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Protein

Protein S100-A3

Gene

S100a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi93ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620260. S100a3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439742 – 101Protein S100-A3Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 68By similarity
Modified residuei51Citrulline; by PAD3By similarity1

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62819.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012008.
ExpressionAtlasiP62819. baseline and differential.
GenevisibleiP62819. RN.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016034.

Structurei

3D structure databases

ProteinModelPortaliP62819.
SMRiP62819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62819.
PhylomeDBiP62819.
TreeFamiTF332727.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
PANTHERiPTHR11639:SF95. PTHR11639:SF95. 1 hit.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140231 mRNA. Translation: AAK28305.1.
RefSeqiNP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.3.
XP_006232622.1. XM_006232560.3.
XP_006232625.1. XM_006232563.3.
XP_017446066.1. XM_017590577.1.
XP_017446067.1. XM_017590578.1.
XP_017446068.1. XM_017590579.1.
XP_017446069.1. XM_017590580.1.
UniGeneiRn.29233.

Genome annotation databases

EnsembliENSRNOT00000016034; ENSRNOP00000016034; ENSRNOG00000012008.
GeneIDi114216.
KEGGirno:114216.
UCSCiRGD:620260. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS10A3_RAT
AccessioniPrimary (citable) accession number: P62819
Secondary accession number(s): P56566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families