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P62816

- HRK_MOUSE

UniProt

P62816 - HRK_MOUSE

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Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Promotes apoptosis.By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. positive regulation of apoptotic process Source: UniProtKB
  3. positive regulation of protein homooligomerization Source: Ensembl
  4. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:Hrk
Synonyms:Bid3, Dp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1201608. Hrk.

Subcellular locationi

Membrane By similarity; Single-pass membrane protein By similarity. Mitochondrion By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 8819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Activator of apoptosis harakiriPRO_0000143107Add
BLAST

Proteomic databases

PRIDEiP62816.

Expressioni

Gene expression databases

BgeeiP62816.
GenevestigatoriP62816.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).By similarity

Protein-protein interaction databases

IntActiP62816. 1 interaction.
STRINGi10090.ENSMUSP00000057532.

Structurei

3D structure databases

ProteinModelPortaliP62816.
SMRiP62816. Positions 22-52, 65-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4715BH3Add
BLAST

Domaini

The BH3 motif is required for the induction of cell death.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41778.
GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiP62816.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG75MW04.
TreeFamiTF338168.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR
60 70 80 90
RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Length:92
Mass (Da):10,078
Last modified:August 16, 2004 - v1
Checksum:i95760B9EEA88F1DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83698 mRNA. Translation: BAA12066.1.
CCDSiCCDS39236.1.
RefSeqiNP_031571.1. NM_007545.2.
UniGeneiMm.384468.

Genome annotation databases

EnsembliENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
GeneIDi12123.
KEGGimmu:12123.
UCSCiuc008zgg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83698 mRNA. Translation: BAA12066.1 .
CCDSi CCDS39236.1.
RefSeqi NP_031571.1. NM_007545.2.
UniGenei Mm.384468.

3D structure databases

ProteinModelPortali P62816.
SMRi P62816. Positions 22-52, 65-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P62816. 1 interaction.
STRINGi 10090.ENSMUSP00000057532.

Proteomic databases

PRIDEi P62816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054836 ; ENSMUSP00000057532 ; ENSMUSG00000046607 .
GeneIDi 12123.
KEGGi mmu:12123.
UCSCi uc008zgg.1. mouse.

Organism-specific databases

CTDi 8739.
MGIi MGI:1201608. Hrk.

Phylogenomic databases

eggNOGi NOG41778.
GeneTreei ENSGT00390000007050.
HOGENOMi HOG000112951.
HOVERGENi HBG005990.
InParanoidi P62816.
KOi K02512.
OMAi AVCACSS.
OrthoDBi EOG75MW04.
TreeFami TF338168.

Miscellaneous databases

ChiTaRSi Hrk. mouse.
NextBioi 280443.
PROi P62816.
SOURCEi Search...

Gene expression databases

Bgeei P62816.
Genevestigatori P62816.

Family and domain databases

InterProi IPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view ]
Pfami PF15196. Harakiri. 1 hit.
[Graphical view ]
PIRSFi PIRSF037635. BID3. 1 hit.
PROSITEi PS01259. BH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death."
    Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.
    J. Biol. Chem. 272:18842-18848(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHRK_MOUSE
AccessioniPrimary (citable) accession number: P62816
Secondary accession number(s): P70678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3