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P62841

- RS15_HUMAN

UniProt

P62841 - RS15_HUMAN

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Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. osteoblast differentiation Source: UniProt
  6. ribosomal small subunit biogenesis Source: UniProtKB
  7. ribosomal small subunit export from nucleus Source: UniProtKB
  8. RNA metabolic process Source: Reactome
  9. rRNA processing Source: UniProtKB
  10. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  11. translation Source: UniProtKB
  12. translational elongation Source: Reactome
  13. translational initiation Source: Reactome
  14. translational termination Source: Reactome
  15. viral life cycle Source: Reactome
  16. viral process Source: Reactome
  17. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
Gene namesi
Name:RPS15
Synonyms:RIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10388. RPS15.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic small ribosomal subunit Source: UniProtKB
  3. focal adhesion Source: UniProtKB
  4. membrane Source: UniProtKB
  5. nucleoplasm Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 14514440S ribosomal protein S15PRO_0000130027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62841.
PaxDbiP62841.
PRIDEiP62841.

PTM databases

PhosphoSiteiP62841.

Miscellaneous databases

PMAP-CutDBP62841.

Expressioni

Gene expression databases

BgeeiP62841.
CleanExiHS_RPS15.
ExpressionAtlasiP62841. baseline.
GenevestigatoriP62841.

Organism-specific databases

HPAiHPA054510.
HPA057793.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0078EBI-372635,EBI-5323863

Protein-protein interaction databases

BioGridi112123. 76 interactions.
IntActiP62841. 10 interactions.
MINTiMINT-5004408.
STRINGi9606.ENSP00000233609.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKQelectron microscopy8.70s1-145[»]
3J3Aelectron microscopy5.00P1-145[»]
ProteinModelPortaliP62841.
SMRiP62841. Positions 4-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62841.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19P family.Curated

Phylogenomic databases

eggNOGiCOG0185.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
HOVERGENiHBG000709.
InParanoidiP62841.
KOiK02958.
OrthoDBiEOG780RPS.
PhylomeDBiP62841.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62841-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR
60 70 80 90 100
RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK
110 120 130 140
TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK
Length:145
Mass (Da):17,040
Last modified:January 23, 2007 - v2
Checksum:iCA2C682302C7B387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.
CCDSiCCDS12067.1.
PIRiA35908. R3HU15.
RefSeqiNP_001009.1. NM_001018.3.
UniGeneiHs.406683.

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268.
GeneIDi6209.
KEGGihsa:6209.
UCSCiuc002lsp.1. human.

Polymorphism databases

DMDMi51338641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1 .
M32405 Genomic DNA. Translation: AAA36568.1 .
AF145025 mRNA. Translation: AAP97277.1 .
BC064908 mRNA. Translation: AAH64908.1 .
BC105810 mRNA. Translation: AAI05811.1 .
BC141832 mRNA. Translation: AAI41833.1 .
CCDSi CCDS12067.1.
PIRi A35908. R3HU15.
RefSeqi NP_001009.1. NM_001018.3.
UniGenei Hs.406683.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZKQ electron microscopy 8.70 s 1-145 [» ]
3J3A electron microscopy 5.00 P 1-145 [» ]
ProteinModelPortali P62841.
SMRi P62841. Positions 4-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112123. 76 interactions.
IntActi P62841. 10 interactions.
MINTi MINT-5004408.
STRINGi 9606.ENSP00000233609.

PTM databases

PhosphoSitei P62841.

Polymorphism databases

DMDMi 51338641.

Proteomic databases

MaxQBi P62841.
PaxDbi P62841.
PRIDEi P62841.

Protocols and materials databases

DNASUi 6209.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000592588 ; ENSP00000467466 ; ENSG00000115268 .
GeneIDi 6209.
KEGGi hsa:6209.
UCSCi uc002lsp.1. human.

Organism-specific databases

CTDi 6209.
GeneCardsi GC19P001438.
HGNCi HGNC:10388. RPS15.
HPAi HPA054510.
HPA057793.
MIMi 180535. gene.
neXtProti NX_P62841.
PharmGKBi PA34787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0185.
GeneTreei ENSGT00390000000475.
HOGENOMi HOG000111561.
HOVERGENi HBG000709.
InParanoidi P62841.
KOi K02958.
OrthoDBi EOG780RPS.
PhylomeDBi P62841.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS15. human.
EvolutionaryTracei P62841.
GeneWikii RPS15.
GenomeRNAii 6209.
NextBioi 24119.
PMAP-CutDB P62841.
PROi P62841.
SOURCEi Search...

Gene expression databases

Bgeei P62841.
CleanExi HS_RPS15.
ExpressionAtlasi P62841. baseline.
Genevestigatori P62841.

Family and domain databases

Gene3Di 3.30.860.10. 1 hit.
HAMAPi MF_00531. Ribosomal_S19.
InterProi IPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view ]
PANTHERi PTHR11880. PTHR11880. 1 hit.
Pfami PF00203. Ribosomal_S19. 1 hit.
[Graphical view ]
PIRSFi PIRSF002144. Ribosomal_S19. 1 hit.
PRINTSi PR00975. RIBOSOMALS19.
SUPFAMi SSF54570. SSF54570. 1 hit.
TIGRFAMsi TIGR01025. rpsS_arch. 1 hit.
PROSITEi PS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of the insulinoma gene rig and its possible function."
    Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H.
    Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes."
    Shiga K., Yamamoto H., Okamoto H.
    Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and characterization of human insulinoma protein."
    Yu L., Zhao S.Y.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  5. "Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid."
    Rosenblatt J.D., Tomkins P., Rosenthal M., Kacena A., Chan G., Valderama R., Harrington W. Jr., Saxton E., Diagne A., Zhao J.-Q., Mitsuyasu R.T., Weisbart R.H.
    AIDS 6:1151-1158(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-145.
    Tissue: Brain.
  6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 101-116.
    Tissue: Placenta.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS15_HUMAN
AccessioniPrimary (citable) accession number: P62841
Secondary accession number(s): A5D8V9
, P11174, Q3KRA1, Q9UDC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3