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P62812

- GBRA1_MOUSE

UniProt

P62812 - GBRA1_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit alpha-1

Gene

Gabra1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel By similarity.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. drug binding Source: Ensembl
    3. extracellular ligand-gated ion channel activity Source: InterPro
    4. GABA-A receptor activity Source: InterPro
    5. protein binding Source: MGI

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: InterPro
    2. synaptic transmission, GABAergic Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-1
    Alternative name(s):
    GABA(A) receptor subunit alpha-1
    Gene namesi
    Name:Gabra1
    Synonyms:Gabra-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:95613. Gabra1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: Ensembl
    4. plasma membrane Source: MGI
    5. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 455428Gamma-aminobutyric acid receptor subunit alpha-1PRO_0000000429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi165 ↔ 179By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP62812.
    PaxDbiP62812.
    PRIDEiP62812.

    PTM databases

    PhosphoSiteiP62812.

    Expressioni

    Gene expression databases

    BgeeiP62812.
    GenevestigatoriP62812.

    Interactioni

    Subunit structurei

    Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Binds UBQLN1 By similarity. Interacts with TRAK1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi199797. 5 interactions.
    IntActiP62812. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP62812.
    SMRiP62812. Positions 42-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 250223ExtracellularCuratedAdd
    BLAST
    Topological domaini334 – 42087CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 27222HelicalCuratedAdd
    BLAST
    Transmembranei278 – 29922HelicalCuratedAdd
    BLAST
    Transmembranei312 – 33322HelicalCuratedAdd
    BLAST
    Transmembranei421 – 44222HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiP62812.
    KOiK05175.
    OMAiAPNIARD.
    OrthoDBiEOG7JX342.
    PhylomeDBiP62812.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005431. GABBAa1_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01614. GABAARALPHA1.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62812-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD    50
    GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER 100
    LKFKGPMTVL RLNNLMASKI WTPDTFFHNG KKSVAHNMTM PNKLLRITED 150
    GTLLYTMRLT VRAECPMHLE DFPMDAHACP LKFGSYAYTR AEVVYEWTRE 200
    PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT THFHLKRKIG 250
    YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 300
    NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP 350
    EKPKKVKDPL IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK 400
    PETKPPEPKK TFNSVSKIDR LSRIAFPLLF GIFNLVYWAT YLNREPQLKA 450
    PTPHQ 455
    Length:455
    Mass (Da):51,754
    Last modified:August 16, 2004 - v1
    Checksum:iA270B43423B4086E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86566 mRNA. Translation: AAB59634.1.
    M63436 mRNA. Translation: AAA37654.1.
    X61430 mRNA. Translation: CAA43672.1.
    CCDSiCCDS24553.1.
    PIRiA39062.
    RefSeqiNP_034380.1. NM_010250.5.
    XP_006532259.1. XM_006532196.1.
    UniGeneiMm.439668.

    Genome annotation databases

    EnsembliENSMUST00000020707; ENSMUSP00000020707; ENSMUSG00000010803.
    GeneIDi14394.
    KEGGimmu:14394.
    UCSCiuc007imf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86566 mRNA. Translation: AAB59634.1 .
    M63436 mRNA. Translation: AAA37654.1 .
    X61430 mRNA. Translation: CAA43672.1 .
    CCDSi CCDS24553.1.
    PIRi A39062.
    RefSeqi NP_034380.1. NM_010250.5.
    XP_006532259.1. XM_006532196.1.
    UniGenei Mm.439668.

    3D structure databases

    ProteinModelPortali P62812.
    SMRi P62812. Positions 42-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199797. 5 interactions.
    IntActi P62812. 1 interaction.

    Chemistry

    BindingDBi P62812.
    ChEMBLi CHEMBL3139.
    GuidetoPHARMACOLOGYi 404.

    PTM databases

    PhosphoSitei P62812.

    Proteomic databases

    MaxQBi P62812.
    PaxDbi P62812.
    PRIDEi P62812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020707 ; ENSMUSP00000020707 ; ENSMUSG00000010803 .
    GeneIDi 14394.
    KEGGi mmu:14394.
    UCSCi uc007imf.1. mouse.

    Organism-specific databases

    CTDi 2554.
    MGIi MGI:95613. Gabra1.

    Phylogenomic databases

    eggNOGi NOG238757.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi P62812.
    KOi K05175.
    OMAi APNIARD.
    OrthoDBi EOG7JX342.
    PhylomeDBi P62812.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Miscellaneous databases

    NextBioi 285923.
    PROi P62812.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62812.
    Genevestigatori P62812.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005431. GABBAa1_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01614. GABAARALPHA1.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
      Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
      J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J and DBA/2J.
      Tissue: Brain.
    2. "The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene."
      Keir W.J., Kozak C.A., Chakraborti A., Deitrich R.A., Sikela J.M.
      Genomics 9:390-395(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "A collection of cDNA clones with specific expression patterns in mouse brain."
      Kato K.
      Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c.
    4. Cited for: INTERACTION WITH TRAK1.

    Entry informationi

    Entry nameiGBRA1_MOUSE
    AccessioniPrimary (citable) accession number: P62812
    Secondary accession number(s): P18504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3