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P62838

- UB2D2_MOUSE

UniProt

P62838 - UB2D2_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 D2

Gene

Ube2d2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3 (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_226192. IKK complex recruitment mediated by RIP1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein D2
Ubiquitin-conjugating enzyme E2(17)KB 2
Ubiquitin-conjugating enzyme E2-17 kDa 2
Ubiquitin-protein ligase D2
Gene namesi
Name:Ube2d2
Synonyms:Ubc4, Ubch4, Ubch5b, Ube2d2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1930715. Ube2d2a.

Subcellular locationi

GO - Cellular componenti

  1. protein complex Source: MGI
  2. ubiquitin ligase complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D2PRO_0000082463Add
BLAST

Proteomic databases

MaxQBiP62838.
PaxDbiP62838.
PRIDEiP62838.

PTM databases

PhosphoSiteiP62838.

Expressioni

Gene expression databases

BgeeiP62838.
CleanExiMM_UBE2D2.
ExpressionAtlasiP62838. baseline and differential.
GenevestigatoriP62838.

Interactioni

Subunit structurei

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.2 Publications

Protein-protein interaction databases

BioGridi208052. 2 interactions.
IntActiP62838. 1 interaction.
MINTiMINT-4139124.

Structurei

3D structure databases

ProteinModelPortaliP62838.
SMRiP62838. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiP62838.
KOiK06689.
OMAiNDLGRDP.
OrthoDBiEOG7PCJGX.
PhylomeDBiP62838.
TreeFamiTF101108.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62838-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM
Length:147
Mass (Da):16,735
Last modified:August 16, 2004 - v1
Checksum:iC942BE7853CBC355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62483 mRNA. Translation: AAB05772.1.
BC003923 mRNA. Translation: AAH03923.1.
CCDSiCCDS50254.1.
RefSeqiNP_064296.1. NM_019912.2.
UniGeneiMm.180052.

Genome annotation databases

EnsembliENSMUST00000167406; ENSMUSP00000131206; ENSMUSG00000091896.
ENSMUST00000170693; ENSMUSP00000132446; ENSMUSG00000091896.
GeneIDi56550.
KEGGimmu:56550.
UCSCiuc012bbj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62483 mRNA. Translation: AAB05772.1 .
BC003923 mRNA. Translation: AAH03923.1 .
CCDSi CCDS50254.1.
RefSeqi NP_064296.1. NM_019912.2.
UniGenei Mm.180052.

3D structure databases

ProteinModelPortali P62838.
SMRi P62838. Positions 1-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208052. 2 interactions.
IntActi P62838. 1 interaction.
MINTi MINT-4139124.

PTM databases

PhosphoSitei P62838.

Proteomic databases

MaxQBi P62838.
PaxDbi P62838.
PRIDEi P62838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167406 ; ENSMUSP00000131206 ; ENSMUSG00000091896 .
ENSMUST00000170693 ; ENSMUSP00000132446 ; ENSMUSG00000091896 .
GeneIDi 56550.
KEGGi mmu:56550.
UCSCi uc012bbj.1. mouse.

Organism-specific databases

CTDi 56550.
MGIi MGI:1930715. Ube2d2a.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
InParanoidi P62838.
KOi K06689.
OMAi NDLGRDP.
OrthoDBi EOG7PCJGX.
PhylomeDBi P62838.
TreeFami TF101108.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_226192. IKK complex recruitment mediated by RIP1.

Miscellaneous databases

NextBioi 28630.
PROi P62838.
SOURCEi Search...

Gene expression databases

Bgeei P62838.
CleanExi MM_UBE2D2.
ExpressionAtlasi P62838. baseline and differential.
Genevestigatori P62838.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a murine ubiquitin conjugating enzyme."
    Richardson P., Zon L.I.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  3. "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
    Yu P., Chen Y., Tagle D.A., Cai T.
    Genomics 79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PJA1.
    Strain: 129/SvJ.
  4. "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction."
    Lu Z., Je H.S., Young P., Gross J., Lu B., Feng G.
    J. Cell Biol. 177:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDZRN3.

Entry informationi

Entry nameiUB2D2_MOUSE
AccessioniPrimary (citable) accession number: P62838
Secondary accession number(s): P51669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3