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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. antigen processing and presentation Source: Ensembl
  2. GTP catabolic process Source: GO_Central
  3. intracellular protein transport Source: GO_Central
  4. protein secretion Source: GO_Central
  5. Rab protein signal transduction Source: GO_Central
  6. regulation of exocytosis Source: GO_Central
  7. synaptic vesicle exocytosis Source: GO_Central
  8. vesicle docking involved in exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620923. Rab3c.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cytosol Source: RGD
  2. endosome Source: GO_Central
  3. perinuclear region of cytoplasm Source: Ensembl
  4. plasma membrane Source: GO_Central
  5. secretory granule membrane Source: GO_Central
  6. synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

PTM databases

PhosphoSiteiP62824.

Expressioni

Gene expression databases

GenevestigatoriP62824.

Interactioni

Subunit structurei

Interacts with RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RIMS1.By similarity1 Publication

Protein-protein interaction databases

BioGridi251075. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62824.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411A → V in AAC52879 (PubMed:8885988).Curated
Sequence conflicti159 – 1602QR → RH in AAC52879 (PubMed:8885988).Curated
Sequence conflicti207 – 2071A → G in AAC52879 (PubMed:8885988).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRiJC5066.
RefSeqiNP_598220.1. NM_133536.2.
UniGeneiRn.11037.

3D structure databases

ProteinModelPortaliP62824.
SMRiP62824. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251075. 1 interaction.

PTM databases

PhosphoSiteiP62824.

Proteomic databases

PaxDbiP62824.
PRIDEiP62824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
GeneIDi171058.
KEGGirno:171058.

Organism-specific databases

CTDi115827.
RGDi620923. Rab3c.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62824.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62824.
TreeFamiTF313199.

Miscellaneous databases

NextBioi324148.
PROiP62824.

Gene expression databases

GenevestigatoriP62824.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rab3C is associated with N-type Ca channel in rat brain."
    Oho C., Nemoto Y., Omori A., Takahashi M.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Cloning and tissue expression of the rat RAB 3C GTP-binding protein."
    Viggeswarapu M., Wildey G.M.
    Biochem. Biophys. Res. Commun. 227:645-650(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  3. "Differential expression of rab3 isoforms in oligodendrocytes and astrocytes."
    Madison D.L., Krueger W.H., Kim T., Pfeiffer S.E.
    J. Neurosci. Res. 45:258-268(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-218.
    Tissue: Brain.
  4. "Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
    Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
    Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1.

Entry informationi

Entry nameiRAB3C_RAT
AccessioniPrimary (citable) accession number: P62824
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: February 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.