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P62812

- GBRA1_MOUSE

UniProt

P62812 - GBRA1_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit alpha-1

Gene
Gabra1, Gabra-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. drug binding Source: Ensembl
  3. extracellular ligand-gated ion channel activity Source: InterPro
  4. GABA-A receptor activity Source: InterPro
  5. protein binding Source: MGI

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: InterPro
  2. synaptic transmission, GABAergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-1
Alternative name(s):
GABA(A) receptor subunit alpha-1
Gene namesi
Name:Gabra1
Synonyms:Gabra-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:95613. Gabra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 250223Extracellular InferredAdd
BLAST
Transmembranei251 – 27222Helical; InferredAdd
BLAST
Transmembranei278 – 29922Helical; InferredAdd
BLAST
Transmembranei312 – 33322Helical; InferredAdd
BLAST
Topological domaini334 – 42087Cytoplasmic InferredAdd
BLAST
Transmembranei421 – 44222Helical; InferredAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. integral component of plasma membrane Source: Ensembl
  4. plasma membrane Source: MGI
  5. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 455428Gamma-aminobutyric acid receptor subunit alpha-1PRO_0000000429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi165 ↔ 179 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP62812.
PaxDbiP62812.
PRIDEiP62812.

PTM databases

PhosphoSiteiP62812.

Expressioni

Gene expression databases

BgeeiP62812.
GenevestigatoriP62812.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with TRAK1.1 Publication

Protein-protein interaction databases

BioGridi199797. 5 interactions.
IntActiP62812. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP62812.
SMRiP62812. Positions 42-340.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238757.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP62812.
KOiK05175.
OMAiAPNIARD.
OrthoDBiEOG7JX342.
PhylomeDBiP62812.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005431. GABBAa1_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01614. GABAARALPHA1.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62812-1 [UniParc]FASTAAdd to Basket

« Hide

MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD    50
GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER 100
LKFKGPMTVL RLNNLMASKI WTPDTFFHNG KKSVAHNMTM PNKLLRITED 150
GTLLYTMRLT VRAECPMHLE DFPMDAHACP LKFGSYAYTR AEVVYEWTRE 200
PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT THFHLKRKIG 250
YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 300
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP 350
EKPKKVKDPL IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK 400
PETKPPEPKK TFNSVSKIDR LSRIAFPLLF GIFNLVYWAT YLNREPQLKA 450
PTPHQ 455
Length:455
Mass (Da):51,754
Last modified:August 16, 2004 - v1
Checksum:iA270B43423B4086E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86566 mRNA. Translation: AAB59634.1.
M63436 mRNA. Translation: AAA37654.1.
X61430 mRNA. Translation: CAA43672.1.
CCDSiCCDS24553.1.
PIRiA39062.
RefSeqiNP_034380.1. NM_010250.5.
XP_006532259.1. XM_006532196.1.
UniGeneiMm.439668.

Genome annotation databases

EnsembliENSMUST00000020707; ENSMUSP00000020707; ENSMUSG00000010803.
GeneIDi14394.
KEGGimmu:14394.
UCSCiuc007imf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86566 mRNA. Translation: AAB59634.1 .
M63436 mRNA. Translation: AAA37654.1 .
X61430 mRNA. Translation: CAA43672.1 .
CCDSi CCDS24553.1.
PIRi A39062.
RefSeqi NP_034380.1. NM_010250.5.
XP_006532259.1. XM_006532196.1.
UniGenei Mm.439668.

3D structure databases

ProteinModelPortali P62812.
SMRi P62812. Positions 42-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199797. 5 interactions.
IntActi P62812. 1 interaction.

Chemistry

BindingDBi P62812.
ChEMBLi CHEMBL3139.
GuidetoPHARMACOLOGYi 404.

PTM databases

PhosphoSitei P62812.

Proteomic databases

MaxQBi P62812.
PaxDbi P62812.
PRIDEi P62812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020707 ; ENSMUSP00000020707 ; ENSMUSG00000010803 .
GeneIDi 14394.
KEGGi mmu:14394.
UCSCi uc007imf.1. mouse.

Organism-specific databases

CTDi 2554.
MGIi MGI:95613. Gabra1.

Phylogenomic databases

eggNOGi NOG238757.
HOGENOMi HOG000231337.
HOVERGENi HBG051707.
InParanoidi P62812.
KOi K05175.
OMAi APNIARD.
OrthoDBi EOG7JX342.
PhylomeDBi P62812.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Miscellaneous databases

NextBioi 285923.
PROi P62812.
SOURCEi Search...

Gene expression databases

Bgeei P62812.
Genevestigatori P62812.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005431. GABBAa1_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view ]
PRINTSi PR01079. GABAARALPHA.
PR01614. GABAARALPHA1.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
    Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
    J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  2. "The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene."
    Keir W.J., Kozak C.A., Chakraborti A., Deitrich R.A., Sikela J.M.
    Genomics 9:390-395(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c.
  4. Cited for: INTERACTION WITH TRAK1.

Entry informationi

Entry nameiGBRA1_MOUSE
AccessioniPrimary (citable) accession number: P62812
Secondary accession number(s): P18504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi