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P62838

- UB2D2_MOUSE

UniProt

P62838 - UB2D2_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 D2

Gene

Ube2d2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3 By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked ubiquitination Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_226192. IKK complex recruitment mediated by RIP1.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein D2
    Ubiquitin-conjugating enzyme E2(17)KB 2
    Ubiquitin-conjugating enzyme E2-17 kDa 2
    Ubiquitin-protein ligase D2
    Gene namesi
    Name:Ube2d2
    Synonyms:Ubc4, Ubch4, Ubch5b, Ube2d2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1930715. Ube2d2a.

    Subcellular locationi

    GO - Cellular componenti

    1. protein complex Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D2PRO_0000082463Add
    BLAST

    Proteomic databases

    MaxQBiP62838.
    PaxDbiP62838.
    PRIDEiP62838.

    PTM databases

    PhosphoSiteiP62838.

    Expressioni

    Gene expression databases

    ArrayExpressiP62838.
    BgeeiP62838.
    CleanExiMM_UBE2D2.
    GenevestigatoriP62838.

    Interactioni

    Subunit structurei

    Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.2 Publications

    Protein-protein interaction databases

    BioGridi208052. 2 interactions.
    IntActiP62838. 1 interaction.
    MINTiMINT-4139124.

    Structurei

    3D structure databases

    ProteinModelPortaliP62838.
    SMRiP62838. Positions 1-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233455.
    HOVERGENiHBG063308.
    InParanoidiP62838.
    KOiK06689.
    OMAiNDLGRDP.
    OrthoDBiEOG7PCJGX.
    PhylomeDBiP62838.
    TreeFamiTF101108.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62838-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF    50
    FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS 100
    KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM 147
    Length:147
    Mass (Da):16,735
    Last modified:August 16, 2004 - v1
    Checksum:iC942BE7853CBC355
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62483 mRNA. Translation: AAB05772.1.
    BC003923 mRNA. Translation: AAH03923.1.
    CCDSiCCDS50254.1.
    RefSeqiNP_064296.1. NM_019912.2.
    UniGeneiMm.180052.

    Genome annotation databases

    EnsembliENSMUST00000167406; ENSMUSP00000131206; ENSMUSG00000091896.
    ENSMUST00000170693; ENSMUSP00000132446; ENSMUSG00000091896.
    GeneIDi56550.
    KEGGimmu:56550.
    UCSCiuc012bbj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62483 mRNA. Translation: AAB05772.1 .
    BC003923 mRNA. Translation: AAH03923.1 .
    CCDSi CCDS50254.1.
    RefSeqi NP_064296.1. NM_019912.2.
    UniGenei Mm.180052.

    3D structure databases

    ProteinModelPortali P62838.
    SMRi P62838. Positions 1-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208052. 2 interactions.
    IntActi P62838. 1 interaction.
    MINTi MINT-4139124.

    PTM databases

    PhosphoSitei P62838.

    Proteomic databases

    MaxQBi P62838.
    PaxDbi P62838.
    PRIDEi P62838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167406 ; ENSMUSP00000131206 ; ENSMUSG00000091896 .
    ENSMUST00000170693 ; ENSMUSP00000132446 ; ENSMUSG00000091896 .
    GeneIDi 56550.
    KEGGi mmu:56550.
    UCSCi uc012bbj.1. mouse.

    Organism-specific databases

    CTDi 56550.
    MGIi MGI:1930715. Ube2d2a.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233455.
    HOVERGENi HBG063308.
    InParanoidi P62838.
    KOi K06689.
    OMAi NDLGRDP.
    OrthoDBi EOG7PCJGX.
    PhylomeDBi P62838.
    TreeFami TF101108.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_226192. IKK complex recruitment mediated by RIP1.

    Miscellaneous databases

    NextBioi 28630.
    PROi P62838.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62838.
    Bgeei P62838.
    CleanExi MM_UBE2D2.
    Genevestigatori P62838.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a murine ubiquitin conjugating enzyme."
      Richardson P., Zon L.I.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary tumor.
    3. "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
      Yu P., Chen Y., Tagle D.A., Cai T.
      Genomics 79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PJA1.
      Strain: 129/SvJ.
    4. "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction."
      Lu Z., Je H.S., Young P., Gross J., Lu B., Feng G.
      J. Cell Biol. 177:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDZRN3.

    Entry informationi

    Entry nameiUB2D2_MOUSE
    AccessioniPrimary (citable) accession number: P62838
    Secondary accession number(s): P51669
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3