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Protein

Myotrophin

Gene

Mtpn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99445. Mtpn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 118117MyotrophinPRO_0000067032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteine1 Publication
Modified residuei4 – 41N6-acetyllysine1 Publication
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62774.
PaxDbiP62774.
PRIDEiP62774.

PTM databases

PhosphoSiteiP62774.

Expressioni

Gene expression databases

BgeeiP62774.
CleanExiMM_MTPN.
GenevisibleiP62774. MM.

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

Protein-protein interaction databases

IntActiP62774. 3 interactions.
MINTiMINT-4102563.
STRINGi10090.ENSMUSP00000031866.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 75Combined sources
Helixi9 – 124Combined sources
Helixi15 – 228Combined sources
Turni23 – 253Combined sources
Beta strandi32 – 354Combined sources
Helixi40 – 456Combined sources
Turni47 – 493Combined sources
Helixi53 – 564Combined sources
Turni60 – 623Combined sources
Helixi71 – 766Combined sources
Helixi82 – 887Combined sources
Beta strandi96 – 1016Combined sources
Helixi102 – 1065Combined sources
Helixi111 – 1144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774.
SMRiP62774. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3029ANK 1Add
BLAST
Repeati34 – 6633ANK 2Add
BLAST
Repeati67 – 9933ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62774.
OMAiKELMWAL.
OrthoDBiEOG7SBNQP.
PhylomeDBiP62774.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → K in BAB22235 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA. Translation: AAA86719.1.
AK002620 mRNA. Translation: BAB22235.1.
AK028027 mRNA. Translation: BAC25707.1.
AK049398 mRNA. Translation: BAC33734.1.
AK083888 mRNA. Translation: BAC39050.1.
AK132029 mRNA. Translation: BAE20953.1.
AK145755 mRNA. Translation: BAE26630.1.
AK146305 mRNA. Translation: BAE27061.1.
AK146473 mRNA. Translation: BAE27198.1.
AK150750 mRNA. Translation: BAE29820.1.
AK151106 mRNA. Translation: BAE30116.1.
AK151147 mRNA. Translation: BAE30153.1.
AK151485 mRNA. Translation: BAE30438.1.
AK151564 mRNA. Translation: BAE30506.1.
AK151640 mRNA. Translation: BAE30570.1.
AK151687 mRNA. Translation: BAE30611.1.
AK152272 mRNA. Translation: BAE31088.1.
BC043084 mRNA. Translation: AAH43084.1.
BC054811 mRNA. Translation: AAH54811.1.
CCDSiCCDS20002.1.
RefSeqiNP_032124.1. NM_008098.4.
UniGeneiMm.182746.

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
GeneIDi14489.
KEGGimmu:14489.
UCSCiuc009bit.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA. Translation: AAA86719.1.
AK002620 mRNA. Translation: BAB22235.1.
AK028027 mRNA. Translation: BAC25707.1.
AK049398 mRNA. Translation: BAC33734.1.
AK083888 mRNA. Translation: BAC39050.1.
AK132029 mRNA. Translation: BAE20953.1.
AK145755 mRNA. Translation: BAE26630.1.
AK146305 mRNA. Translation: BAE27061.1.
AK146473 mRNA. Translation: BAE27198.1.
AK150750 mRNA. Translation: BAE29820.1.
AK151106 mRNA. Translation: BAE30116.1.
AK151147 mRNA. Translation: BAE30153.1.
AK151485 mRNA. Translation: BAE30438.1.
AK151564 mRNA. Translation: BAE30506.1.
AK151640 mRNA. Translation: BAE30570.1.
AK151687 mRNA. Translation: BAE30611.1.
AK152272 mRNA. Translation: BAE31088.1.
BC043084 mRNA. Translation: AAH43084.1.
BC054811 mRNA. Translation: AAH54811.1.
CCDSiCCDS20002.1.
RefSeqiNP_032124.1. NM_008098.4.
UniGeneiMm.182746.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774.
SMRiP62774. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62774. 3 interactions.
MINTiMINT-4102563.
STRINGi10090.ENSMUSP00000031866.

PTM databases

PhosphoSiteiP62774.

Proteomic databases

MaxQBiP62774.
PaxDbiP62774.
PRIDEiP62774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
GeneIDi14489.
KEGGimmu:14489.
UCSCiuc009bit.2. mouse.

Organism-specific databases

CTDi136319.
MGIiMGI:99445. Mtpn.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62774.
OMAiKELMWAL.
OrthoDBiEOG7SBNQP.
PhylomeDBiP62774.
TreeFamiTF327387.

Miscellaneous databases

ChiTaRSiMtpn. mouse.
NextBioi286160.
PROiP62774.
SOURCEiSearch...

Gene expression databases

BgeeiP62774.
CleanExiMM_MTPN.
GenevisibleiP62774. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones encoding the mouse protein V-1."
    Pennica D., Shaw K.J., Luoh S., Wood W.I.
    Gene 158:305-306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Bone marrow, Kidney, Spinal ganglion and Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. "Structural basis for capping protein sequestration by myotrophin (V-1)."
    Zwolak A., Fujiwara I., Hammer J.A. III, Tjandra N.
    J. Biol. Chem. 285:25767-25781(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH CAPZA1 AND CAPZB, FUNCTION.

Entry informationi

Entry nameiMTPN_MOUSE
AccessioniPrimary (citable) accession number: P62774
Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.