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Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi93ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338849. S100a3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439732 – 101Protein S100-A3Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 68By similarity
Modified residuei51Citrulline; by PAD3By similarity1

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62818.
PeptideAtlasiP62818.
PRIDEiP62818.

Expressioni

Tissue specificityi

Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

Gene expression databases

BgeeiENSMUSG00000001021.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevisibleiP62818. MM.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiYFKDCPP.
OrthoDBiEOG091G10JX.
PhylomeDBiP62818.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.3.
XP_006501236.1. XM_006501173.3.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.2.
XP_006501239.1. XM_006501176.2.
XP_011238349.1. XM_011240047.1.
XP_017174998.1. XM_017319509.1.
UniGeneiMm.440044.
Mm.464895.

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
ENSMUST00000200290; ENSMUSP00000142334; ENSMUSG00000001021.
ENSMUST00000200508; ENSMUSP00000142747; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA. Translation: AAC64107.1.
AF004941 mRNA. Translation: AAC78730.1.
CCDSiCCDS17537.1.
RefSeqiNP_035440.1. NM_011310.2.
XP_006501234.1. XM_006501171.3.
XP_006501236.1. XM_006501173.3.
XP_006501237.1. XM_006501174.1.
XP_006501238.1. XM_006501175.2.
XP_006501239.1. XM_006501176.2.
XP_011238349.1. XM_011240047.1.
XP_017174998.1. XM_017319509.1.
UniGeneiMm.440044.
Mm.464895.

3D structure databases

ProteinModelPortaliP62818.
SMRiP62818.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP62818.
PeptideAtlasiP62818.
PRIDEiP62818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021.
ENSMUST00000200290; ENSMUSP00000142334; ENSMUSG00000001021.
ENSMUST00000200508; ENSMUSP00000142747; ENSMUSG00000001021.
GeneIDi20197.
KEGGimmu:20197.
UCSCiuc008qcy.1. mouse.

Organism-specific databases

CTDi6274.
MGIiMGI:1338849. S100a3.

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP62818.
OMAiYFKDCPP.
OrthoDBiEOG091G10JX.
PhylomeDBiP62818.
TreeFamiTF332727.

Miscellaneous databases

PROiP62818.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001021.
CleanExiMM_S100A3.
ExpressionAtlasiP62818. baseline and differential.
GenevisibleiP62818. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A3_MOUSE
AccessioniPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.