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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 459GTPBy similarity
Nucleotide bindingi56 – 627GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity
Nucleotide bindingi173 – 1753GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620923. Rab3c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphothreonineBy similarity
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

PTM databases

iPTMnetiP62824.
PhosphoSiteiP62824.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011623.
GenevisibleiP62824. RN.

Interactioni

Subunit structurei

Interacts with RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RIMS1.By similarity1 Publication

Protein-protein interaction databases

BioGridi251075. 1 interaction.
STRINGi10116.ENSRNOP00000015871.

Structurei

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiQMASSQD.
PhylomeDBiP62824.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411A → V in AAC52879 (PubMed:8885988).Curated
Sequence conflicti159 – 1602QR → RH in AAC52879 (PubMed:8885988).Curated
Sequence conflicti207 – 2071A → G in AAC52879 (PubMed:8885988).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
ENSRNOT00000086851; ENSRNOP00000073277; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251075. 1 interaction.
STRINGi10116.ENSRNOP00000015871.

PTM databases

iPTMnetiP62824.
PhosphoSiteiP62824.

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
ENSRNOT00000086851; ENSRNOP00000073277; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Organism-specific databases

CTDi115827.
RGDi620923. Rab3c.

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiQMASSQD.
PhylomeDBiP62824.
TreeFamiTF313199.

Miscellaneous databases

PROiP62824.

Gene expression databases

BgeeiENSRNOG00000011623.
GenevisibleiP62824. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3C_RAT
AccessioniPrimary (citable) accession number: P62824
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.