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P62824 (RAB3C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-3C
Gene names
Name:Rab3c
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Probably involved in vesicular traffic By similarity.

Subunit structure

Interacts with RIMS2, RPH3A and RPH3AL By similarity. Interacts with RIMS1. Ref.4

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Ras-related protein Rab-3C
PRO_0000121087

Regions

Nucleotide binding37 – 448GTP By similarity
Nucleotide binding85 – 895GTP By similarity
Nucleotide binding143 – 1464GTP By similarity
Motif59 – 679Effector region By similarity

Amino acid modifications

Modified residue2271Cysteine methyl ester By similarity
Lipidation2251S-geranylgeranyl cysteine By similarity
Lipidation2271S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict1411A → V in AAC52879. Ref.2
Sequence conflict159 – 1602QR → RH in AAC52879. Ref.2
Sequence conflict2071A → G in AAC52879. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P62824 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 179DF4D9B451B7B0

FASTA22725,872
        10         20         30         40         50         60 
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV 

        70         80         90        100        110        120 
STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA 

       130        140        150        160        170        180 
VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE RVVSTERGQR LGEQLGFEFF ETSAKDNINV 

       190        200        210        220 
KQTFERLVDI ICDKMSESLE TDPAITAAKQ STRLKETPPP PQPNCGC 

« Hide

References

[1]"Rab3C is associated with N-type Ca channel in rat brain."
Oho C., Nemoto Y., Omori A., Takahashi M.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Cloning and tissue expression of the rat RAB 3C GTP-binding protein."
Viggeswarapu M., Wildey G.M.
Biochem. Biophys. Res. Commun. 227:645-650(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pheochromocytoma.
[3]"Differential expression of rab3 isoforms in oligodendrocytes and astrocytes."
Madison D.L., Krueger W.H., Kim T., Pfeiffer S.E.
J. Neurosci. Res. 45:258-268(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-218.
Tissue: Brain.
[4]"Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RIMS1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78197 mRNA. Translation: BAA11302.1.
U54807 mRNA. Translation: AAC52879.1.
U37099 mRNA. Translation: AAC52704.1.
PIRJC5066.
RefSeqNP_598220.1. NM_133536.2.
UniGeneRn.11037.

3D structure databases

ProteinModelPortalP62824.
SMRP62824. Positions 26-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid251075. 1 interaction.

PTM databases

PhosphoSiteP62824.

Proteomic databases

PaxDbP62824.
PRIDEP62824.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015871; ENSRNOP00000015871; ENSRNOG00000011623.
GeneID171058.
KEGGrno:171058.

Organism-specific databases

CTD115827.
RGD620923. Rab3c.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00740000115041.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidP62824.
KOK07883.
OMAQMASSQD.
OrthoDBEOG7JQBPC.
PhylomeDBP62824.
TreeFamTF313199.

Gene expression databases

GenevestigatorP62824.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio324148.
PROP62824.

Entry information

Entry nameRAB3C_RAT
AccessionPrimary (citable) accession number: P62824
Secondary accession number(s): Q62858 expand/collapse secondary AC list , Q62974, Q63482, Q9CXQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families