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Protein

Activator of apoptosis harakiri

Gene

Hrk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Promotes apoptosis.By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. positive regulation of apoptotic process Source: UniProtKB
  3. positive regulation of protein homooligomerization Source: Ensembl
  4. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:Hrk
Synonyms:Bid3, Dp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1201608. Hrk.

Subcellular locationi

Membrane By similarity; Single-pass membrane protein By similarity. Mitochondrion By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 8819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Activator of apoptosis harakiriPRO_0000143107Add
BLAST

Proteomic databases

PRIDEiP62816.

Expressioni

Gene expression databases

BgeeiP62816.
GenevestigatoriP62816.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).By similarity

Protein-protein interaction databases

IntActiP62816. 1 interaction.
STRINGi10090.ENSMUSP00000057532.

Structurei

3D structure databases

ProteinModelPortaliP62816.
SMRiP62816. Positions 22-52, 65-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4715BH3Add
BLAST

Domaini

The BH3 motif is required for the induction of cell death.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41778.
GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiP62816.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG75MW04.
TreeFamiTF338168.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR
60 70 80 90
RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Length:92
Mass (Da):10,078
Last modified:August 15, 2004 - v1
Checksum:i95760B9EEA88F1DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83698 mRNA. Translation: BAA12066.1.
CCDSiCCDS39236.1.
RefSeqiNP_031571.1. NM_007545.2.
UniGeneiMm.384468.

Genome annotation databases

EnsembliENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
GeneIDi12123.
KEGGimmu:12123.
UCSCiuc008zgg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83698 mRNA. Translation: BAA12066.1.
CCDSiCCDS39236.1.
RefSeqiNP_031571.1. NM_007545.2.
UniGeneiMm.384468.

3D structure databases

ProteinModelPortaliP62816.
SMRiP62816. Positions 22-52, 65-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62816. 1 interaction.
STRINGi10090.ENSMUSP00000057532.

Proteomic databases

PRIDEiP62816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
GeneIDi12123.
KEGGimmu:12123.
UCSCiuc008zgg.1. mouse.

Organism-specific databases

CTDi8739.
MGIiMGI:1201608. Hrk.

Phylogenomic databases

eggNOGiNOG41778.
GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiP62816.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG75MW04.
TreeFamiTF338168.

Miscellaneous databases

ChiTaRSiHrk. mouse.
NextBioi280443.
PROiP62816.
SOURCEiSearch...

Gene expression databases

BgeeiP62816.
GenevestigatoriP62816.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death."
    Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.
    J. Biol. Chem. 272:18842-18848(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHRK_MOUSE
AccessioniPrimary (citable) accession number: P62816
Secondary accession number(s): P70678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2004
Last sequence update: August 15, 2004
Last modified: March 31, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.