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Protein

Visinin-like protein 1

Gene

VSNL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

Miscellaneous

Probably binds three calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi159 – 1703PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visinin-like protein 1
Alternative name(s):
Neurocalcin-alpha
Gene namesi
Name:VSNL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:36841 VSNL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737622 – 191Visinin-like protein 1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP62763
PRIDEiP62763

Expressioni

Tissue specificityi

Brain and retina. Neuron-specific in the central and peripheral nervous system.

Gene expression databases

BgeeiENSBTAG00000017158

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022814

Structurei

3D structure databases

ProteinModelPortaliP62763
SMRiP62763
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini146 – 181EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP62763
KOiK19936
OMAiDRIFSKM
OrthoDBiEOG091G11T4
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029533 VILIP-1
PANTHERiPTHR23055:SF113 PTHR23055:SF113, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ
60 70 80 90 100
LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK
110 120 130 140 150
LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR
160 170 180 190
VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
Length:191
Mass (Da):22,142
Last modified:January 23, 2007 - v2
Checksum:iACDC3B4FE8C79265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25H → A AA sequence (PubMed:1527077).Curated1
Sequence conflicti118R → P AA sequence (PubMed:1527077).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006006 mRNA Translation: BAA28716.1
BC103271 mRNA Translation: AAI03272.1
RefSeqiNP_776915.1, NM_174490.3
UniGeneiBt.49702

Genome annotation databases

EnsembliENSBTAT00000022814; ENSBTAP00000022814; ENSBTAG00000017158
GeneIDi282124
KEGGibta:282124

Similar proteinsi

Entry informationi

Entry nameiVISL1_BOVIN
AccessioniPrimary (citable) accession number: P62763
Secondary accession number(s): P28677
, P29103, P42323, Q3ZBI8, Q9UM20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health