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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 45GTPBy similarity9
Nucleotide bindingi56 – 62GTPBy similarity7
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4
Nucleotide bindingi173 – 175GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620923. Rab3c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210871 – 227Ras-related protein Rab-3CAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei206PhosphothreonineBy similarity1
Lipidationi225S-geranylgeranyl cysteineBy similarity1
Modified residuei227Cysteine methyl esterBy similarity1
Lipidationi227S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

PTM databases

iPTMnetiP62824.
PhosphoSitePlusiP62824.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011623.
GenevisibleiP62824. RN.

Interactioni

Subunit structurei

Interacts with RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RIMS1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251075. 1 interactor.
IntActiP62824. 1 interactor.
STRINGi10116.ENSRNOP00000015871.

Structurei

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 67Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00890000139330.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiQQPGCNC.
PhylomeDBiP62824.
TreeFamiTF313199.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

P62824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141A → V in AAC52879 (PubMed:8885988).Curated1
Sequence conflicti159 – 160QR → RH in AAC52879 (PubMed:8885988).Curated2
Sequence conflicti207A → G in AAC52879 (PubMed:8885988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
ENSRNOT00000086851; ENSRNOP00000073277; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Similar proteinsi

Entry informationi

Entry nameiRAB3C_RAT
AccessioniPrimary (citable) accession number: P62824
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families