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Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • osteoblast differentiation Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • ribosomal small subunit biogenesis Source: UniProtKB
  • ribosomal small subunit export from nucleus Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
Gene namesi
Name:RPS15
Synonyms:RIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10388. RPS15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6209.
OpenTargetsiENSG00000115268.
PharmGKBiPA34787.

Polymorphism and mutation databases

BioMutaiRPS15.
DMDMi51338641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001300272 – 14540S ribosomal protein S15Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62841.
MaxQBiP62841.
PaxDbiP62841.
PeptideAtlasiP62841.
PRIDEiP62841.
TopDownProteomicsiP62841.

PTM databases

iPTMnetiP62841.
PhosphoSitePlusiP62841.
SwissPalmiP62841.

Miscellaneous databases

PMAP-CutDBP62841.

Expressioni

Gene expression databases

BgeeiENSG00000115268.
CleanExiHS_RPS15.
ExpressionAtlasiP62841. baseline and differential.
GenevisibleiP62841. HS.

Organism-specific databases

HPAiHPA054510.
HPA057793.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2E3Q7L6223EBI-372635,EBI-751757
LRRK2Q5S0079EBI-372635,EBI-5323863

Protein-protein interaction databases

BioGridi112123. 142 interactors.
IntActiP62841. 22 interactors.
MINTiMINT-5004408.
STRINGi9606.ENSP00000467676.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SP1-145[»]
4V6Xelectron microscopy5.00AP1-145[»]
5A2Qelectron microscopy3.90P1-145[»]
5AJ0electron microscopy3.50BP1-145[»]
5FLXelectron microscopy3.90P1-145[»]
ProteinModelPortaliP62841.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62841.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19P family.Curated

Phylogenomic databases

eggNOGiKOG0898. Eukaryota.
COG0185. LUCA.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
HOVERGENiHBG000709.
InParanoidiP62841.
KOiK02958.
PhylomeDBiP62841.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19. 1 hit.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. uS19_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR
60 70 80 90 100
RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK
110 120 130 140
TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK
Length:145
Mass (Da):17,040
Last modified:January 23, 2007 - v2
Checksum:iCA2C682302C7B387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.
CCDSiCCDS12067.1.
PIRiA35908. R3HU15.
RefSeqiNP_001009.1. NM_001018.4.
UniGeneiHs.406683.

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268.
GeneIDi6209.
KEGGihsa:6209.
UCSCiuc002lsp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.
CCDSiCCDS12067.1.
PIRiA35908. R3HU15.
RefSeqiNP_001009.1. NM_001018.4.
UniGeneiHs.406683.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SP1-145[»]
4V6Xelectron microscopy5.00AP1-145[»]
5A2Qelectron microscopy3.90P1-145[»]
5AJ0electron microscopy3.50BP1-145[»]
5FLXelectron microscopy3.90P1-145[»]
ProteinModelPortaliP62841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112123. 142 interactors.
IntActiP62841. 22 interactors.
MINTiMINT-5004408.
STRINGi9606.ENSP00000467676.

PTM databases

iPTMnetiP62841.
PhosphoSitePlusiP62841.
SwissPalmiP62841.

Polymorphism and mutation databases

BioMutaiRPS15.
DMDMi51338641.

Proteomic databases

EPDiP62841.
MaxQBiP62841.
PaxDbiP62841.
PeptideAtlasiP62841.
PRIDEiP62841.
TopDownProteomicsiP62841.

Protocols and materials databases

DNASUi6209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268.
GeneIDi6209.
KEGGihsa:6209.
UCSCiuc002lsp.2. human.

Organism-specific databases

CTDi6209.
DisGeNETi6209.
GeneCardsiRPS15.
HGNCiHGNC:10388. RPS15.
HPAiHPA054510.
HPA057793.
MIMi180535. gene.
neXtProtiNX_P62841.
OpenTargetsiENSG00000115268.
PharmGKBiPA34787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0898. Eukaryota.
COG0185. LUCA.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
HOVERGENiHBG000709.
InParanoidiP62841.
KOiK02958.
PhylomeDBiP62841.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS15. human.
EvolutionaryTraceiP62841.
GeneWikiiRPS15.
GenomeRNAii6209.
PMAP-CutDBP62841.
PROiP62841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115268.
CleanExiHS_RPS15.
ExpressionAtlasiP62841. baseline and differential.
GenevisibleiP62841. HS.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19. 1 hit.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. uS19_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS15_HUMAN
AccessioniPrimary (citable) accession number: P62841
Secondary accession number(s): A5D8V9
, P11174, Q3KRA1, Q9UDC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.