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Protein

Histone H2B type 1-C/E/F/G/I

Gene

HIST1H2BC

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168154-MONOMER.
ReactomeiR-HSA-1221632. Meiotic synapsis.
R-HSA-171306. Packaging Of Telomere Ends.
R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-212300. PRC2 methylates histones and DNA.
R-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-3214815. HDACs deacetylate histones.
R-HSA-3214847. HATs acetylate histones.
R-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-5334118. DNA methylation.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-HSA-5693571. Nonhomologous End-Joining (NHEJ).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-69473. G2/M DNA damage checkpoint.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-912446. Meiotic recombination.
R-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B type 1-C/E/F/G/I
Alternative name(s):
Histone H2B.1 A
Histone H2B.a
Short name:
H2B/a
Histone H2B.g
Short name:
H2B/g
Histone H2B.h
Short name:
H2B/h
Histone H2B.k
Short name:
H2B/k
Histone H2B.l
Short name:
H2B/l
Gene namesi
Name:HIST1H2BC
Synonyms:H2BFL
AND
Name:HIST1H2BE
Synonyms:H2BFH
AND
Name:HIST1H2BF
Synonyms:H2BFG
AND
Name:HIST1H2BG
Synonyms:H2BFA
AND
Name:HIST1H2BI
Synonyms:H2BFK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4757. HIST1H2BC.
HGNC:4753. HIST1H2BE.
HGNC:4752. HIST1H2BF.
HGNC:4746. HIST1H2BG.
HGNC:4756. HIST1H2BI.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nuclear nucleosome Source: GO_Central
  • nucleoplasm Source: HPA
  • nucleosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3017.
8339.
8343.
8344.
8346.
8347.
OpenTargetsiENSG00000180596.
ENSG00000273802.
ENSG00000274290.
ENSG00000277224.
ENSG00000278588.
PharmGKBiPA29132.

Polymorphism and mutation databases

BioMutaiHIST1H2BC.
DMDMi290457686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity5 Publications
ChainiPRO_00000718262 – 126Histone H2B type 1-C/E/F/G/IAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei6N6-acetyllysine; alternate2 Publications1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei12N6-acetyllysine; alternate1 Publication1
Modified residuei12N6-crotonyllysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternate2 Publications1
Modified residuei13N6-crotonyllysine; alternate1 Publication1
Modified residuei15Phosphoserine; by STK4/MST11 Publication1
Modified residuei16N6-acetyllysine; alternate2 Publications1
Modified residuei16N6-crotonyllysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternate1 Publication1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei21N6-acetyllysine; alternate2 Publications1
Modified residuei21N6-crotonyllysine; alternate1 Publication1
Modified residuei24N6-acetyllysine; alternateBy similarity1
Modified residuei24N6-crotonyllysine; alternate1 Publication1
Modified residuei35N6-crotonyllysine; alternate1 Publication1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei37Phosphoserine; by AMPKBy similarity1
Modified residuei47N6-methyllysine1 Publication1
Modified residuei58N6,N6-dimethyllysine1 Publication1
Modified residuei80Dimethylated arginineBy similarity1
Modified residuei86N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei86N6-acetyllysine; alternateBy similarity1
Modified residuei87Omega-N-methylarginineBy similarity1
Modified residuei93Omega-N-methylarginineBy similarity1
Modified residuei109N6-methyllysine1 Publication1
Glycosylationi113O-linked (GlcNAc)1 Publication1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei117N6-methylated lysineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)4 Publications

Post-translational modificationi

Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.1 Publication
Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.By similarity1 Publication
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62807.
MaxQBiP62807.
PaxDbiP62807.
PeptideAtlasiP62807.
PRIDEiP62807.
TopDownProteomicsiP62807.

PTM databases

iPTMnetiP62807.
PhosphoSitePlusiP62807.
SwissPalmiP62807.

Expressioni

Gene expression databases

BgeeiENSG00000168242.
CleanExiHS_HIST1H2BC.
HS_HIST1H2BE.
HS_HIST1H2BF.
HS_HIST1H2BG.
HS_HIST1H2BI.
ExpressionAtlasiP62807. baseline and differential.
GenevisibleiP62807. HS.

Organism-specific databases

HPAiHPA042205.
HPA043013.
HPA048671.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53BP2Q13625-33EBI-354552,EBI-10175039

Protein-protein interaction databases

BioGridi109270. 17 interactors.
113935. 219 interactors.
113939. 4 interactors.
113940. 7 interactors.
113942. 4 interactors.
113943. 22 interactors.
DIPiDIP-32890N.
IntActiP62807. 26 interactors.
MINTiMINT-276222.
STRINGi9606.ENSP00000366962.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KGFelectron microscopy4.54D/H1-126[»]
ProteinModelPortaliP62807.
SMRiP62807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP62807.
KOiK11252.
OMAiKATHAFN.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62807.
TreeFamiTF300212.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:March 2, 2010 - v4
Checksum:iFAE1479F44BE703D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → S in CAB02545 (PubMed:9119399).Curated1
Sequence conflicti33S → T in CAB02545 (PubMed:9119399).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05588727G → S.1 PublicationCorresponds to variant rs7766641dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60750 Genomic DNA. Translation: AAA63189.1.
Z80782 Genomic DNA. Translation: CAB02544.1.
Z80779 Genomic DNA. Translation: CAB02541.1.
Z80780 Genomic DNA. Translation: CAB02542.1.
Z80783 Genomic DNA. Translation: CAB02545.1.
AF531286 Genomic DNA. Translation: AAN06686.1.
AF531288 Genomic DNA. Translation: AAN06688.1.
AF531289 Genomic DNA. Translation: AAN06689.1.
AF531290 Genomic DNA. Translation: AAN06690.1.
AF531292 Genomic DNA. Translation: AAN06692.1.
AL031777 Genomic DNA. Translation: CAC03411.1.
AL031777 Genomic DNA. Translation: CAC03417.1.
AL031777 Genomic DNA. Translation: CAC03420.1.
AL353759 Genomic DNA. Translation: CAC04130.1.
BC001131 mRNA. No translation available.
BC009612 mRNA. No translation available.
BC096120 mRNA. Translation: AAH96120.1.
BC096122 mRNA. Translation: AAH96122.1.
BC096123 mRNA. Translation: AAH96123.1.
BC101653 mRNA. Translation: AAI01654.1.
BC101655 mRNA. Translation: AAI01656.1.
BC101748 mRNA. Translation: AAI01749.1.
BC101750 mRNA. Translation: AAI01751.1.
BC106899 mRNA. Translation: AAI06900.1.
CCDSiCCDS4584.1.
CCDS4588.1.
CCDS4592.1.
CCDS4594.1.
CCDS4603.1.
PIRiE40335. HSHUB2.
S65409.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
NP_066407.1. NM_021063.3.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

Genome annotation databases

EnsembliENST00000314332; ENSP00000321744; ENSG00000180596.
ENST00000356530; ENSP00000348924; ENSG00000277224.
ENST00000377733; ENSP00000366962; ENSG00000278588.
ENST00000396984; ENSP00000380180; ENSG00000180596.
ENST00000541790; ENSP00000445633; ENSG00000273802.
ENST00000614097; ENSP00000483237; ENSG00000274290.
ENST00000634910; ENSP00000489317; ENSG00000274290.
GeneIDi3017.
8339.
8343.
8344.
8346.
8347.
KEGGihsa:3017.
hsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.
UCSCiuc003ngk.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60750 Genomic DNA. Translation: AAA63189.1.
Z80782 Genomic DNA. Translation: CAB02544.1.
Z80779 Genomic DNA. Translation: CAB02541.1.
Z80780 Genomic DNA. Translation: CAB02542.1.
Z80783 Genomic DNA. Translation: CAB02545.1.
AF531286 Genomic DNA. Translation: AAN06686.1.
AF531288 Genomic DNA. Translation: AAN06688.1.
AF531289 Genomic DNA. Translation: AAN06689.1.
AF531290 Genomic DNA. Translation: AAN06690.1.
AF531292 Genomic DNA. Translation: AAN06692.1.
AL031777 Genomic DNA. Translation: CAC03411.1.
AL031777 Genomic DNA. Translation: CAC03417.1.
AL031777 Genomic DNA. Translation: CAC03420.1.
AL353759 Genomic DNA. Translation: CAC04130.1.
BC001131 mRNA. No translation available.
BC009612 mRNA. No translation available.
BC096120 mRNA. Translation: AAH96120.1.
BC096122 mRNA. Translation: AAH96122.1.
BC096123 mRNA. Translation: AAH96123.1.
BC101653 mRNA. Translation: AAI01654.1.
BC101655 mRNA. Translation: AAI01656.1.
BC101748 mRNA. Translation: AAI01749.1.
BC101750 mRNA. Translation: AAI01751.1.
BC106899 mRNA. Translation: AAI06900.1.
CCDSiCCDS4584.1.
CCDS4588.1.
CCDS4592.1.
CCDS4594.1.
CCDS4603.1.
PIRiE40335. HSHUB2.
S65409.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
NP_066407.1. NM_021063.3.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KGFelectron microscopy4.54D/H1-126[»]
ProteinModelPortaliP62807.
SMRiP62807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109270. 17 interactors.
113935. 219 interactors.
113939. 4 interactors.
113940. 7 interactors.
113942. 4 interactors.
113943. 22 interactors.
DIPiDIP-32890N.
IntActiP62807. 26 interactors.
MINTiMINT-276222.
STRINGi9606.ENSP00000366962.

PTM databases

iPTMnetiP62807.
PhosphoSitePlusiP62807.
SwissPalmiP62807.

Polymorphism and mutation databases

BioMutaiHIST1H2BC.
DMDMi290457686.

Proteomic databases

EPDiP62807.
MaxQBiP62807.
PaxDbiP62807.
PeptideAtlasiP62807.
PRIDEiP62807.
TopDownProteomicsiP62807.

Protocols and materials databases

DNASUi8339.
8344.
8347.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314332; ENSP00000321744; ENSG00000180596.
ENST00000356530; ENSP00000348924; ENSG00000277224.
ENST00000377733; ENSP00000366962; ENSG00000278588.
ENST00000396984; ENSP00000380180; ENSG00000180596.
ENST00000541790; ENSP00000445633; ENSG00000273802.
ENST00000614097; ENSP00000483237; ENSG00000274290.
ENST00000634910; ENSP00000489317; ENSG00000274290.
GeneIDi3017.
8339.
8343.
8344.
8346.
8347.
KEGGihsa:3017.
hsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.
UCSCiuc003ngk.5. human.

Organism-specific databases

CTDi3017.
8339.
8343.
8344.
8346.
8347.
DisGeNETi3017.
8339.
8343.
8344.
8346.
8347.
GeneCardsiHIST1H2BC.
HIST1H2BE.
HIST1H2BF.
HIST1H2BG.
HIST1H2BI.
HGNCiHGNC:4757. HIST1H2BC.
HGNC:4753. HIST1H2BE.
HGNC:4752. HIST1H2BF.
HGNC:4746. HIST1H2BG.
HGNC:4756. HIST1H2BI.
HPAiHPA042205.
HPA043013.
HPA048671.
MIMi602798. gene.
602804. gene.
602805. gene.
602807. gene.
602847. gene.
neXtProtiNX_P62807.
OpenTargetsiENSG00000180596.
ENSG00000273802.
ENSG00000274290.
ENSG00000277224.
ENSG00000278588.
PharmGKBiPA29132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP62807.
KOiK11252.
OMAiKATHAFN.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62807.
TreeFamiTF300212.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168154-MONOMER.
ReactomeiR-HSA-1221632. Meiotic synapsis.
R-HSA-171306. Packaging Of Telomere Ends.
R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-212300. PRC2 methylates histones and DNA.
R-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-3214815. HDACs deacetylate histones.
R-HSA-3214847. HATs acetylate histones.
R-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-5334118. DNA methylation.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-HSA-5693571. Nonhomologous End-Joining (NHEJ).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-69473. G2/M DNA damage checkpoint.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-912446. Meiotic recombination.
R-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

ChiTaRSiHIST1H2BC. human.
HIST1H2BE. human.
HIST1H2BG. human.
GeneWikiiHIST1H2BE.
HIST1H2BF.
HIST1H2BG.
HIST1H2BI.
Histone_H2B_type_1-C.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168242.
CleanExiHS_HIST1H2BC.
HS_HIST1H2BE.
HS_HIST1H2BF.
HS_HIST1H2BG.
HS_HIST1H2BI.
ExpressionAtlasiP62807. baseline and differential.
GenevisibleiP62807. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2B1C_HUMAN
AccessioniPrimary (citable) accession number: P62807
Secondary accession number(s): P02278
, Q3B872, Q4VB69, Q93078, Q93080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.