P62829 (RL23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L23

Alternative name(s):
60S ribosomal protein L17

Gene names

Name:

RPL23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L14P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome ribosomal protein import into nucleus Non-traceable author statement Ref.2. Source: UniProtKB translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB nucleolus Inferred from electronic annotation. Source: Compara
Molecular_function	structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	60S ribosomal protein L23		PRO_0000128612
Amino acid modifications
	Modified residue	17	1	Phosphoserine Ref.6
	Modified residue	38	1	Phosphotyrosine Ref.5
Experimental info
	Sequence conflict	77	1	H → R in AAH62716. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P62829 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 807E14139B2EB0B5	FASTA	140	14,865
	10 20 30 40 50 60 MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM 70 80 90 100 110 120 VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP 130 140 VAKECADLWP RIASNAGSIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17." Herault Y., Michel D., Chatelain G., Brun G. Nucleic Acids Res. 19:4001-4001(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein." Berchtold M.W., Berger M.C. Gene 102:283-288(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Kidney and Uterus.
[5]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-38, MASS SPECTROMETRY.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52839 mRNA. Translation: CAA37023.1. X55954 mRNA. Translation: CAA39417.1. AB061827 Genomic DNA. Translation: BAB79465.1. BC010114 mRNA. Translation: AAH10114.1. BC062716 mRNA. Translation: AAH62716.1. BC104651 mRNA. Translation: AAI04652.1. BC106061 mRNA. Translation: AAI06062.1.
IPI	IPI00010153.
PIR	R5HU23. S18815.
RefSeq	NP_000969.1. NM_000978.3.
UniGene	Hs.406300.
3D structure databases
ProteinModelPortal	P62829.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62829. 25 interactions.
MINT	MINT-5001181.
STRING	9606.ENSP00000377865.
PTM databases
PhosphoSite	P62829.
Polymorphism databases
DMDM	51338639.
2D gel databases
SWISS-2DPAGE	P62829.
Proteomic databases
PaxDb	P62829.
PRIDE	P62829.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394332; ENSP00000377865; ENSG00000125691. ENST00000479035; ENSP00000420311; ENSG00000125691.
GeneID	9349.
KEGG	hsa:9349.
UCSC	uc002hqx.1. human.
Organism-specific databases
CTD	9349.
GeneCards	GC17M037005.
HGNC	HGNC:10316. RPL23.
HPA	HPA003373.
MIM	603662. gene.
neXtProt	NX_P62829.
PharmGKB	PA34690.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0093.
HOGENOM	HOG000183703.
HOVERGEN	HBG000282.
InParanoid	P62829.
KO	K02894.
OMA	QRKEYRR.
OrthoDB	EOG4CRM1G.
PhylomeDB	P62829.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62829.
Bgee	P62829.
CleanEx	HS_RPL23.
Genevestigator	P62829.
GermOnline	ENSG00000125691. Homo sapiens.
Family and domain databases
Gene3D	2.40.150.20. 1 hit.
InterPro	IPR019972. Ribosomal_L14_CS. IPR023571. Ribosomal_L14_dom. IPR000218. Ribosomal_L14b/L23e. [Graphical view]
PANTHER	PTHR11761. PTHR11761. 1 hit.
Pfam	PF00238. Ribosomal_L14. 1 hit. [Graphical view]
SUPFAM	SSF50193. Ribosomal_L14. 1 hit.
PROSITE	PS00049. RIBOSOMAL_L14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RpL23. human.
GenomeRNAi	9349.
NextBio	35009.
SOURCE	Search...

Entry information

Entry name

RL23_HUMAN

Accession

Primary (citable) accession number: P62829
Secondary accession number(s): P23131 , P24048, Q29246, Q3SWV7, Q6P5S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.