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Protein

Gamma-aminobutyric acid receptor subunit alpha-1

Gene

Gabra1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225AgonistBy similarity1

GO - Molecular functioni

  • benzodiazepine receptor activity Source: RGD
  • drug binding Source: RGD
  • GABA-A receptor activity Source: RGD
  • GABA-gated chloride ion channel activity Source: Ensembl
  • inhibitory extracellular ligand-gated ion channel activity Source: RGD
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: Ensembl

GO - Biological processi

  • cellular response to histamine Source: UniProtKB
  • chloride transport Source: RGD
  • gamma-aminobutyric acid signaling pathway Source: RGD
  • synaptic transmission, GABAergic Source: BHF-UCL

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-RNO-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-1
Alternative name(s):
GABA(A) receptor subunit alpha-1
Gene namesi
Name:Gabra1
Synonyms:Gabra-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61855 Gabra1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 250ExtracellularCuratedAdd BLAST223
Transmembranei251 – 272HelicalCuratedAdd BLAST22
Transmembranei278 – 299HelicalCuratedAdd BLAST22
Transmembranei312 – 333HelicalCuratedAdd BLAST22
Topological domaini334 – 420CytoplasmicCuratedAdd BLAST87
Transmembranei421 – 442HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91F → L: Strongly decreases the affinity for GABA-dependent channel gating. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000043028 – 455Gamma-aminobutyric acid receptor subunit alpha-1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 179By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP62813
PRIDEiP62813

PTM databases

iPTMnetiP62813
PhosphoSitePlusiP62813

Expressioni

Tissue specificityi

Expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000003512
GenevisibleiP62813 RN

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:18281286, PubMed:2540033). Interacts with UBQLN1 (PubMed:11528422). Interacts with TRAK1 (By similarity). Interacts with KIF21B (PubMed:25172774).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Pik3r1Q637874EBI-6258192,EBI-518443

Protein-protein interaction databases

BioGridi248322, 1 interactor
IntActiP62813, 2 interactors
MINTiP62813
STRINGi10116.ENSRNOP00000004725

Chemistry databases

BindingDBiP62813

Structurei

3D structure databases

ProteinModelPortaliP62813
SMRiP62813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122Agonist bindingBy similarity3
Regioni180 – 182Agonist bindingBy similarity3
Regioni290 – 311Allosteric effector bindingBy similarityAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP62813
KOiK05175
OMAiEYLWAWT
OrthoDBiEOG091G0805
PhylomeDBiP62813
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005431 GABBAa1_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01614 GABAARALPHA1
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD
60 70 80 90 100
GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER
110 120 130 140 150
LKFKGPMTVL RLNNLMASKI WTPDTFFHNG KKSVAHNMTM PNKLLRITED
160 170 180 190 200
GTLLYTMRLT VRAECPMHLE DFPMDAHACP LKFGSYAYTR AEVVYEWTRE
210 220 230 240 250
PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT THFHLKRKIG
260 270 280 290 300
YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR
310 320 330 340 350
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP
360 370 380 390 400
EKPKKVKDPL IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK
410 420 430 440 450
PETKPPEPKK TFNSVSKIDR LSRIAFPLLF GIFNLVYWAT YLNREPQLKA

PTPHQ
Length:455
Mass (Da):51,754
Last modified:August 16, 2004 - v1
Checksum:iA270B43423B4086E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91F → L no nucleotide entry (PubMed:1977069).Curated1
Sequence conflicti435L → I no nucleotide entry (PubMed:2540033).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08490 Genomic DNA Translation: AAC42029.1
AY574250 mRNA Translation: AAS90346.1
BC100061 mRNA Translation: AAI00062.1
PIRiJQ0158
RefSeqiNP_899155.1, NM_183326.2
XP_006246185.1, XM_006246123.3
XP_006246186.1, XM_006246124.3
XP_017452668.1, XM_017597179.1
UniGeneiRn.28463

Genome annotation databases

EnsembliENSRNOT00000004725; ENSRNOP00000004725; ENSRNOG00000003512
GeneIDi29705
KEGGirno:29705
UCSCiRGD:61855 rat

Similar proteinsi

Entry informationi

Entry nameiGBRA1_RAT
AccessioniPrimary (citable) accession number: P62813
Secondary accession number(s): P18504, Q53YK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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