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Protein

Visinin-like protein 1

Gene

VSNL1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi159 – 1703PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visinin-like protein 1
Short name:
VILIP
Alternative name(s):
OZ1
Gene namesi
Name:VSNL1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737662 – 191Visinin-like protein 1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP62764.
PRIDEiP62764.

Expressioni

Tissue specificityi

Widely expressed in the brain but not detectable in liver, heart or skeletal muscle.1 Publication

Gene expression databases

BgeeiENSGALG00000016464.

Interactioni

Protein-protein interaction databases

BioGridi676449. 2 interactors.
IntActiP62764. 1 interactor.
STRINGi9031.ENSGALP00000026514.

Structurei

3D structure databases

ProteinModelPortaliP62764.
SMRiP62764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini146 – 181EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62764.
KOiK19936.
OMAiAEHAFRT.
OrthoDBiEOG091G11T4.
PhylomeDBiP62764.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ
60 70 80 90 100
LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK
110 120 130 140 150
LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR
160 170 180 190
VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
Length:191
Mass (Da):22,142
Last modified:January 23, 2007 - v2
Checksum:iACDC3B4FE8C79265
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63530 mRNA. Translation: CAA45093.1.
PIRiA48979.
RefSeqiNP_990586.1. NM_205255.1.
XP_015140438.1. XM_015284952.1.
XP_015140439.1. XM_015284953.1.
XP_015140440.1. XM_015284954.1.
XP_015140441.1. XM_015284955.1.
XP_015140442.1. XM_015284956.1.
UniGeneiGga.10425.

Genome annotation databases

EnsembliENSGALT00000026565; ENSGALP00000026514; ENSGALG00000016464.
GeneIDi396189.
KEGGigga:396189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63530 mRNA. Translation: CAA45093.1.
PIRiA48979.
RefSeqiNP_990586.1. NM_205255.1.
XP_015140438.1. XM_015284952.1.
XP_015140439.1. XM_015284953.1.
XP_015140440.1. XM_015284954.1.
XP_015140441.1. XM_015284955.1.
XP_015140442.1. XM_015284956.1.
UniGeneiGga.10425.

3D structure databases

ProteinModelPortaliP62764.
SMRiP62764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676449. 2 interactors.
IntActiP62764. 1 interactor.
STRINGi9031.ENSGALP00000026514.

Proteomic databases

PaxDbiP62764.
PRIDEiP62764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000026565; ENSGALP00000026514; ENSGALG00000016464.
GeneIDi396189.
KEGGigga:396189.

Organism-specific databases

CTDi7447.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62764.
KOiK19936.
OMAiAEHAFRT.
OrthoDBiEOG091G11T4.
PhylomeDBiP62764.
TreeFamiTF300009.

Miscellaneous databases

PROiP62764.

Gene expression databases

BgeeiENSGALG00000016464.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVISL1_CHICK
AccessioniPrimary (citable) accession number: P62764
Secondary accession number(s): P28677
, P29103, P42323, Q9UM20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds three calcium ions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.