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P62818

- S10A3_MOUSE

UniProt

P62818 - S10A3_MOUSE

Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831ZincBy similarity
    Metal bindingi86 – 861ZincBy similarity
    Metal bindingi87 – 871ZincBy similarity
    Metal bindingi93 – 931ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinitySequence AnalysisAdd
    BLAST
    Calcium bindingi63 – 74122; high affinitySequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A3
    Alternative name(s):
    Protein S-100E
    S100 calcium-binding protein A3
    Gene namesi
    Name:S100a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1338849. S100a3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 101100Protein S100-A3PRO_0000143973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 68By similarity
    Modified residuei51 – 511Citrulline; by PAD3By similarity

    Post-translational modificationi

    More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization By similarity.By similarity

    Keywords - PTMi

    Citrullination, Disulfide bond

    Proteomic databases

    PaxDbiP62818.
    PRIDEiP62818.

    Expressioni

    Tissue specificityi

    Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

    Gene expression databases

    BgeeiP62818.
    CleanExiMM_S100A3.
    GenevestigatoriP62818.

    Interactioni

    Subunit structurei

    Homodimer and homotetramer for the citrullinated form.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP62818.
    SMRiP62818. Positions 3-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1Add
    BLAST
    Domaini50 – 8536EF-hand 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG40471.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP62818.
    OMAiCEVDFAE.
    OrthoDBiEOG779P19.
    PhylomeDBiP62818.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028488. S100A3.
    [Graphical view]
    PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62818-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF    50
    RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP 100
    Q 101
    Length:101
    Mass (Da):11,747
    Last modified:August 16, 2004 - v1
    Checksum:iEE46EABF16646CCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087470 mRNA. Translation: AAC64107.1.
    AF004941 mRNA. Translation: AAC78730.1.
    CCDSiCCDS17537.1.
    RefSeqiNP_035440.1. NM_011310.2.
    XP_006501234.1. XM_006501171.1.
    XP_006501235.1. XM_006501172.1.
    XP_006501236.1. XM_006501173.1.
    XP_006501237.1. XM_006501174.1.
    XP_006501238.1. XM_006501175.1.
    XP_006501239.1. XM_006501176.1.
    UniGeneiMm.440044.

    Genome annotation databases

    EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
    GeneIDi20197.
    KEGGimmu:20197.
    UCSCiuc008qcy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087470 mRNA. Translation: AAC64107.1 .
    AF004941 mRNA. Translation: AAC78730.1 .
    CCDSi CCDS17537.1.
    RefSeqi NP_035440.1. NM_011310.2.
    XP_006501234.1. XM_006501171.1.
    XP_006501235.1. XM_006501172.1.
    XP_006501236.1. XM_006501173.1.
    XP_006501237.1. XM_006501174.1.
    XP_006501238.1. XM_006501175.1.
    XP_006501239.1. XM_006501176.1.
    UniGenei Mm.440044.

    3D structure databases

    ProteinModelPortali P62818.
    SMRi P62818. Positions 3-94.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P62818.
    PRIDEi P62818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001047 ; ENSMUSP00000001047 ; ENSMUSG00000001021 .
    GeneIDi 20197.
    KEGGi mmu:20197.
    UCSCi uc008qcy.1. mouse.

    Organism-specific databases

    CTDi 6274.
    MGIi MGI:1338849. S100a3.

    Phylogenomic databases

    eggNOGi NOG40471.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P62818.
    OMAi CEVDFAE.
    OrthoDBi EOG779P19.
    PhylomeDBi P62818.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 297763.
    PROi P62818.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62818.
    CleanExi MM_S100A3.
    Genevestigatori P62818.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028488. S100A3.
    [Graphical view ]
    PANTHERi PTHR11639:SF12. PTHR11639:SF12. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle."
      Kizawa K., Tsuchimoto S., Hashimoto K., Uchiwa H.
      J. Invest. Dermatol. 111:879-886(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: ICR.
      Tissue: Skin.

    Entry informationi

    Entry nameiS10A3_MOUSE
    AccessioniPrimary (citable) accession number: P62818
    Secondary accession number(s): P56566
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3