Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Promotes apoptosis.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:Hrk
Synonyms:Bid3, Dp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1201608. Hrk.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 88HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431071 – 92Activator of apoptosis harakiriAdd BLAST92

Proteomic databases

PaxDbiP62816.
PRIDEiP62816.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046607.
GenevisibleiP62816. MM.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).By similarity

Protein-protein interaction databases

IntActiP62816. 1 interactor.
STRINGi10090.ENSMUSP00000057532.

Structurei

3D structure databases

ProteinModelPortaliP62816.
SMRiP62816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 47BH3Add BLAST15

Domaini

The BH3 motif is required for the induction of cell death.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiP62816.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG091G16Q4.
TreeFamiTF338168.

Family and domain databases

InterProiView protein in InterPro
IPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiView protein in Pfam
PF15196. Harakiri. 1 hit.
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiView protein in PROSITE
PS01259. BH3. 1 hit.

Sequencei

Sequence statusi: Complete.

P62816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR
60 70 80 90
RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Length:92
Mass (Da):10,078
Last modified:August 16, 2004 - v1
Checksum:i95760B9EEA88F1DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83698 mRNA. Translation: BAA12066.1.
CCDSiCCDS39236.1.
RefSeqiNP_031571.1. NM_007545.2.
UniGeneiMm.384468.

Genome annotation databases

EnsembliENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
GeneIDi12123.
KEGGimmu:12123.
UCSCiuc008zgg.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHRK_MOUSE
AccessioniPrimary (citable) accession number: P62816
Secondary accession number(s): P70678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot