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P62824

- RAB3C_RAT

UniProt

P62824 - RAB3C_RAT

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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. antigen processing and presentation Source: Ensembl
  2. calcium ion-dependent exocytosis Source: RGD
  3. neurotransmitter secretion Source: RGD
  4. protein transport Source: UniProtKB-KW
  5. regulation of exocytosis Source: Ensembl
  6. small GTPase mediated signal transduction Source: InterPro
  7. vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620923. Rab3c.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cytosol Source: RGD
  2. perinuclear region of cytoplasm Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
  4. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

PTM databases

PhosphoSiteiP62824.

Expressioni

Gene expression databases

GenevestigatoriP62824.

Interactioni

Subunit structurei

Interacts with RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RIMS1.By similarity1 Publication

Protein-protein interaction databases

BioGridi251075. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiNGFQIAN.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62824.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62824-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411A → V in AAC52879. (PubMed:8885988)Curated
Sequence conflicti159 – 1602QR → RH in AAC52879. (PubMed:8885988)Curated
Sequence conflicti207 – 2071A → G in AAC52879. (PubMed:8885988)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78197 mRNA. Translation: BAA11302.1 .
U54807 mRNA. Translation: AAC52879.1 .
U37099 mRNA. Translation: AAC52704.1 .
PIRi JC5066.
RefSeqi NP_598220.1. NM_133536.2.
UniGenei Rn.11037.

3D structure databases

ProteinModelPortali P62824.
SMRi P62824. Positions 26-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251075. 1 interaction.

PTM databases

PhosphoSitei P62824.

Proteomic databases

PaxDbi P62824.
PRIDEi P62824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015871 ; ENSRNOP00000015871 ; ENSRNOG00000011623 .
GeneIDi 171058.
KEGGi rno:171058.

Organism-specific databases

CTDi 115827.
RGDi 620923. Rab3c.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118937.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P62824.
KOi K07883.
OMAi NGFQIAN.
OrthoDBi EOG7JQBPC.
PhylomeDBi P62824.
TreeFami TF313199.

Miscellaneous databases

NextBioi 324148.
PROi P62824.

Gene expression databases

Genevestigatori P62824.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rab3C is associated with N-type Ca channel in rat brain."
    Oho C., Nemoto Y., Omori A., Takahashi M.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Cloning and tissue expression of the rat RAB 3C GTP-binding protein."
    Viggeswarapu M., Wildey G.M.
    Biochem. Biophys. Res. Commun. 227:645-650(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  3. "Differential expression of rab3 isoforms in oligodendrocytes and astrocytes."
    Madison D.L., Krueger W.H., Kim T., Pfeiffer S.E.
    J. Neurosci. Res. 45:258-268(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-218.
    Tissue: Brain.
  4. "Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
    Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
    Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1.

Entry informationi

Entry nameiRAB3C_RAT
AccessioniPrimary (citable) accession number: P62824
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3