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Reviewed, UniProtKB/Swiss-Prot P62838 (UB2D2_MOUSE)

Last modified November 25, 2008. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin-conjugating enzyme E2 D2
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase D2
    Ubiquitin carrier protein D2
    Ubiquitin-conjugating enzyme E2-17 kDa 2
    E2(17)KB 2
Gene names
Name: Ube2d2
Synonyms: Ubc4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 147147Ubiquitin-conjugating enzyme E2 D2
PRO_0000082463

Sites

Active site851Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P62838-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: C942BE7853CBC355

FASTA14716,735
        10         20         30         40         50         60 
MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 

        70         80         90        100        110        120 
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 

       130        140 
PEIARIYKTD REKYNRIARE WTQKYAM 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a murine ubiquitin conjugating enzyme."
Richardson P., Zon L.I.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

U62483 mRNA. Translation: AAB05772.1.
BC003923 mRNA. Translation: AAH03923.1.
RefSeqNP_064296.1.
XP_001476589.1.
UniGeneMm.180052
Mm.316489

3D structure databases

HSSPHSSP built from PDB template 1QCQ based on UniProtKB P15731.
SMRP62838. Positions 1-147.
ModBaseSearch...

PTM databases

PhosphoSiteP62838.

Genome annotation databases

EnsemblENSMUSG00000037096. Mus musculus. [Contig view]
GeneID100041766.
56550.
KEGGmmu:100041766.
mmu:56550.

Organism-specific databases

MGIMGI:1930715. Ube2d2.

Phylogenomic databases

HOGENOMP62838.
HOVERGENP62838.

Gene expression databases

ArrayExpressP62838.
CleanExMM_UBE2D2.
GermOnlineENSMUSG00000037096. Mus musculus.

Family and domain databases

InterProIPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHERPTHR11621. UBQ-conjugat_E2. 1 hit.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio452043.
SOURCESearch...

Entry information

Entry nameUB2D2_MOUSE
AccessionPrimary (citable) accession number: P62838
Secondary accession number(s): P51669
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 25, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents