P62821 (RAB1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-1A

Alternative name(s):
YPT1-related protein

Gene names

Name:	Rab1A
Synonyms:	Rab1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity.
Subunit structure	May interact with YIPF5 By similarity.
Subcellular location	Golgi apparatus. Endoplasmic reticulum.
Post-translational modification	Phosphorylated by CDK1 kinase during mitosis By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Lipoprotein Phosphoprotein Prenylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Traceable author statement. Source: MGI small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from direct assay. Source: MGI endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 205	204	Ras-related protein Rab-1A		PRO_0000121057
Regions
	Nucleotide binding	18 – 26	9	GTP By similarity
	Nucleotide binding	66 – 70	5	GTP By similarity
	Nucleotide binding	124 – 127	4	GTP By similarity
	Nucleotide binding	154 – 156	3	GTP By similarity
	Motif	40 – 48	9	Effector region By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	194	1	Phosphoserine; by CDK1 By similarity
	Lipidation	204	1	S-geranylgeranyl cysteine By similarity
	Lipidation	205	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62821 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B2A8F4E3B0FB17D6	FASTA	205	22,678
	10 20 30 40 50 60 MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI 70 80 90 100 110 120 KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL 130 140 150 160 170 180 LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN VEQSFMTMAA EIKKRMGPGA 190 200 TAGGAEKSNV KIQSTPVKQS GGGCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene." Haubruck H., Disela C., Wagner P., Gallwitz D. EMBO J. 6:4049-4053(1987) [PubMed: 3127202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Nucleotide sequence of the mouse ypt1 gene encoding a ras-related GTP-binding protein." Wichmann H., Disela C., Haubruck H., Gallwitz D. Nucleic Acids Res. 17:6737-6738(1989) [PubMed: 2506528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Mouse Rab1A, member of RAS oncogene family mRNA." Wu G., Dorn G.W. II Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Diencephalon and Mammary gland.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[6]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 14-24; 31-49; 62-72; 75-103; 112-125 AND 132-156, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y00094 mRNA. Translation: CAA68284.1. X15744 , X15745, X15746, X15747 Genomic DNA. Translation: CAA33760.1. AF226873 mRNA. Translation: AAF33844.1. AK034408 mRNA. Translation: BAC28697.1. AK159425 mRNA. Translation: BAE35072.1. AK166249 mRNA. Translation: BAE38660.1. AK167150 mRNA. Translation: BAE39292.1. BC002077 mRNA. Translation: AAH02077.3.
IPI	IPI00114560.
PIR	TVMSYP. S05551.
RefSeq	NP_033022.1. NM_008996.3.
UniGene	Mm.271944.
3D structure databases
ProteinModelPortal	P62821.
SMR	P62821. Positions 3-176.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62821. 2 interactions.
STRING	P62821.
PTM databases
PhosphoSite	P62821.
Proteomic databases
PRIDE	P62821.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000163483; ENSMUSP00000127330; ENSMUSG00000020149.
GeneID	19324.
KEGG	mmu:19324.
Organism-specific databases
CTD	19324.
MGI	MGI:97842. Rab1.
Phylogenomic databases
eggNOG	roNOG07724.
HOVERGEN	HBG009351.
InParanoid	P62821.
OMA	NRVGPPS.
PhylomeDB	P62821.
Gene expression databases
ArrayExpress	P62821.
Bgee	P62821.
CleanEx	MM_RAB1.
Genevestigator	P62821.
GermOnline	ENSMUSG00000020149. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
KO	K07874.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296283.
SOURCE	Search...

Entry information

Entry name

RAB1A_MOUSE

Accession

Primary (citable) accession number: P62821
Secondary accession number(s): P11476 , Q3TX44, Q811M4, Q96N61, Q9Y3T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program