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P62823

- RAB3C_MOUSE

UniProt

P62823 - RAB3C_MOUSE

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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. antigen processing and presentation Source: Ensembl
  2. protein transport Source: UniProtKB-KW
  3. regulation of exocytosis Source: MGI
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1914545. Rab3c.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. perinuclear region of cytoplasm Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
  4. synaptic vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP62823.
PaxDbiP62823.
PRIDEiP62823.

PTM databases

PhosphoSiteiP62823.

Expressioni

Gene expression databases

BgeeiP62823.
CleanExiMM_RAB3C.
ExpressionAtlasiP62823. baseline and differential.
GenevestigatoriP62823.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.1 Publication

Protein-protein interaction databases

BioGridi212082. 1 interaction.
IntActiP62823. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP62823.
SMRiP62823. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62823.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62823.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62823-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310532 mRNA. Translation: CAC32042.1.
AF312037 mRNA. Translation: AAG60047.1.
AY026947 mRNA. Translation: AAK08980.1.
AK014132 mRNA. Translation: BAB29172.1.
CCDSiCCDS26764.1.
RefSeqiNP_076341.1. NM_023852.5.
UniGeneiMm.151600.

Genome annotation databases

EnsembliENSMUST00000167824; ENSMUSP00000132945; ENSMUSG00000021700.
GeneIDi67295.
KEGGimmu:67295.
UCSCiuc007rvo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310532 mRNA. Translation: CAC32042.1 .
AF312037 mRNA. Translation: AAG60047.1 .
AY026947 mRNA. Translation: AAK08980.1 .
AK014132 mRNA. Translation: BAB29172.1 .
CCDSi CCDS26764.1.
RefSeqi NP_076341.1. NM_023852.5.
UniGenei Mm.151600.

3D structure databases

ProteinModelPortali P62823.
SMRi P62823. Positions 26-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212082. 1 interaction.
IntActi P62823. 1 interaction.

PTM databases

PhosphoSitei P62823.

Proteomic databases

MaxQBi P62823.
PaxDbi P62823.
PRIDEi P62823.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167824 ; ENSMUSP00000132945 ; ENSMUSG00000021700 .
GeneIDi 67295.
KEGGi mmu:67295.
UCSCi uc007rvo.3. mouse.

Organism-specific databases

CTDi 115827.
MGIi MGI:1914545. Rab3c.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P62823.
KOi K07883.
OMAi QMASSQD.
OrthoDBi EOG7JQBPC.
PhylomeDBi P62823.
TreeFami TF313199.

Miscellaneous databases

ChiTaRSi RAB3C. mouse.
NextBioi 324148.
PROi P62823.
SOURCEi Search...

Gene expression databases

Bgeei P62823.
CleanExi MM_RAB3C.
ExpressionAtlasi P62823. baseline and differential.
Genevestigatori P62823.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Wang X., Hu B., Kilimann M.W.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Schluter O.M., Benseler F., Suedhof T.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Molecular cloning and tissue expression of the mouse homolog of Rab3C."
    Pavlos N.J., Xu J., Zheng M.H.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-16; 21-43; 50-68; 81-91; 161-175 AND 187-209, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
    Fukuda M.
    J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1; RIMS2; RPH3A AND RPH3AL.

Entry informationi

Entry nameiRAB3C_MOUSE
AccessioniPrimary (citable) accession number: P62823
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3