Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myotrophin

Gene

Mtpn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99445. Mtpn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 118117MyotrophinPRO_0000067032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteineCombined sources
Modified residuei4 – 41N6-acetyllysineCombined sources
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei31 – 311PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62774.
MaxQBiP62774.
PaxDbiP62774.
PeptideAtlasiP62774.
PRIDEiP62774.

PTM databases

iPTMnetiP62774.
PhosphoSiteiP62774.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029840.
CleanExiMM_MTPN.
ExpressionAtlasiP62774. baseline and differential.
GenevisibleiP62774. MM.

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

Protein-protein interaction databases

IntActiP62774. 3 interactions.
MINTiMINT-4102563.
STRINGi10090.ENSMUSP00000031866.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 75Combined sources
Helixi9 – 124Combined sources
Helixi15 – 228Combined sources
Turni23 – 253Combined sources
Beta strandi32 – 354Combined sources
Helixi40 – 456Combined sources
Turni47 – 493Combined sources
Helixi53 – 564Combined sources
Turni60 – 623Combined sources
Helixi71 – 766Combined sources
Helixi82 – 887Combined sources
Beta strandi96 – 1016Combined sources
Helixi102 – 1065Combined sources
Helixi111 – 1144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774.
SMRiP62774. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3029ANK 1Add
BLAST
Repeati34 – 6633ANK 2Add
BLAST
Repeati67 – 9933ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62774.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP62774.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → K in BAB22235 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA. Translation: AAA86719.1.
AK002620 mRNA. Translation: BAB22235.1.
AK028027 mRNA. Translation: BAC25707.1.
AK049398 mRNA. Translation: BAC33734.1.
AK083888 mRNA. Translation: BAC39050.1.
AK132029 mRNA. Translation: BAE20953.1.
AK145755 mRNA. Translation: BAE26630.1.
AK146305 mRNA. Translation: BAE27061.1.
AK146473 mRNA. Translation: BAE27198.1.
AK150750 mRNA. Translation: BAE29820.1.
AK151106 mRNA. Translation: BAE30116.1.
AK151147 mRNA. Translation: BAE30153.1.
AK151485 mRNA. Translation: BAE30438.1.
AK151564 mRNA. Translation: BAE30506.1.
AK151640 mRNA. Translation: BAE30570.1.
AK151687 mRNA. Translation: BAE30611.1.
AK152272 mRNA. Translation: BAE31088.1.
BC043084 mRNA. Translation: AAH43084.1.
BC054811 mRNA. Translation: AAH54811.1.
CCDSiCCDS20002.1.
RefSeqiNP_032124.1. NM_008098.4.
UniGeneiMm.182746.

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
GeneIDi14489.
KEGGimmu:14489.
UCSCiuc009bit.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA. Translation: AAA86719.1.
AK002620 mRNA. Translation: BAB22235.1.
AK028027 mRNA. Translation: BAC25707.1.
AK049398 mRNA. Translation: BAC33734.1.
AK083888 mRNA. Translation: BAC39050.1.
AK132029 mRNA. Translation: BAE20953.1.
AK145755 mRNA. Translation: BAE26630.1.
AK146305 mRNA. Translation: BAE27061.1.
AK146473 mRNA. Translation: BAE27198.1.
AK150750 mRNA. Translation: BAE29820.1.
AK151106 mRNA. Translation: BAE30116.1.
AK151147 mRNA. Translation: BAE30153.1.
AK151485 mRNA. Translation: BAE30438.1.
AK151564 mRNA. Translation: BAE30506.1.
AK151640 mRNA. Translation: BAE30570.1.
AK151687 mRNA. Translation: BAE30611.1.
AK152272 mRNA. Translation: BAE31088.1.
BC043084 mRNA. Translation: AAH43084.1.
BC054811 mRNA. Translation: AAH54811.1.
CCDSiCCDS20002.1.
RefSeqiNP_032124.1. NM_008098.4.
UniGeneiMm.182746.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774.
SMRiP62774. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62774. 3 interactions.
MINTiMINT-4102563.
STRINGi10090.ENSMUSP00000031866.

PTM databases

iPTMnetiP62774.
PhosphoSiteiP62774.

Proteomic databases

EPDiP62774.
MaxQBiP62774.
PaxDbiP62774.
PeptideAtlasiP62774.
PRIDEiP62774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
GeneIDi14489.
KEGGimmu:14489.
UCSCiuc009bit.2. mouse.

Organism-specific databases

CTDi136319.
MGIiMGI:99445. Mtpn.

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62774.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP62774.
TreeFamiTF327387.

Miscellaneous databases

ChiTaRSiMtpn. mouse.
PROiP62774.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029840.
CleanExiMM_MTPN.
ExpressionAtlasiP62774. baseline and differential.
GenevisibleiP62774. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_MOUSE
AccessioniPrimary (citable) accession number: P62774
Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.