GTP-binding nuclear protein Ran - Rattus norvegicus (Rat)

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Reviewed, UniProtKB/Swiss-Prot P62828 (RAN_RAT)

Last modified December 15, 2009. Version 64. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    GTP-binding nuclear protein Ran
Alternative name(s):
    GTPase Ran
    Ras-related nuclear protein
    Ras-like protein TC4

Gene names

Name:

Ran

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules By similarity.
Subunit structure	Monomer. Also forms a complex with CHC1. Found in a complex with nuclear export signal-cargo peptides, RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle By similarity.
Subcellular location	Nucleus. Cytoplasm. Melanosome By similarity. Note: Becomes dispersed throughout the cytoplasm during mitosis.
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Protein transport Transport
Cellular component	Cytoplasm Nucleus
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW microtubule cytoskeleton organization Traceable author statement. Source: RGD mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein export from nucleus Traceable author statement. Source: RGD protein import into nucleus Traceable author statement. Source: RGD signal transduction Inferred from electronic annotation. Source: InterPro spermatid development Inferred from expression pattern. Source: RGD
Cellular component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: RGD
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement. Source: RGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 216

215

GTP-binding nuclear protein Ran

PRO_0000208698

Regions

Nucleotide binding

17 – 24

GTP By similarity

Nucleotide binding

65 – 69

GTP By similarity

Nucleotide binding

122 – 125

GTP By similarity

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

147

Phosphotyrosine By similarity

Modified residue

155

Phosphotyrosine By similarity

Modified residue

159

N6-acetyllysine By similarity

Cross-link

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P62828-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D5C9B7275C34BCE0
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FASTA

216

24,423

        10         20         30         40         50         60 
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 

        70         80         90        100        110        120 
FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 

       130        140        150        160        170        180 
GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 

       190        200        210 
ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel genes expressed in rat dorsal root ganglion." Xiao H., Huang Q., Zhang F., Yang Z., Chen Z., Han Z., Zhang X. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Spinal ganglion.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	Lubec G., Chen W.-Q. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 39-56 AND 153-166, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AF306457 mRNA. Translation: AAG33229.1. BC059123 mRNA. Translation: AAH59123.1.
IPI	IPI00212796.
RefSeq	NP_445891.1.
UniGene	Rn.107698
3D structure databases
SMR	P62828. Positions 1-215, 2-216.
ModBase	Search...
Protein-protein interaction databases
STRING	P62828.
PTM databases
PhosphoSite	P62828.
Proteomic databases
PRIDE	P62828.
Genome annotation databases
Ensembl	ENSRNOT00000001247; ENSRNOP00000001247; ENSRNOG00000000938; Rattus norvegicus. [Genome view]
GeneID	84509.
KEGG	rno:84509.
UCSC	NM_053439. rat.
Organism-specific databases
CTD	84509.
RGD	620367. Ran.
Phylogenomic databases
HOVERGEN	P62828.
InParanoid	P62828.
OMA	HTNRGAI.
Gene expression databases
ArrayExpress	P62828.
Genevestigator	P62828.
GermOnline	ENSRNOG00000000938. Rattus norvegicus.
Family and domain databases
InterPro	IPR002041. Ran_GTPase. IPR013753. Ras. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	617085.

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Entry information

Entry name

RAN_RAT

Accession

Primary (citable) accession number: P62828
Secondary accession number(s): P17080

Q9UEU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	December 15, 2009
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents