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Protein

Gamma-aminobutyric acid receptor subunit alpha-1

Gene

Gabra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-1
Alternative name(s):
GABA(A) receptor subunit alpha-1
Gene namesi
Name:Gabra1
Synonyms:Gabra-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95613 Gabra1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 250ExtracellularCuratedAdd BLAST223
Transmembranei251 – 272HelicalCuratedAdd BLAST22
Transmembranei278 – 299HelicalCuratedAdd BLAST22
Transmembranei312 – 333HelicalCuratedAdd BLAST22
Topological domaini334 – 420CytoplasmicCuratedAdd BLAST87
Transmembranei421 – 442HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3139

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000042928 – 455Gamma-aminobutyric acid receptor subunit alpha-1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 179By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP62812
PeptideAtlasiP62812
PRIDEiP62812

PTM databases

iPTMnetiP62812
PhosphoSitePlusiP62812

Expressioni

Gene expression databases

BgeeiENSMUSG00000010803
ExpressionAtlasiP62812 baseline and differential
GenevisibleiP62812 MM

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (PubMed:16380713). Interacts with KIF21B (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199797, 18 interactors
DIPiDIP-32219N
IntActiP62812, 2 interactors
STRINGi10090.ENSMUSP00000020707

Chemistry databases

BindingDBiP62812

Structurei

Secondary structure

1455
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi250 – 255Combined sources6
Helixi257 – 268Combined sources12
Helixi269 – 272Combined sources4
Helixi278 – 284Combined sources7
Helixi287 – 300Combined sources14
Helixi311 – 335Combined sources25
Helixi417 – 441Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OSBX-ray3.80A/B/C/D/E250-338[»]
A/B/C/D/E417-455[»]
5OSCX-ray3.10A/B/C/D/E417-455[»]
ProteinModelPortaliP62812
SMRiP62812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP62812
KOiK05175
OMAiEYLWAWT
OrthoDBiEOG091G0805
PhylomeDBiP62812
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005431 GABBAa1_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01614 GABAARALPHA1
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD
60 70 80 90 100
GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER
110 120 130 140 150
LKFKGPMTVL RLNNLMASKI WTPDTFFHNG KKSVAHNMTM PNKLLRITED
160 170 180 190 200
GTLLYTMRLT VRAECPMHLE DFPMDAHACP LKFGSYAYTR AEVVYEWTRE
210 220 230 240 250
PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT THFHLKRKIG
260 270 280 290 300
YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR
310 320 330 340 350
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP
360 370 380 390 400
EKPKKVKDPL IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK
410 420 430 440 450
PETKPPEPKK TFNSVSKIDR LSRIAFPLLF GIFNLVYWAT YLNREPQLKA

PTPHQ
Length:455
Mass (Da):51,754
Last modified:August 16, 2004 - v1
Checksum:iA270B43423B4086E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86566 mRNA Translation: AAB59634.1
M63436 mRNA Translation: AAA37654.1
X61430 mRNA Translation: CAA43672.1
CCDSiCCDS24553.1
PIRiA39062
RefSeqiNP_034380.1, NM_010250.5
XP_006532259.1, XM_006532196.3
XP_017169748.1, XM_017314259.1
XP_017169749.1, XM_017314260.1
UniGeneiMm.439668

Genome annotation databases

EnsembliENSMUST00000020707; ENSMUSP00000020707; ENSMUSG00000010803
ENSMUST00000205546; ENSMUSP00000146133; ENSMUSG00000010803
GeneIDi14394
KEGGimmu:14394
UCSCiuc007imf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGBRA1_MOUSE
AccessioniPrimary (citable) accession number: P62812
Secondary accession number(s): P18504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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