral process Source: Reactome
    17. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S15
    Alternative name(s):
    RIG protein
    Gene namesi
    Name:RPS15
    Synonyms:RIG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10388. RPS15.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic small ribosomal subunit Source: UniProtKB
    3. membrane Source: UniProtKB
    4. nucleoplasm Source: UniProtKB
    5. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 14514440S ribosomal protein S15PRO_0000130027Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP62841.
    PaxDbiP62841.
    PRIDEiP62841.

    PTM databases

    PhosphoSiteiP62841.

    Miscellaneous databases

    PMAP-CutDBP62841.

    Expressioni

    Gene expression databases

    BgeeiP62841.
    CleanExiHS_RPS15.
    GenevestigatoriP62841.

    Organism-specific databases

    HPAiHPA054510.
    HPA057793.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0078EBI-372635,EBI-5323863

    Protein-protein interaction databases

    BioGridi112123. 67 interactions.
    IntActiP62841. 10 interactions.
    MINTiMINT-5004408.
    STRINGi9606.ENSP00000233609.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZKQelectron microscopy8.70s1-145[»]
    3J3Aelectron microscopy5.00P1-145[»]
    ProteinModelPortaliP62841.
    SMRiP62841. Positions 4-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62841.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S19P family.Curated

    Phylogenomic databases

    eggNOGiCOG0185.
    HOGENOMiHOG000111561.
    HOVERGENiHBG000709.
    InParanoidiP62841.
    KOiK02958.
    OrthoDBiEOG780RPS.
    PhylomeDBiP62841.

    Family and domain databases

    Gene3Di3.30.860.10. 1 hit.
    HAMAPiMF_00531. Ribosomal_S19.
    InterProiIPR002222. Ribosomal_S19.
    IPR020934. Ribosomal_S19_CS.
    IPR023575. Ribosomal_S19_SF.
    IPR005713. Ribosomal_S19A/S15e.
    [Graphical view]
    PANTHERiPTHR11880. PTHR11880. 1 hit.
    PfamiPF00203. Ribosomal_S19. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
    PRINTSiPR00975. RIBOSOMALS19.
    SUPFAMiSSF54570. SSF54570. 1 hit.
    TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
    PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR    50
    RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK 100
    TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK 145
    Length:145
    Mass (Da):17,040
    Last modified:January 23, 2007 - v2
    Checksum:iCA2C682302C7B387
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02984 mRNA. Translation: AAA36036.1.
    M32405 Genomic DNA. Translation: AAA36568.1.
    AF145025 mRNA. Translation: AAP97277.1.
    BC064908 mRNA. Translation: AAH64908.1.
    BC105810 mRNA. Translation: AAI05811.1.
    BC141832 mRNA. Translation: AAI41833.1.
    CCDSiCCDS12067.1.
    PIRiA35908. R3HU15.
    RefSeqiNP_001009.1. NM_001018.3.
    UniGeneiHs.406683.

    Genome annotation databases

    EnsembliENST00000586686; ENSP00000467676; ENSG00000115268.
    GeneIDi6209.
    KEGGihsa:6209.
    UCSCiuc002lsp.1. human.

    Polymorphism databases

    DMDMi51338641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02984 mRNA. Translation: AAA36036.1 .
    M32405 Genomic DNA. Translation: AAA36568.1 .
    AF145025 mRNA. Translation: AAP97277.1 .
    BC064908 mRNA. Translation: AAH64908.1 .
    BC105810 mRNA. Translation: AAI05811.1 .
    BC141832 mRNA. Translation: AAI41833.1 .
    CCDSi CCDS12067.1.
    PIRi A35908. R3HU15.
    RefSeqi NP_001009.1. NM_001018.3.
    UniGenei Hs.406683.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZKQ electron microscopy 8.70 s 1-145 [» ]
    3J3A electron microscopy 5.00 P 1-145 [» ]
    ProteinModelPortali P62841.
    SMRi P62841. Positions 4-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112123. 67 interactions.
    IntActi P62841. 10 interactions.
    MINTi MINT-5004408.
    STRINGi 9606.ENSP00000233609.

    PTM databases

    PhosphoSitei P62841.

    Polymorphism databases

    DMDMi 51338641.

    Proteomic databases

    MaxQBi P62841.
    PaxDbi P62841.
    PRIDEi P62841.

    Protocols and materials databases

    DNASUi 6209.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000586686 ; ENSP00000467676 ; ENSG00000115268 .
    GeneIDi 6209.
    KEGGi hsa:6209.
    UCSCi uc002lsp.1. human.

    Organism-specific databases

    CTDi 6209.
    GeneCardsi GC19P001438.
    HGNCi HGNC:10388. RPS15.
    HPAi HPA054510.
    HPA057793.
    MIMi 180535. gene.
    neXtProti NX_P62841.
    PharmGKBi PA34787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0185.
    HOGENOMi HOG000111561.
    HOVERGENi HBG000709.
    InParanoidi P62841.
    KOi K02958.
    OrthoDBi EOG780RPS.
    PhylomeDBi P62841.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    EvolutionaryTracei P62841.
    GeneWikii RPS15.
    GenomeRNAii 6209.
    NextBioi 24119.
    PMAP-CutDB P62841.
    PROi P62841.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62841.
    CleanExi HS_RPS15.
    Genevestigatori P62841.

    Family and domain databases

    Gene3Di 3.30.860.10. 1 hit.
    HAMAPi MF_00531. Ribosomal_S19.
    InterProi IPR002222. Ribosomal_S19.
    IPR020934. Ribosomal_S19_CS.
    IPR023575. Ribosomal_S19_SF.
    IPR005713. Ribosomal_S19A/S15e.
    [Graphical view ]
    PANTHERi PTHR11880. PTHR11880. 1 hit.
    Pfami PF00203. Ribosomal_S19. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002144. Ribosomal_S19. 1 hit.
    PRINTSi PR00975. RIBOSOMALS19.
    SUPFAMi SSF54570. SSF54570. 1 hit.
    TIGRFAMsi TIGR01025. rpsS_arch. 1 hit.
    PROSITEi PS00323. RIBOSOMAL_S19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation of the insulinoma gene rig and its possible function."
      Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H.
      Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes."
      Shiga K., Yamamoto H., Okamoto H.
      Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and characterization of human insulinoma protein."
      Yu L., Zhao S.Y.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    5. "Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid."
      Rosenblatt J.D., Tomkins P., Rosenthal M., Kacena A., Chan G., Valderama R., Harrington W. Jr., Saxton E., Diagne A., Zhao J.-Q., Mitsuyasu R.T., Weisbart R.H.
      AIDS 6:1151-1158(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-145.
      Tissue: Brain.
    6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 101-116.
      Tissue: Placenta.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS15_HUMAN
    AccessioniPrimary (citable) accession number: P62841
    Secondary accession number(s): A5D8V9
    , P11174, Q3KRA1, Q9UDC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3