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P62838

- UB2D2_MOUSE

UniProt

P62838 - UB2D2_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2 D2
Gene
Ube2d2, Ubc4, Ubch4, Ubch5b, Ube2d2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3 By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. protein binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_226192. IKK complex recruitment mediated by RIP1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein D2
Ubiquitin-conjugating enzyme E2(17)KB 2
Ubiquitin-conjugating enzyme E2-17 kDa 2
Ubiquitin-protein ligase D2
Gene namesi
Name:Ube2d2
Synonyms:Ubc4, Ubch4, Ubch5b, Ube2d2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1930715. Ube2d2a.

Subcellular locationi

GO - Cellular componenti

  1. protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D2
PRO_0000082463Add
BLAST

Proteomic databases

MaxQBiP62838.
PaxDbiP62838.
PRIDEiP62838.

PTM databases

PhosphoSiteiP62838.

Expressioni

Gene expression databases

ArrayExpressiP62838.
BgeeiP62838.
CleanExiMM_UBE2D2.
GenevestigatoriP62838.

Interactioni

Subunit structurei

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.2 Publications

Protein-protein interaction databases

BioGridi208052. 1 interaction.
IntActiP62838. 1 interaction.
MINTiMINT-4139124.

Structurei

3D structure databases

ProteinModelPortaliP62838.
SMRiP62838. Positions 1-147.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiP62838.
KOiK06689.
OMAiNDLGRDP.
OrthoDBiEOG7PCJGX.
PhylomeDBiP62838.
TreeFamiTF101108.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62838-1 [UniParc]FASTAAdd to Basket

« Hide

MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF    50
FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS 100
KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM 147
Length:147
Mass (Da):16,735
Last modified:August 16, 2004 - v1
Checksum:iC942BE7853CBC355
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62483 mRNA. Translation: AAB05772.1.
BC003923 mRNA. Translation: AAH03923.1.
CCDSiCCDS50254.1.
RefSeqiNP_064296.1. NM_019912.2.
UniGeneiMm.180052.

Genome annotation databases

EnsembliENSMUST00000167406; ENSMUSP00000131206; ENSMUSG00000091896.
ENSMUST00000170693; ENSMUSP00000132446; ENSMUSG00000091896.
GeneIDi56550.
KEGGimmu:56550.
UCSCiuc012bbj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62483 mRNA. Translation: AAB05772.1 .
BC003923 mRNA. Translation: AAH03923.1 .
CCDSi CCDS50254.1.
RefSeqi NP_064296.1. NM_019912.2.
UniGenei Mm.180052.

3D structure databases

ProteinModelPortali P62838.
SMRi P62838. Positions 1-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208052. 1 interaction.
IntActi P62838. 1 interaction.
MINTi MINT-4139124.

PTM databases

PhosphoSitei P62838.

Proteomic databases

MaxQBi P62838.
PaxDbi P62838.
PRIDEi P62838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167406 ; ENSMUSP00000131206 ; ENSMUSG00000091896 .
ENSMUST00000170693 ; ENSMUSP00000132446 ; ENSMUSG00000091896 .
GeneIDi 56550.
KEGGi mmu:56550.
UCSCi uc012bbj.1. mouse.

Organism-specific databases

CTDi 56550.
MGIi MGI:1930715. Ube2d2a.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
InParanoidi P62838.
KOi K06689.
OMAi NDLGRDP.
OrthoDBi EOG7PCJGX.
PhylomeDBi P62838.
TreeFami TF101108.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_226192. IKK complex recruitment mediated by RIP1.

Miscellaneous databases

NextBioi 28630.
PROi P62838.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62838.
Bgeei P62838.
CleanExi MM_UBE2D2.
Genevestigatori P62838.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a murine ubiquitin conjugating enzyme."
    Richardson P., Zon L.I.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  3. "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
    Yu P., Chen Y., Tagle D.A., Cai T.
    Genomics 79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PJA1.
    Strain: 129/SvJ.
  4. "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction."
    Lu Z., Je H.S., Young P., Gross J., Lu B., Feng G.
    J. Cell Biol. 177:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDZRN3.

Entry informationi

Entry nameiUB2D2_MOUSE
AccessioniPrimary (citable) accession number: P62838
Secondary accession number(s): P51669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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