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P62819 (S10A3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene names
Name:S100a3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation By similarity.

Subunit structure

Homodimer and homotetramer for the citrullinated form By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandCalcium
Metal-binding
Zinc
   PTMCitrullination
Disulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 101100Protein S100-A3
PRO_0000143974

Regions

Domain12 – 4736EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity Potential
Calcium binding63 – 74122; high affinity Potential

Sites

Metal binding831Zinc By similarity
Metal binding861Zinc By similarity
Metal binding871Zinc By similarity
Metal binding931Zinc By similarity

Amino acid modifications

Modified residue511Citrulline; by PAD3 By similarity
Disulfide bond30 ↔ 68 By similarity

Sequences

Sequence LengthMass (Da)Tools
P62819 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: EE46EABF16646CCA

FASTA10111,747
        10         20         30         40         50         60 
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF RECDYNKFMS 

        70         80         90        100 
VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP Q 

« Hide

References

[1]"Expression of S100 genes in hair follicle epithelium."
Ito M., Kizawa K.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Hair follicle.
[2]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 58-66, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF140231 mRNA. Translation: AAK28305.1.
RefSeqNP_446133.1. NM_053681.1.
XP_006232621.1. XM_006232559.1.
XP_006232622.1. XM_006232560.1.
XP_006232623.1. XM_006232561.1.
XP_006232624.1. XM_006232562.1.
XP_006232625.1. XM_006232563.1.
XP_006232626.1. XM_006232564.1.
UniGeneRn.29233.

3D structure databases

ProteinModelPortalP62819.
SMRP62819. Positions 3-94.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016034; ENSRNOP00000016034; ENSRNOG00000012008.
GeneID114216.
KEGGrno:114216.
UCSCRGD:620260. rat.

Organism-specific databases

CTD6274.
RGD620260. S100a3.

Phylogenomic databases

eggNOGNOG40471.
GeneTreeENSGT00740000114986.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP62819.
OMACEVDFAE.
OrthoDBEOG779P19.
PhylomeDBP62819.
TreeFamTF332727.

Gene expression databases

GenevestigatorP62819.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297763.
PROP62819.

Entry information

Entry nameS10A3_RAT
AccessionPrimary (citable) accession number: P62819
Secondary accession number(s): P56566
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families