Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-1A

Gene

Rab1A

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPBy similarity
Nucleotide bindingi36 – 438GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • autophagy Source: UniProtKB
  • cargo loading into COPII-coated vesicle Source: MGI
  • cell migration Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • endocytosis Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi organization Source: MGI
  • growth hormone secretion Source: UniProtKB
  • interleukin-8 secretion Source: UniProtKB
  • intracellular protein transport Source: MGI
  • melanosome transport Source: UniProtKB
  • positive regulation of glycoprotein metabolic process Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
  • substrate adhesion-dependent cell spreading Source: UniProtKB
  • vesicle transport along microtubule Source: UniProtKB
  • virion assembly Source: MGI
Complete GO annotation...

Keywords - Biological processi

Autophagy, ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-1A
Alternative name(s):
YPT1-related protein
Gene namesi
Name:Rab1A
Synonyms:Rab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97842. Rab1.

Subcellular locationi

  • Golgi apparatus By similarity
  • Endoplasmic reticulum By similarity
  • Early endosome By similarity
  • Cytoplasmcytosol By similarity
  • Membrane By similarity
  • Melanosome 1 Publication

  • Note: Alternates between membrane-associated and cytosolic forms.By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • early endosome Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: GO_Central
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: GO_Central
  • melanosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 205204Ras-related protein Rab-1APRO_0000121057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei79 – 791O-(2-cholinephosphoryl)serineBy similarity
Modified residuei194 – 1941Phosphoserine; by CDK1By similarity
Lipidationi204 – 2041S-geranylgeranyl cysteineBy similarity
Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiP62821.
PaxDbiP62821.
PeptideAtlasiP62821.
PRIDEiP62821.

PTM databases

iPTMnetiP62821.
PhosphoSiteiP62821.
SwissPalmiP62821.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020149.
CleanExiMM_RAB1.
ExpressionAtlasiP62821. baseline and differential.
GenevisibleiP62821. MM.

Interactioni

Subunit structurei

May interact with YIPF5. Interacts with GDI1; this promotes dissociation from membranes (By similarity). Interacts with C9orf72.By similarity1 Publication

Protein-protein interaction databases

BioGridi202530. 2 interactions.
IntActiP62821. 38 interactions.
MINTiMINT-1865041.
STRINGi10090.ENSMUSP00000127330.

Structurei

3D structure databases

ProteinModelPortaliP62821.
SMRiP62821. Positions 6-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
HOVERGENiHBG009351.
InParanoidiP62821.
KOiK07874.
OMAiKERMGNT.
OrthoDBiEOG091G0LA6.
PhylomeDBiP62821.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI
60 70 80 90 100
RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN
110 120 130 140 150
NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF
160 170 180 190 200
LETSAKNATN VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS

GGGCC
Length:205
Mass (Da):22,678
Last modified:January 23, 2007 - v3
Checksum:iB2A8F4E3B0FB17D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00094 mRNA. Translation: CAA68284.1.
X15744
, X15745, X15746, X15747 Genomic DNA. Translation: CAA33760.1.
AF226873 mRNA. Translation: AAF33844.1.
AK034408 mRNA. Translation: BAC28697.1.
AK159425 mRNA. Translation: BAE35072.1.
AK166249 mRNA. Translation: BAE38660.1.
AK167150 mRNA. Translation: BAE39292.1.
BC002077 mRNA. Translation: AAH02077.3.
CCDSiCCDS36115.1.
PIRiS05551. TVMSYP.
RefSeqiNP_033022.1. NM_008996.3.
UniGeneiMm.271944.

Genome annotation databases

EnsembliENSMUST00000163483; ENSMUSP00000127330; ENSMUSG00000020149.
GeneIDi19324.
KEGGimmu:19324.
UCSCiuc007icv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00094 mRNA. Translation: CAA68284.1.
X15744
, X15745, X15746, X15747 Genomic DNA. Translation: CAA33760.1.
AF226873 mRNA. Translation: AAF33844.1.
AK034408 mRNA. Translation: BAC28697.1.
AK159425 mRNA. Translation: BAE35072.1.
AK166249 mRNA. Translation: BAE38660.1.
AK167150 mRNA. Translation: BAE39292.1.
BC002077 mRNA. Translation: AAH02077.3.
CCDSiCCDS36115.1.
PIRiS05551. TVMSYP.
RefSeqiNP_033022.1. NM_008996.3.
UniGeneiMm.271944.

3D structure databases

ProteinModelPortaliP62821.
SMRiP62821. Positions 6-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202530. 2 interactions.
IntActiP62821. 38 interactions.
MINTiMINT-1865041.
STRINGi10090.ENSMUSP00000127330.

PTM databases

iPTMnetiP62821.
PhosphoSiteiP62821.
SwissPalmiP62821.

Proteomic databases

EPDiP62821.
PaxDbiP62821.
PeptideAtlasiP62821.
PRIDEiP62821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163483; ENSMUSP00000127330; ENSMUSG00000020149.
GeneIDi19324.
KEGGimmu:19324.
UCSCiuc007icv.1. mouse.

Organism-specific databases

CTDi5861.
MGIiMGI:97842. Rab1.

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
HOVERGENiHBG009351.
InParanoidiP62821.
KOiK07874.
OMAiKERMGNT.
OrthoDBiEOG091G0LA6.
PhylomeDBiP62821.
TreeFamiTF300097.

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiP62821.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020149.
CleanExiMM_RAB1.
ExpressionAtlasiP62821. baseline and differential.
GenevisibleiP62821. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB1A_MOUSE
AccessioniPrimary (citable) accession number: P62821
Secondary accession number(s): P11476
, Q3TX44, Q811M4, Q96N61, Q9Y3T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.