P62795 (H4_PLADU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Histone H4
Organism	Platynereis dumerilii (Dumeril's clam worm)
Taxonomic identifier	6359 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Annelida › Polychaeta › Palpata › Aciculata › Phyllodocida › Nereididae › Platynereis

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subunit structure	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the histone H4 family.

Ontologies

Keywords
Cellular component	Chromosome Nucleosome core Nucleus
Ligand	DNA-binding
PTM	Acetylation Methylation
Gene Ontology (GO)
Biological_process	nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 103	102	Histone H4		PRO_0000158351
Regions
	DNA binding	17 – 21	5
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	6	1	N6-acetyllysine By similarity
	Modified residue	9	1	N6-acetyllysine By similarity
	Modified residue	13	1	N6-acetyllysine By similarity
	Modified residue	17	1	N6-acetyllysine By similarity
	Modified residue	21	1	N6-methylated lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62795 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A9E5DFD3F8B97598	FASTA	103	11,367
	10 20 30 40 50 60 MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK 70 80 90 100 VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG

References

[1]	"Organization and complete nucleotide sequence of the core-histone-gene cluster of the annelid Platynereis dumerilii." Sellos D., Krawetz S.A., Dixon G.H. Eur. J. Biochem. 190:21-29(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Sperm.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53330 Genomic DNA. Translation: CAA37414.1.
3D structure databases
ProteinModelPortal	P62795.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62795. 2 interactions.
Proteomic databases
PRIDE	P62795.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.20.10. 1 hit.
InterPro	IPR009072. Histone-fold. IPR007125. Histone_core_D. IPR001951. Histone_H4. IPR019809. Histone_H4_CS. [Graphical view]
PANTHER	PTHR10484. PTHR10484. 1 hit.
Pfam	PF00125. Histone. 1 hit. [Graphical view]
PRINTS	PR00623. HISTONEH4.
SMART	SM00417. H4. 1 hit. [Graphical view]
SUPFAM	SSF47113. Histone-fold. 1 hit.
PROSITE	PS00047. HISTONE_H4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H4_PLADU

Accession

Primary (citable) accession number: P62795
Secondary accession number(s): P02304, P02305

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)