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P62829 (RL23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L23
Alternative name(s):
60S ribosomal protein L17
Gene names
Name:RPL23
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L14P family.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

ribosomal protein import into nucleus

Non-traceable author statement Ref.2. Source: UniProtKB

translation

Non-traceable author statement PubMed 12962325. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

cytosolic large ribosomal subunit

Inferred from direct assay PubMed 12962325. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

nucleolus

Inferred from electronic annotation. Source: Ensembl

ribosome

Non-traceable author statement Ref.2. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

structural constituent of ribosome

Non-traceable author statement PubMed 12962325. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDM2Q009873EBI-353303,EBI-389668

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14014060S ribosomal protein L23 HAMAP-Rule MF_01367
PRO_0000128612

Amino acid modifications

Modified residue171Phosphoserine Ref.6
Modified residue381Phosphotyrosine Ref.5

Experimental info

Sequence conflict771H → R in AAH62716. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P62829 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 807E14139B2EB0B5

FASTA14014,865
        10         20         30         40         50         60 
MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM 

        70         80         90        100        110        120 
VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP 

       130        140 
VAKECADLWP RIASNAGSIA 

« Hide

References

« Hide 'large scale' references
[1]"cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17."
Herault Y., Michel D., Chatelain G., Brun G.
Nucleic Acids Res. 19:4001-4001(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein."
Berchtold M.W., Berger M.C.
Gene 102:283-288(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Kidney and Uterus.
[5]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52839 mRNA. Translation: CAA37023.1.
X55954 mRNA. Translation: CAA39417.1.
AB061827 Genomic DNA. Translation: BAB79465.1.
BC010114 mRNA. Translation: AAH10114.1.
BC062716 mRNA. Translation: AAH62716.1.
BC104651 mRNA. Translation: AAI04652.1.
BC106061 mRNA. Translation: AAI06062.1.
PIRR5HU23. S18815.
RefSeqNP_000969.1. NM_000978.3.
UniGeneHs.406300.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00V1-140[»]
ProteinModelPortalP62829.
SMRP62829. Positions 8-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114752. 158 interactions.
IntActP62829. 31 interactions.
MINTMINT-5001181.
STRING9606.ENSP00000377865.

PTM databases

PhosphoSiteP62829.

Polymorphism databases

DMDM51338639.

2D gel databases

SWISS-2DPAGEP62829.

Proteomic databases

PaxDbP62829.
PRIDEP62829.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394332; ENSP00000377865; ENSG00000125691.
ENST00000479035; ENSP00000420311; ENSG00000125691.
GeneID9349.
KEGGhsa:9349.
UCSCuc002hqx.1. human.

Organism-specific databases

CTD9349.
GeneCardsGC17M037005.
HGNCHGNC:10316. RPL23.
HPAHPA003373.
MIM603662. gene.
neXtProtNX_P62829.
PharmGKBPA34690.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0093.
HOGENOMHOG000183703.
HOVERGENHBG000282.
InParanoidP62829.
KOK02894.
OMAELRKKTM.
OrthoDBEOG7ZD1X5.
PhylomeDBP62829.
TreeFamTF300913.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressP62829.
BgeeP62829.
CleanExHS_RPL23.
GenevestigatorP62829.

Family and domain databases

Gene3D2.40.150.20. 1 hit.
HAMAPMF_01367. Ribosomal_L14.
InterProIPR019972. Ribosomal_L14_CS.
IPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
[Graphical view]
PANTHERPTHR11761. PTHR11761. 1 hit.
PfamPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMSSF50193. SSF50193. 1 hit.
PROSITEPS00049. RIBOSOMAL_L14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRpL23. human.
GeneWikiRPL23.
GenomeRNAi9349.
NextBio35009.
PROP62829.
SOURCESearch...

Entry information

Entry nameRL23_HUMAN
AccessionPrimary (citable) accession number: P62829
Secondary accession number(s): P23131 expand/collapse secondary AC list , P24048, Q29246, Q3SWV7, Q6P5S1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM