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Protein

Ras-related protein Rab-3C

Gene

Rab3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:Rab3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914545. Rab3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP62823.
PaxDbiP62823.
PRIDEiP62823.

PTM databases

PhosphoSiteiP62823.

Expressioni

Gene expression databases

BgeeiP62823.
CleanExiMM_RAB3C.
ExpressionAtlasiP62823. baseline and differential.
GenevisibleiP62823. MM.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.1 Publication

Protein-protein interaction databases

BioGridi212082. 1 interaction.
IntActiP62823. 1 interaction.
STRINGi10090.ENSMUSP00000132945.

Structurei

3D structure databases

ProteinModelPortaliP62823.
SMRiP62823. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62823.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62823.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE
160 170 180 190 200
RVVSTERGQR LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ STRLKETPPP PQPNCGC
Length:227
Mass (Da):25,872
Last modified:August 16, 2004 - v1
Checksum:i179DF4D9B451B7B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310532 mRNA. Translation: CAC32042.1.
AF312037 mRNA. Translation: AAG60047.1.
AY026947 mRNA. Translation: AAK08980.1.
AK014132 mRNA. Translation: BAB29172.1.
CCDSiCCDS26764.1.
RefSeqiNP_076341.1. NM_023852.5.
UniGeneiMm.151600.

Genome annotation databases

EnsembliENSMUST00000167824; ENSMUSP00000132945; ENSMUSG00000021700.
GeneIDi67295.
KEGGimmu:67295.
UCSCiuc007rvo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310532 mRNA. Translation: CAC32042.1.
AF312037 mRNA. Translation: AAG60047.1.
AY026947 mRNA. Translation: AAK08980.1.
AK014132 mRNA. Translation: BAB29172.1.
CCDSiCCDS26764.1.
RefSeqiNP_076341.1. NM_023852.5.
UniGeneiMm.151600.

3D structure databases

ProteinModelPortaliP62823.
SMRiP62823. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212082. 1 interaction.
IntActiP62823. 1 interaction.
STRINGi10090.ENSMUSP00000132945.

PTM databases

PhosphoSiteiP62823.

Proteomic databases

MaxQBiP62823.
PaxDbiP62823.
PRIDEiP62823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167824; ENSMUSP00000132945; ENSMUSG00000021700.
GeneIDi67295.
KEGGimmu:67295.
UCSCiuc007rvo.3. mouse.

Organism-specific databases

CTDi115827.
MGIiMGI:1914545. Rab3c.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62823.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiP62823.
TreeFamiTF313199.

Miscellaneous databases

ChiTaRSiRab3c. mouse.
NextBioi324148.
PROiP62823.
SOURCEiSearch...

Gene expression databases

BgeeiP62823.
CleanExiMM_RAB3C.
ExpressionAtlasiP62823. baseline and differential.
GenevisibleiP62823. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wang X., Hu B., Kilimann M.W.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Schluter O.M., Benseler F., Suedhof T.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Molecular cloning and tissue expression of the mouse homolog of Rab3C."
    Pavlos N.J., Xu J., Zheng M.H.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-16; 21-43; 50-68; 81-91; 161-175 AND 187-209, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
    Fukuda M.
    J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1; RIMS2; RPH3A AND RPH3AL.

Entry informationi

Entry nameiRAB3C_MOUSE
AccessioniPrimary (citable) accession number: P62823
Secondary accession number(s): Q62858
, Q62974, Q63482, Q9CXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.