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Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: GO_Central

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. osteoblast differentiation Source: UniProtKB
  6. ribosomal small subunit assembly Source: GO_Central
  7. ribosomal small subunit biogenesis Source: UniProtKB
  8. ribosomal small subunit export from nucleus Source: UniProtKB
  9. RNA metabolic process Source: Reactome
  10. rRNA processing Source: UniProtKB
  11. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  12. translation Source: UniProtKB
  13. translational elongation Source: Reactome
  14. translational initiation Source: Reactome
  15. translational termination Source: Reactome
  16. viral life cycle Source: Reactome
  17. viral process Source: Reactome
  18. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
Gene namesi
Name:RPS15
Synonyms:RIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10388. RPS15.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. focal adhesion Source: UniProtKB
  5. membrane Source: UniProtKB
  6. nucleoplasm Source: UniProtKB
  7. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 14514440S ribosomal protein S15PRO_0000130027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62841.
PaxDbiP62841.
PRIDEiP62841.

PTM databases

PhosphoSiteiP62841.

Miscellaneous databases

PMAP-CutDBP62841.

Expressioni

Gene expression databases

BgeeiP62841.
CleanExiHS_RPS15.
ExpressionAtlasiP62841. baseline.
GenevestigatoriP62841.

Organism-specific databases

HPAiHPA054510.
HPA057793.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0078EBI-372635,EBI-5323863

Protein-protein interaction databases

BioGridi112123. 77 interactions.
IntActiP62841. 10 interactions.
MINTiMINT-5004408.
STRINGi9606.ENSP00000233609.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKQelectron microscopy8.70s1-145[»]
4V6Xelectron microscopy5.00P1-145[»]
ProteinModelPortaliP62841.
SMRiP62841. Positions 4-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62841.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19P family.Curated

Phylogenomic databases

eggNOGiCOG0185.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
HOVERGENiHBG000709.
InParanoidiP62841.
KOiK02958.
OrthoDBiEOG780RPS.
PhylomeDBiP62841.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62841-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR
60 70 80 90 100
RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK
110 120 130 140
TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK
Length:145
Mass (Da):17,040
Last modified:January 23, 2007 - v2
Checksum:iCA2C682302C7B387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.
CCDSiCCDS12067.1.
PIRiA35908. R3HU15.
RefSeqiNP_001009.1. NM_001018.3.
UniGeneiHs.406683.

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268.
GeneIDi6209.
KEGGihsa:6209.
UCSCiuc002lsp.1. human.

Polymorphism databases

DMDMi51338641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.
CCDSiCCDS12067.1.
PIRiA35908. R3HU15.
RefSeqiNP_001009.1. NM_001018.3.
UniGeneiHs.406683.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKQelectron microscopy8.70s1-145[»]
4V6Xelectron microscopy5.00P1-145[»]
ProteinModelPortaliP62841.
SMRiP62841. Positions 4-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112123. 77 interactions.
IntActiP62841. 10 interactions.
MINTiMINT-5004408.
STRINGi9606.ENSP00000233609.

PTM databases

PhosphoSiteiP62841.

Polymorphism databases

DMDMi51338641.

Proteomic databases

MaxQBiP62841.
PaxDbiP62841.
PRIDEiP62841.

Protocols and materials databases

DNASUi6209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268.
GeneIDi6209.
KEGGihsa:6209.
UCSCiuc002lsp.1. human.

Organism-specific databases

CTDi6209.
GeneCardsiGC19P001438.
HGNCiHGNC:10388. RPS15.
HPAiHPA054510.
HPA057793.
MIMi180535. gene.
neXtProtiNX_P62841.
PharmGKBiPA34787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0185.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
HOVERGENiHBG000709.
InParanoidiP62841.
KOiK02958.
OrthoDBiEOG780RPS.
PhylomeDBiP62841.

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSiRPS15. human.
EvolutionaryTraceiP62841.
GeneWikiiRPS15.
GenomeRNAii6209.
NextBioi24119.
PMAP-CutDBP62841.
PROiP62841.
SOURCEiSearch...

Gene expression databases

BgeeiP62841.
CleanExiHS_RPS15.
ExpressionAtlasiP62841. baseline.
GenevestigatoriP62841.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of the insulinoma gene rig and its possible function."
    Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H.
    Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes."
    Shiga K., Yamamoto H., Okamoto H.
    Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and characterization of human insulinoma protein."
    Yu L., Zhao S.Y.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  5. "Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid."
    Rosenblatt J.D., Tomkins P., Rosenthal M., Kacena A., Chan G., Valderama R., Harrington W. Jr., Saxton E., Diagne A., Zhao J.-Q., Mitsuyasu R.T., Weisbart R.H.
    AIDS 6:1151-1158(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-145.
    Tissue: Brain.
  6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 101-116.
    Tissue: Placenta.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS15_HUMAN
AccessioniPrimary (citable) accession number: P62841
Secondary accession number(s): A5D8V9
, P11174, Q3KRA1, Q9UDC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.