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Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Promotes apoptosis.By similarity

GO - Biological processi

  • apoptotic process Source: RGD
  • cellular response to potassium ion starvation Source: RGD
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:Hrk
Synonyms:Bid3, Dp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70549. Hrk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 8819HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Activator of apoptosis harakiriPRO_0000143108Add
BLAST

Proteomic databases

PRIDEiP62817.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-87016.

Structurei

3D structure databases

ProteinModelPortaliP62817.
SMRiP62817. Positions 22-52, 65-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4715BH3Add
BLAST

Domaini

The BH3 motif is required for the induction of cell death.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005990.
InParanoidiP62817.
KOiK02512.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR
60 70 80 90
RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Length:92
Mass (Da):10,078
Last modified:August 16, 2004 - v1
Checksum:i95760B9EEA88F1DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83697 mRNA. Translation: BAA12065.1.
RefSeqiNP_476471.1. NM_057130.4.
UniGeneiRn.233779.
Rn.233846.
Rn.233915.
Rn.89639.

Genome annotation databases

GeneIDi117271.
KEGGirno:117271.
UCSCiRGD:70549. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83697 mRNA. Translation: BAA12065.1.
RefSeqiNP_476471.1. NM_057130.4.
UniGeneiRn.233779.
Rn.233846.
Rn.233915.
Rn.89639.

3D structure databases

ProteinModelPortaliP62817.
SMRiP62817. Positions 22-52, 65-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-87016.

Proteomic databases

PRIDEiP62817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117271.
KEGGirno:117271.
UCSCiRGD:70549. rat.

Organism-specific databases

CTDi8739.
RGDi70549. Hrk.

Phylogenomic databases

HOVERGENiHBG005990.
InParanoidiP62817.
KOiK02512.

Miscellaneous databases

PROiP62817.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death."
    Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.
    J. Biol. Chem. 272:18842-18848(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHRK_RAT
AccessioniPrimary (citable) accession number: P62817
Secondary accession number(s): P70678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.