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P62818

- S10A3_MOUSE

UniProt

P62818 - S10A3_MOUSE

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Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831ZincBy similarity
Metal bindingi86 – 861ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi93 – 931ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinitySequence AnalysisAdd
BLAST
Calcium bindingi63 – 74122; high affinitySequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1338849. S100a3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A3PRO_0000143973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 68By similarity
Modified residuei51 – 511Citrulline; by PAD3By similarity

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62818.
PRIDEiP62818.

Expressioni

Tissue specificityi

Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

Gene expression databases

BgeeiP62818.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevestigatoriP62818.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1Add
BLAST
Domaini50 – 8536EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40471.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62818.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62818-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.1.
XP_006501235.1. XM_006501172.1.
XP_006501236.1. XM_006501173.1.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.1.
XP_006501239.1. XM_006501176.1.
UniGeneiMm.440044.

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087470 mRNA. Translation: AAC64107.1 .
AF004941 mRNA. Translation: AAC78730.1 .
CCDSi CCDS17537.1.
RefSeqi NP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.1.
XP_006501235.1. XM_006501172.1.
XP_006501236.1. XM_006501173.1.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.1.
XP_006501239.1. XM_006501176.1.
UniGenei Mm.440044.

3D structure databases

ProteinModelPortali P62818.
SMRi P62818. Positions 3-94.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P62818.
PRIDEi P62818.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001047 ; ENSMUSP00000001047 ; ENSMUSG00000001021 .
GeneIDi 20197.
KEGGi mmu:20197.
UCSCi uc008qcy.1. mouse.

Organism-specific databases

CTDi 6274.
MGIi MGI:1338849. S100a3.

Phylogenomic databases

eggNOGi NOG40471.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P62818.
OMAi CEVDFAE.
OrthoDBi EOG779P19.
PhylomeDBi P62818.
TreeFami TF332727.

Miscellaneous databases

NextBioi 297763.
PROi P62818.
SOURCEi Search...

Gene expression databases

Bgeei P62818.
CleanExi MM_S100A3.
ExpressionAtlasi P62818. baseline and differential.
Genevestigatori P62818.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view ]
PANTHERi PTHR11639:SF12. PTHR11639:SF12. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle."
    Kizawa K., Tsuchimoto S., Hashimoto K., Uchiwa H.
    J. Invest. Dermatol. 111:879-886(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Skin.

Entry informationi

Entry nameiS10A3_MOUSE
AccessioniPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3