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P62829

- RL23_HUMAN

UniProt

P62829 - RL23_HUMAN

Protein

60S ribosomal protein L23

Gene

RPL23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. ribosomal protein import into nucleus Source: UniProtKB
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L23
    Alternative name(s):
    60S ribosomal protein L17
    Gene namesi
    Name:RPL23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10316. RPL23.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. nucleolus Source: Ensembl
    7. ribosome Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34690.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14014060S ribosomal protein L23PRO_0000128612Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei38 – 381Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP62829.
    PaxDbiP62829.
    PRIDEiP62829.

    2D gel databases

    SWISS-2DPAGEP62829.

    PTM databases

    PhosphoSiteiP62829.

    Expressioni

    Gene expression databases

    ArrayExpressiP62829.
    BgeeiP62829.
    CleanExiHS_RPL23.
    GenevestigatoriP62829.

    Organism-specific databases

    HPAiHPA003373.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDM2Q009873EBI-353303,EBI-389668

    Protein-protein interaction databases

    BioGridi114752. 130 interactions.
    IntActiP62829. 32 interactions.
    MINTiMINT-5001181.
    STRINGi9606.ENSP00000377865.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00V1-140[»]
    ProteinModelPortaliP62829.
    SMRiP62829. Positions 8-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L14P family.Curated

    Phylogenomic databases

    eggNOGiCOG0093.
    HOGENOMiHOG000183703.
    HOVERGENiHBG000282.
    InParanoidiP62829.
    KOiK02894.
    OMAiQITISKV.
    OrthoDBiEOG7ZD1X5.
    PhylomeDBiP62829.
    TreeFamiTF300913.

    Family and domain databases

    Gene3Di2.40.150.20. 1 hit.
    HAMAPiMF_01367. Ribosomal_L14.
    InterProiIPR019972. Ribosomal_L14_CS.
    IPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view]
    PANTHERiPTHR11761. PTHR11761. 1 hit.
    PfamiPF00238. Ribosomal_L14. 1 hit.
    [Graphical view]
    SUPFAMiSSF50193. SSF50193. 1 hit.
    PROSITEiPS00049. RIBOSOMAL_L14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN    50
    RLPAAGVGDM VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED 100
    NAGVIVNNKG EMKGSAITGP VAKECADLWP RIASNAGSIA 140
    Length:140
    Mass (Da):14,865
    Last modified:August 16, 2004 - v1
    Checksum:i807E14139B2EB0B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771H → R in AAH62716. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52839 mRNA. Translation: CAA37023.1.
    X55954 mRNA. Translation: CAA39417.1.
    AB061827 Genomic DNA. Translation: BAB79465.1.
    BC010114 mRNA. Translation: AAH10114.1.
    BC062716 mRNA. Translation: AAH62716.1.
    BC104651 mRNA. Translation: AAI04652.1.
    BC106061 mRNA. Translation: AAI06062.1.
    CCDSiCCDS11330.1.
    PIRiS18815. R5HU23.
    RefSeqiNP_000969.1. NM_000978.3.
    UniGeneiHs.406300.

    Genome annotation databases

    EnsembliENST00000394332; ENSP00000377865; ENSG00000125691.
    ENST00000479035; ENSP00000420311; ENSG00000125691.
    GeneIDi9349.
    KEGGihsa:9349.
    UCSCiuc002hqx.1. human.

    Polymorphism databases

    DMDMi51338639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52839 mRNA. Translation: CAA37023.1 .
    X55954 mRNA. Translation: CAA39417.1 .
    AB061827 Genomic DNA. Translation: BAB79465.1 .
    BC010114 mRNA. Translation: AAH10114.1 .
    BC062716 mRNA. Translation: AAH62716.1 .
    BC104651 mRNA. Translation: AAI04652.1 .
    BC106061 mRNA. Translation: AAI06062.1 .
    CCDSi CCDS11330.1.
    PIRi S18815. R5HU23.
    RefSeqi NP_000969.1. NM_000978.3.
    UniGenei Hs.406300.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 V 1-140 [» ]
    ProteinModelPortali P62829.
    SMRi P62829. Positions 8-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114752. 130 interactions.
    IntActi P62829. 32 interactions.
    MINTi MINT-5001181.
    STRINGi 9606.ENSP00000377865.

    PTM databases

    PhosphoSitei P62829.

    Polymorphism databases

    DMDMi 51338639.

    2D gel databases

    SWISS-2DPAGE P62829.

    Proteomic databases

    MaxQBi P62829.
    PaxDbi P62829.
    PRIDEi P62829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394332 ; ENSP00000377865 ; ENSG00000125691 .
    ENST00000479035 ; ENSP00000420311 ; ENSG00000125691 .
    GeneIDi 9349.
    KEGGi hsa:9349.
    UCSCi uc002hqx.1. human.

    Organism-specific databases

    CTDi 9349.
    GeneCardsi GC17M037005.
    HGNCi HGNC:10316. RPL23.
    HPAi HPA003373.
    MIMi 603662. gene.
    neXtProti NX_P62829.
    PharmGKBi PA34690.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0093.
    HOGENOMi HOG000183703.
    HOVERGENi HBG000282.
    InParanoidi P62829.
    KOi K02894.
    OMAi QITISKV.
    OrthoDBi EOG7ZD1X5.
    PhylomeDBi P62829.
    TreeFami TF300913.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RpL23. human.
    GeneWikii RPL23.
    GenomeRNAii 9349.
    NextBioi 35009.
    PROi P62829.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62829.
    Bgeei P62829.
    CleanExi HS_RPL23.
    Genevestigatori P62829.

    Family and domain databases

    Gene3Di 2.40.150.20. 1 hit.
    HAMAPi MF_01367. Ribosomal_L14.
    InterProi IPR019972. Ribosomal_L14_CS.
    IPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view ]
    PANTHERi PTHR11761. PTHR11761. 1 hit.
    Pfami PF00238. Ribosomal_L14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50193. SSF50193. 1 hit.
    PROSITEi PS00049. RIBOSOMAL_L14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17."
      Herault Y., Michel D., Chatelain G., Brun G.
      Nucleic Acids Res. 19:4001-4001(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein."
      Berchtold M.W., Berger M.C.
      Gene 102:283-288(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Kidney and Uterus.
    5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL23_HUMAN
    AccessioniPrimary (citable) accession number: P62829
    Secondary accession number(s): P23131
    , P24048, Q29246, Q3SWV7, Q6P5S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3