Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P62819

- S10A3_RAT

UniProt

P62819 - S10A3_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein S100-A3

Gene

S100a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831ZincBy similarity
Metal bindingi86 – 861ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi93 – 931ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinitySequence AnalysisAdd
BLAST
Calcium bindingi63 – 74122; high affinitySequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620260. S100a3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A3PRO_0000143974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 68By similarity
Modified residuei51 – 511Citrulline; by PAD3By similarity

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP62819.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62819.
SMRiP62819. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1Add
BLAST
Domaini50 – 8536EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40471.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62819.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62819.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62819-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140231 mRNA. Translation: AAK28305.1.
RefSeqiNP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.2.
XP_006232622.1. XM_006232560.2.
XP_006232625.1. XM_006232563.2.
XP_008759345.1. XM_008761123.1.
UniGeneiRn.29233.

Genome annotation databases

EnsembliENSRNOT00000016034; ENSRNOP00000016034; ENSRNOG00000012008.
GeneIDi114216.
KEGGirno:114216.
UCSCiRGD:620260. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140231 mRNA. Translation: AAK28305.1 .
RefSeqi NP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.2.
XP_006232622.1. XM_006232560.2.
XP_006232625.1. XM_006232563.2.
XP_008759345.1. XM_008761123.1.
UniGenei Rn.29233.

3D structure databases

ProteinModelPortali P62819.
SMRi P62819. Positions 3-94.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016034 ; ENSRNOP00000016034 ; ENSRNOG00000012008 .
GeneIDi 114216.
KEGGi rno:114216.
UCSCi RGD:620260. rat.

Organism-specific databases

CTDi 6274.
RGDi 620260. S100a3.

Phylogenomic databases

eggNOGi NOG40471.
GeneTreei ENSGT00760000119034.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P62819.
OMAi CEVDFAE.
OrthoDBi EOG779P19.
PhylomeDBi P62819.
TreeFami TF332727.

Miscellaneous databases

NextBioi 297763.
PROi P62819.

Gene expression databases

Genevestigatori P62819.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view ]
PANTHERi PTHR11639:SF12. PTHR11639:SF12. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of S100 genes in hair follicle epithelium."
    Ito M., Kizawa K.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Hair follicle.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 58-66, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS10A3_RAT
AccessioniPrimary (citable) accession number: P62819
Secondary accession number(s): P56566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3