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Protein

Histone H4

Gene

Hist1h4a

more
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-2299718. Condensation of Prophase Chromosomes.
R-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-3214841. PKMTs methylate histone lysines.
R-MMU-3214842. HDMs demethylate histones.
R-MMU-3214847. HATs acetylate histones.
R-MMU-3214858. RMTs methylate histone arginines.
R-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-69473. G2/M DNA damage checkpoint.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
AND
Name:Hist1h4b
Synonyms:H4-53
AND
Name:Hist1h4c
Synonyms:H4-12
AND
AND
AND
AND
AND
AND
AND
AND
Name:Hist2h4a
Synonyms:Hist2h4
AND
Name:Hist4h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 13, Chromosome 3, Chromosome 6

Organism-specific databases

MGIiMGI:2448419. Hist1h4a.
MGI:2448420. Hist1h4b.
MGI:2448421. Hist1h4c.
MGI:2448423. Hist1h4d.
MGI:2448425. Hist1h4f.
MGI:2448427. Hist1h4h.
MGI:2448432. Hist1h4i.
MGI:2448436. Hist1h4j.
MGI:2448439. Hist1h4k.
MGI:2448441. Hist1h4m.
MGI:2140113. Hist2h4.
MGI:2448443. Hist4h4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001583292 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei4Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei4Citrulline; alternateBy similarity1
Modified residuei4Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei4Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate1 Publication1
Modified residuei6N6-acetyllysine; alternateCombined sources1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-acetyllysine; alternateCombined sources1
Modified residuei9N6-crotonyllysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternateCombined sources1
Modified residuei13N6-crotonyllysine; alternateBy similarity1
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei17N6-acetyllysine; alternateCombined sources1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei21N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei21N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei21N6-methyllysine; alternateBy similarity1
Modified residuei32N6-acetyllysineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei52PhosphotyrosineCombined sources1
Modified residuei81PhosphothreonineCombined sources1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateCombined sources1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Post-translational modificationi

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.2 Publications
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).By similarity
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).By similarity
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).By similarity
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).By similarity
Sumoylated, which is associated with transcriptional repression.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62806.
MaxQBiP62806.
PaxDbiP62806.
PRIDEiP62806.
TopDownProteomicsiP62806.

PTM databases

iPTMnetiP62806.
PhosphoSitePlusiP62806.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060093.
CleanExiMM_HIST1H4A.
MM_HIST1H4B.
MM_HIST1H4C.
MM_HIST1H4D.
MM_HIST1H4F.
MM_HIST1H4H.
MM_HIST1H4I.
MM_HIST1H4J.
MM_HIST1H4K.
MM_HIST1H4M.
MM_HIST2H4.
MM_HIST4H4.
ExpressionAtlasiP62806. baseline and differential.
GenevisibleiP62806. MM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Atad2Q8CDM12EBI-299632,EBI-2944582
Mgea5Q9EQQ92EBI-299632,EBI-8321615

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213404. 1 interactor.
220610. 5 interactors.
235074. 1 interactor.
235075. 1 interactor.
235079. 1 interactor.
235942. 10 interactors.
236472. 3 interactors.
236473. 1 interactor.
DIPiDIP-45837N.
IntActiP62806. 12 interactors.
MINTiMINT-1866189.
STRINGi10090.ENSMUSP00000136357.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi26 – 29Combined sources4
Helixi32 – 41Combined sources10
Helixi51 – 76Combined sources26
Beta strandi80 – 82Combined sources3
Helixi84 – 93Combined sources10
Beta strandi98 – 101Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F66X-ray2.60B/F1-103[»]
1U35X-ray3.00B/F1-103[»]
2WP2X-ray2.37P/Q2-21[»]
4AU7X-ray2.07C18-25[»]
4DOWX-ray1.95C/D15-26[»]
ProteinModelPortaliP62806.
SMRiP62806.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62806.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOVERGENiHBG051878.
InParanoidiP62806.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62806.

Family and domain databases

CDDicd00076. H4. 1 hit.
Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
IPR004823. TAF_TATA-bd.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
SM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:January 23, 2007 - v2
Checksum:iA9E5DFD3F8B97598
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → V in BAB26692 (PubMed:16141072).Curated1
Sequence conflicti80K → E in BAB27698 (PubMed:16141072).Curated1
Sequence conflicti90A → R in CAA31622 (PubMed:2915930).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00753 Genomic DNA. Translation: CAA24130.1.
X13235 Genomic DNA. Translation: CAA31621.1.
X13236 Genomic DNA. Translation: CAA31622.1.
U62672 Genomic DNA. Translation: AAB04766.1.
Y12290 Genomic DNA. Translation: CAA72967.1.
AY158956 Genomic DNA. Translation: AAO06266.1.
AY158957 Genomic DNA. Translation: AAO06267.1.
AY158958 Genomic DNA. Translation: AAO06268.1.
AY158959 Genomic DNA. Translation: AAO06269.1.
AY158960 Genomic DNA. Translation: AAO06270.1.
AY158961 Genomic DNA. Translation: AAO06271.1.
AY158962 Genomic DNA. Translation: AAO06272.1.
AY158963 Genomic DNA. Translation: AAO06273.1.
AY158964 Genomic DNA. Translation: AAO06274.1.
AY158965 Genomic DNA. Translation: AAO06275.1.
AY158966 Genomic DNA. Translation: AAO06276.1.
AY158967 Genomic DNA. Translation: AAO06277.1.
AK007642 mRNA. Translation: BAB25157.1.
AK010085 mRNA. Translation: BAB26692.1.
AK011560 mRNA. Translation: BAB27698.1.
AK139521 mRNA. Translation: BAE24047.1.
AL589651 Genomic DNA. Translation: CAI24108.1.
AL589651 Genomic DNA. Translation: CAI24109.1.
AL590388 Genomic DNA. Translation: CAI25838.1.
AL590388 Genomic DNA. Translation: CAI25839.1.
AL590614 Genomic DNA. Translation: CAI26128.1.
BC028550 mRNA. Translation: AAH28550.3.
BC052219 mRNA. No translation available.
BC057955 mRNA. Translation: AAH57955.1.
BC058529 mRNA. Translation: AAH58529.2.
BC087952 mRNA. Translation: AAH87952.1.
BC092144 mRNA. Translation: AAH92144.1.
BC115446 mRNA. Translation: AAI15447.1.
BC115447 mRNA. Translation: AAI15448.1.
BC115451 mRNA. Translation: AAI15452.1.
BC115448 mRNA. Translation: AAI15449.1.
BC115449 mRNA. Translation: AAI15450.1.
BC115450 mRNA. Translation: AAI15451.1.
BC117010 mRNA. Translation: AAI17011.1.
BC117012 mRNA. Translation: AAI17013.1.
BC111813 mRNA. Translation: AAI11814.1.
BC119241 mRNA. Translation: AAI19242.1.
BC119243 mRNA. Translation: AAI19244.1.
BC119611 mRNA. Translation: AAI19612.1.
BC119612 mRNA. Translation: AAI19613.1.
BC125598 mRNA. Translation: AAI25599.1.
BC125600 mRNA. Translation: AAI25601.1.
BC132186 mRNA. Translation: AAI32187.1.
BC132212 mRNA. Translation: AAI32213.1.
BC139809 mRNA. Translation: AAI39810.1.
BC152397 mRNA. Translation: AAI52398.1.
CCDSiCCDS26291.1.
CCDS26292.1.
CCDS26300.1.
CCDS26306.1.
CCDS26340.1.
CCDS26345.1.
CCDS26353.1.
CCDS26359.1.
CCDS26366.1.
CCDS26367.1.
CCDS39684.1.
CCDS51002.1.
PIRiS03426.
S03427.
RefSeqiNP_001182350.1. NM_001195421.1.
NP_291074.1. NM_033596.3.
NP_694813.1. NM_153173.4.
NP_783583.1. NM_175652.3.
NP_783585.1. NM_175654.2.
NP_783586.1. NM_175655.2.
NP_783587.1. NM_175656.3.
NP_783588.1. NM_175657.2.
NP_835499.1. NM_178192.2.
NP_835500.1. NM_178193.2.
NP_835515.1. NM_178208.2.
NP_835582.1. NM_178210.2.
NP_835583.1. NM_178211.2.
UniGeneiMm.14775.
Mm.158272.
Mm.227295.
Mm.228709.
Mm.246720.
Mm.255646.
Mm.260530.
Mm.261642.
Mm.261662.
Mm.261664.
Mm.442307.
Mm.486099.

Genome annotation databases

EnsembliENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455.
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093.
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266.
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678.
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482.
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274.
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981.
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639.
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305.
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288.
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306.
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405.
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010.
GeneIDi100041230.
319155.
319156.
319157.
319158.
319159.
319160.
319161.
320332.
326619.
326620.
69386.
97122.
KEGGimmu:100041230.
mmu:319155.
mmu:319156.
mmu:319157.
mmu:319158.
mmu:319159.
mmu:319160.
mmu:319161.
mmu:320332.
mmu:326619.
mmu:326620.
mmu:69386.
mmu:97122.
UCSCiuc007pre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00753 Genomic DNA. Translation: CAA24130.1.
X13235 Genomic DNA. Translation: CAA31621.1.
X13236 Genomic DNA. Translation: CAA31622.1.
U62672 Genomic DNA. Translation: AAB04766.1.
Y12290 Genomic DNA. Translation: CAA72967.1.
AY158956 Genomic DNA. Translation: AAO06266.1.
AY158957 Genomic DNA. Translation: AAO06267.1.
AY158958 Genomic DNA. Translation: AAO06268.1.
AY158959 Genomic DNA. Translation: AAO06269.1.
AY158960 Genomic DNA. Translation: AAO06270.1.
AY158961 Genomic DNA. Translation: AAO06271.1.
AY158962 Genomic DNA. Translation: AAO06272.1.
AY158963 Genomic DNA. Translation: AAO06273.1.
AY158964 Genomic DNA. Translation: AAO06274.1.
AY158965 Genomic DNA. Translation: AAO06275.1.
AY158966 Genomic DNA. Translation: AAO06276.1.
AY158967 Genomic DNA. Translation: AAO06277.1.
AK007642 mRNA. Translation: BAB25157.1.
AK010085 mRNA. Translation: BAB26692.1.
AK011560 mRNA. Translation: BAB27698.1.
AK139521 mRNA. Translation: BAE24047.1.
AL589651 Genomic DNA. Translation: CAI24108.1.
AL589651 Genomic DNA. Translation: CAI24109.1.
AL590388 Genomic DNA. Translation: CAI25838.1.
AL590388 Genomic DNA. Translation: CAI25839.1.
AL590614 Genomic DNA. Translation: CAI26128.1.
BC028550 mRNA. Translation: AAH28550.3.
BC052219 mRNA. No translation available.
BC057955 mRNA. Translation: AAH57955.1.
BC058529 mRNA. Translation: AAH58529.2.
BC087952 mRNA. Translation: AAH87952.1.
BC092144 mRNA. Translation: AAH92144.1.
BC115446 mRNA. Translation: AAI15447.1.
BC115447 mRNA. Translation: AAI15448.1.
BC115451 mRNA. Translation: AAI15452.1.
BC115448 mRNA. Translation: AAI15449.1.
BC115449 mRNA. Translation: AAI15450.1.
BC115450 mRNA. Translation: AAI15451.1.
BC117010 mRNA. Translation: AAI17011.1.
BC117012 mRNA. Translation: AAI17013.1.
BC111813 mRNA. Translation: AAI11814.1.
BC119241 mRNA. Translation: AAI19242.1.
BC119243 mRNA. Translation: AAI19244.1.
BC119611 mRNA. Translation: AAI19612.1.
BC119612 mRNA. Translation: AAI19613.1.
BC125598 mRNA. Translation: AAI25599.1.
BC125600 mRNA. Translation: AAI25601.1.
BC132186 mRNA. Translation: AAI32187.1.
BC132212 mRNA. Translation: AAI32213.1.
BC139809 mRNA. Translation: AAI39810.1.
BC152397 mRNA. Translation: AAI52398.1.
CCDSiCCDS26291.1.
CCDS26292.1.
CCDS26300.1.
CCDS26306.1.
CCDS26340.1.
CCDS26345.1.
CCDS26353.1.
CCDS26359.1.
CCDS26366.1.
CCDS26367.1.
CCDS39684.1.
CCDS51002.1.
PIRiS03426.
S03427.
RefSeqiNP_001182350.1. NM_001195421.1.
NP_291074.1. NM_033596.3.
NP_694813.1. NM_153173.4.
NP_783583.1. NM_175652.3.
NP_783585.1. NM_175654.2.
NP_783586.1. NM_175655.2.
NP_783587.1. NM_175656.3.
NP_783588.1. NM_175657.2.
NP_835499.1. NM_178192.2.
NP_835500.1. NM_178193.2.
NP_835515.1. NM_178208.2.
NP_835582.1. NM_178210.2.
NP_835583.1. NM_178211.2.
UniGeneiMm.14775.
Mm.158272.
Mm.227295.
Mm.228709.
Mm.246720.
Mm.255646.
Mm.260530.
Mm.261642.
Mm.261662.
Mm.261664.
Mm.442307.
Mm.486099.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F66X-ray2.60B/F1-103[»]
1U35X-ray3.00B/F1-103[»]
2WP2X-ray2.37P/Q2-21[»]
4AU7X-ray2.07C18-25[»]
4DOWX-ray1.95C/D15-26[»]
ProteinModelPortaliP62806.
SMRiP62806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213404. 1 interactor.
220610. 5 interactors.
235074. 1 interactor.
235075. 1 interactor.
235079. 1 interactor.
235942. 10 interactors.
236472. 3 interactors.
236473. 1 interactor.
DIPiDIP-45837N.
IntActiP62806. 12 interactors.
MINTiMINT-1866189.
STRINGi10090.ENSMUSP00000136357.

PTM databases

iPTMnetiP62806.
PhosphoSitePlusiP62806.

Proteomic databases

EPDiP62806.
MaxQBiP62806.
PaxDbiP62806.
PRIDEiP62806.
TopDownProteomicsiP62806.

Protocols and materials databases

DNASUi319156.
319157.
319159.
320332.
326620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455.
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093.
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266.
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678.
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482.
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274.
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981.
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639.
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305.
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288.
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306.
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405.
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010.
GeneIDi100041230.
319155.
319156.
319157.
319158.
319159.
319160.
319161.
320332.
326619.
326620.
69386.
97122.
KEGGimmu:100041230.
mmu:319155.
mmu:319156.
mmu:319157.
mmu:319158.
mmu:319159.
mmu:319160.
mmu:319161.
mmu:320332.
mmu:326619.
mmu:326620.
mmu:69386.
mmu:97122.
UCSCiuc007pre.1. mouse.

Organism-specific databases

CTDi100041230.
121504.
319161.
8294.
8359.
8360.
8361.
8362.
8363.
8364.
8365.
8366.
97122.
MGIiMGI:2448419. Hist1h4a.
MGI:2448420. Hist1h4b.
MGI:2448421. Hist1h4c.
MGI:2448423. Hist1h4d.
MGI:2448425. Hist1h4f.
MGI:2448427. Hist1h4h.
MGI:2448432. Hist1h4i.
MGI:2448436. Hist1h4j.
MGI:2448439. Hist1h4k.
MGI:2448441. Hist1h4m.
MGI:2140113. Hist2h4.
MGI:2448443. Hist4h4.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOVERGENiHBG051878.
InParanoidiP62806.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62806.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-2299718. Condensation of Prophase Chromosomes.
R-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-3214841. PKMTs methylate histone lysines.
R-MMU-3214842. HDMs demethylate histones.
R-MMU-3214847. HATs acetylate histones.
R-MMU-3214858. RMTs methylate histone arginines.
R-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-69473. G2/M DNA damage checkpoint.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-912497. Meiotic Recombination.

Miscellaneous databases

EvolutionaryTraceiP62806.
PROiP62806.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060093.
CleanExiMM_HIST1H4A.
MM_HIST1H4B.
MM_HIST1H4C.
MM_HIST1H4D.
MM_HIST1H4F.
MM_HIST1H4H.
MM_HIST1H4I.
MM_HIST1H4J.
MM_HIST1H4K.
MM_HIST1H4M.
MM_HIST2H4.
MM_HIST4H4.
ExpressionAtlasiP62806. baseline and differential.
GenevisibleiP62806. MM.

Family and domain databases

CDDicd00076. H4. 1 hit.
Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
IPR004823. TAF_TATA-bd.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
SM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH4_MOUSE
AccessioniPrimary (citable) accession number: P62806
Secondary accession number(s): A0AUM5
, A4FUP8, A4QMY0, P02304, P02305, Q0VDL9, Q2M2Q5, Q5T006, Q6PDS7, Q811M0, Q9D0C9, Q9D6Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.