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P62812 (GBRA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit alpha-1
Alternative name(s):
GABA(A) receptor subunit alpha-1
Gene names
Name:Gabra1
Synonyms:Gabra-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with TRAK1. Ref.4

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 455428Gamma-aminobutyric acid receptor subunit alpha-1
PRO_0000000429

Regions

Topological domain28 – 250223Extracellular Probable
Transmembrane251 – 27222Helical; Probable
Transmembrane278 – 29922Helical; Probable
Transmembrane312 – 33322Helical; Probable
Topological domain334 – 42087Cytoplasmic Probable
Transmembrane421 – 44222Helical; Probable

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Disulfide bond165 ↔ 179 By similarity

Sequences

Sequence LengthMass (Da)Tools
P62812 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: A270B43423B4086E

FASTA45551,754
        10         20         30         40         50         60 
MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL 

        70         80         90        100        110        120 
GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER LKFKGPMTVL RLNNLMASKI 

       130        140        150        160        170        180 
WTPDTFFHNG KKSVAHNMTM PNKLLRITED GTLLYTMRLT VRAECPMHLE DFPMDAHACP 

       190        200        210        220        230        240 
LKFGSYAYTR AEVVYEWTRE PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT 

       250        260        270        280        290        300 
THFHLKRKIG YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 

       310        320        330        340        350        360 
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP EKPKKVKDPL 

       370        380        390        400        410        420 
IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK PETKPPEPKK TFNSVSKIDR 

       430        440        450 
LSRIAFPLLF GIFNLVYWAT YLNREPQLKA PTPHQ 

« Hide

References

« Hide 'large scale' references
[1]"The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J and DBA/2J.
Tissue: Brain.
[2]"The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene."
Keir W.J., Kozak C.A., Chakraborti A., Deitrich R.A., Sikela J.M.
Genomics 9:390-395(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"A collection of cDNA clones with specific expression patterns in mouse brain."
Kato K.
Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c.
[4]"Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice."
Gilbert S.L., Zhang L., Forster M.L., Anderson J.R., Iwase T., Soliven B., Donahue L.R., Sweet H.O., Bronson R.T., Davisson M.T., Wollmann R.L., Lahn B.T.
Nat. Genet. 38:245-250(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRAK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86566 mRNA. Translation: AAB59634.1.
M63436 mRNA. Translation: AAA37654.1.
X61430 mRNA. Translation: CAA43672.1.
CCDSCCDS24553.1.
PIRA39062.
RefSeqNP_034380.1. NM_010250.5.
XP_006532259.1. XM_006532196.1.
UniGeneMm.439668.

3D structure databases

ProteinModelPortalP62812.
SMRP62812. Positions 42-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199797. 5 interactions.
IntActP62812. 1 interaction.

Chemistry

BindingDBP62812.
ChEMBLCHEMBL3139.
GuidetoPHARMACOLOGY404.

PTM databases

PhosphoSiteP62812.

Proteomic databases

MaxQBP62812.
PaxDbP62812.
PRIDEP62812.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020707; ENSMUSP00000020707; ENSMUSG00000010803.
GeneID14394.
KEGGmmu:14394.
UCSCuc007imf.1. mouse.

Organism-specific databases

CTD2554.
MGIMGI:95613. Gabra1.

Phylogenomic databases

eggNOGNOG238757.
HOGENOMHOG000231337.
HOVERGENHBG051707.
InParanoidP62812.
KOK05175.
OMAAPNIARD.
OrthoDBEOG7JX342.
PhylomeDBP62812.
TreeFamTF315453.

Gene expression databases

BgeeP62812.
GenevestigatorP62812.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005431. GABBAa1_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSPR01079. GABAARALPHA.
PR01614. GABAARALPHA1.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285923.
PROP62812.
SOURCESearch...

Entry information

Entry nameGBRA1_MOUSE
AccessionPrimary (citable) accession number: P62812
Secondary accession number(s): P18504
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot