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P62824

- RAB3C_RAT

UniProt

P62824 - RAB3C_RAT

Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448GTPBy similarity
    Nucleotide bindingi85 – 895GTPBy similarity
    Nucleotide bindingi143 – 1464GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: RGD
    2. neurotransmitter secretion Source: RGD
    3. protein transport Source: UniProtKB-KW
    4. regulation of exocytosis Source: Ensembl
    5. small GTPase mediated signal transduction Source: InterPro
    6. vesicle-mediated transport Source: RGD

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-3C
    Gene namesi
    Name:Rab3c
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi620923. Rab3c.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. plasma membrane Source: UniProtKB-SubCell
    3. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
    Modified residuei227 – 2271Cysteine methyl esterBy similarity
    Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP62824.
    PRIDEiP62824.

    PTM databases

    PhosphoSiteiP62824.

    Expressioni

    Gene expression databases

    GenevestigatoriP62824.

    Interactioni

    Subunit structurei

    Interacts with RIMS2, RPH3A and RPH3AL By similarity. Interacts with RIMS1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi251075. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP62824.
    SMRiP62824. Positions 26-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi59 – 679Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00740000115041.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP62824.
    KOiK07883.
    OMAiNGFQIAN.
    OrthoDBiEOG7JQBPC.
    PhylomeDBiP62824.
    TreeFamiTF313199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62824-1 [UniParc]FASTAAdd to Basket

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    MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY    50
    ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY 100
    RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE 150
    RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE 200
    TDPAITAAKQ STRLKETPPP PQPNCGC 227
    Length:227
    Mass (Da):25,872
    Last modified:August 16, 2004 - v1
    Checksum:i179DF4D9B451B7B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411A → V in AAC52879. (PubMed:8885988)Curated
    Sequence conflicti159 – 1602QR → RH in AAC52879. (PubMed:8885988)Curated
    Sequence conflicti207 – 2071A → G in AAC52879. (PubMed:8885988)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78197 mRNA. Translation: BAA11302.1.
    U54807 mRNA. Translation: AAC52879.1.
    U37099 mRNA. Translation: AAC52704.1.
    PIRiJC5066.
    RefSeqiNP_598220.1. NM_133536.2.
    UniGeneiRn.11037.

    Genome annotation databases

    EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
    GeneIDi171058.
    KEGGirno:171058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78197 mRNA. Translation: BAA11302.1 .
    U54807 mRNA. Translation: AAC52879.1 .
    U37099 mRNA. Translation: AAC52704.1 .
    PIRi JC5066.
    RefSeqi NP_598220.1. NM_133536.2.
    UniGenei Rn.11037.

    3D structure databases

    ProteinModelPortali P62824.
    SMRi P62824. Positions 26-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 251075. 1 interaction.

    PTM databases

    PhosphoSitei P62824.

    Proteomic databases

    PaxDbi P62824.
    PRIDEi P62824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015871 ; ENSRNOP00000015871 ; ENSRNOG00000011623 .
    GeneIDi 171058.
    KEGGi rno:171058.

    Organism-specific databases

    CTDi 115827.
    RGDi 620923. Rab3c.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00740000115041.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P62824.
    KOi K07883.
    OMAi NGFQIAN.
    OrthoDBi EOG7JQBPC.
    PhylomeDBi P62824.
    TreeFami TF313199.

    Miscellaneous databases

    NextBioi 324148.
    PROi P62824.

    Gene expression databases

    Genevestigatori P62824.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rab3C is associated with N-type Ca channel in rat brain."
      Oho C., Nemoto Y., Omori A., Takahashi M.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Cloning and tissue expression of the rat RAB 3C GTP-binding protein."
      Viggeswarapu M., Wildey G.M.
      Biochem. Biophys. Res. Commun. 227:645-650(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pheochromocytoma.
    3. "Differential expression of rab3 isoforms in oligodendrocytes and astrocytes."
      Madison D.L., Krueger W.H., Kim T., Pfeiffer S.E.
      J. Neurosci. Res. 45:258-268(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-218.
      Tissue: Brain.
    4. "Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
      Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
      Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS1.

    Entry informationi

    Entry nameiRAB3C_RAT
    AccessioniPrimary (citable) accession number: P62824
    Secondary accession number(s): Q62858
    , Q62974, Q63482, Q9CXQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3