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P62816 (HRK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene names
Name:Hrk
Synonyms:Bid3, Dp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes apoptosis By similarity.

Subunit structure

Interacts with BCL2 and BCL2L1. Interacts with C1QBP By similarity.

Subcellular location

Membrane; Single-pass membrane protein By similarity. Mitochondrion By similarity.

Domain

The BH3 motif is required for the induction of cell death By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Activator of apoptosis harakiri
PRO_0000143107

Regions

Transmembrane70 – 8819Helical; Potential
Motif33 – 4715BH3

Sequences

Sequence LengthMass (Da)Tools
P62816 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 95760B9EEA88F1DE

FASTA9210,078
        10         20         30         40         50         60 
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR RRARPRDPLP 

        70         80         90 
ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA 

« Hide

References

[1]"Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death."
Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.
J. Biol. Chem. 272:18842-18848(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83698 mRNA. Translation: BAA12066.1.
RefSeqNP_031571.1. NM_007545.2.
UniGeneMm.384468.

3D structure databases

ProteinModelPortalP62816.
SMRP62816. Positions 22-52, 65-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP62816. 1 interaction.
STRING10090.ENSMUSP00000057532.

Proteomic databases

PRIDEP62816.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
GeneID12123.
KEGGmmu:12123.
UCSCuc008zgg.1. mouse.

Organism-specific databases

CTD8739.
MGIMGI:1201608. Hrk.

Phylogenomic databases

eggNOGNOG41778.
GeneTreeENSGT00390000007050.
HOGENOMHOG000112951.
HOVERGENHBG005990.
InParanoidP62816.
KOK02512.
OMASALPTYW.
OrthoDBEOG75MW04.
TreeFamTF338168.

Gene expression databases

BgeeP62816.
GenevestigatorP62816.

Family and domain databases

InterProIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PfamPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFPIRSF037635. BID3. 1 hit.
PROSITEPS01259. BH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHRK. mouse.
NextBio280443.
PROP62816.
SOURCESearch...

Entry information

Entry nameHRK_MOUSE
AccessionPrimary (citable) accession number: P62816
Secondary accession number(s): P70678
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot