##gff-version 3 P62805 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17967882;Dbxref=PMID:17967882 P62805 UniProtKB Chain 2 103 . . . ID=PRO_0000158320;Note=Histone H4 P62805 UniProtKB DNA binding 17 21 . . . . P62805 UniProtKB Region 1 20 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P62805 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17967882;Dbxref=PMID:17967882 P62805 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17967882;Dbxref=PMID:17967882 P62805 UniProtKB Modified residue 4 4 . . . Note=Asymmetric dimethylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11387442,ECO:0000269|PubMed:11448779,ECO:0000269|PubMed:15345777;Dbxref=PMID:11387442,PMID:11448779,PMID:15345777 P62805 UniProtKB Modified residue 4 4 . . . Note=Citrulline%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15345777,ECO:0000269|PubMed:16567635;Dbxref=PMID:15345777,PMID:16567635 P62805 UniProtKB Modified residue 4 4 . . . Note=Omega-N-methylarginine%3B by PRMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11387442,ECO:0000269|PubMed:11448779,ECO:0000269|PubMed:15345777;Dbxref=PMID:11387442,PMID:11448779,PMID:15345777 P62805 UniProtKB Modified residue 4 4 . . . Note=Symmetric dimethylarginine%3B by PRMT5 and PRMT7%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62806 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-acetyl-N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37731000;Dbxref=PMID:37731000 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:2474456,ECO:0000269|PubMed:7664735,ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861,PMID:2474456,PMID:7664735 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105113;Dbxref=PMID:27105113 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-crotonyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21925322;Dbxref=PMID:21925322 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 6 6 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-(beta-hydroxybutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105115;Dbxref=PMID:27105115 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:2474456,ECO:0000269|PubMed:7664735,ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861,PMID:2474456,PMID:7664735 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17267393,ECO:0000269|PubMed:27105113;Dbxref=PMID:17267393,PMID:27105113 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-crotonyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21925322,ECO:0000269|PubMed:28497810;Dbxref=PMID:21925322,PMID:28497810 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 9 9 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-(beta-hydroxybutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105115;Dbxref=PMID:27105115 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-acetyl-N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37731000;Dbxref=PMID:37731000 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:17967882,ECO:0000269|PubMed:2474456,ECO:0000269|PubMed:7664735,ECO:0007744|PubMed:19608861;Dbxref=PMID:17967882,PMID:19608861,PMID:2474456,PMID:7664735 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105113;Dbxref=PMID:27105113 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-crotonyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21925322,ECO:0000269|PubMed:28497810;Dbxref=PMID:21925322,PMID:28497810 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31061526;Dbxref=PMID:31061526 P62805 UniProtKB Modified residue 13 13 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22389435;Dbxref=PMID:22389435 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:17967882,ECO:0000269|PubMed:2474456,ECO:0000269|PubMed:7664735,ECO:0007744|PubMed:19608861;Dbxref=PMID:17967882,PMID:19608861,PMID:2474456,PMID:7664735 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17267393,ECO:0000269|PubMed:27105113;Dbxref=PMID:17267393,PMID:27105113 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-crotonyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62806 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 17 17 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 21 21 . . . Note=N6%2CN6%2CN6-trimethyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12086618,ECO:0000269|PubMed:15964846,ECO:0000269|PubMed:17967882;Dbxref=PMID:12086618,PMID:15964846,PMID:17967882 P62805 UniProtKB Modified residue 21 21 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12086618,ECO:0000269|PubMed:15964846,ECO:0000269|PubMed:17967882;Dbxref=PMID:12086618,PMID:15964846,PMID:17967882 P62805 UniProtKB Modified residue 21 21 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12086618,ECO:0000269|PubMed:15964846,ECO:0000269|PubMed:17967882,ECO:0000269|PubMed:27338793;Dbxref=PMID:12086618,PMID:15964846,PMID:17967882,PMID:27338793 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-(beta-hydroxybutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105115;Dbxref=PMID:27105115 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 32 32 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22389435;Dbxref=PMID:22389435 P62805 UniProtKB Modified residue 45 45 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 45 45 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 45 45 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 48 48 . . . Note=Phosphoserine%3B by PAK2;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:21724829,ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:21724829,PMID:23186163,PMID:24275569 P62805 UniProtKB Modified residue 52 52 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:15592455,ECO:0007744|PubMed:20068231;Dbxref=PMID:15592455,PMID:20068231 P62805 UniProtKB Modified residue 60 60 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 60 60 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-(beta-hydroxybutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105115;Dbxref=PMID:27105115 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 78 78 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22389435;Dbxref=PMID:22389435 P62805 UniProtKB Modified residue 80 80 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 80 80 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 80 80 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 80 80 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 80 80 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62806 P62805 UniProtKB Modified residue 81 81 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62806 P62805 UniProtKB Modified residue 89 89 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-(2-hydroxyisobutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24681537;Dbxref=PMID:24681537 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-(beta-hydroxybutyryl)lysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27105115;Dbxref=PMID:27105115 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19818714;Dbxref=PMID:19818714 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-butyryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-glutaryllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31542297;Dbxref=PMID:31542297 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-lactoyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645732;Dbxref=PMID:31645732 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-propionyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267393;Dbxref=PMID:17267393 P62805 UniProtKB Modified residue 92 92 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22389435;Dbxref=PMID:22389435 P62805 UniProtKB Cross-link 13 13 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25218447;Dbxref=PMID:25218447 P62805 UniProtKB Cross-link 21 21 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P62805 UniProtKB Cross-link 32 32 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P62805 UniProtKB Cross-link 32 32 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30886146;Dbxref=PMID:30886146 P62805 UniProtKB Cross-link 60 60 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P62805 UniProtKB Cross-link 80 80 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P62805 UniProtKB Cross-link 92 92 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P62805 UniProtKB Cross-link 92 92 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19818714;Dbxref=PMID:19818714 P62805 UniProtKB Natural variant 32 32 . . . ID=VAR_086990;Note=In TEBIVANED3%3B results in early developmental defects when expressed in zebrafish embryos. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 33 33 . . . ID=VAR_086991;Note=In TEBIVANED1. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 33 33 . . . ID=VAR_086992;Note=In TEBIVANED1. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 33 33 . . . ID=VAR_086993;Note=In TEBIVANED3%3B results in early developmental defects when expressed in zebrafish embryos. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 36 36 . . . ID=VAR_086994;Note=In TEBIVANED3%3B results in early developmental defects when expressed in zebrafish embryos. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 38 38 . . . ID=VAR_086995;Note=In TEBIVANED3%3B results in early developmental defects when expressed in zebrafish embryos. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 41 41 . . . ID=VAR_086996;Note=In TEBIVANED2 and TEBIVANED3%3B uncertain significance%3B does not affect early development when expressed in zebrafish embryos. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 41 41 . . . ID=VAR_086997;Note=Found in a patient with a neurodevelopmental disorder%3B uncertain significance%3B results in early developmental defects when expressed in zebrafish embryos. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 41 41 . . . ID=VAR_086998;Note=In TEBIVANED4%3B results in early developmental defects when expressed in zebrafish embryos. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 46 46 . . . ID=VAR_086999;Note=In TEBIVANED3. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 64 64 . . . ID=VAR_036206;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs747622981,PMID:16959974 P62805 UniProtKB Natural variant 76 76 . . . ID=VAR_087000;Note=In TEBIVANED4%3B results in severe early developmental defects when expressed in zebrafish embryos. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 92 92 . . . ID=VAR_087001;Note=In TEBIVANED2%3B results in severe early developmental defects when expressed in zebrafish embryos. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31804630;Dbxref=PMID:31804630 P62805 UniProtKB Natural variant 92 92 . . . ID=VAR_087002;Note=In TEBIVANED1%3B results in severe early developmental defects when expressed in zebrafish embryos%3B results in defective cell cycle progression when expressed in zebrafish embryos. K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28920961,ECO:0000269|PubMed:35202563;Dbxref=PMID:28920961,PMID:35202563 P62805 UniProtKB Natural variant 92 92 . . . ID=VAR_087003;Note=In TEBIVANED1%3B results in severe early developmental defects when expressed in zebrafish embryos%3B results in defective cell cycle progression when expressed in zebrafish embryos. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28920961;Dbxref=PMID:28920961 P62805 UniProtKB Natural variant 95 95 . . . ID=VAR_087004;Note=Found in a patient with a neurodevelopmental disorder%3B uncertain significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Natural variant 99 99 . . . ID=VAR_087005;Note=In TEBIVANED3%3B results in early developmental defects when expressed in zebrafish embryos. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35202563;Dbxref=PMID:35202563 P62805 UniProtKB Mutagenesis 13 13 . . . Note=Impaired methylation by N6AMT1. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31061526;Dbxref=PMID:31061526 P62805 UniProtKB Mutagenesis 32 32 . . . Note=Abolished ufmylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30886146;Dbxref=PMID:30886146 P62805 UniProtKB Sequence conflict 71 71 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P62805 UniProtKB Sequence conflict 77 77 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P62805 UniProtKB Turn 7 10 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YYM P62805 UniProtKB Beta strand 16 18 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6MLC P62805 UniProtKB Beta strand 21 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F9X P62805 UniProtKB Helix 26 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CIZ P62805 UniProtKB Helix 32 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CIZ P62805 UniProtKB Beta strand 45 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6KE9 P62805 UniProtKB Helix 51 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CIZ P62805 UniProtKB Beta strand 79 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CIZ P62805 UniProtKB Helix 84 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CIZ P62805 UniProtKB Turn 99 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H9O