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Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831ZincBy similarity
Metal bindingi86 – 861ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi93 – 931ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinitySequence AnalysisAdd
BLAST
Calcium bindingi63 – 74122; high affinitySequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1338849. S100a3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 101100Protein S100-A3PRO_0000143973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 68By similarity
Modified residuei51 – 511Citrulline; by PAD3By similarity

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62818.
PRIDEiP62818.

Expressioni

Tissue specificityi

Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

Gene expression databases

BgeeiP62818.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevestigatoriP62818.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1Add
BLAST
Domaini50 – 8536EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40471.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62818.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.1.
XP_006501235.1. XM_006501172.1.
XP_006501236.1. XM_006501173.1.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.1.
XP_006501239.1. XM_006501176.1.
UniGeneiMm.440044.

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.1.
XP_006501235.1. XM_006501172.1.
XP_006501236.1. XM_006501173.1.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.1.
XP_006501239.1. XM_006501176.1.
UniGeneiMm.440044.

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP62818.
PRIDEiP62818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Organism-specific databases

CTDi6274.
MGIiMGI:1338849. S100a3.

Phylogenomic databases

eggNOGiNOG40471.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiCEVDFAE.
OrthoDBiEOG779P19.
PhylomeDBiP62818.
TreeFamiTF332727.

Miscellaneous databases

NextBioi297763.
PROiP62818.
SOURCEiSearch...

Gene expression databases

BgeeiP62818.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevestigatoriP62818.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle."
    Kizawa K., Tsuchimoto S., Hashimoto K., Uchiwa H.
    J. Invest. Dermatol. 111:879-886(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Skin.

Entry informationi

Entry nameiS10A3_MOUSE
AccessioniPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.