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Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi93ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338849. S100a3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439731 – 101Protein S100-A3Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 68By similarity
Modified residuei51Citrulline; by PAD3By similarity1

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62818.
PeptideAtlasiP62818.
PRIDEiP62818.

Expressioni

Tissue specificityi

Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

Gene expression databases

BgeeiENSMUSG00000001021.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevisibleiP62818. MM.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001047.

Structurei

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiYFKDCPP.
OrthoDBiEOG091G10JX.
PhylomeDBiP62818.
TreeFamiTF332727.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P62818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.3.
XP_006501236.1. XM_006501173.3.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.2.
XP_006501239.1. XM_006501176.2.
XP_011238349.1. XM_011240047.1.
XP_017174998.1. XM_017319509.1.
UniGeneiMm.440044.
Mm.464895.

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
ENSMUST00000200290; ENSMUSP00000142334; ENSMUSG00000001021.
ENSMUST00000200508; ENSMUSP00000142747; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiS10A3_MOUSE
AccessioniPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families