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P62818 (S10A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene names
Name:S100a3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation By similarity.

Subunit structure

Homodimer and homotetramer for the citrullinated form By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Skin specific, specifically expressed in cuticle of pelage follicle. Ref.2

Post-translational modification

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandCalcium
Metal-binding
Zinc
   PTMCitrullination
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 101100Protein S100-A3
PRO_0000143973

Regions

Domain12 – 4736EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity Potential
Calcium binding63 – 74122; high affinity Potential

Sites

Metal binding831Zinc By similarity
Metal binding861Zinc By similarity
Metal binding871Zinc By similarity
Metal binding931Zinc By similarity

Amino acid modifications

Modified residue511Citrulline; by PAD3 By similarity
Disulfide bond30 ↔ 68 By similarity

Sequences

Sequence LengthMass (Da)Tools
P62818 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: EE46EABF16646CCA

FASTA10111,747
        10         20         30         40         50         60 
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF RECDYNKFMS 

        70         80         90        100 
VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP Q 

« Hide

References

[1]"Clustered organization of S100 genes in human and mouse."
Ridinger K., Ilg E.C., Niggli F.K., Heizmann C.W., Schaefer B.W.
Biochim. Biophys. Acta 1448:254-263(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle."
Kizawa K., Tsuchimoto S., Hashimoto K., Uchiwa H.
J. Invest. Dermatol. 111:879-886(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: ICR.
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSCCDS17537.1.
RefSeqNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.1.
XP_006501235.1. XM_006501172.1.
XP_006501236.1. XM_006501173.1.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.1.
XP_006501239.1. XM_006501176.1.
UniGeneMm.440044.

3D structure databases

ProteinModelPortalP62818.
SMRP62818. Positions 3-94.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP62818.
PRIDEP62818.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
GeneID20197.
KEGGmmu:20197.
UCSCuc008qcy.1. mouse.

Organism-specific databases

CTD6274.
MGIMGI:1338849. S100a3.

Phylogenomic databases

eggNOGNOG40471.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP62818.
OMACEVDFAE.
OrthoDBEOG779P19.
PhylomeDBP62818.
TreeFamTF332727.

Gene expression databases

BgeeP62818.
CleanExMM_S100A3.
GenevestigatorP62818.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297763.
PROP62818.
SOURCESearch...

Entry information

Entry nameS10A3_MOUSE
AccessionPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot