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P62774

- MTPN_MOUSE

UniProt

P62774 - MTPN_MOUSE

Protein

Myotrophin

Gene

Mtpn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy By similarity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

    GO - Biological processi

    1. catecholamine metabolic process Source: Ensembl
    2. cell growth Source: Ensembl
    3. cerebellar granule cell differentiation Source: Ensembl
    4. positive regulation of cardiac muscle hypertrophy Source: UniProtKB
    5. positive regulation of cell growth Source: UniProtKB
    6. positive regulation of macromolecule biosynthetic process Source: UniProtKB
    7. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    8. positive regulation of protein metabolic process Source: UniProtKB
    9. regulation of barbed-end actin filament capping Source: UniProtKB
    10. skeletal muscle tissue regeneration Source: Ensembl
    11. striated muscle cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotrophin
    Alternative name(s):
    Granule cell differentiation protein
    Protein V-1
    Gene namesi
    Name:Mtpn
    Synonyms:Gcdp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:99445. Mtpn.

    Subcellular locationi

    Cytoplasm Curated. Nucleus By similarity. Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: UniProtKB
    3. F-actin capping protein complex Source: Ensembl
    4. nucleus Source: UniProtKB
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 118117MyotrophinPRO_0000067032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylcysteine1 Publication
    Modified residuei4 – 41N6-acetyllysine1 Publication
    Modified residuei11 – 111N6-acetyllysineBy similarity
    Modified residuei24 – 241N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP62774.
    PaxDbiP62774.
    PRIDEiP62774.

    PTM databases

    PhosphoSiteiP62774.

    Expressioni

    Gene expression databases

    BgeeiP62774.
    CleanExiMM_MTPN.
    GenevestigatoriP62774.

    Interactioni

    Subunit structurei

    Interacts with RELA By similarity. Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

    Protein-protein interaction databases

    IntActiP62774. 3 interactions.
    MINTiMINT-4102563.

    Structurei

    Secondary structure

    1
    118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 75
    Helixi9 – 124
    Helixi15 – 228
    Turni23 – 253
    Beta strandi32 – 354
    Helixi40 – 456
    Turni47 – 493
    Helixi53 – 564
    Turni60 – 623
    Helixi71 – 766
    Helixi82 – 887
    Beta strandi96 – 1016
    Helixi102 – 1065
    Helixi111 – 1144

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KXPNMR-C1-118[»]
    ProteinModelPortaliP62774.
    SMRiP62774. Positions 1-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 3029ANK 1Add
    BLAST
    Repeati34 – 6633ANK 2Add
    BLAST
    Repeati67 – 9933ANK 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the myotrophin family.Curated
    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00430000031071.
    HOGENOMiHOG000276399.
    HOVERGENiHBG019067.
    InParanoidiP62774.
    OMAiYEGHVTC.
    OrthoDBiEOG7SBNQP.
    PhylomeDBiP62774.
    TreeFamiTF327387.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI    50
    LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD 100
    GLTALEATDN QAIKALLQ 118
    Length:118
    Mass (Da):12,861
    Last modified:January 23, 2007 - v2
    Checksum:i9097FFDF61DB8BA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261E → K in BAB22235. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20290 mRNA. Translation: AAA86719.1.
    AK002620 mRNA. Translation: BAB22235.1.
    AK028027 mRNA. Translation: BAC25707.1.
    AK049398 mRNA. Translation: BAC33734.1.
    AK083888 mRNA. Translation: BAC39050.1.
    AK132029 mRNA. Translation: BAE20953.1.
    AK145755 mRNA. Translation: BAE26630.1.
    AK146305 mRNA. Translation: BAE27061.1.
    AK146473 mRNA. Translation: BAE27198.1.
    AK150750 mRNA. Translation: BAE29820.1.
    AK151106 mRNA. Translation: BAE30116.1.
    AK151147 mRNA. Translation: BAE30153.1.
    AK151485 mRNA. Translation: BAE30438.1.
    AK151564 mRNA. Translation: BAE30506.1.
    AK151640 mRNA. Translation: BAE30570.1.
    AK151687 mRNA. Translation: BAE30611.1.
    AK152272 mRNA. Translation: BAE31088.1.
    BC043084 mRNA. Translation: AAH43084.1.
    BC054811 mRNA. Translation: AAH54811.1.
    CCDSiCCDS20002.1.
    RefSeqiNP_032124.1. NM_008098.4.
    UniGeneiMm.182746.

    Genome annotation databases

    EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840.
    GeneIDi14489.
    KEGGimmu:14489.
    UCSCiuc009bit.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20290 mRNA. Translation: AAA86719.1 .
    AK002620 mRNA. Translation: BAB22235.1 .
    AK028027 mRNA. Translation: BAC25707.1 .
    AK049398 mRNA. Translation: BAC33734.1 .
    AK083888 mRNA. Translation: BAC39050.1 .
    AK132029 mRNA. Translation: BAE20953.1 .
    AK145755 mRNA. Translation: BAE26630.1 .
    AK146305 mRNA. Translation: BAE27061.1 .
    AK146473 mRNA. Translation: BAE27198.1 .
    AK150750 mRNA. Translation: BAE29820.1 .
    AK151106 mRNA. Translation: BAE30116.1 .
    AK151147 mRNA. Translation: BAE30153.1 .
    AK151485 mRNA. Translation: BAE30438.1 .
    AK151564 mRNA. Translation: BAE30506.1 .
    AK151640 mRNA. Translation: BAE30570.1 .
    AK151687 mRNA. Translation: BAE30611.1 .
    AK152272 mRNA. Translation: BAE31088.1 .
    BC043084 mRNA. Translation: AAH43084.1 .
    BC054811 mRNA. Translation: AAH54811.1 .
    CCDSi CCDS20002.1.
    RefSeqi NP_032124.1. NM_008098.4.
    UniGenei Mm.182746.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KXP NMR - C 1-118 [» ]
    ProteinModelPortali P62774.
    SMRi P62774. Positions 1-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P62774. 3 interactions.
    MINTi MINT-4102563.

    PTM databases

    PhosphoSitei P62774.

    Proteomic databases

    MaxQBi P62774.
    PaxDbi P62774.
    PRIDEi P62774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031866 ; ENSMUSP00000031866 ; ENSMUSG00000029840 .
    GeneIDi 14489.
    KEGGi mmu:14489.
    UCSCi uc009bit.2. mouse.

    Organism-specific databases

    CTDi 136319.
    MGIi MGI:99445. Mtpn.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00430000031071.
    HOGENOMi HOG000276399.
    HOVERGENi HBG019067.
    InParanoidi P62774.
    OMAi YEGHVTC.
    OrthoDBi EOG7SBNQP.
    PhylomeDBi P62774.
    TreeFami TF327387.

    Miscellaneous databases

    ChiTaRSi MTPN. mouse.
    NextBioi 286160.
    PROi P62774.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62774.
    CleanExi MM_MTPN.
    Genevestigatori P62774.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA clones encoding the mouse protein V-1."
      Pennica D., Shaw K.J., Luoh S., Wood W.I.
      Gene 158:305-306(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Bone marrow, Kidney, Spinal ganglion and Stomach.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    5. "Structural basis for capping protein sequestration by myotrophin (V-1)."
      Zwolak A., Fujiwara I., Hammer J.A. III, Tjandra N.
      J. Biol. Chem. 285:25767-25781(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR IN COMPLEX WITH CAPZA1 AND CAPZB, FUNCTION.

    Entry informationi

    Entry nameiMTPN_MOUSE
    AccessioniPrimary (citable) accession number: P62774
    Secondary accession number(s): P80144, Q543M6, Q9DCN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3