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Protein

Protein S100-A3

Gene

S100a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831ZincBy similarity
Metal bindingi86 – 861ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi93 – 931ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinitySequence AnalysisAdd
BLAST
Calcium bindingi63 – 74122; high affinitySequence AnalysisAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620260. S100a3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A3PRO_0000143974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 68By similarity
Modified residuei51 – 511Citrulline; by PAD3By similarity

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Expressioni

Gene expression databases

GenevisibleiP62819. RN.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62819.
SMRiP62819. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1Add
BLAST
Domaini50 – 8536EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40471.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62819.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62819.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140231 mRNA. Translation: AAK28305.1.
RefSeqiNP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.2.
XP_006232622.1. XM_006232560.2.
XP_006232625.1. XM_006232563.2.
XP_008759345.1. XM_008761123.1.
UniGeneiRn.29233.

Genome annotation databases

EnsembliENSRNOT00000016034; ENSRNOP00000016034; ENSRNOG00000012008.
GeneIDi114216.
KEGGirno:114216.
UCSCiRGD:620260. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140231 mRNA. Translation: AAK28305.1.
RefSeqiNP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.2.
XP_006232622.1. XM_006232560.2.
XP_006232625.1. XM_006232563.2.
XP_008759345.1. XM_008761123.1.
UniGeneiRn.29233.

3D structure databases

ProteinModelPortaliP62819.
SMRiP62819. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016034; ENSRNOP00000016034; ENSRNOG00000012008.
GeneIDi114216.
KEGGirno:114216.
UCSCiRGD:620260. rat.

Organism-specific databases

CTDi6274.
RGDi620260. S100a3.

Phylogenomic databases

eggNOGiNOG40471.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62819.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62819.
TreeFamiTF332727.

Miscellaneous databases

NextBioi297763.
PROiP62819.

Gene expression databases

GenevisibleiP62819. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of S100 genes in hair follicle epithelium."
    Ito M., Kizawa K.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Hair follicle.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 58-66, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS10A3_RAT
AccessioniPrimary (citable) accession number: P62819
Secondary accession number(s): P56566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.