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Protein

Histone H4

Gene

his-1

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-3214841. PKMTs methylate histone lysines.
R-CEL-3214842. HDMs demethylate histones.
R-CEL-3214847. HATs acetylate histones.
R-CEL-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:his-1
ORF Names:T10C6.14
AND
Name:his-5
ORF Names:F45F2.3
AND
Name:his-10
ORF Names:ZK131.4
AND
Name:his-14
ORF Names:ZK131.8
AND
Name:his-18
ORF Names:K06C4.10
AND
Name:his-26
ORF Names:ZK131.1
AND
Name:his-28
ORF Names:K06C4.2
AND
Name:his-31
ORF Names:F17E9.12
AND
Name:his-37
ORF Names:C50F4.7
AND
Name:his-38
ORF Names:K03A1.6
AND
Name:his-46
ORF Names:B0035.9
AND
Name:his-50
ORF Names:F07B7.9
AND
Name:his-56
ORF Names:F54E12.3
AND
Name:his-60
ORF Names:F55G1.11
AND
Name:his-64
ORF Names:F22B3.1
AND
Name:his-67
ORF Names:T23D8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V, Chromosome X

Organism-specific databases

WormBaseiB0035.9; CE03252; WBGene00001920; his-46.
C50F4.7; CE03252; WBGene00001911; his-37.
F07B7.9; CE03252; WBGene00001924; his-50.
F17E9.12; CE03252; WBGene00001905; his-31.
F22B3.1; CE03252; WBGene00001938; his-64.
F45F2.3; CE03252; WBGene00001879; his-5.
F54E12.3; CE03252; WBGene00001930; his-56.
F55G1.11; CE03252; WBGene00001934; his-60.
K03A1.6; CE03252; WBGene00001912; his-38.
K06C4.10; CE03252; WBGene00001892; his-18.
K06C4.2; CE03252; WBGene00001902; his-28.
T10C6.14; CE03252; WBGene00001875; his-1.
T23D8.5; CE03252; WBGene00001941; his-67.
ZK131.1; CE03252; WBGene00001900; his-26.
ZK131.4; CE03252; WBGene00001884; his-10.
ZK131.8; CE03252; WBGene00001888; his-14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 103102Histone H4PRO_0000158290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei17 – 171N6-acetyllysineBy similarity
Modified residuei21 – 211N6-methyllysine1 Publication

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP62784.
PaxDbiP62784.
PRIDEiP62784.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi43149. 1 interaction.
44273. 1 interaction.
44379. 2 interactions.
53446. 1 interaction.
56168. 1 interaction.
56177. 1 interaction.
IntActiP62784. 2 interactions.
STRINGi6239.ZK131.8.

Structurei

3D structure databases

ProteinModelPortaliP62784.
SMRiP62784. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
InParanoidiP62784.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG77T174.
PhylomeDBiP62784.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,369
Last modified:January 23, 2007 - v2
Checksum:iA9E5DFD3F8AF04FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31G → E AA sequence (PubMed:3665432).Curated
Sequence conflicti29 – 291Missing AA sequence (PubMed:3665432).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA. Translation: CAA33643.1.
FO081018 Genomic DNA. Translation: CCD68533.1.
FO081059 Genomic DNA. Translation: CCD68871.1.
FO081135 Genomic DNA. Translation: CCD69398.1.
FO081223 Genomic DNA. Translation: CCD70020.1.
FO081551 Genomic DNA. Translation: CCD72360.1.
FO081551 Genomic DNA. Translation: CCD72370.1.
FO081579 Genomic DNA. Translation: CCD72542.1.
Z68336 Genomic DNA. Translation: CAA92734.1.
Z70750 Genomic DNA. Translation: CAA94742.1.
Z73102 Genomic DNA. Translation: CAA97407.1.
Z81128 Genomic DNA. Translation: CAB03396.1.
Z82271 Genomic DNA. Translation: CAB05210.1.
Z83245 Genomic DNA. Translation: CAB05835.4.
Z83245 Genomic DNA. Translation: CAB05837.1.
Z83245 Genomic DNA. Translation: CAB05839.1.
Z93388 Genomic DNA. Translation: CAB07657.1.
PIRiJS0314.
S04240.
T27741.
T29230.
RefSeqiNP_492641.1. NM_060240.4.
NP_496889.1. NM_064488.1.
NP_496893.1. NM_064492.1.
NP_496896.1. NM_064495.1.
NP_501203.2. NM_068802.5.
NP_501406.1. NM_069005.1.
NP_502133.1. NM_069732.1.
NP_502139.1. NM_069738.1.
NP_502154.1. NM_069753.3.
NP_505200.1. NM_072799.3.
NP_505275.1. NM_072874.1.
NP_505291.1. NM_072890.1.
NP_505298.1. NM_072897.4.
NP_505466.1. NM_073065.6.
NP_507034.1. NM_074633.1.
NP_509231.1. NM_076830.1.
UniGeneiCel.12858.
Cel.12870.
Cel.17998.
Cel.21434.
Cel.24406.
Cel.24432.
Cel.25563.
Cel.28726.
Cel.28998.
Cel.29185.
Cel.29404.
Cel.32620.
Cel.32860.
Cel.33123.
Cel.770.

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920.
C50F4.7; C50F4.7; WBGene00001911.
F07B7.9; F07B7.9; WBGene00001924.
F17E9.12; F17E9.12; WBGene00001905.
F22B3.1; F22B3.1; WBGene00001938.
F45F2.3; F45F2.3; WBGene00001879.
F54E12.3; F54E12.3; WBGene00001930.
F55G1.11; F55G1.11; WBGene00001934.
K03A1.6; K03A1.6; WBGene00001912.
K06C4.10; K06C4.10; WBGene00001892.
K06C4.2; K06C4.2; WBGene00001902.
T10C6.14; T10C6.14; WBGene00001875.
T23D8.5; T23D8.5; WBGene00001941.
ZK131.1; ZK131.1; WBGene00001900.
ZK131.4; ZK131.4; WBGene00001884.
ZK131.8; ZK131.8; WBGene00001888.
GeneIDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
KEGGicel:CELE_B0035.9.
cel:CELE_C50F4.7.
cel:CELE_F07B7.9.
cel:CELE_F17E9.12.
cel:CELE_F22B3.1.
cel:CELE_F45F2.3.
cel:CELE_F54E12.3.
cel:CELE_F55G1.11.
cel:CELE_K03A1.6.
cel:CELE_K06C4.10.
cel:CELE_K06C4.2.
cel:CELE_T10C6.14.
cel:CELE_T23D8.5.
cel:CELE_ZK131.1.
cel:CELE_ZK131.4.
cel:CELE_ZK131.8.
UCSCiT23D8.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA. Translation: CAA33643.1.
FO081018 Genomic DNA. Translation: CCD68533.1.
FO081059 Genomic DNA. Translation: CCD68871.1.
FO081135 Genomic DNA. Translation: CCD69398.1.
FO081223 Genomic DNA. Translation: CCD70020.1.
FO081551 Genomic DNA. Translation: CCD72360.1.
FO081551 Genomic DNA. Translation: CCD72370.1.
FO081579 Genomic DNA. Translation: CCD72542.1.
Z68336 Genomic DNA. Translation: CAA92734.1.
Z70750 Genomic DNA. Translation: CAA94742.1.
Z73102 Genomic DNA. Translation: CAA97407.1.
Z81128 Genomic DNA. Translation: CAB03396.1.
Z82271 Genomic DNA. Translation: CAB05210.1.
Z83245 Genomic DNA. Translation: CAB05835.4.
Z83245 Genomic DNA. Translation: CAB05837.1.
Z83245 Genomic DNA. Translation: CAB05839.1.
Z93388 Genomic DNA. Translation: CAB07657.1.
PIRiJS0314.
S04240.
T27741.
T29230.
RefSeqiNP_492641.1. NM_060240.4.
NP_496889.1. NM_064488.1.
NP_496893.1. NM_064492.1.
NP_496896.1. NM_064495.1.
NP_501203.2. NM_068802.5.
NP_501406.1. NM_069005.1.
NP_502133.1. NM_069732.1.
NP_502139.1. NM_069738.1.
NP_502154.1. NM_069753.3.
NP_505200.1. NM_072799.3.
NP_505275.1. NM_072874.1.
NP_505291.1. NM_072890.1.
NP_505298.1. NM_072897.4.
NP_505466.1. NM_073065.6.
NP_507034.1. NM_074633.1.
NP_509231.1. NM_076830.1.
UniGeneiCel.12858.
Cel.12870.
Cel.17998.
Cel.21434.
Cel.24406.
Cel.24432.
Cel.25563.
Cel.28726.
Cel.28998.
Cel.29185.
Cel.29404.
Cel.32620.
Cel.32860.
Cel.33123.
Cel.770.

3D structure databases

ProteinModelPortaliP62784.
SMRiP62784. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43149. 1 interaction.
44273. 1 interaction.
44379. 2 interactions.
53446. 1 interaction.
56168. 1 interaction.
56177. 1 interaction.
IntActiP62784. 2 interactions.
STRINGi6239.ZK131.8.

Proteomic databases

EPDiP62784.
PaxDbiP62784.
PRIDEiP62784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920.
C50F4.7; C50F4.7; WBGene00001911.
F07B7.9; F07B7.9; WBGene00001924.
F17E9.12; F17E9.12; WBGene00001905.
F22B3.1; F22B3.1; WBGene00001938.
F45F2.3; F45F2.3; WBGene00001879.
F54E12.3; F54E12.3; WBGene00001930.
F55G1.11; F55G1.11; WBGene00001934.
K03A1.6; K03A1.6; WBGene00001912.
K06C4.10; K06C4.10; WBGene00001892.
K06C4.2; K06C4.2; WBGene00001902.
T10C6.14; T10C6.14; WBGene00001875.
T23D8.5; T23D8.5; WBGene00001941.
ZK131.1; ZK131.1; WBGene00001900.
ZK131.4; ZK131.4; WBGene00001884.
ZK131.8; ZK131.8; WBGene00001888.
GeneIDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
KEGGicel:CELE_B0035.9.
cel:CELE_C50F4.7.
cel:CELE_F07B7.9.
cel:CELE_F17E9.12.
cel:CELE_F22B3.1.
cel:CELE_F45F2.3.
cel:CELE_F54E12.3.
cel:CELE_F55G1.11.
cel:CELE_K03A1.6.
cel:CELE_K06C4.10.
cel:CELE_K06C4.2.
cel:CELE_T10C6.14.
cel:CELE_T23D8.5.
cel:CELE_ZK131.1.
cel:CELE_ZK131.4.
cel:CELE_ZK131.8.
UCSCiT23D8.5. c. elegans.

Organism-specific databases

CTDi175027.
175032.
177522.
178050.
178055.
178066.
179233.
179260.
179264.
179267.
179341.
188792.
191667.
191671.
191677.
191680.
WormBaseiB0035.9; CE03252; WBGene00001920; his-46.
C50F4.7; CE03252; WBGene00001911; his-37.
F07B7.9; CE03252; WBGene00001924; his-50.
F17E9.12; CE03252; WBGene00001905; his-31.
F22B3.1; CE03252; WBGene00001938; his-64.
F45F2.3; CE03252; WBGene00001879; his-5.
F54E12.3; CE03252; WBGene00001930; his-56.
F55G1.11; CE03252; WBGene00001934; his-60.
K03A1.6; CE03252; WBGene00001912; his-38.
K06C4.10; CE03252; WBGene00001892; his-18.
K06C4.2; CE03252; WBGene00001902; his-28.
T10C6.14; CE03252; WBGene00001875; his-1.
T23D8.5; CE03252; WBGene00001941; his-67.
ZK131.1; CE03252; WBGene00001900; his-26.
ZK131.4; CE03252; WBGene00001884; his-10.
ZK131.8; CE03252; WBGene00001888; his-14.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
InParanoidiP62784.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG77T174.
PhylomeDBiP62784.

Enzyme and pathway databases

ReactomeiR-CEL-3214841. PKMTs methylate histone lysines.
R-CEL-3214842. HDMs demethylate histones.
R-CEL-3214847. HATs acetylate histones.
R-CEL-3214858. RMTs methylate histone arginines.

Miscellaneous databases

NextBioi886464.
PROiP62784.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements."
    Roberts S.B., Emmons S.W., Childs G.
    J. Mol. Biol. 206:567-577(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The primary structure of histone H4 from the nematode Caenorhabditis elegans."
    Vanfleteren J.R., van Bun S.M., van Beeumen J.J.
    Comp. Biochem. Physiol. 87B:847-849(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-103, ACETYLATION AT SER-2, METHYLATION AT LYS-21.

Entry informationi

Entry nameiH4_CAEEL
AccessioniPrimary (citable) accession number: P62784
Secondary accession number(s): O02619
, P02306, P18678, Q7JNV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.