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Protein

Myotrophin

Gene

Mtpn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99445 Mtpn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000670322 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei11N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei31PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62774
MaxQBiP62774
PaxDbiP62774
PeptideAtlasiP62774
PRIDEiP62774

PTM databases

iPTMnetiP62774
PhosphoSitePlusiP62774
SwissPalmiP62774

Expressioni

Gene expression databases

BgeeiENSMUSG00000029840
CleanExiMM_MTPN
ExpressionAtlasiP62774 baseline and differential
GenevisibleiP62774 MM

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

Protein-protein interaction databases

BioGridi199860, 1 interactor
IntActiP62774, 3 interactors
MINTiP62774
STRINGi10090.ENSMUSP00000031866

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 7Combined sources5
Helixi9 – 12Combined sources4
Helixi15 – 22Combined sources8
Turni23 – 25Combined sources3
Beta strandi32 – 35Combined sources4
Helixi40 – 45Combined sources6
Turni47 – 49Combined sources3
Helixi53 – 56Combined sources4
Turni60 – 62Combined sources3
Helixi71 – 76Combined sources6
Helixi82 – 88Combined sources7
Beta strandi96 – 101Combined sources6
Helixi102 – 106Combined sources5
Helixi111 – 114Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774
SMRiP62774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiP62774
OMAiKNIDVNQ
OrthoDBiEOG091G0Y4J
PhylomeDBiP62774
TreeFamiTF327387

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → K in BAB22235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA Translation: AAA86719.1
AK002620 mRNA Translation: BAB22235.1
AK028027 mRNA Translation: BAC25707.1
AK049398 mRNA Translation: BAC33734.1
AK083888 mRNA Translation: BAC39050.1
AK132029 mRNA Translation: BAE20953.1
AK145755 mRNA Translation: BAE26630.1
AK146305 mRNA Translation: BAE27061.1
AK146473 mRNA Translation: BAE27198.1
AK150750 mRNA Translation: BAE29820.1
AK151106 mRNA Translation: BAE30116.1
AK151147 mRNA Translation: BAE30153.1
AK151485 mRNA Translation: BAE30438.1
AK151564 mRNA Translation: BAE30506.1
AK151640 mRNA Translation: BAE30570.1
AK151687 mRNA Translation: BAE30611.1
AK152272 mRNA Translation: BAE31088.1
BC043084 mRNA Translation: AAH43084.1
BC054811 mRNA Translation: AAH54811.1
CCDSiCCDS20002.1
RefSeqiNP_032124.1, NM_008098.4
UniGeneiMm.182746

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840
GeneIDi14489
KEGGimmu:14489
UCSCiuc009bit.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMTPN_MOUSE
AccessioniPrimary (citable) accession number: P62774
Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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