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Protein

Myotrophin

Gene

Mtpn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity2 Publications

GO - Molecular functioni

  • sequence-specific DNA binding Source: RGD

GO - Biological processi

  • catecholamine metabolic process Source: RGD
  • cell growth Source: Ensembl
  • cellular response to mechanical stimulus Source: RGD
  • cerebellar granule cell differentiation Source: RGD
  • neuron differentiation Source: UniProtKB
  • positive regulation of cardiac muscle hypertrophy Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of macromolecule biosynthetic process Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of protein metabolic process Source: UniProtKB
  • regulation of barbed-end actin filament capping Source: UniProtKB
  • skeletal muscle tissue regeneration Source: RGD
  • striated muscle cell differentiation Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619806. Mtpn.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytoplasm Source: RGD
  • cytosol Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • F-actin capping protein complex Source: Ensembl
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33E → A: Reduced interaction with RELA. Reduced translocation to the nucleus. Reduced activation of NF-kappa-B transcription factor activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000670332 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine1 Publication1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei11N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei31PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62775.
PRIDEiP62775.

PTM databases

iPTMnetiP62775.
PhosphoSitePlusiP62775.

Expressioni

Developmental stagei

At the completion of differentiation and migration of granular cells and at the initiation of the formation of synapses in cerebellar neurons.

Gene expression databases

BgeeiENSRNOG00000011857.
GenevisibleiP62775. RN.

Interactioni

Subunit structurei

Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity). Interacts with RELA.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CapzbQ5XI323EBI-2128047,EBI-2128068

Protein-protein interaction databases

IntActiP62775. 1 interactor.
MINTiMINT-254002.
STRINGi10116.ENSRNOP00000015808.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9
Helixi15 – 22Combined sources8
Turni23 – 25Combined sources3
Beta strandi32 – 35Combined sources4
Helixi40 – 45Combined sources6
Turni47 – 49Combined sources3
Helixi50 – 56Combined sources7
Turni60 – 62Combined sources3
Beta strandi65 – 67Combined sources3
Helixi71 – 76Combined sources6
Helixi82 – 88Combined sources7
Beta strandi94 – 100Combined sources7
Helixi102 – 106Combined sources5
Turni111 – 113Combined sources3
Helixi114 – 117Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MYONMR-A1-118[»]
2MYONMR-A1-118[»]
ProteinModelPortaliP62775.
SMRiP62775.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62775.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62775.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP62775.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26179 mRNA. Translation: BAA05167.1.
U21661 mRNA. Translation: AAC52498.1.
AY951952 mRNA. Translation: AAX54865.1.
BC088136 mRNA. Translation: AAH88136.1.
PIRiA54412.
RefSeqiNP_077350.1. NM_024374.4.
UniGeneiRn.3239.

Genome annotation databases

EnsembliENSRNOT00000015808; ENSRNOP00000015808; ENSRNOG00000011857.
GeneIDi79215.
KEGGirno:79215.
UCSCiRGD:619806. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26179 mRNA. Translation: BAA05167.1.
U21661 mRNA. Translation: AAC52498.1.
AY951952 mRNA. Translation: AAX54865.1.
BC088136 mRNA. Translation: AAH88136.1.
PIRiA54412.
RefSeqiNP_077350.1. NM_024374.4.
UniGeneiRn.3239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MYONMR-A1-118[»]
2MYONMR-A1-118[»]
ProteinModelPortaliP62775.
SMRiP62775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62775. 1 interactor.
MINTiMINT-254002.
STRINGi10116.ENSRNOP00000015808.

PTM databases

iPTMnetiP62775.
PhosphoSitePlusiP62775.

Proteomic databases

PaxDbiP62775.
PRIDEiP62775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015808; ENSRNOP00000015808; ENSRNOG00000011857.
GeneIDi79215.
KEGGirno:79215.
UCSCiRGD:619806. rat.

Organism-specific databases

CTDi136319.
RGDi619806. Mtpn.

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62775.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP62775.
TreeFamiTF327387.

Miscellaneous databases

EvolutionaryTraceiP62775.
PROiP62775.

Gene expression databases

BgeeiENSRNOG00000011857.
GenevisibleiP62775. RN.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_RAT
AccessioniPrimary (citable) accession number: P62775
Secondary accession number(s): P80144, Q58HB3, Q9DCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.