ID VISL1_MOUSE Reviewed; 191 AA. AC P62761; P28677; P29103; P42323; Q9UM20; DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 24-JAN-2024, entry version 147. DE RecName: Full=Visinin-like protein 1; DE Short=VILIP; DE AltName: Full=Neural visinin-like protein 1; DE Short=NVL-1; DE Short=NVP-1; GN Name=Vsnl1; Synonyms=Visl1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; RA Shirai Y., Asami M., Mukai H., Chang C., Shuntoh H., Kuno T., Tanaka C.; RT "cDNA cloning and primary structure of mouse neural visinin-like CA2+- RT binding protein type 1 (NVP-1)."; RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/cJ; TISSUE=Brain; RA Anton B., Matus M., Leff P., Calva J.C., Acevedo R., Hernandez A., RA Medecigo M., Valdez A., Sanchez Lopez R., Vergara P., Torner C., RA Segovia J., Alagon A.; RT "Searching for the endomorphin-1-2 pro-peptide precursor(s) protein(s): RT cloning of a protein encoding an endomorphin-2-like peptide sequence."; RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PROTEIN SEQUENCE OF 8-18; 43-63 AND 119-150, AND IDENTIFICATION BY MASS RP SPECTROMETRY. RC STRAIN=C57BL/6J; TISSUE=Brain; RA Lubec G., Kang S.U.; RL Submitted (APR-2007) to UniProtKB. RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Regulates (in vitro) the inhibition of rhodopsin CC phosphorylation in a calcium-dependent manner. {ECO:0000250}. CC -!- MISCELLANEOUS: Probably binds three calcium ions. CC -!- SIMILARITY: Belongs to the recoverin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D21165; BAA04701.1; -; mRNA. DR EMBL; AY101375; AAM48292.1; -; mRNA. DR EMBL; BC046226; AAH46226.1; -; mRNA. DR CCDS; CCDS25816.1; -. DR RefSeq; NP_036168.1; NM_012038.4. DR AlphaFoldDB; P62761; -. DR SMR; P62761; -. DR BioGRID; 205085; 5. DR IntAct; P62761; 1. DR MINT; P62761; -. DR STRING; 10090.ENSMUSP00000072145; -. DR GlyGen; P62761; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P62761; -. DR PhosphoSitePlus; P62761; -. DR SwissPalm; P62761; -. DR PaxDb; 10090-ENSMUSP00000072145; -. DR PeptideAtlas; P62761; -. DR ProteomicsDB; 297922; -. DR Antibodypedia; 27025; 1599 antibodies from 35 providers. DR DNASU; 26950; -. DR Ensembl; ENSMUST00000072299.7; ENSMUSP00000072145.6; ENSMUSG00000054459.9. DR Ensembl; ENSMUST00000220506.2; ENSMUSP00000152711.2; ENSMUSG00000054459.9. DR GeneID; 26950; -. DR KEGG; mmu:26950; -. DR UCSC; uc011ykf.1; mouse. DR AGR; MGI:1349453; -. DR CTD; 7447; -. DR MGI; MGI:1349453; Vsnl1. DR VEuPathDB; HostDB:ENSMUSG00000054459; -. DR eggNOG; KOG0044; Eukaryota. DR GeneTree; ENSGT00940000156513; -. DR HOGENOM; CLU_072366_1_0_1; -. DR InParanoid; P62761; -. DR OMA; HISRREM; -. DR OrthoDB; 339700at2759; -. DR PhylomeDB; P62761; -. DR TreeFam; TF300009; -. DR BioGRID-ORCS; 26950; 2 hits in 79 CRISPR screens. DR ChiTaRS; Vsnl1; mouse. DR PRO; PR:P62761; -. DR Proteomes; UP000000589; Chromosome 12. DR RNAct; P62761; Protein. DR Bgee; ENSMUSG00000054459; Expressed in retrosplenial region and 162 other cell types or tissues. DR ExpressionAtlas; P62761; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:MGI. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central. DR GO; GO:0046676; P:negative regulation of insulin secretion; IMP:MGI. DR GO; GO:0045921; P:positive regulation of exocytosis; IDA:MGI. DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IDA:MGI. DR CDD; cd00051; EFh; 2. DR Gene3D; 1.10.238.10; EF-hand; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR028846; Recoverin. DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1. DR PANTHER; PTHR23055:SF101; VISININ-LIKE PROTEIN 1; 1. DR Pfam; PF00036; EF-hand_1; 1. DR Pfam; PF13499; EF-hand_7; 1. DR PRINTS; PR00450; RECOVERIN. DR SMART; SM00054; EFh; 3. DR SUPFAM; SSF47473; EF-hand; 1. DR PROSITE; PS00018; EF_HAND_1; 3. DR PROSITE; PS50222; EF_HAND_2; 4. DR Genevisible; P62761; MM. PE 1: Evidence at protein level; KW Calcium; Direct protein sequencing; Lipoprotein; Metal-binding; Myristate; KW Reference proteome; Repeat. FT INIT_MET 1 FT /note="Removed" FT CHAIN 2..191 FT /note="Visinin-like protein 1" FT /id="PRO_0000073764" FT DOMAIN 40..58 FT /note="EF-hand 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 60..95 FT /note="EF-hand 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 96..131 FT /note="EF-hand 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 146..181 FT /note="EF-hand 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 73 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 75 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 77 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 79 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 84 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 109 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 111 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 113 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 115 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 120 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 159 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 161 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 163 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 165 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 170 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT LIPID 2 FT /note="N-myristoyl glycine" FT /evidence="ECO:0000250" SQ SEQUENCE 191 AA; 22142 MW; ACDC3B4FE8C79265 CRC64; MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K //