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P62774

- MTPN_MOUSE

UniProt

P62774 - MTPN_MOUSE

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Protein

Myotrophin

Gene
Mtpn, Gcdp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy By similarity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.1 Publication

GO - Biological processi

  1. catecholamine metabolic process Source: Ensembl
  2. cell growth Source: Ensembl
  3. cerebellar granule cell differentiation Source: Ensembl
  4. positive regulation of cardiac muscle hypertrophy Source: UniProtKB
  5. positive regulation of cell growth Source: UniProtKB
  6. positive regulation of macromolecule biosynthetic process Source: UniProtKB
  7. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  8. positive regulation of protein metabolic process Source: UniProtKB
  9. regulation of barbed-end actin filament capping Source: UniProtKB
  10. skeletal muscle tissue regeneration Source: Ensembl
  11. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99445. Mtpn.

Subcellular locationi

Cytoplasm Inferred. Nucleus By similarity. Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytosol Source: UniProtKB
  3. F-actin capping protein complex Source: Ensembl
  4. nucleus Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 118117MyotrophinPRO_0000067032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteine1 Publication
Modified residuei4 – 41N6-acetyllysine1 Publication
Modified residuei11 – 111N6-acetyllysine By similarity
Modified residuei24 – 241N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62774.
PaxDbiP62774.
PRIDEiP62774.

PTM databases

PhosphoSiteiP62774.

Expressioni

Gene expression databases

BgeeiP62774.
CleanExiMM_MTPN.
GenevestigatoriP62774.

Interactioni

Subunit structurei

Interacts with RELA By similarity. Interacts with the heterodimer formed by CAPZA1 and CAPZB.

Protein-protein interaction databases

IntActiP62774. 3 interactions.
MINTiMINT-4102563.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 75
Helixi9 – 124
Helixi15 – 228
Turni23 – 253
Beta strandi32 – 354
Helixi40 – 456
Turni47 – 493
Helixi53 – 564
Turni60 – 623
Helixi71 – 766
Helixi82 – 887
Beta strandi96 – 1016
Helixi102 – 1065
Helixi111 – 1144

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774.
SMRiP62774. Positions 1-118.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3029ANK 1Add
BLAST
Repeati34 – 6633ANK 2Add
BLAST
Repeati67 – 9933ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the myotrophin family.
Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP62774.
OMAiYEGHVTC.
OrthoDBiEOG7SBNQP.
PhylomeDBiP62774.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62774-1 [UniParc]FASTAAdd to Basket

« Hide

MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI    50
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD 100
GLTALEATDN QAIKALLQ 118
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → K in BAB22235. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20290 mRNA. Translation: AAA86719.1.
AK002620 mRNA. Translation: BAB22235.1.
AK028027 mRNA. Translation: BAC25707.1.
AK049398 mRNA. Translation: BAC33734.1.
AK083888 mRNA. Translation: BAC39050.1.
AK132029 mRNA. Translation: BAE20953.1.
AK145755 mRNA. Translation: BAE26630.1.
AK146305 mRNA. Translation: BAE27061.1.
AK146473 mRNA. Translation: BAE27198.1.
AK150750 mRNA. Translation: BAE29820.1.
AK151106 mRNA. Translation: BAE30116.1.
AK151147 mRNA. Translation: BAE30153.1.
AK151485 mRNA. Translation: BAE30438.1.
AK151564 mRNA. Translation: BAE30506.1.
AK151640 mRNA. Translation: BAE30570.1.
AK151687 mRNA. Translation: BAE30611.1.
AK152272 mRNA. Translation: BAE31088.1.
BC043084 mRNA. Translation: AAH43084.1.
BC054811 mRNA. Translation: AAH54811.1.
CCDSiCCDS20002.1.
RefSeqiNP_032124.1. NM_008098.4.
UniGeneiMm.182746.

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
GeneIDi14489.
KEGGimmu:14489.
UCSCiuc009bit.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20290 mRNA. Translation: AAA86719.1 .
AK002620 mRNA. Translation: BAB22235.1 .
AK028027 mRNA. Translation: BAC25707.1 .
AK049398 mRNA. Translation: BAC33734.1 .
AK083888 mRNA. Translation: BAC39050.1 .
AK132029 mRNA. Translation: BAE20953.1 .
AK145755 mRNA. Translation: BAE26630.1 .
AK146305 mRNA. Translation: BAE27061.1 .
AK146473 mRNA. Translation: BAE27198.1 .
AK150750 mRNA. Translation: BAE29820.1 .
AK151106 mRNA. Translation: BAE30116.1 .
AK151147 mRNA. Translation: BAE30153.1 .
AK151485 mRNA. Translation: BAE30438.1 .
AK151564 mRNA. Translation: BAE30506.1 .
AK151640 mRNA. Translation: BAE30570.1 .
AK151687 mRNA. Translation: BAE30611.1 .
AK152272 mRNA. Translation: BAE31088.1 .
BC043084 mRNA. Translation: AAH43084.1 .
BC054811 mRNA. Translation: AAH54811.1 .
CCDSi CCDS20002.1.
RefSeqi NP_032124.1. NM_008098.4.
UniGenei Mm.182746.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KXP NMR - C 1-118 [» ]
ProteinModelPortali P62774.
SMRi P62774. Positions 1-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P62774. 3 interactions.
MINTi MINT-4102563.

PTM databases

PhosphoSitei P62774.

Proteomic databases

MaxQBi P62774.
PaxDbi P62774.
PRIDEi P62774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031866 ; ENSMUSP00000031866 ; ENSMUSG00000029840 .
GeneIDi 14489.
KEGGi mmu:14489.
UCSCi uc009bit.2. mouse.

Organism-specific databases

CTDi 136319.
MGIi MGI:99445. Mtpn.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00430000031071.
HOGENOMi HOG000276399.
HOVERGENi HBG019067.
InParanoidi P62774.
OMAi YEGHVTC.
OrthoDBi EOG7SBNQP.
PhylomeDBi P62774.
TreeFami TF327387.

Miscellaneous databases

ChiTaRSi MTPN. mouse.
NextBioi 286160.
PROi P62774.
SOURCEi Search...

Gene expression databases

Bgeei P62774.
CleanExi MM_MTPN.
Genevestigatori P62774.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones encoding the mouse protein V-1."
    Pennica D., Shaw K.J., Luoh S., Wood W.I.
    Gene 158:305-306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Bone marrow, Kidney, Spinal ganglion and Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. "Structural basis for capping protein sequestration by myotrophin (V-1)."
    Zwolak A., Fujiwara I., Hammer J.A. III, Tjandra N.
    J. Biol. Chem. 285:25767-25781(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH CAPZA1 AND CAPZB, FUNCTION.

Entry informationi

Entry nameiMTPN_MOUSE
AccessioniPrimary (citable) accession number: P62774
Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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