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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 45GTPBy similarity9
Nucleotide bindingi56 – 62GTPBy similarity7
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4
Nucleotide bindingi173 – 175GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: MGI

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914545 Rab3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210861 – 227Ras-related protein Rab-3CAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei206PhosphothreonineCombined sources1
Lipidationi225S-geranylgeranyl cysteineBy similarity1
Modified residuei227Cysteine methyl esterBy similarity1
Lipidationi227S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP62823
PeptideAtlasiP62823
PRIDEiP62823

PTM databases

iPTMnetiP62823
PhosphoSitePlusiP62823

Expressioni

Gene expression databases

BgeeiENSMUSG00000021700
CleanExiMM_RAB3C
ExpressionAtlasiP62823 baseline and differential
GenevisibleiP62823 MM

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.1 Publication

GO - Molecular functioni

  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

Protein-protein interaction databases

BioGridi212082, 6 interactors
IntActiP62823, 16 interactors
STRINGi10090.ENSMUSP00000132945

Structurei

3D structure databases

ProteinModelPortaliP62823
SMRiP62823
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 67Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP62823
KOiK07883
OMAiQQPGCNC
OrthoDBiEOG091G0J64
PhylomeDBiP62823
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

P62823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310532 mRNA Translation: CAC32042.1
AF312037 mRNA Translation: AAG60047.1
AY026947 mRNA Translation: AAK08980.1
AK014132 mRNA Translation: BAB29172.1
CCDSiCCDS26764.1
RefSeqiNP_076341.1, NM_023852.5
UniGeneiMm.151600

Genome annotation databases

EnsembliENSMUST00000167824; ENSMUSP00000132945; ENSMUSG00000021700
GeneIDi67295
KEGGimmu:67295
UCSCiuc007rvo.3 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB3C_MOUSE
AccessioniPrimary (citable) accession number: P62823
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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