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Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Promotes apoptosis.By similarity

GO - Biological processi

  • apoptotic process Source: RGD
  • cellular response to potassium ion starvation Source: RGD
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: RGD

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:Hrk
Synonyms:Bid3, Dp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70549 Hrk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 88HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431081 – 92Activator of apoptosis harakiriAdd BLAST92

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP62817
SMRiP62817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 47BH3Add BLAST15

Domaini

The BH3 motif is required for the induction of cell death.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005990
InParanoidiP62817
KOiK02512

Family and domain databases

InterProiView protein in InterPro
IPR017249 Apoptosis_activator_harakiri
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15056 PTHR15056, 1 hit
PfamiView protein in Pfam
PF15196 Harakiri, 1 hit
PIRSFiPIRSF037635 BID3, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit

Sequencei

Sequence statusi: Complete.

P62817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR
60 70 80 90
RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Length:92
Mass (Da):10,078
Last modified:August 16, 2004 - v1
Checksum:i95760B9EEA88F1DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83697 mRNA Translation: BAA12065.1
RefSeqiNP_476471.1, NM_057130.4
UniGeneiRn.233779
Rn.233846
Rn.233915
Rn.89639

Genome annotation databases

GeneIDi117271
KEGGirno:117271
UCSCiRGD:70549 rat

Similar proteinsi

Entry informationi

Entry nameiHRK_RAT
AccessioniPrimary (citable) accession number: P62817
Secondary accession number(s): P70678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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