P62841 (RS15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S15

Alternative name(s):
RIG protein

Gene names

Name:	RPS15
Synonyms:	RIG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S19P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome rRNA processing Inferred from mutant phenotype PubMed 18697920. Source: UniProtKB ribosomal small subunit biogenesis Inferred from mutant phenotype PubMed 18697920. Source: UniProtKB ribosomal small subunit export from nucleus Inferred from mutant phenotype PubMed 16037817. Source: UniProtKB translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.6. Source: UniProtKB nucleoplasm Non-traceable author statement PubMed 16037817. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement Ref.2Ref.1. Source: UniProtKB RNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UPF2	Q9HAU5	1	EBI-372635,EBI-372073

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 145	144	40S ribosomal protein S15 HAMAP-Rule MF_00531		PRO_0000130027
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62841 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CA2C682302C7B387	FASTA	145	17,040
	10 20 30 40 50 60 MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 70 80 90 100 110 120 RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 130 140 ITYKPVKHGR PGIGATHSSR FIPLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary conservation of the insulinoma gene rig and its possible function." Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes." Shiga K., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and characterization of human insulinoma protein." Yu L., Zhao S.Y. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[5]	"Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid." Rosenblatt J.D., Tomkins P., Rosenthal M., Kacena A., Chan G., Valderama R., Harrington W. Jr., Saxton E., Diagne A., Zhao J.-Q., Mitsuyasu R.T., Weisbart R.H. AIDS 6:1151-1158(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-145. Tissue: Brain.
[6]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 101-116. Tissue: Placenta.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02984 mRNA. Translation: AAA36036.1. M32405 Genomic DNA. Translation: AAA36568.1. AF145025 mRNA. Translation: AAP97277.1. BC064908 mRNA. Translation: AAH64908.1. BC105810 mRNA. Translation: AAI05811.1. BC141832 mRNA. Translation: AAI41833.1.
IPI	IPI00479058.
PIR	R3HU15. A35908.
RefSeq	NP_001009.1. NM_001018.3.
UniGene	Hs.406683.
3D structure databases
ProteinModelPortal	P62841.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62841. 7 interactions.
STRING	9606.ENSP00000233609.
PTM databases
PhosphoSite	P62841.
Polymorphism databases
DMDM	51338641.
Proteomic databases
PaxDb	P62841.
PRIDE	P62841.
Protocols and materials databases
DNASU	6209.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000586686; ENSP00000467676; ENSG00000115268.
GeneID	6209.
KEGG	hsa:6209.
UCSC	uc002lsp.1. human.
Organism-specific databases
CTD	6209.
GeneCards	GC19P001438.
HGNC	HGNC:10388. RPS15.
MIM	180535. gene.
neXtProt	NX_P62841.
PharmGKB	PA34787.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0185.
HOGENOM	HOG000111561.
HOVERGEN	HBG000709.
InParanoid	P62841.
KO	K02958.
OMA	VIRTHCR.
OrthoDB	EOG45MN6X.
PhylomeDB	P62841.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	P62841.
CleanEx	HS_RPS15.
Genevestigator	P62841.
GermOnline	ENSG00000115268. Homo sapiens.
Family and domain databases
Gene3D	3.30.860.10. 1 hit.
HAMAP	MF_00531. Ribosomal_S19.
InterPro	IPR002222. Ribosomal_S19. IPR020934. Ribosomal_S19_CS. IPR023575. Ribosomal_S19_SF. IPR005713. Ribosomal_S19A/S15e. [Graphical view]
PANTHER	PTHR11880. PTHR11880. 1 hit.
Pfam	PF00203. Ribosomal_S19. 1 hit. [Graphical view]
PIRSF	PIRSF002144. Ribosomal_S19. 1 hit.
PRINTS	PR00975. RIBOSOMALS19.
SUPFAM	SSF54570. Ribosomal_S19. 1 hit.
TIGRFAMs	TIGR01025. rpsS_arch. 1 hit.
PROSITE	PS00323. RIBOSOMAL_S19. 1 hit. [Graphical view]
ProtoNet	Search...
Other
EvolutionaryTrace	P62841.
GenomeRNAi	6209.
NextBio	24119.
PMAP-CutDB	P62841.
SOURCE	Search...

Entry information

Entry name

RS15_HUMAN

Accession

Primary (citable) accession number: P62841
Secondary accession number(s): A5D8V9 , P11174, Q3KRA1, Q9UDC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.