Gamma-aminobutyric acid receptor subunit alpha-1 precursor

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P62812 (GBRA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-1

Alternative name(s):
GABA(A) receptor subunit alpha-1

Gene names

Name:	Gabra1
Synonyms:	Gabra-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with TRAK1. Ref.4
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: InterPro synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW drug binding Inferred from electronic annotation. Source: Compara extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

Potential

Chain

28 – 455

428

Gamma-aminobutyric acid receptor subunit alpha-1

PRO_0000000429

Regions

Topological domain

28 – 250

223

Extracellular Probable

Transmembrane

251 – 272

Helical; Probable

Transmembrane

278 – 299

Helical; Probable

Transmembrane

312 – 333

Helical; Probable

Topological domain

334 – 420

Cytoplasmic Probable

Transmembrane

421 – 442

Helical; Probable

Amino acid modifications

Modified residue

367

Phosphotyrosine Ref.5

Modified residue

374

Phosphotyrosine Ref.6

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

137

N-linked (GlcNAc...) Potential

Disulfide bond

165 ↔ 179

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P62812 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: A270B43423B4086E
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FASTA

455

51,754

        10         20         30         40         50         60 
MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL 

        70         80         90        100        110        120 
GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER LKFKGPMTVL RLNNLMASKI 

       130        140        150        160        170        180 
WTPDTFFHNG KKSVAHNMTM PNKLLRITED GTLLYTMRLT VRAECPMHLE DFPMDAHACP 

       190        200        210        220        230        240 
LKFGSYAYTR AEVVYEWTRE PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT 

       250        260        270        280        290        300 
THFHLKRKIG YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 

       310        320        330        340        350        360 
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP EKPKKVKDPL 

       370        380        390        400        410        420 
IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK PETKPPEPKK TFNSVSKIDR 

       430        440        450 
LSRIAFPLLF GIFNLVYWAT YLNREPQLKA PTPHQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development." Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R. J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J and DBA/2J. Tissue: Brain.
[2]	"The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene." Keir W.J., Kozak C.A., Chakraborti A., Deitrich R.A., Sikela J.M. Genomics 9:390-395(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"A collection of cDNA clones with specific expression patterns in mouse brain." Kato K. Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: BALB/c.
[4]	"Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice." Gilbert S.L., Zhang L., Forster M.L., Anderson J.R., Iwase T., Soliven B., Donahue L.R., Sweet H.O., Bronson R.T., Davisson M.T., Wollmann R.L., Lahn B.T. Nat. Genet. 38:245-250(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TRAK1.
[5]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-367, MASS SPECTROMETRY. Tissue: Brain.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-374, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M86566 mRNA. Translation: AAB59634.1. M63436 mRNA. Translation: AAA37654.1. X61430 mRNA. Translation: CAA43672.1.
IPI	IPI00113772.
PIR	A39062.
RefSeq	NP_034380.1. NM_010250.4.
UniGene	Mm.439668.
3D structure databases
ProteinModelPortal	P62812.
SMR	P62812. Positions 42-340.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62812. 1 interaction.
PTM databases
PhosphoSite	P62812.
Proteomic databases
PaxDb	P62812.
PRIDE	P62812.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020707; ENSMUSP00000020707; ENSMUSG00000010803.
GeneID	14394.
KEGG	mmu:14394.
Organism-specific databases
CTD	2554.
MGI	MGI:95613. Gabra1.
Phylogenomic databases
eggNOG	NOG238757.
HOGENOM	HOG000231337.
HOVERGEN	HBG051707.
InParanoid	P62812.
KO	K05175.
OMA	APNIARD.
OrthoDB	EOG4ZS935.
Gene expression databases
ArrayExpress	P62812.
Bgee	P62812.
Genevestigator	P62812.
GermOnline	ENSMUSG00000010803. Mus musculus.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR001390. GABAAa_rcpt. IPR005431. GABBAa1_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 2 hits. [Graphical view]
PRINTS	PR01079. GABAARALPHA. PR01614. GABAARALPHA1. PR00253. GABAARECEPTR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P62812.
ChEMBL	CHEMBL3139.
NextBio	285923.
SOURCE	Search...

Entry information

Entry name

GBRA1_MOUSE

Accession

Primary (citable) accession number: P62812
Secondary accession number(s): P18504

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents