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P62816

- HRK_MOUSE

UniProt

P62816 - HRK_MOUSE

Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Promotes apoptosis.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. positive regulation of apoptotic process Source: UniProtKB
    3. positive regulation of protein homooligomerization Source: Ensembl
    4. positive regulation of release of cytochrome c from mitochondria Source: Ensembl

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activator of apoptosis harakiri
    Alternative name(s):
    BH3-interacting domain-containing protein 3
    Neuronal death protein DP5
    Gene namesi
    Name:Hrk
    Synonyms:Bid3, Dp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1201608. Hrk.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Activator of apoptosis harakiriPRO_0000143107Add
    BLAST

    Proteomic databases

    PRIDEiP62816.

    Expressioni

    Gene expression databases

    BgeeiP62816.
    GenevestigatoriP62816.

    Interactioni

    Subunit structurei

    Interacts with BCL2 and BCL2L1. Interacts with C1QBP By similarity.By similarity

    Protein-protein interaction databases

    IntActiP62816. 1 interaction.
    STRINGi10090.ENSMUSP00000057532.

    Structurei

    3D structure databases

    ProteinModelPortaliP62816.
    SMRiP62816. Positions 22-52, 65-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 8819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi33 – 4715BH3Add
    BLAST

    Domaini

    The BH3 motif is required for the induction of cell death.By similarity

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41778.
    GeneTreeiENSGT00390000007050.
    HOGENOMiHOG000112951.
    HOVERGENiHBG005990.
    InParanoidiP62816.
    KOiK02512.
    OMAiAVCACSS.
    OrthoDBiEOG75MW04.
    TreeFamiTF338168.

    Family and domain databases

    InterProiIPR017249. Apoptosis_activator_harakiri.
    IPR020728. Bcl2_BH3_motif_CS.
    [Graphical view]
    PfamiPF15196. Harakiri. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037635. BID3. 1 hit.
    PROSITEiPS01259. BH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62816-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR   50
    RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA 92
    Length:92
    Mass (Da):10,078
    Last modified:August 16, 2004 - v1
    Checksum:i95760B9EEA88F1DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83698 mRNA. Translation: BAA12066.1.
    CCDSiCCDS39236.1.
    RefSeqiNP_031571.1. NM_007545.2.
    UniGeneiMm.384468.

    Genome annotation databases

    EnsembliENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
    GeneIDi12123.
    KEGGimmu:12123.
    UCSCiuc008zgg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83698 mRNA. Translation: BAA12066.1 .
    CCDSi CCDS39236.1.
    RefSeqi NP_031571.1. NM_007545.2.
    UniGenei Mm.384468.

    3D structure databases

    ProteinModelPortali P62816.
    SMRi P62816. Positions 22-52, 65-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P62816. 1 interaction.
    STRINGi 10090.ENSMUSP00000057532.

    Proteomic databases

    PRIDEi P62816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054836 ; ENSMUSP00000057532 ; ENSMUSG00000046607 .
    GeneIDi 12123.
    KEGGi mmu:12123.
    UCSCi uc008zgg.1. mouse.

    Organism-specific databases

    CTDi 8739.
    MGIi MGI:1201608. Hrk.

    Phylogenomic databases

    eggNOGi NOG41778.
    GeneTreei ENSGT00390000007050.
    HOGENOMi HOG000112951.
    HOVERGENi HBG005990.
    InParanoidi P62816.
    KOi K02512.
    OMAi AVCACSS.
    OrthoDBi EOG75MW04.
    TreeFami TF338168.

    Miscellaneous databases

    ChiTaRSi HRK. mouse.
    NextBioi 280443.
    PROi P62816.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62816.
    Genevestigatori P62816.

    Family and domain databases

    InterProi IPR017249. Apoptosis_activator_harakiri.
    IPR020728. Bcl2_BH3_motif_CS.
    [Graphical view ]
    Pfami PF15196. Harakiri. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037635. BID3. 1 hit.
    PROSITEi PS01259. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death."
      Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.
      J. Biol. Chem. 272:18842-18848(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHRK_MOUSE
    AccessioniPrimary (citable) accession number: P62816
    Secondary accession number(s): P70678
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3