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Protein

Histone H4

Gene

his-1

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:his-1
ORF Names:T10C6.14
AND
Name:his-5
ORF Names:F45F2.3
AND
Name:his-10
ORF Names:ZK131.4
AND
Name:his-14
ORF Names:ZK131.8
AND
Name:his-18
ORF Names:K06C4.10
AND
Name:his-26
ORF Names:ZK131.1
AND
Name:his-28
ORF Names:K06C4.2
AND
Name:his-31
ORF Names:F17E9.12
AND
Name:his-37
ORF Names:C50F4.7
AND
Name:his-38
ORF Names:K03A1.6
AND
Name:his-46
ORF Names:B0035.9
AND
Name:his-50
ORF Names:F07B7.9
AND
Name:his-56
ORF Names:F54E12.3
AND
Name:his-60
ORF Names:F55G1.11
AND
Name:his-64
ORF Names:F22B3.1
AND
Name:his-67
ORF Names:T23D8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V, Chromosome X

Organism-specific databases

WormBaseiB0035.9; CE03252; WBGene00001920; his-46.
C50F4.7; CE03252; WBGene00001911; his-37.
F07B7.9; CE03252; WBGene00001924; his-50.
F17E9.12; CE03252; WBGene00001905; his-31.
F22B3.1; CE03252; WBGene00001938; his-64.
F45F2.3; CE03252; WBGene00001879; his-5.
F54E12.3; CE03252; WBGene00001930; his-56.
F55G1.11; CE03252; WBGene00001934; his-60.
K03A1.6; CE03252; WBGene00001912; his-38.
K06C4.10; CE03252; WBGene00001892; his-18.
K06C4.2; CE03252; WBGene00001902; his-28.
T10C6.14; CE03252; WBGene00001875; his-1.
T23D8.5; CE03252; WBGene00001941; his-67.
ZK131.1; CE03252; WBGene00001900; his-26.
ZK131.4; CE03252; WBGene00001884; his-10.
ZK131.8; CE03252; WBGene00001888; his-14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 103102Histone H4PRO_0000158290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei17 – 171N6-acetyllysineBy similarity
Modified residuei21 – 211N6-methyllysine1 Publication

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP62784.
PaxDbiP62784.
PRIDEiP62784.

Expressioni

Gene expression databases

BgeeiWBGene00001875.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi43149. 1 interaction.
44273. 1 interaction.
44379. 2 interactions.
53446. 1 interaction.
56168. 1 interaction.
56177. 1 interaction.
IntActiP62784. 2 interactions.
STRINGi6239.ZK131.8.

Structurei

3D structure databases

ProteinModelPortaliP62784.
SMRiP62784. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
InParanoidiP62784.
KOiK11254.
OMAiVMDVVYA.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62784.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,369
Last modified:January 23, 2007 - v2
Checksum:iA9E5DFD3F8AF04FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31G → E AA sequence (PubMed:3665432).Curated
Sequence conflicti29 – 291Missing AA sequence (PubMed:3665432).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA. Translation: CAA33643.1.
FO081018 Genomic DNA. Translation: CCD68533.1.
FO081059 Genomic DNA. Translation: CCD68871.1.
FO081135 Genomic DNA. Translation: CCD69398.1.
FO081223 Genomic DNA. Translation: CCD70020.1.
FO081551 Genomic DNA. Translation: CCD72360.1.
FO081551 Genomic DNA. Translation: CCD72370.1.
FO081579 Genomic DNA. Translation: CCD72542.1.
Z68336 Genomic DNA. Translation: CAA92734.1.
Z70750 Genomic DNA. Translation: CAA94742.1.
Z73102 Genomic DNA. Translation: CAA97407.1.
Z81128 Genomic DNA. Translation: CAB03396.1.
Z82271 Genomic DNA. Translation: CAB05210.1.
Z83245 Genomic DNA. Translation: CAB05835.4.
Z83245 Genomic DNA. Translation: CAB05837.1.
Z83245 Genomic DNA. Translation: CAB05839.1.
Z93388 Genomic DNA. Translation: CAB07657.1.
PIRiJS0314.
S04240.
T27741.
T29230.
RefSeqiNP_492641.1. NM_060240.4.
NP_496889.1. NM_064488.1.
NP_496893.1. NM_064492.1.
NP_496896.1. NM_064495.1.
NP_501203.2. NM_068802.5.
NP_501406.1. NM_069005.1.
NP_502133.1. NM_069732.1.
NP_502139.1. NM_069738.1.
NP_502154.1. NM_069753.3.
NP_505200.1. NM_072799.3.
NP_505275.1. NM_072874.1.
NP_505291.1. NM_072890.1.
NP_505298.1. NM_072897.4.
NP_505466.1. NM_073065.6.
NP_507034.1. NM_074633.1.
NP_509231.1. NM_076830.1.
UniGeneiCel.12858.
Cel.12870.
Cel.17998.
Cel.21434.
Cel.24406.
Cel.24432.
Cel.25563.
Cel.28726.
Cel.28998.
Cel.29185.
Cel.29404.
Cel.32620.
Cel.32860.
Cel.33123.
Cel.770.

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920.
C50F4.7; C50F4.7; WBGene00001911.
F07B7.9; F07B7.9; WBGene00001924.
F17E9.12; F17E9.12; WBGene00001905.
F22B3.1; F22B3.1; WBGene00001938.
F45F2.3; F45F2.3; WBGene00001879.
F54E12.3; F54E12.3; WBGene00001930.
F55G1.11; F55G1.11; WBGene00001934.
K03A1.6; K03A1.6; WBGene00001912.
K06C4.10; K06C4.10; WBGene00001892.
K06C4.2; K06C4.2; WBGene00001902.
T10C6.14; T10C6.14; WBGene00001875.
T23D8.5; T23D8.5; WBGene00001941.
ZK131.1; ZK131.1; WBGene00001900.
ZK131.4; ZK131.4; WBGene00001884.
ZK131.8; ZK131.8; WBGene00001888.
GeneIDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
KEGGicel:CELE_B0035.9.
cel:CELE_C50F4.7.
cel:CELE_F07B7.9.
cel:CELE_F17E9.12.
cel:CELE_F22B3.1.
cel:CELE_F45F2.3.
cel:CELE_F54E12.3.
cel:CELE_F55G1.11.
cel:CELE_K03A1.6.
cel:CELE_K06C4.10.
cel:CELE_K06C4.2.
cel:CELE_T10C6.14.
cel:CELE_T23D8.5.
cel:CELE_ZK131.1.
cel:CELE_ZK131.4.
cel:CELE_ZK131.8.
UCSCiT23D8.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA. Translation: CAA33643.1.
FO081018 Genomic DNA. Translation: CCD68533.1.
FO081059 Genomic DNA. Translation: CCD68871.1.
FO081135 Genomic DNA. Translation: CCD69398.1.
FO081223 Genomic DNA. Translation: CCD70020.1.
FO081551 Genomic DNA. Translation: CCD72360.1.
FO081551 Genomic DNA. Translation: CCD72370.1.
FO081579 Genomic DNA. Translation: CCD72542.1.
Z68336 Genomic DNA. Translation: CAA92734.1.
Z70750 Genomic DNA. Translation: CAA94742.1.
Z73102 Genomic DNA. Translation: CAA97407.1.
Z81128 Genomic DNA. Translation: CAB03396.1.
Z82271 Genomic DNA. Translation: CAB05210.1.
Z83245 Genomic DNA. Translation: CAB05835.4.
Z83245 Genomic DNA. Translation: CAB05837.1.
Z83245 Genomic DNA. Translation: CAB05839.1.
Z93388 Genomic DNA. Translation: CAB07657.1.
PIRiJS0314.
S04240.
T27741.
T29230.
RefSeqiNP_492641.1. NM_060240.4.
NP_496889.1. NM_064488.1.
NP_496893.1. NM_064492.1.
NP_496896.1. NM_064495.1.
NP_501203.2. NM_068802.5.
NP_501406.1. NM_069005.1.
NP_502133.1. NM_069732.1.
NP_502139.1. NM_069738.1.
NP_502154.1. NM_069753.3.
NP_505200.1. NM_072799.3.
NP_505275.1. NM_072874.1.
NP_505291.1. NM_072890.1.
NP_505298.1. NM_072897.4.
NP_505466.1. NM_073065.6.
NP_507034.1. NM_074633.1.
NP_509231.1. NM_076830.1.
UniGeneiCel.12858.
Cel.12870.
Cel.17998.
Cel.21434.
Cel.24406.
Cel.24432.
Cel.25563.
Cel.28726.
Cel.28998.
Cel.29185.
Cel.29404.
Cel.32620.
Cel.32860.
Cel.33123.
Cel.770.

3D structure databases

ProteinModelPortaliP62784.
SMRiP62784. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43149. 1 interaction.
44273. 1 interaction.
44379. 2 interactions.
53446. 1 interaction.
56168. 1 interaction.
56177. 1 interaction.
IntActiP62784. 2 interactions.
STRINGi6239.ZK131.8.

Proteomic databases

EPDiP62784.
PaxDbiP62784.
PRIDEiP62784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920.
C50F4.7; C50F4.7; WBGene00001911.
F07B7.9; F07B7.9; WBGene00001924.
F17E9.12; F17E9.12; WBGene00001905.
F22B3.1; F22B3.1; WBGene00001938.
F45F2.3; F45F2.3; WBGene00001879.
F54E12.3; F54E12.3; WBGene00001930.
F55G1.11; F55G1.11; WBGene00001934.
K03A1.6; K03A1.6; WBGene00001912.
K06C4.10; K06C4.10; WBGene00001892.
K06C4.2; K06C4.2; WBGene00001902.
T10C6.14; T10C6.14; WBGene00001875.
T23D8.5; T23D8.5; WBGene00001941.
ZK131.1; ZK131.1; WBGene00001900.
ZK131.4; ZK131.4; WBGene00001884.
ZK131.8; ZK131.8; WBGene00001888.
GeneIDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
KEGGicel:CELE_B0035.9.
cel:CELE_C50F4.7.
cel:CELE_F07B7.9.
cel:CELE_F17E9.12.
cel:CELE_F22B3.1.
cel:CELE_F45F2.3.
cel:CELE_F54E12.3.
cel:CELE_F55G1.11.
cel:CELE_K03A1.6.
cel:CELE_K06C4.10.
cel:CELE_K06C4.2.
cel:CELE_T10C6.14.
cel:CELE_T23D8.5.
cel:CELE_ZK131.1.
cel:CELE_ZK131.4.
cel:CELE_ZK131.8.
UCSCiT23D8.5. c. elegans.

Organism-specific databases

CTDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
WormBaseiB0035.9; CE03252; WBGene00001920; his-46.
C50F4.7; CE03252; WBGene00001911; his-37.
F07B7.9; CE03252; WBGene00001924; his-50.
F17E9.12; CE03252; WBGene00001905; his-31.
F22B3.1; CE03252; WBGene00001938; his-64.
F45F2.3; CE03252; WBGene00001879; his-5.
F54E12.3; CE03252; WBGene00001930; his-56.
F55G1.11; CE03252; WBGene00001934; his-60.
K03A1.6; CE03252; WBGene00001912; his-38.
K06C4.10; CE03252; WBGene00001892; his-18.
K06C4.2; CE03252; WBGene00001902; his-28.
T10C6.14; CE03252; WBGene00001875; his-1.
T23D8.5; CE03252; WBGene00001941; his-67.
ZK131.1; CE03252; WBGene00001900; his-26.
ZK131.4; CE03252; WBGene00001884; his-10.
ZK131.8; CE03252; WBGene00001888; his-14.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
InParanoidiP62784.
KOiK11254.
OMAiVMDVVYA.
OrthoDBiEOG091G0XGD.
PhylomeDBiP62784.

Miscellaneous databases

PROiP62784.

Gene expression databases

BgeeiWBGene00001875.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH4_CAEEL
AccessioniPrimary (citable) accession number: P62784
Secondary accession number(s): O02619
, P02306, P18678, Q7JNV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.