ID   HRK_MOUSE               Reviewed;          92 AA.
AC   P62816; P70678;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   24-JAN-2024, entry version 108.
DE   RecName: Full=Activator of apoptosis harakiri;
DE   AltName: Full=BH3-interacting domain-containing protein 3;
DE   AltName: Full=Neuronal death protein DP5;
GN   Name=Hrk; Synonyms=Bid3, Dp5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9228060; DOI=10.1074/jbc.272.30.18842;
RA   Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.;
RT   "Molecular cloning of a novel polypeptide, DP5, induced during programmed
RT   neuronal death.";
RL   J. Biol. Chem. 272:18842-18848(1997).
CC   -!- FUNCTION: Promotes apoptosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Mitochondrion {ECO:0000250}.
CC   -!- DOMAIN: The BH3 motif is required for the induction of cell death.
CC       {ECO:0000250}.
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DR   EMBL; D83698; BAA12066.1; -; mRNA.
DR   CCDS; CCDS39236.1; -.
DR   RefSeq; NP_031571.1; NM_007545.2.
DR   AlphaFoldDB; P62816; -.
DR   SMR; P62816; -.
DR   IntAct; P62816; 1.
DR   MINT; P62816; -.
DR   STRING; 10090.ENSMUSP00000057532; -.
DR   PaxDb; 10090-ENSMUSP00000057532; -.
DR   Antibodypedia; 18831; 225 antibodies from 29 providers.
DR   Ensembl; ENSMUST00000054836.7; ENSMUSP00000057532.5; ENSMUSG00000046607.7.
DR   GeneID; 12123; -.
DR   KEGG; mmu:12123; -.
DR   UCSC; uc008zgg.1; mouse.
DR   AGR; MGI:1201608; -.
DR   CTD; 8739; -.
DR   MGI; MGI:1201608; Hrk.
DR   VEuPathDB; HostDB:ENSMUSG00000046607; -.
DR   eggNOG; ENOG502T2F4; Eukaryota.
DR   GeneTree; ENSGT00390000007050; -.
DR   HOGENOM; CLU_2426351_0_0_1; -.
DR   InParanoid; P62816; -.
DR   OMA; QERTMWR; -.
DR   OrthoDB; 4851492at2759; -.
DR   TreeFam; TF338168; -.
DR   BioGRID-ORCS; 12123; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Hrk; mouse.
DR   PRO; PR:P62816; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; P62816; Protein.
DR   Bgee; ENSMUSG00000046607; Expressed in dentate gyrus of hippocampal formation granule cell and 99 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0051365; P:cellular response to potassium ion starvation; ISO:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISO:MGI.
DR   GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISO:MGI.
DR   InterPro; IPR017249; Apoptosis_activator_harakiri.
DR   InterPro; IPR020728; Bcl2_BH3_motif_CS.
DR   PANTHER; PTHR15056; ACTIVATOR OF APOPTOSIS HARAKIRI; 1.
DR   PANTHER; PTHR15056:SF0; ACTIVATOR OF APOPTOSIS HARAKIRI; 1.
DR   Pfam; PF15196; Harakiri; 1.
DR   PIRSF; PIRSF037635; BID3; 1.
DR   PROSITE; PS01259; BH3; 1.
DR   Genevisible; P62816; MM.
PE   3: Inferred from homology;
KW   Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..92
FT                   /note="Activator of apoptosis harakiri"
FT                   /id="PRO_0000143107"
FT   TRANSMEM        70..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           33..47
FT                   /note="BH3"
SQ   SEQUENCE   92 AA;  10078 MW;  95760B9EEA88F1DE CRC64;
     MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR RRARPRDPLP
     ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
//