40S ribosomal protein S15 - Homo sapiens (Human)

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P62841 (RS15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
40S ribosomal protein S15

Alternative name(s):
RIG protein

Gene names

Name:	RPS15
Synonyms:	RIG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S19P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	endocrine pancreas development Traceable author statement. Source: Reactome mRNA metabolic process Traceable author statement. Source: Reactome rRNA processing Inferred from mutant phenotype. Source: UniProtKB ribosomal small subunit biogenesis Inferred from mutant phenotype. Source: UniProtKB ribosomal small subunit export from nucleus Inferred from mutant phenotype. Source: UniProtKB translational elongation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular component	cytosolic small ribosomal subunit Inferred from direct assay Ref.6. Source: UniProtKB nucleoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	DNA binding Non-traceable author statement Ref.2 Ref.1. Source: UniProtKB RNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UPF2	Q9HAU5	1	EBI-372635,EBI-372073

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 145

144

40S ribosomal protein S15

PRO_0000130027

Amino acid modifications

Modified residue

N-acetylalanine Ref.7

Sequences

Sequence

Length

Mass (Da)

Tools

P62841 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CA2C682302C7B387
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FASTA

145

17,040

        10         20         30         40         50         60 
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 

        70         80         90        100        110        120 
RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 

       130        140 
ITYKPVKHGR PGIGATHSSR FIPLK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary conservation of the insulinoma gene rig and its possible function." Inoue C., Shiga K., Takasawa S., Kitagawa M., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 84:6659-6662(1987) [PubMed: 2821540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes." Shiga K., Yamamoto H., Okamoto H. Proc. Natl. Acad. Sci. U.S.A. 87:3594-3598(1990) [PubMed: 2159154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and characterization of human insulinoma protein." Yu L., Zhao S.Y. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[5]	"Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid." Rosenblatt J.D., Tomkins P., Rosenthal M., Kacena A., Chan G., Valderama R., Harrington W. Jr., Saxton E., Diagne A., Zhao J.-Q., Mitsuyasu R.T., Weisbart R.H. AIDS 6:1151-1158(1992) [PubMed: 1466847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-145. Tissue: Brain.
[6]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract] Cited for: PROTEIN SEQUENCE OF 101-116. Tissue: Placenta.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J02984 mRNA. Translation: AAA36036.1.
M32405 Genomic DNA. Translation: AAA36568.1.
AF145025 mRNA. Translation: AAP97277.1.
BC064908 mRNA. Translation: AAH64908.1.
BC105810 mRNA. Translation: AAI05811.1.
BC141832 mRNA. Translation: AAI41833.1.

IPI

IPI00479058.

PIR

R3HU15. A35908.

RefSeq

NP_001009.1. NM_001018.3.

UniGene

Hs.406683.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ZKQ	electron microscopy	-	s	1-145	[»]

ProteinModelPortal

P62841.

SMR

P62841. Positions 43-130.

ModBase

Search...

Protein-protein interaction databases

IntAct

P62841. 5 interactions.

STRING

P62841.

PTM databases

PhosphoSite

P62841.

Polymorphism databases

DMDM

51338641.

Proteomic databases

PRIDE

P62841.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000233609; ENSP00000233609; ENSG00000115268.

GeneID

6209.

KEGG

hsa:6209.

UCSC

uc002lsp.1. human.

Organism-specific databases

CTD

6209.

GeneCards

GC19P001438.

H-InvDB

HIX0202917.

HGNC

HGNC:10388. RPS15.

MIM

180535. gene.

neXtProt

NX_P62841.

PharmGKB

PA34787.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20926.

GeneTree

ENSGT00390000000475.

HOGENOM

HBG307515.

HOVERGEN

HBG000709.

InParanoid

P62841.

OMA

THCRDMI.

OrthoDB

EOG45MN6X.

PhylomeDB

P62841.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.
REACT_111217. Metabolism.
REACT_15380. Diabetes pathways.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_6167. Influenza Infection.
REACT_71. Gene Expression.

Gene expression databases

Bgee

P62841.

CleanEx

HS_RPS15.

Genevestigator

P62841.

GermOnline

ENSG00000115268. Homo sapiens.

Family and domain databases

InterPro

IPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]

Gene3D

G3DSA:3.30.860.10. Ribosomal_S19. 1 hit.

K02958.

PANTHER

PTHR11880. Ribosomal_S19. 1 hit.

Pfam

PF00203. Ribosomal_S19. 1 hit.
[Graphical view]

PIRSF

PIRSF002144. Ribosomal_S19. 1 hit.

PRINTS

PR00975. RIBOSOMALS19.

SUPFAM

SSF54570. Ribosomal_S19. 1 hit.

TIGRFAMs

TIGR01025. RpsS_arch. 1 hit.

PROSITE

PS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

24119.

PMAP-CutDB

P62841.

SOURCE

Search...

Entry information

Entry name

RS15_HUMAN

Accession

Primary (citable) accession number: P62841
Secondary accession number(s): A5D8V9

Q9UDC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents