UniProtKB - P62821 (RAB1A_MOUSE)
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Protein
Ras-related protein Rab-1A
Gene
Rab1A
Organism
Mus musculus (Mouse)
Status
Functioni
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.By similarity2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | GTPBy similarity | 9 | |
Nucleotide bindingi | 36 – 43 | GTPBy similarity | 8 | |
Nucleotide bindingi | 66 – 70 | GTPBy similarity | 5 | |
Nucleotide bindingi | 124 – 127 | GTPBy similarity | 4 | |
Nucleotide bindingi | 154 – 156 | GTPBy similarity | 3 |
GO - Molecular functioni
- cadherin binding Source: MGI
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- autophagosome assembly Source: UniProtKB
- autophagy Source: UniProtKB
- cargo loading into COPII-coated vesicle Source: MGI
- cell migration Source: UniProtKB
- defense response to bacterium Source: UniProtKB
- endocytosis Source: UniProtKB
- ER to Golgi vesicle-mediated transport Source: UniProtKB
- Golgi organization Source: MGI
- growth hormone secretion Source: UniProtKB
- interleukin-8 secretion Source: UniProtKB
- intracellular protein transport Source: MGI
- melanosome transport Source: UniProtKB
- positive regulation of glycoprotein metabolic process Source: MGI
- substrate adhesion-dependent cell spreading Source: UniProtKB
- vesicle transport along microtubule Source: UniProtKB
- virion assembly Source: MGI
Keywordsi
Biological process | Autophagy, ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization. R-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport. R-MMU-6807878. COPI-mediated anterograde transport. R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic. R-MMU-8873719. RAB geranylgeranylation. R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs. |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-1AAlternative name(s): YPT1-related protein |
Gene namesi | Name:Rab1A Synonyms:Rab1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97842. Rab1. |
Subcellular locationi
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121057 | 2 – 205 | Ras-related protein Rab-1AAdd BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 79 | O-(2-cholinephosphoryl)serineBy similarity | 1 | |
Modified residuei | 194 | Phosphoserine; by CDK1By similarity | 1 | |
Lipidationi | 204 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 205 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Phosphorylated by CDK1 kinase during mitosis.By similarity
Keywords - PTMi
Acetylation, Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | P62821. |
PaxDbi | P62821. |
PeptideAtlasi | P62821. |
PRIDEi | P62821. |
PTM databases
iPTMneti | P62821. |
PhosphoSitePlusi | P62821. |
SwissPalmi | P62821. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020149. |
CleanExi | MM_RAB1. |
ExpressionAtlasi | P62821. baseline and differential. |
Genevisiblei | P62821. MM. |
Interactioni
Subunit structurei
May interact with YIPF5 (By similarity). Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:24549040). Interacts with GDI1; this promotes dissociation from membranes (By similarity).By similarity1 Publication
GO - Molecular functioni
- cadherin binding Source: MGI
Protein-protein interaction databases
BioGridi | 202530. 5 interactors. |
IntActi | P62821. 39 interactors. |
MINTi | P62821. |
STRINGi | 10090.ENSMUSP00000127330. |
Structurei
3D structure databases
ProteinModelPortali | P62821. |
SMRi | P62821. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 48 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0084. Eukaryota. ENOG410XQN5. LUCA. |
GeneTreei | ENSGT00900000140786. |
HOVERGENi | HBG009351. |
InParanoidi | P62821. |
KOi | K07874. |
OMAi | VTDNDTF. |
OrthoDBi | EOG091G0LA6. |
PhylomeDBi | P62821. |
TreeFami | TF300097. |
Family and domain databases
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. |
Pfami | View protein in Pfam PF00071. Ras. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR00231. small_GTP. 1 hit. |
PROSITEi | View protein in PROSITE PS51419. RAB. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P62821-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI
60 70 80 90 100
RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN
110 120 130 140 150
NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF
160 170 180 190 200
LETSAKNATN VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS
GGGCC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00094 mRNA. Translation: CAA68284.1. X15744 X15747 Genomic DNA. Translation: CAA33760.1. AF226873 mRNA. Translation: AAF33844.1. AK034408 mRNA. Translation: BAC28697.1. AK159425 mRNA. Translation: BAE35072.1. AK166249 mRNA. Translation: BAE38660.1. AK167150 mRNA. Translation: BAE39292.1. BC002077 mRNA. Translation: AAH02077.3. |
CCDSi | CCDS36115.1. |
PIRi | S05551. TVMSYP. |
RefSeqi | NP_033022.1. NM_008996.3. |
UniGenei | Mm.271944. |
Genome annotation databases
Ensembli | ENSMUST00000163483; ENSMUSP00000127330; ENSMUSG00000020149. |
GeneIDi | 19324. |
KEGGi | mmu:19324. |
UCSCi | uc007icv.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | RAB1A_MOUSE | |
Accessioni | P62821Primary (citable) accession number: P62821 Secondary accession number(s): P11476 Q9Y3T2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |